Cited by 880Sarcoma Diagnosis and TreatmentChromatin Remodeling and CancerAcute Lymphoblastic Leukemia research

The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.

Ewing sarcoma

Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta·2018·Nature Reviews Disease Primers

DOI 10.1038/s41572-018-0003-x

Open this paper in CoChat — free account

Abstract

Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic disease. Treatment comprises local surgery, radiotherapy and polychemotherapy, which are associated with acute and chronic adverse effects that may compromise quality of life in survivors. Histologically, Ewing sarcomas are composed of small round cells expressing high levels of CD99. Genetically, they are characterized by balanced chromosomal translocations in which a member of the FET gene family is fused with an ETS transcription factor, with the most common fusion being EWSR1-FLI1 (85% of cases). Ewing sarcoma breakpoint region 1 protein (EWSR1)-Friend leukaemia integration 1 transcription factor (FLI1) is a tumour-specific chimeric transcription factor (EWSR1-FLI1) with neomorphic effects that massively rewires the transcriptome. Additionally, EWSR1-FLI1 reprogrammes the epigenome by inducing de novo enhancers at GGAA microsatellites and by altering the state of gene regulatory elements, creating a unique epigenetic signature. Additional mutations at diagnosis are rare and mainly involve STAG2, TP53 and CDKN2A deletions. Emerging studies on the molecular mechanisms of Ewing sarcoma hold promise for improvements in early detection, disease monitoring, lower treatment-related toxicity, overall survival and quality of life.

Integrity signals

Registry

Crossref · 10.1038/s41572-018-0003-x

Cites

251 of 251 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED ARTICLE: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Javaheri, T., Kazemi, Z., Pěnčík, J., Pham, H. T., Kauer, M. O., Noorizadeh, R., Sax, B., Nivarthi, H., Schlederer, M., Maurer, B., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.268 · Cited by 18
Self-citation
Retracted
Bone marrow transplant
Szer, J. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127745.x · Cited by 3,373
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., et al. (1992) · Nature · doi:10.1038/359162a0 · Cited by 1,907
Self-citation
Targeting EZH2 in cancer
Kim, K. H., & Roberts, C. W. M. (2016) · Nature Medicine · doi:10.1038/nm.4036 · Cited by 1,471
Germline Mutations in Predisposition Genes in Pediatric Cancer
Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1508054 · Cited by 1,345
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,160
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Shi, J., & Vakoc, C. R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.016 · Cited by 888
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
Kadoch, C., & Crabtree, G. R. (2015) · Science Advances · doi:10.1126/sciadv.1500447 · Cited by 877
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
Yamane, K., Toumazou, C., Tsukada, Y.-I., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Cell · doi:10.1016/j.cell.2006.03.027 · Cited by 860

Show all 250 references

Research works printed but not linked: 8

Ewing, J. Diffuse endothelioma of bone. Proc. N. Y. Pathol. Soc. 21, 17 (1921).
Lessnick, S. L., Braun, B. S., Denny, C. T. & May, W. A. Multiple domains mediate transformation by the Ewing’s sarcoma EWS/FLI-1 fusion gene. Oncogene 10, 423–431 (1995).
Ohno, T., Rao, V. N. & Reddy, E. S. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 53, 5859–5863 (1993).
Pizzo, P. A. & Poplack, D. G. (eds) Principles and Practice of Pediatric Oncology 7th edn (Lippincott Wililiams & Wilkins, Philadelphia, 2015).
ESMO/European Sarcoma Network Working Group. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 25 (Suppl 3), iii113–iii123 (2014).
Machado, I., López-Guerrero, J. A., Scotlandi, K., Picci, P. & Llombart-Bosch, A. Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing’s sarcoma family of tumors (ESFT). Virchows Arch. Int. J. Pathol. 472, 815–824 (2018).
Wang, Y. X. et al. Inhibiting platelet-derived growth factor beta reduces Ewing’s sarcoma growth and metastasis in a novel orthotopic human xenograft model. In Vivo 23, 903–909 (2009).
Bhan, A. & Mandal, S. S. LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer. Biochim. Biophys. Acta 1856, 151–164 (2015).

Sorted by citations

Items 301–400 of 880

Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis
Fahr, L., Sunami, Y., Maeritz, N., Steiger, K., Grünewald, T. G. P., Gericke, M. T., Kong, B., Raulefs, S., Mayerle, J. V., Michalski, C. W., et al. (2020) · Pancreatology · doi:10.1016/j.pan.2020.10.033 · Cited by 9
Self-citation
Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
Sevim, H., Çelik, H., Düşünceli, L., Ceyhan, C. S., Molotkova, A., Nakazawa, K., Graham, G. T., Petro, J. R., Toretsky, J. A., & Üren, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253170 · Cited by 9
Ubiquitin-specific proteases as therapeutic targets in paediatric primary bone tumours?
Mullard, M., Lavaud, M., Regnier, L., Tesfaye, R. A., Ory, B., Rédiní, F., & Verrecchia, F. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114797 · Cited by 9
A Novel Defined Hypoxia-Related Gene Signature for Prognostic Prediction of Patients With Ewing Sarcoma
Jiang, R., Hu, J., Zhou, H., Wei, H., He, S., & Xiao, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.908113 · Cited by 9
PET/MR of pediatric bone tumors: what the radiologist needs to know
Padwal, J. A., Baratto, L., Chakraborty, A. K., Hawk, K. E., Spunt, S. L., Avedian, R. S., & Daldrup-Link, H. E. (2022) · Skeletal Radiology · doi:10.1007/s00256-022-04113-6 · Cited by 9
Polymorphic variants of IGF2BP3 and SENCR have an impact on predisposition and/or progression of Ewing sarcoma
Martinelli, M., Mancarella, C., Scapoli, L., Palmieri, A., Sanctis, P. D., Ferrari, C., Pasello, M., Zucchini, C., & Scotlandi, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.968884 · Cited by 9
Ewing’s Sarcoma of Mandible: Practical Approach to a Challenging Case
Ahmadi, M. S., Sheida, F., Ameri, A., Javadinia, S. A., Farahani, F., Soltaninia, O., Shoar, L. M., Pashaki, A. S., Gharib, M. H., Abbasi, R., et al. (2022) · Case Reports in Oncology · doi:10.1159/000525608 · Cited by 9
Ewing sarcoma: what trends in recent works? A holistic analysis with global productivity: A cross-sectional study
Hassa, E., & Alıç, T. (2022) · Medicine · doi:10.1097/md.0000000000031406 · Cited by 9
Global chromatin landscapes identify candidate noncoding modifiers of cardiac rhythm
Bhattacharyya, S., Kollipara, R. K., Orquera-Tornakian, G., Goetsch, S. C., Zhang, M., Perry, C., Li, B., Shelton, J. M., Bhakta, M., Duan, J., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153635 · Cited by 13
Distribution and Surgical Management of Visceral Ewing Sarcoma Among Children and Adolescents
Wallace, M. W., Niec, J. A., Ghani, M. O. A., McKay, K. G., Idrees, K., Liang, J., Borinstein, S. C., & Lovvorn, H. N. (2023) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2023.01.006 · Cited by 9
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
Olmedo-Pelayo, J., Granado-Calle, E., Delgado‐Bellido, D., Lobo-Selma, L., Jordán-Pérez, C., Amaral, A. T., Ehlers, A. C., Ohmura, S., García-Domínguez, D. J., Mackintosh, C., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03496-9 · Cited by 9
Self-citation
The Optimal Outcome of Suppressing Ewing Sarcoma Growth in vivo With Biocompatible Bioengineered miR-34a-5p Prodrug
Li, D., Yuan, Y., Tu, M., Hu, X., Li, Y.-Z., Yi, W.-R., Li, P.-C., Zhao, Y., Cheng, Z., Yu, A., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00222 · Cited by 9
Western Blot Analysis in Ewing Sarcoma
Marchetto, A., & Romero‐Pérez, L. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1020-6_2 · Cited by 9
Update of pediatric soft tissue tumors with review of conventional MRI appearance—part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas
Maloney, E. J., Al‐Dasuqi, K., Irshaid, L., Wang, A. R., Kani, K. K., Haims, A. H., & Porrino, J. (2021) · Skeletal Radiology · doi:10.1007/s00256-021-03837-1 · Cited by 9
Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?
van Oost, S., Meijer, D. M., Kuijjer, M. L., Bovée, J. V. M. G., & de Miranda, N. F. C. C. (2021) · Biomedicines · doi:10.3390/biomedicines9081048 · Cited by 9
Targeting the Tumor Microenvironment of Ewing Sarcoma
Morales, E., Olson, M., Cardenas, F. I., Luetkens, T., & Atanackovic, D. (2021) · Immunotherapy · doi:10.2217/imt-2020-0341 · Cited by 9
Targeting CD99 Compromises the Oncogenic Effects of the Chimera EWS–FLI1 by Inducing Reexpression of Zyxin and Inhibition of GLI1 Activity
Balestra, T., Manara, M. C., Laginestra, M. A., Pasello, M., Feo, A. D., Bassi, C., Guerzoni, C., Landuzzi, L., Lollini, P., Donati, D. M., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0189 · Cited by 9
Identification of a novel translocation producing an in-frame fusion of TAF15 and ETV4 in a case of extraosseous Ewing sarcoma revealed in the prenatal period
Picard, C., Macagno, N., Corradini, N., Marec‐Bérard, P., Cabet, S., Guibaud, L., Viremouneix, L., Raux, S., Chotel, F., Weinbreck, N., et al. (2022) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-022-03335-2 · Cited by 9
Comparative characteristics of small cell lung cancer and Ewing’s sarcoma: a narrative review
Hamilton, G. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-58 · Cited by 9
Mitochondrial DNA haplogroup, genetic ancestry, and susceptibility to Ewing sarcoma
Kaneva, K., Schurr, T. G., Tatarinova, T. V., Buckley, J. D., Merkurjev, D., Tříska, P., Liu, X., Done, J., Maglinte, D. T., Deapen, D., et al. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.09.002 · Cited by 9
Slit2 signaling stimulates Ewing sarcoma growth
Suvarna, K., Jayabal, P., Ma, X., & Shiio, Y. (2022) · Genes & Cancer · doi:10.18632/genesandcancer.227 · Cited by 9
Treatment-driven selection of chemoresistant Ewing sarcoma tumors with limited drug distribution
Castillo‐Ecija, H., Monterrubio, C., Pascual‐Pasto, G., Gómez‐González, S., García-Domínguez, D. J., Hontecillas‐Prieto, L., Resa‐Pares, C., Burgueño, V., Paco, S., Olaciregui, N. G., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.032 · Cited by 10
Primary Ewing’s sarcoma of the uterine cervix: a case report and review of the literature
Xiao, Y., Zhi, Y., Cao, G., Ma, H., Gao, J., & Li, F. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05698-2 · Cited by 8
Targeted inactivation of EWSR1 : : FLI1 gene in Ewing sarcoma via CRISPR/Cas9 driven by an Ewing-specific GGAA promoter
Cervera, S. T., Martínez, S., Iranzo-Martínez, M., Notario, L., de Mera, R. M. M.-F., & Alonso, J. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00887-8 · Cited by 8
Global bone cancer incidence and death rate analysis at 40 years
Liu, P., Lv, H., Li, Y., Liu, Z., Yang, X., & Hu, H. (2025) · Discover Oncology · doi:10.1007/s12672-025-02917-1 · Cited by 8
p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma
Godfrey, L., Regalado, B. D., Schweber, S. R., Hatton, C., Wenge, D. V., Wen, Y., Boileau, M., Wessels, M., Qi, J., Ott, C. J., et al. (2025) · EMBO Reports · doi:10.1038/s44319-025-00552-z · Cited by 8
Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center
Violon, F., Burns, R., Bouvier, F. M., Audard, V., Biau, D. J., Feydy, A., & Larousserie, F. (2022) · Skeletal Radiology · doi:10.1007/s00256-021-03983-6 · Cited by 8
Routine EWS Fusion Analysis in the Oncology Clinic to Identify Cancer-Specific Peptide Sequence Patterns That Span Breakpoints in Ewing Sarcoma and DSRCT
Anderson, P. M., Tu, Z. J., Kilpatrick, S. E., Trucco, M. M., Hanna, R., & Chan, T. A.-T. (2023) · Cancers · doi:10.3390/cancers15051623 · Cited by 8
Overall survival comparison between pediatric and adult Ewing sarcoma of bone and adult nomogram construction: a large population-based analysis
Hsu, C., Ma, Y., Xiao, P., Hsu, C.-C., Wang, D., Fok, M. N., Peng, R., Xu, X., & Lu, H. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1103565 · Cited by 8
Comprehensive genomic analysis of primary bone sarcomas reveals different genetic patterns compared with soft tissue sarcomas
Zhang, Q., Yang, Y., You, X., Ju, Y., Zhang, Q., Sun, T., & Liu, W. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1173275 · Cited by 8
The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
Chellini, L., Scarfò, M., Bonvissuto, D., Sette, C., & Paronetto, M. P. (2023) · Oncogene · doi:10.1038/s41388-023-02894-1 · Cited by 8
METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4
Huo, X., Lu, D., Chen, D., Ye, M., Wang, X., & Shang, F. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2903120 · Cited by 8
STAG2 loss in Ewing sarcoma alters enhancer-promoter contacts dependent and independent of EWS::FLI1
Giménez-Llorente, D., Cuadrado, A., Andreu, M. J., Sanclemente-Alamán, I., Solé-Ferran, M., Rodríguez-Corsino, M., & Losada, A. (2024) · EMBO Reports · doi:10.1038/s44319-024-00303-6 · Cited by 8
Assessment of Synergistic Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Sarcoma
Mastoraki, A. T., Schizas, D., Vlachou, P., Melissaridou, N., Charalampakis, N., Fioretzaki, R., Kole, C., Savvidou, O. D., Vassiliu, P., & Pikoulis, E. A. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00487-2 · Cited by 8
Penis as a primary site of an extraskeletal Ewing sarcoma
Krákorová, D. A., Halámková, J., Tuček, Š., Bílek, O., Křístek, J., Kazda, T., Zambo, I. S., Demlová, R., & Kišš, I. (2021) · Medicine · doi:10.1097/md.0000000000025074 · Cited by 8
An Immune-Related Long Non-Coding RNA Signature to Predict the Prognosis of Ewing’s Sarcoma Based on a Machine Learning Iterative Lasso Regression
Ren, E., Deng, Y.-J., Yuan, W., Zhang, G., Wu, Z., Li, C., & Xie, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651593 · Cited by 8
Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma
Robles, A. J., Dai, W., Haldar, S., Ma, H., Anderson, V. M., Overacker, R. D., Risinger, A. L., Loesgen, S., Houghton, P. J., Cichewicz, R. H., et al. (2021) · Cancers · doi:10.3390/cancers13246176 · Cited by 8
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis
Katakam, S. K., Anand, S. K., Martin, P., Riggi, N., & Stamenkovic, I. (2022) · Life Science Alliance · doi:10.26508/lsa.202101256 · Cited by 9
Correlation of Transcriptomics and FDG-PET SUVmax Indicates Reciprocal Expression of Stemness-Related Transcription Factor and Neuropeptide Signaling Pathways in Glucose Metabolism of Ewing Sarcoma
Prexler, C., Knape, M. S., Erlewein-Schweizer, J., Roll, W., Specht, K., Woertler, K., Weichert, W., von Luettichau, I., Rössig, C., Hauer, J., et al. (2022) · Cancers · doi:10.3390/cancers14235999 · Cited by 8
The SWI/SNF Complex in Neural Crest Cell Development and Disease
Fountain, D. M., & Sauka‐Spengler, T. (2023) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-011723-082913 · Cited by 10
Extraosseous Ewing Sarcoma of the Cervical Esophagus: Case Report and Literature Review
Wang, S., Zhu, W., Zhang, H., & Yang, X. (2020) · Ear Nose & Throat Journal · doi:10.1177/0145561320953696 · Cited by 8
Patterns of Translocation Testing in Patients Enrolling in a Cooperative Group Trial for Newly Diagnosed Metastatic Ewing Sarcoma
DuBois, S. G., Krailo, M., Buxton, A. B., Lessnick, S. L., Teot, L. A., Rakheja, D., Crompton, B. D., Janeway, K. A., Gorlick, R. G., & Bender, J. G. (2021) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2020-0671-oa · Cited by 8
EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells
Croushore, E. E., Stipp, C. S., & Gordon, D. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168595 · Cited by 7
Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells
Ziener, J., Henao-Restrepo, J. A., Leonhardi, J., Sturm, M.-J., Becker, S., Prieto, D. M. M., Milde, T., Beck, J. F., & Sonnemann, J. (2025) · BMC Cancer · doi:10.1186/s12885-025-13691-2 · Cited by 7
Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells
Koppenhafer, S. L., Geary, E. L., Thomas, M. V., Croushore, E. E., Zimmerman, J. A. O., Gedminas, J. M., Quelle, D. E., Dodd, R. D., & Gordon, D. J. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0058 · Cited by 7
Identification of genes contributing to cisplatin resistance in osteosarcoma cells
Xie, M., Dai, H., Gu, Q., Xiao, C., Wang, H., Yang, L., Wu, C., Li, X., Lin, B., & Li, S. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13524 · Cited by 7
Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review
Tang, Y., Lu, X., & Zhan, R. (2023) · BMC Nephrology · doi:10.1186/s12882-023-03404-x · Cited by 7
New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee
Daley, J. D., Whiteway, S. L., Heske, C. M., Cruz, F. S. D., Whittle, S. B., Cohen‐Gogo, S., Collier, A. B., Gupta, A. K., Ohm, J. E., Clark, A., et al. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.31917 · Cited by 8
Prognostic significance of survivin expression in pediatric ewing sarcoma
Mahmoud, A. M., Zekri, W., Khorshed, E. N., & Shalaby, L. (2021) · Pediatric Hematology and Oncology · doi:10.1080/08880018.2021.1931588 · Cited by 7
Management of Unresectable Localized Pelvic Bone Sarcomas: Current Practice and Future Perspectives
do Brito, J. S., Esperança‐Martins, M., Abrunhosa-Branquinho, A. N., Melo-Alvim, C., Lopes-Brás, R., Janeiro, J., Lopéz‐Presa, D., Fernandes, I., Portela, J., & Costa, L. (2022) · Cancers · doi:10.3390/cancers14102546 · Cited by 7
Pathogenic Roles of RNA-Binding Proteins in Sarcomas
Hai, Y., Kawachi, A., He, X., & Yoshimi, A. (2022) · Cancers · doi:10.3390/cancers14153812 · Cited by 7
Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis
Molnar, C., Reina, J., Herrero, A., Heinen, J. P., Méndiz, V., Bonnal, S., Irimia, M., Sánchez-Jiménez, M., Sánchez-Molina, S., Mora, J., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac222 · Cited by 10
Ewing Sarcoma as Secondary Malignant Neoplasm—Epidemiological and Clinical Analysis of an International Trial Registry
Zöllner, S. K., Kauertz, K. L., Kaiser, I., Kerkhoff, M., Schaefer, C., Tassius, M., Jabar, S., Jürgens, H., Ladenstein, R. L., Kühne, T., et al. (2022) · Cancers · doi:10.3390/cancers14235935 · Cited by 7
Self-citation
Clinical characteristics of primary cutaneous and subcutaneous Ewing sarcoma
Aiba, H., Kojima, Y., Shimoi, T., Sudo, K., Yazaki, S., Imai, T., Yoshida, A., Iwata, S., Kobayashi, E., Kawai, A., et al. (2023) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyad031 · Cited by 7
PARP inhibitor combinations with high-dose vitamin C in the treatment of Ewing sarcoma: two case reports and mechanistic overview
Adibi, A., Tokat, Ü. M., Özgü, E., Aydın, E., Demiray, İ., & Demiray, M. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359231213841 · Cited by 7
Frequency of Translocation t(11;22)(q24;q12) Using Fluorescence In Situ Hybridization (FISH) in Histologically and Immunohistochemically Diagnosed Cases of Ewing’s Sarcoma
Bashir, M. R., Pervez, S., Hashmi, A. A., & Irfan, M. (2020) · Cureus · doi:10.7759/cureus.9885 · Cited by 7
Challenges of Diagnosing Primary Ewing’s Sarcoma in the Small Intestine of the Elderly: A Case Report
Yang, J., Wei, H., Lin, Y., Lin, N., Wu, S., & Yu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.565196 · Cited by 7
Undifferentiated Small Round Cell Sarcomas of Bone
Dickson, B. C. (2021) · Surgical pathology clinics · doi:10.1016/j.path.2021.06.009 · Cited by 7
Unlocking epigenetics for precision treatment of Ewing’s sarcoma
Fan, Z., Dong, S., Wang, N., Khawar, M. B., Wang, J., & Sun, H. (2024) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2024.03.08 · Cited by 6
Statistics of Primary Malignant Spine Tumors in Japan
Tsuchiya, R., Ogura, K., Ohtori, S., & Kawai, A. (2025) · Spine · doi:10.1097/brs.0000000000005361 · Cited by 6
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates
Lombardi, S., Zilocchi, M., Nicsanu, R., & Barabino, S. M. L. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103846 · Cited by 6
KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
Figuerola-Bou, E., Ríos-Astorch, C., Blanco, E., Sánchez-Jiménez, M., Táboas, P., Fernández, G., Gómez‐González, S., Muñoz, O., Castellano‐Escuder, P., Pérez‐Jaume, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3452 · Cited by 6
Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules
Bond, M. J., Golden, R. P., DiGiovanni, G., Howard, B., Sarott, R. C., Karim, B. A., Gourisankar, S. P., Alexe, G., Ross, K. N., Jones, H. M., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c05634 · Cited by 6
Intratumor heterogeneity and clonal evolution in sarcomas: Molecular, cellular, and functional drivers of therapy resistance
Grünewald, T. G. P., Oehme, I., Wagner, J., & Fröhling, S. (2026) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2026.02.001 · Cited by 6
Self-citation
Analysis of Migration and Invasion in Ewing Sarcoma
Cidre‐Aranaz, F. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1020-6_13 · Cited by 6
Self-citation
Splice variants denote differences between a cancer stem cell side population of EWSR1‑ERG‑based Ewing sarcoma cells, its main population and EWSR1‑FLI‑based cells
Korsching, E., Matschke, J., & Hotfilder, M. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5094 · Cited by 6
The occurrence of bone and joint cancers and their association with rural living and radon exposure in Iowa
Nilles, J. D., Lim, D., Boyer, M. P., Wilson, B. D., Betar, R., Showalter, H. A., Liu, D., & Ananieva, E. A. (2022) · Environmental Geochemistry and Health · doi:10.1007/s10653-022-01261-5 · Cited by 6
TCR-transgenic T cells and YB-1-based oncolytic virotherapy improve survival in a preclinical Ewing sarcoma xenograft mouse model
Schober, S. J., Thiede, M., Gassmann, H., von Ofen, A. J., Knoch, P., Eck, J., Prexler, C., Kordass, C., Hauer, J., Burdach, S. E. G., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1330868 · Cited by 11
Enhancing Standard of Care Chemotherapy Efficacy Using DNA-Dependent Protein Kinase (DNA-PK) Inhibition in Preclinical Models of Ewing Sarcoma
Collins, V. J., Ludwig, K. R., Nelson, A. E., Rajan, S. S., Yeung, C. L., Vulikh, K., Isanogle, K. A., Mendoza, A., Difilippantonio, S., Karim, B. O., et al. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0641 · Cited by 6
Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis
Chicón‐Bosch, M., Sánchez‐Serra, S., Rosàs‐Lapeña, M., Costa‐Fraga, N., Besalú‐Velázquez, J., Illa‐Bernadí, J., Mateo‐Lozano, S., Cidre‐Aranaz, F., Grünewald, T. G. P., Díaz‐Lagares, Á., et al. (2025) · Molecular Oncology · doi:10.1002/1878-0261.13788 · Cited by 6
Self-citation
Clinicopathologic and molecular characterization of primitive neuroectodermal tumors (PNET) in the female genital tract: a retrospective study of 8 cases
Zhang, Z., Shi, H., Shao, Y., & Lü, B. (2025) · Human Pathology · doi:10.1016/j.humpath.2025.105769 · Cited by 6
Results of the Latin American Pediatric Oncology Group (GALOP) Trial for Patients With Metastatic Ewing Sarcoma: Multicentric Study of Interval‐Compressed Multiagent and Metronomic Chemotherapy
Rosé, A., Gregianin, L. J., Boldrini, É., Macedo, C. R. P. D., Ferman, S., Costa, T. E. J. B., Scopinaro, M. J., Brunetto, A. L., Brunetto, A. T., Milena Villarroel, C., et al. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.31707 · Cited by 6
Dive into the bone: new insights into molecular mechanisms of cancer bone invasion
Tsukasaki, M. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf054 · Cited by 6
Parotid Ewing's sarcoma: Extra-skeletal uncommon condition
Sabr, A., Aloua, R., Kerdoud, O., & Slimani, F. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.102304 · Cited by 6
Prognostic value of detection of CD99+, CD45− cells in peripheral blood by flow cytometry in children with Ewing sarcoma
Zakzok, O., El-Shanshory, M. R., Zekri, W., El-Sharkawy, N., Zaky, I., Salama, A., Kamel, A., Elantably, I. M., & Said, S. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29298 · Cited by 6
Comorbidities rather than older age define outcome in adult patients with tumors of the Ewing sarcoma family
Striefler, J. K., Schmiester, M., Brandes, F., Dörr, A., Pahl, S., Kaul, D., Rau, D., Dobrindt, E. M., Koulaxouzidis, G., Bullinger, L., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.4688 · Cited by 6
Identification of Common Oncogenic Genes and Pathways Both in Osteosarcoma and Ewing’s Sarcoma Using Bioinformatics Analysis
Zhang, J., Huang, J., Liu, W., Ding, L., Cheng, D., & Xiao, H. (2022) · Journal of Immunology Research · doi:10.1155/2022/3655908 · Cited by 6
Exploiting the Stemness and Chemoresistance Transcriptome of Ewing Sarcoma to Identify Candidate Therapeutic Targets and Drug-Repurposing Candidates
Roundhill, E. A., Pantziarka, P., Liddle, D. E., Shaw, L. A., Albadrani, G. M., & Burchill, S. A. (2023) · Cancers · doi:10.3390/cancers15030769 · Cited by 5
MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
Vital, T., Wali, A., Butler, K. V., Xiong, Y., Foster, J. P., Marcel, S. S., McFadden, A. W., Nguyen, V. U., Bailey, B. M., Lamb, K. N., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1099550 · Cited by 6
Screening for DAX1 / EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma
Watanabe, M., Kosaka, H., Sugawara, M., Maemoto, M., Ono, Y., Uemori, T., Shizu, R., & Yoshinari, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5741 · Cited by 6
Primary angiomatoid fibrous histiocytoma of the mandible with EWSR1-ATF1 fusion in an adult patient: case report and review of literature
Hu, M., Guo, F., Xiao, S., Zhangyang, G., Wang, M., Yue, J., & Fang, N. (2023) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2023.04.007 · Cited by 6
Osteohematology: To be or Notch to be
Rothzerg, E., Erber, W. N., Gibbons, C. L. M. H., Wood, D., & Xu, J. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31042 · Cited by 6
Proteomics in orthopedic research: Recent studies and their translational implications
Li, G., Stampas, A., Komatsu, Y., Gao, X., Huard, J., & Pan, S. (2024) · Journal of Orthopaedic Research® · doi:10.1002/jor.25917 · Cited by 6
Ewing Sarcoma of the Lung: Imaging of a Rare Tumor
Tsetsou, I., Moschouris, H., Spanomanolis, N., & Soumpourou, E. (2022) · Cureus · doi:10.7759/cureus.32395 · Cited by 6
Bone sarcoma: Success through interdisciplinary collaboration
Hecker‐Nolting, S., Ferreira, A. M., & Bielack, S. (2021) · Journal of Children s Orthopaedics · doi:10.1302/1863-2548.15.210122 · Cited by 6
Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibitionPreprint
Funk, C. M., Ehlers, A. C., Orth, M. F., Aljakouch, K., Li, J., Hölting, T. L. B., Will, R. D., Ceranski, A. K., Willis, F. M., Vinca, E., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.11.519935 · Cited by 6
Self-citation
Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
Haight, J. A., Koppenhafer, S. L., Geary, E. L., & Gordon, D. J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1394653 · Cited by 5
Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors
Ghufran, S. M., Brown, M. L., & Beierle, E. A. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200930 · Cited by 5
SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Daley, J. D., Mukherjee, E., Ferraro, D., Bhaskar, S., Green, A., Meyer, E. M., Tawbi, H. A., Burgess, M. A., Bruno, T. C., Cillo, A. R., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-3882 · Cited by 5
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration
Colombo, M. V., Arrigoni, C., Faehling, T., Verrillo, A., Secci, V., Grünewald, T. G. P., Talò, G., Kummer, A., Gonzalez, J., Rosa, V. D., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202418470 · Cited by 5
Self-citation
Blocking PCSK9 suppresses hepatocellular carcinoma immune escape by decreasing FLI1-mediated SPP1 and PD-L1 expression
Hu, C., Qin, M., Lai, W., Zhou, H., Yuan, C., Liu, Y., Dai, Y., Yang, M., Hu, M., Wang, X., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-012586 · Cited by 5
Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
Wrenn, E. D., Harris, J. C., Apfelbaum, A. A., Valenti, J. R., Lipson, P. A., Walter, S. I., Garcia, N. M., Miyaki, A., Chen, S. C., Olson, J. M., et al. (2026) · Science Advances · doi:10.1126/sciadv.ady0550 · Cited by 5
A Large-Scale Method to Measure the Stoichiometries of Protein Poly-ADP-Ribosylation
Li, P., Zhang, Y., Kim, C., & Yu, Y. (2026) · ACS Chemical Biology · doi:10.1021/acschembio.5c00817 · Cited by 5
Downregulated annexin A1 expression correlates with poor prognosis, metastasis, and immunosuppressive microenvironment in Ewing’s sarcoma
Shi, X., Wu, Y., Tang, L., Ni, H., & Xu, Y. (2023) · Aging · doi:10.18632/aging.204615 · Cited by 5
Impact of age on survival according to molecular tumor findings in children and adolescents with soft-tissue and bone sarcoma: The BIOSCA project
Désandes, E., Lapouble, E., Lacour, B., Guissou, S., Goujon, S., Defachelles, A. S., Maréchal, V., Gaspar, N., Gomez‐Brouchet, A., Karanian, M., et al. (2023) · Cancer Epidemiology · doi:10.1016/j.canep.2023.102398 · Cited by 5
Self-citation
Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma
Suvarna, K., Jayabal, P., Ma, X., Wang, H., Chen, Y., Weintraub, S. T., Han, X., Houghton, P. J., & Shiio, Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114497 · Cited by 5
Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas
Petrescu, D. I., Yustein, J. T., & Dasgupta, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1388484 · Cited by 5
Ewing Sarcoma in the Pediatric Population: Predictors of Survival Within the United States
Wells, M. E., Eckhoff, M. D., Davis, W., Singh, V., Rajani, R., & Polfer, E. M. (2024) · JAAOS Global Research and Reviews · doi:10.5435/jaaosglobal-d-24-00281 · Cited by 7
Ewing Sarcoma of the Sinonasal Tract: A Scoping Review
Shaari, A. L., Ho, R., Patel, A. M., Haimowitz, S. Z., Eloy, J. A., & Fang, C. H. (2024) · The Laryngoscope · doi:10.1002/lary.31925 · Cited by 5
Disruption of microhomology-mediated end joining in Ewing sarcoma
Asada, S., Zhu, G., Abeykoon, J. P., Tanaka, Y., Nguyen, H., Hirohashi, Y., Iyer, D., Ashton, N. W., Mukkavalli, S., Velazquez, M., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.06.038 · Cited by 5

Authors: Grünewald, T. G. P., Cidre-Aranaz, F., Surdez, D., Tomazou, E. M., de Álava, E., Kovar, H., Sorensen, P. H., Delattre, O., & Dirksen, U.
Affiliations: German Cancer Research Center (DE)
Inserm (FR)
St. Anna Children's Cancer Research Institute (AT)
University of British Columbia (CA)
Corresponding author: Grünewald, Thomas G. P.
ORCID: Grünewald, Thomas G. P.
Surdez, Didier
Tomazou, Eleni M.
Kovar, Heinrich
Sorensen, Poul H.
Delattre, Olivier
Dirksen, Uta
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2018-07-05
Volume: 4
Issue: 1
Pages: 5-5
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/s41572-018-0003-x
OpenAlex: W4211227438
Cited by: 873
References: 250
Citations by year: 2026: 114 · 2025: 155 · 2024: 104 · 2023: 103 · 2022: 158 · 2021: 115 · 2020: 66 · 2019: 49 · 2018: 8
FWCI: 10.61
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: Ewing sarcoma, EWSR1-FLI1 fusion, CD99, epigenetic reprogramming, STAG2 mutation, TP53 mutation, CDKN2A deletion, treatment toxicity, cancer survivorship, soft tissue sarcoma
MeSH terms: 12E7 Antigen, Humans, Neoplasm Metastasis, Quality of Life, Radiography, Risk Factors, Sarcoma, Ewing, RNA-Binding Protein EWS, Proto-Oncogene Protein c-fli-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ewing sarcoma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks