Cited by 880Sarcoma Diagnosis and TreatmentChromatin Remodeling and CancerAcute Lymphoblastic Leukemia research

The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.

Ewing sarcoma

Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta·2018·Nature Reviews Disease Primers

DOI 10.1038/s41572-018-0003-x

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Abstract

Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic disease. Treatment comprises local surgery, radiotherapy and polychemotherapy, which are associated with acute and chronic adverse effects that may compromise quality of life in survivors. Histologically, Ewing sarcomas are composed of small round cells expressing high levels of CD99. Genetically, they are characterized by balanced chromosomal translocations in which a member of the FET gene family is fused with an ETS transcription factor, with the most common fusion being EWSR1-FLI1 (85% of cases). Ewing sarcoma breakpoint region 1 protein (EWSR1)-Friend leukaemia integration 1 transcription factor (FLI1) is a tumour-specific chimeric transcription factor (EWSR1-FLI1) with neomorphic effects that massively rewires the transcriptome. Additionally, EWSR1-FLI1 reprogrammes the epigenome by inducing de novo enhancers at GGAA microsatellites and by altering the state of gene regulatory elements, creating a unique epigenetic signature. Additional mutations at diagnosis are rare and mainly involve STAG2, TP53 and CDKN2A deletions. Emerging studies on the molecular mechanisms of Ewing sarcoma hold promise for improvements in early detection, disease monitoring, lower treatment-related toxicity, overall survival and quality of life.

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RETRACTED ARTICLE: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Javaheri, T., Kazemi, Z., Pěnčík, J., Pham, H. T., Kauer, M. O., Noorizadeh, R., Sax, B., Nivarthi, H., Schlederer, M., Maurer, B., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.268 · Cited by 18
Self-citation
Retracted
Bone marrow transplant
Szer, J. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127745.x · Cited by 3,373
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., et al. (1992) · Nature · doi:10.1038/359162a0 · Cited by 1,907
Self-citation
Targeting EZH2 in cancer
Kim, K. H., & Roberts, C. W. M. (2016) · Nature Medicine · doi:10.1038/nm.4036 · Cited by 1,471
Germline Mutations in Predisposition Genes in Pediatric Cancer
Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1508054 · Cited by 1,345
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,160
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Shi, J., & Vakoc, C. R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.016 · Cited by 888
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
Kadoch, C., & Crabtree, G. R. (2015) · Science Advances · doi:10.1126/sciadv.1500447 · Cited by 877
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
Yamane, K., Toumazou, C., Tsukada, Y.-I., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Cell · doi:10.1016/j.cell.2006.03.027 · Cited by 860

Show all 250 references

Research works printed but not linked: 8

Ewing, J. Diffuse endothelioma of bone. Proc. N. Y. Pathol. Soc. 21, 17 (1921).
Lessnick, S. L., Braun, B. S., Denny, C. T. & May, W. A. Multiple domains mediate transformation by the Ewing’s sarcoma EWS/FLI-1 fusion gene. Oncogene 10, 423–431 (1995).
Ohno, T., Rao, V. N. & Reddy, E. S. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 53, 5859–5863 (1993).
Pizzo, P. A. & Poplack, D. G. (eds) Principles and Practice of Pediatric Oncology 7th edn (Lippincott Wililiams & Wilkins, Philadelphia, 2015).
ESMO/European Sarcoma Network Working Group. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 25 (Suppl 3), iii113–iii123 (2014).
Machado, I., López-Guerrero, J. A., Scotlandi, K., Picci, P. & Llombart-Bosch, A. Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing’s sarcoma family of tumors (ESFT). Virchows Arch. Int. J. Pathol. 472, 815–824 (2018).
Wang, Y. X. et al. Inhibiting platelet-derived growth factor beta reduces Ewing’s sarcoma growth and metastasis in a novel orthotopic human xenograft model. In Vivo 23, 903–909 (2009).
Bhan, A. & Mandal, S. S. LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer. Biochim. Biophys. Acta 1856, 151–164 (2015).

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Additional file 2 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
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Additional file 1 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253756
Additional file 3 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253762
Additional file 3 of Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Hölting, T. L. B., Cidre‐Aranaz, F., Matzek, D., Popper, B., Jacobi, S. J., Funk, C. M., Geyer, F. H., Li, J., Piseddu, I., Cadilha, B. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21332795
Self-citation
Additional file 6 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253774
Additional file 1 of Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Hölting, T. L. B., Cidre‐Aranaz, F., Matzek, D., Popper, B., Jacobi, S. J., Funk, C. M., Geyer, F. H., Li, J., Piseddu, I., Cadilha, B. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21332786
Self-citation
Additional file 5 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253768
Additional file 8 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253780
Additional file 4 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253765
Additional file 9 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253783
Additional file 3 of The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma
Wen, J., Wan, L., & Dong, X. (2022) · Figshare · doi:10.6084/m9.figshare.20401346
Additional file 1 of The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma
Wen, J., Wan, L., & Dong, X. (2022) · Figshare · doi:10.6084/m9.figshare.20401340
Additional file 1 of Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication
Waters, T. W., Goss, K. L., Koppenhafer, S. L., Terry, W. W., & Gordon, D. J. (2020) · Figshare · doi:10.6084/m9.figshare.13311274
Additional file 10 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253747
Additional file 4 of The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma
Wen, J., Wan, L., & Dong, X. (2022) · Figshare · doi:10.6084/m9.figshare.20401349
Additional file 2 of The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma
Wen, J., Wan, L., & Dong, X. (2022) · Figshare · doi:10.6084/m9.figshare.20401343
Additional file 1 of A nomogram for predicting overall survival in patients with Ewing sarcoma: a SEER-based study
Zhou, Z., Wang, J., Fang, L., Ma, J., & Guo, M. (2020) · Figshare · doi:10.6084/m9.figshare.13233126
Additional file 7 of Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Marx, C., Schaarschmidt, M. U., Kirkpatrick, J., Marx-Blümel, L., Halilovic, M., Westermann, M., Hoelzer, D., Meyer, F. B., Geng, Y., Buder, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14253777
Additional file 1 of Study on the role of transcription factor SPI1 in the development of glioma
Du, B., Gao, W., Qin, Y., Zhong, J., & Zhang, Z. (2022) · Figshare · doi:10.6084/m9.figshare.19498080
Additional file 2 of Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication
Waters, T. W., Goss, K. L., Koppenhafer, S. L., Terry, W. W., & Gordon, D. J. (2020) · Figshare · doi:10.6084/m9.figshare.13311277
Adamantinoma-like Ewing sarcoma with NRAS Q61R mutation—a hitherto unreported mutation in a case from the nasal cavity
Wu, B., Qu, X., Lai, Y. T., Oon, M. L., Lee, J. J. L., Goh, J. Y., Xu, X., & Petersson, F. (2025) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-025-04373-2
RT‐PCR–Based Detection of Bone Marrow Involvement in Ewing Sarcoma: Diagnostic Validity and Prognostic Relevance
Pham, T., Ranft, A., Rechl, V., Jabar, S., Hartmann, W., Falkenberg, K. D., Jürgens, H., Graf, N. M., Keßler, T., Metzler, M., et al. (2025) · Pediatric Blood & Cancer · doi:10.1002/1545-5017.70056
Self-citation
Investigating Pediatric Diseases with Organoid Systems: When Pediatric Oncology Meets Organoid Technology
Aycan, F. (2026) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-032-10024-5_7
Fusion oncoproteins orchestrate tumorigenesis and sustain malignant progression via a positive feedback mechanism
Ying, W., Wang, X., Yu, J., Wang, J., He, Q., Yang, B., Chen, Y., & Ying, M. (2026) · Cell & Bioscience · doi:10.1186/s13578-025-01523-6
Classic Ewing Sarcoma of the Ankle With Ewing Sarcoma RNA-Binding Protein 1-Friend Leukemia Integration 1 (EWSR1/FLI1) Fusion: A Case Report and Review of Diagnostic Considerations
Nikolaus, Y., & Urbelz, G. (2026) · Cureus · doi:10.7759/cureus.101021
Proteomics analysis of human mesenchymal stromal/stem cell sarcomagenesis model identifies ALDH1A3 and CD99 as potential targets in the transformation process
Gobin, J., Gao, J., Rey, V., Tornín, J., Muradia, G., Halabi, H., Bueno, C., Guerrero-Murillo, M., López‐Millán, B., Menendez, P., et al. (2026) · BMC Biology · doi:10.1186/s12915-025-02498-z
Non-Traumatic Clavicular Lesions in Children: Case Series and Literature Review
Diomeda, F., Greco, R., Lazzari, P., Loiacono, G., Taurisano, M., Pinna, A., Torre, F. L., Cocciolo, A., Giordano, L., Indrio, F., et al. (2026) · Children · doi:10.3390/children13010112
PET/Computed Tomography and PET/MR Imaging in Pediatric Osteosarcoma and Ewing Sarcoma
Li, M., Liu, T., Liu, Y., Tan, R., Feng, Y., Yang, B., Lin, Z., & Lan, X. (2026) · PET Clinics · doi:10.1016/j.cpet.2025.11.003
Ewing Sarcoma
Vanhoenacker, F. M. H. M., Kerkhove, F. V., Bosmans, F., & Brys, P. (2026) · Medical radiology · doi:10.1007/174_2025_636
ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis
Molotkova, A., Deniz, E., Swift, M., Glasgow, E., Ma, J., Petro, J. A., Frye, I., Ozdemirli, M., Pesic, D., Ahern, G. P., et al. (2026) · Cancer Research Communications · doi:10.1158/2767-9764.crc-26-0068
Genomic innovation in precision oncology: integrated CRISPR-TTP bioengineering architecture for Ewing Sarcoma (version 4.0 – complete architectural specification)
Burlai, A. M. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1727708
A Diagnostic Challenge: Retroperitoneal Extraskeletal Ewing Sarcoma with Subaortic Growth and Partial Aortic Encasement Presenting with Nephrolithiasis-Like Symptoms in a Middle-Aged South Asian Male
Alexander, D., Konda, M., & Ganti, L. (2026) · Orthopedic Reviews · doi:10.52965/001c.156465
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Secuenciación de próxima generación. ¿Es la última frontera?
Ruíz-Patiño, A. (2026) · Revista Colombiana de Hematología y Oncología · doi:10.51643/22562915.833

Authors: Grünewald, T. G. P., Cidre-Aranaz, F., Surdez, D., Tomazou, E. M., de Álava, E., Kovar, H., Sorensen, P. H., Delattre, O., & Dirksen, U.
Affiliations: German Cancer Research Center (DE)
Inserm (FR)
St. Anna Children's Cancer Research Institute (AT)
University of British Columbia (CA)
Corresponding author: Grünewald, Thomas G. P.
ORCID: Grünewald, Thomas G. P.
Surdez, Didier
Tomazou, Eleni M.
Kovar, Heinrich
Sorensen, Poul H.
Delattre, Olivier
Dirksen, Uta
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2018-07-05
Volume: 4
Issue: 1
Pages: 5-5
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/s41572-018-0003-x
OpenAlex: W4211227438
Cited by: 873
References: 250
Citations by year: 2026: 114 · 2025: 155 · 2024: 104 · 2023: 103 · 2022: 158 · 2021: 115 · 2020: 66 · 2019: 49 · 2018: 8
FWCI: 10.61
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: Ewing sarcoma, EWSR1-FLI1 fusion, CD99, epigenetic reprogramming, STAG2 mutation, TP53 mutation, CDKN2A deletion, treatment toxicity, cancer survivorship, soft tissue sarcoma
MeSH terms: 12E7 Antigen, Humans, Neoplasm Metastasis, Quality of Life, Radiography, Risk Factors, Sarcoma, Ewing, RNA-Binding Protein EWS, Proto-Oncogene Protein c-fli-1

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