Cited by 1,271Alcohol Consumption and Health EffectsLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation

The DOI matches its Crossref record; 242 of the 244 references it cites were found in a registry or an index.

Alcoholic liver disease

Seitz, Helmut K., Bataller, Ramon, Cortez-Pinto, Helena, Gao, Bin, Gual, Antoni, Lackner, Carolin, Mathurin, Philippe, Mueller, Sebastian, Szabo, Gyongyi, Tsukamoto, Hidekazu·2018·Nature Reviews Disease Primers

DOI 10.1038/s41572-018-0014-7

Open this paper in CoChat — free account

Abstract

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease. Genetic, epigenetic and non-genetic factors might explain the considerable interindividual variation in ALD phenotype. The pathogenesis of ALD includes hepatic steatosis, oxidative stress, acetaldehyde-mediated toxicity and cytokine and chemokine-induced inflammation. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Alcohol abstinence achieved by psychosomatic intervention is the best treatment for all stages of ALD. In the case of advanced disease such as cirrhosis or HCC, liver transplantation may be required. Thus, new therapies are urgently needed.

Integrity signals

Registry

Crossref · 10.1038/s41572-018-0014-7

Cites

242 of 242 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
Chen, C., Tsukamoto, H., Liu, J.-C., Kashiwabara, C., Feldman, D. E., Sher, L. S., Dooley, S., French, S. W., Mishra, L., Petrovic, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65859 · Cited by 161
Self-citation
Retracted
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
The AUDIT Alcohol Consumption Questions (AUDIT-C)<subtitle>An Effective Brief Screening Test for Problem Drinking</subtitle>
Bush, K. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.16.1789 · Cited by 6,196
Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016
Naghavi, M., Abajobir, A. A., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abera, S. F., Aboyans, V., Adetokunboh, O., Afshin, A., Agrawal, A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32152-9 · Cited by 4,821
AASLD guidelines for the treatment of hepatocellular carcinoma
Heimbach, J. K., Kulik, L., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H., & Marrero, J. A. (2017) · Hepatology · doi:10.1002/hep.29086 · Cited by 4,107
Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219

Show all 244 references

Research works printed but not linked: 4

Pone, E. J. Toll-like receptors. Signal. Pathways Liver Diseases 1390, 149–159 (2016).
French, S. W. & Bardag-Gorce, F. in Signaling Pathways in Liver Diseases (eds Dufour, J.-F. et al.) 377–389 (Springer, 2005).
Thiele, M. et al. Controlled attenuation parameter and alcoholic hepatic steatosis: diagnostic accuracy and role of alcohol detoxification. J. Hepatol. 68, 1025–1032 (2018). · DOI
[No authors listed.]. Alcoholic liver disease: morphological manifestations. Review by an international group. Lancet 1, 707–711 (1981).

Sorted by citations

Items 301–400 of 999

Review article: current and emerging therapies for acute alcohol‐associated hepatitis
Rattan, P., & Shah, V. H. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16969 · Cited by 28
Analysis of alcohol use, consumption of micronutrient and macronutrients, and liver health in the 2017–2018 National Health and Nutrition Examination Survey
Warner, J. B., Zirnheld, K. H., Hu, H., Floyd, A., Kong, M., McClain, C. J., & Kirpich, I. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14944 · Cited by 27
Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice
Hsu, M.-F., Koike, S., Mello, A., Nagy, L. E., & Haj, F. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101658 · Cited by 25
Spermidine Prevents Ethanol and Lipopolysaccharide-Induced Hepatic Injury in Mice
Adhikari, R., Shah, R., Reyes‐Gordillo, K., Arellanes‐Robledo, J., Cheng, Y., Ibrahim, J., & Tuma, P. L. (2021) · Molecules · doi:10.3390/molecules26061786 · Cited by 26
Day-4 Lille Score Is a Good Prognostic Factor and Early Predictor in Assessing Therapy Response in Patients with Liver Cirrhosis and Severe Alcoholic Hepatitis
Foncea, C. G., Sporea, I., Lupușoru, R., Moga, T. V., Bende, F., Șirli, R., & Popescu, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112338 · Cited by 25
NFATc4 mediates ethanol-triggered hepatocyte senescence
Wu, R., Wang, X., Shao, Y., Jiang, Y., Zhou, Y., & Lu, C. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.06.018 · Cited by 25
Alcohol Abstinence Rescues Hepatic Steatosis and Liver Injury via Improving Metabolic Reprogramming in Chronic Alcohol-Fed Mice
Pi, A., Jiang, K., Ding, Q., Lai, S., Yang, W., Zhu, J., Guo, R., Fan, Y., Chi, L., & Li, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.752148 · Cited by 25
Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases
Sharma, S. P., Suk, K. T., & Kim, D. J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i37.6161 · Cited by 28
Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17/Treg imbalance after long-term alcohol exposure
Zhao, H., Guo, P., Zuo, Y., Wang, Y., Zhao, H. J., Lan, T., Xue, M., Zhang, H., & Liang, H. (2022) · Food & Function · doi:10.1039/d1fo04267j · Cited by 25
Targeting ferroptosis, a novel programmed cell death, for the potential of alcohol-related liver disease therapy
Shi, J., Liu, Y., Wang, Y., Gao, R., Wang, Y., & Liu, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1194343 · Cited by 26
Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation
Novi, S., Vestuto, V., Campiglia, P., Tecce, N., Bertamino, A., & Tecce, M. F. (2023) · Nutrients · doi:10.3390/nu15122748 · Cited by 26
Sex- and Age-Related Differences in the Contribution of Ultrasound-Measured Visceral and Subcutaneous Abdominal Fat to Fatty Liver Index in Overweight and Obese Caucasian Adults
Leone, A., Battezzati, A., Bedogni, G., Vignati, L., Vanzulli, A., Amicis, R. S. D., Foppiani, A., & Bertoli, S. (2019) · Nutrients · doi:10.3390/nu11123008 · Cited by 25
Liver-lung axes in alcohol-related liver disease
Arteel, G. E. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0174 · Cited by 27
Alcoholic liver disease and autoimmune hepatitis: Sometimes a closer look under the surface is needed
Rigopoulou, E. I., Gatselis, N., Arvaniti, P., Koukoulis, G. Κ., & Dalekos, G. Ν. (2021) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.12.024 · Cited by 25
Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells
Liao, X., Zhan, W., Li, R., Tian, T., Yu, L., & Yang, Q. (2021) · Biological Chemistry · doi:10.1515/hsz-2020-0251 · Cited by 24
Long non-coding RNA CRNDE as potential biomarkers facilitate inflammation and apoptosis in alcoholic liver disease
Yan, Y., Ren, L., Liu, Y., & Liu, L. (2021) · Aging · doi:10.18632/aging.203614 · Cited by 24
Prevalence and Correlates of Physical Comorbidities in Alcohol Use Disorder (AUD): a Pilot Study in Treatment-Seeking Population
Asharani, P. V., Karuvetil, M. Z., Brian, T. Y. W., Satghare, P., Roystonn, K., Wang, P., Cetty, L., Zainuldin, N. A. B., & Subramaniam, M. (2022) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-021-00734-5 · Cited by 24
The Translational Bridge between Inflammation and Hepatocarcinogenesis
Gufler, S., Seeboeck, R., Schatz, C., & Haybaeck, J. (2022) · Cells · doi:10.3390/cells11030533 · Cited by 26
Expression and functions of transient receptor potential channels in liver diseases
Wang, W., Liu, P., Zhang, Y., Li, Y., Zhu, M. X., Wang, J., & Ye, Y. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.09.005 · Cited by 24
Magnetic Fields Affect Alcoholic Liver Disease by Liver Cell Oxidative Stress and Proliferation Regulation
Song, C., Chen, H., Yu, B., Zhang, L., Wang, J., Feng, C., Yang, X., Tian, X., Fan, Y., Ji, X., et al. (2023) · Research · doi:10.34133/research.0097 · Cited by 24
Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats
Fang, C., Zhang, J., Han, J., Lei, Y., Cao, Z., Pan, J., Pan, Z. J., Zhang, Z., Qu, N., Luo, H., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116838 · Cited by 24
Design and preparation of multifunctional astaxanthin nanoparticles with good acid stability and hepatocyte-targeting ability for alcoholic liver injury alleviation
Hua, Z., Zhang, X., Xing, S., Li, J., Liang, D., Chen, Y., El‐Aty, A. M. A., Zhu, B., Liu, D., & Tan, M. (2023) · Materials Today Nano · doi:10.1016/j.mtnano.2023.100436 · Cited by 24
Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease
Mrdjen, M., Huang, E., Pathak, V., Bellar, A., Welch, N., Dasarathy, J., Streem, D. W., McClain, C. J., Mitchell, M. C., Radaeva, S., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000284 · Cited by 23
Prevalence, severity and determinants of steatotic liver disease among individuals with metabolic and alcohol risk from the community
Hansen, C. D., Hansen, J. K., Israelsen, M. E., Andersen, P., Pikkupeura, L. M., Lindvig, K. P., Stinson, S. E., Schnefeld, H. L., Tellerup, J., Fogt, M., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.06.020 · Cited by 23
Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link
Saha, B., Banerjee, A., Pathak, R., Duttaroy, A. K., & Pathak, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118592 · Cited by 25
Alcoholic liver disease: A registry view on comorbidities and disease prediction
Grissa, D., Rasmussen, D. N., Krag, A. A., Brunak, S., & Jensen, L. J. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008244 · Cited by 26
Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease
Mello, A., Hsu, M.-F., Koike, S., Chu, B., Cheng, J., Yang, J., Morisseau, C. H. P., Torok, N. J., Hammock, B. D., & Haj, F. G. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.10.002 · Cited by 23
Regulatory effect of volatile compounds in fermented alcoholic beverages on gut microbiota and serum metabolism in a mouse model
Ji, M., Fang, C., Jia, W. P., Du, H., & Xu, Y. (2021) · Food & Function · doi:10.1039/d0fo03028g · Cited by 24
Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo
Sun, J. Y., Hong, Z., Shao, S., Li, L., Yang, B., Hou, Y., Wang, H., Xu, Y., Zhang, Q., Pi, J., et al. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115617 · Cited by 23
Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
Zhang, Y., Lu, J., Zhong, Y., Yang, C., Chen, L., Wu, D., Song, M., Shi, L., Ma, Z., Li, L., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112462 · Cited by 23
Insight into the binding characteristics of rutin and alcohol dehydrogenase: Based on the biochemical method, spectroscopic experimental and molecular model
Huang, X., Zhang, S., Li, Y., Yang, X. N., Li, N., Zeng, G., Chen, F., & Tuo, X. (2022) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2022.112394 · Cited by 23
Preclinical mouse models of hepatocellular carcinoma: An overview and update
Gu, C. Y., & Lee, T. K. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113042 · Cited by 24
Extracts of Dracocephalum tanguticum Maxim Ameliorate Acute Alcoholic Liver Disease via Regulating Transcription Factors in Mice
Guo, M., Gu, L., Hui, H., Li, X., & Jin, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.830532 · Cited by 23
Gender disparity and temporal trend of liver cancer in China from 1990 to 2019 and predictions in a 25-year period
Yue, T., Xu, M., Cai, T., Zhu, H., Pourkarim, M. R., Clercq, E. D., & Li, G. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.956712 · Cited by 23
Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma
Sasaki, R., Ray, R., Moriyama, M., Ray, R. B., & Kanda, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179679 · Cited by 23
Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Kim, H., Shim, Y., Choi, S. E., Kim, M., Lee, G., You, H. J., Choi, W., Yang, K., Ryu, T., Kim, M. J., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00921-x · Cited by 25
Self-citation
Outcomes of hepatocellular carcinoma by etiology with first-line atezolizumab and bevacizumab: a real-world analysis
Brown, T. J., Mamtani, R., Gimotty, P. A., Karasic, T. B., & Yang, Y. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04590-9 · Cited by 24
Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress
Wei, L., Luo, H., Jin, Y., Shu, Y. L., Wen, C., Qin, T., Yang, X., Ma, L., Liu, Y., You, Y., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155080 · Cited by 23
Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin
Shibamoto, A., Kaji, K., Nishimura, N., Kubo, T., Iwai, S., Tomooka, F., Suzuki, J., Tsuji, Y., Fujinaga, Y., Kawaratani, H., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109450 · Cited by 23
Racial and ethnic disparities in alcohol-associated liver disease in the United States: A systematic review and meta-analysis
Anouti, A., Dahan, K. S. E., Rich, N. E., Louissaint, J., Lee, W. M., Lieber, S. R., Arab, J. P., Zhang, B. Y., Patel, M. J., Thimphittaya, C., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000409 · Cited by 23
Growth differentiation factor 15: Emerging role in liver diseases
Li, Y., Zhang, J., Chen, S., Ke, Y., Ke, Y., & Chen, Y. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156727 · Cited by 23
Lipophagy: A potential therapeutic target for nonalcoholic and alcoholic fatty liver disease
Han, Y., He, X.-M., Jin, M., Sun, H., & Kwon, T. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.06.030 · Cited by 23
An Update on Animal Models of Alcohol-Associated Liver Disease
Cao, P., Chao, X., Ni, H., & Ding, W. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.11.011 · Cited by 22
Treatment of severe alcoholic hepatitis: A systematic review
Melkebeke, L. V., Korf, H., Tsochatzis, E. A., der Merwe, V., Nevens, F., & Verbeek, J. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.06.011 · Cited by 22
The Emerging Role of Stress Granules in Hepatocellular Carcinoma
Dolicka, D., Foti, M., & Sobolewski, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179428 · Cited by 22
Crosstalk between gut microbiota and host lipid metabolism in a mouse model of alcoholic liver injury by chronic baijiu or ethanol feeding
Fang, C., Zhou, Q., Liu, Q., Jia, W. P., & Xu, Y. (2021) · Food & Function · doi:10.1039/d1fo02892h · Cited by 22
Cell-to-Cell Communications in Alcohol-Associated Liver Disease
Osna, N. A., Eguchi, A., Feldstein, A. E., Tsukamoto, H., Dagur, R. S., Ganesan, M., New‐Aaron, M., Arumugam, M. K., Chava, S. P., Ribeiro, M. D. C., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.831004 · Cited by 22
Self-citation
Butyrate ameliorates inflammation of alcoholic liver disease by suppressing the LPS-TLR4-NF-κB/NLRP3 axis via binding GPR43-β-arrestin2
Ren, Y., Wang, R., Yu, J., Bao, T., Liu, Y., Bai, Z., Wang, T., Li, Y., Zhang, X., Wang, H., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105351 · Cited by 24
Single-Cell RNA Transcriptome Profiling of Liver Cells of Short-Term Alcoholic Liver Injury in Mice
Cao, L., Wu, D., Qin, L., Tan, D., Fan, Q., Jia, X., Yang, M., Zhou, T., Feng, C., Lu, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054344 · Cited by 20
The emerging role of the gut mycobiome in liver diseases
Szóstak, N., Figlerowicz, M., & Philips, A. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2211922 · Cited by 22
Exploring the microscopic changes of lipid droplets and mitochondria in alcoholic liver disease via fluorescent probes with high polarity specificity
Li, W., Nie, G., Yang, A., Qu, J., Zhong, C., & Chen, D. (2023) · Talanta · doi:10.1016/j.talanta.2023.124819 · Cited by 22
Physiopathologie des stéatoses hépatiques métaboliques
Anty, R., & Gual, P. (2019) · La Presse Médicale · doi:10.1016/j.lpm.2019.09.051 · Cited by 25
Bacillus subtilis pretreatment alleviates ethanol-induced acute liver injury by regulating the Gut-liver axis in mice
Wang, S., Liu, J., Cheng, D., Ren, L., Zheng, L., Chen, F., & Zeng, T. (2023) · Toxicology · doi:10.1016/j.tox.2023.153487 · Cited by 21
Chronic alcohol consumption aggravates acute kidney injury through integrin β1/JNK signaling
Zhan, Z., Chen, J., Zhou, H., Hong, X., Li, L., Qin, X., Fu, H., & Liu, Y. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103386 · Cited by 26
Rice Protein Peptides Alleviate Alcoholic Liver Disease via the PPARγ Signaling Pathway: Through Liver Metabolomics and Gut Microbiota Analysis
Tian, Y., He, Y., Xiong, H., & Sun, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02671 · Cited by 21
Lipid droplet dynamics in alcoholic fatty liver disease
Schulze, R. J., & Ding, W. (2019) · Liver Research · doi:10.1016/j.livres.2019.09.002 · Cited by 21
Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice
Liu, X., Guan-Nan, C. H. E. N., Guo-Ming, D. U., Pan, Y., Song, W., Jiang, T., & Liu, H. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)30020-0 · Cited by 21
The early identification of alcohol use disorders and liver injury: proposal for a diagnostic algorithm
Testino, G., Fagoonee, S., Caputo, F., & Pellicano, R. (2021) · Panminerva Medica · doi:10.23736/s0031-0808.21.04272-5 · Cited by 21
Mechano-structural alteration in proximal femora of individuals with alcoholic liver disease: Implications for increased bone fragility
Jadzic, J. S., Milovanovic, P. D., Cvetković, D., Ivović, M., Tomanović, N., Bracanovic, M., Živković, V., Nikolić, S., Djuric, M. P., & Djonić, D. (2021) · Bone · doi:10.1016/j.bone.2021.116020 · Cited by 22
Application of Fluorescent Probes in Reactive Oxygen Species Disease Model
Niu, P., Zhu, J., Wei, L., & Liu, X. (2022) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2022.2080495 · Cited by 21
Mesenchymal stem cells-based therapy in liver diseases
Han, H., Jin, W., & Li, X. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00088-x · Cited by 24
Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis
Zuo, R., Jiao, J.-Y., Chen, N., Jiang, X., Wu, Y., Nan, J., & Lian, L. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154599 · Cited by 24
CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence
Liu, Z., Wu, B., Liu, X., Wu, X., Du, J., Xia, G., Cai, J.-N., Zhu, H., Sheng, X., Zhang, M., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.80461 · Cited by 21
Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases
Hikisz, P., & Jacenik, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076579 · Cited by 21
Kupffer cell pyroptosis mediated by METTL3 contributes to the progression of alcoholic steatohepatitis
Pan, X., Li, B., Wang, L., Li, N., Lin, H., Zhang, J., Du, N., Zhu, Y., Wu, X. G., Hu, C., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202300059rr · Cited by 22
Gut mycobiome in metabolic diseases: Mechanisms and clinical implication
Zhou, X., Zhang, X., & Yu, J. Q. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100625 · Cited by 22
Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis
Luyao, X., Guo, W., Jiaying, D., Cheng, Y., Chen, Y., Liu, W., Xu, J., Su, W., Zhang, X., Wang, C., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111399 · Cited by 21
The role of hydrogen sulfide regulation of pyroptosis in different pathological processes
Zhang, Y.-T. Y., Zhao, H., Fu, X., Kexiao, W., Yang, J., Zhang, X., & Wang, H. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116254 · Cited by 21
Natural Saponins on Cholesterol‐Related Diseases: Treatment and Mechanism
Xiao, M., Li, S., Pei, W., Gu, Y., & Piao, X. (2025) · Phytotherapy Research · doi:10.1002/ptr.8432 · Cited by 21
Dietary Copper Plays an Important Role in Maintaining Intestinal Barrier Integrity During Alcohol-Induced Liver Disease Through Regulation of the Intestinal HIF-1α Signaling Pathway and Oxidative Stress
Lin, H., Chen, D., Du, Q., Pan, T., Tu, H., Xu, Y., Teng, T., Tu, J., Li, J., Lin, Z., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00369 · Cited by 21
Beneficial effects of an endogenous enrichment in n3‐PUFAs on Wnt signaling are associated with attenuation of alcohol‐mediated liver disease in mice
Warner, D. R., Warner, J. B., Hardesty, J., Song, Y., Chen, C., Chen, Z., Kang, J. X., McClain, C. J., & Kirpich, I. (2021) · The FASEB Journal · doi:10.1096/fj.202001202r · Cited by 21
Moderate Alcoholic Hepatitis
Clemente, A. P. G., Oliveira-Mello, A., & Bataller, R. A. (2021) · Clinics in Liver Disease · doi:10.1016/j.cld.2021.03.001 · Cited by 21
Self-citation
Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease
Hohmann, N., Schröder, F., Moreira, B., Teng, H., Burhenne, J., Bruckner, T. M., Mueller, S., Haefeli, W. E., & Seitz, H. K. (2021) · Gut · doi:10.1136/gutjnl-2021-324727 · Cited by 21
Self-citation
Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats
Mahmoudabad, A. G., Gheybi, F., Mehrabi, M., Masoudi, A., Mobasher, Z., Vahedi, H., Gharravi, A. M., Bitaraf, F. S., & Rezayat, S. M. (2023) · Bioimpacts · doi:10.34172/bi.2023.24128 · Cited by 22
The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target
Wang, M., Zhao, J., Chen, J., Long, T., Xu, M., Luo, T., Che, Q., He, Y.-H., & Xu, D. (2024) · PeerJ · doi:10.7717/peerj.17094 · Cited by 20
Understanding the Role of Alcohol in Metabolic Dysfunction and Male Infertility
Genchi, V. A., Cignarelli, A., Sansone, A., Yannas, D., Valentina, L. D., Livraghi, D. R., Spaggiari, G., & Santi, D. (2024) · Metabolites · doi:10.3390/metabo14110626 · Cited by 20
Association Between the Triglyceride–Glucose Index and Outcomes of Nonalcoholic Fatty Liver Disease: A Large-Scale Health Management Cohort Study
Liu, J., Guan, L., Zhao, M., Li, Q., Song, A., Gao, L., Lin, H., & Zhao, J. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s316864 · Cited by 19
Subclinical versus advanced forms of alcohol-related liver disease: Need for early detection
Gómez, C., Melo, L., Aguado, D. M., & Bataller, R. A. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0017 · Cited by 20
Self-citation
Clinic-radiological features and radiomics signatures based on Gd-BOPTA-enhanced MRI for predicting advanced liver fibrosis
Zheng, W., Guo, W., Xiong, M., Chen, X., Gao, L., Song, Y. S., & Cao, D. (2022) · European Radiology · doi:10.1007/s00330-022-08992-0 · Cited by 20
“Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
Guo, K., Xu, S., & Zeng, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1050709 · Cited by 20
Resolvin D1 attenuated liver injury caused by chronic ethanol and acute LPS challenge in mice
Hardesty, J., Warner, J. B., Song, Y., Rouchka, E. C., McClain, C. J., Warner, D. R., & Kirpich, I. (2022) · The FASEB Journal · doi:10.1096/fj.202200778r · Cited by 20
Engineering bacteria to modulate host metabolism
Ciocan, D. M., & Elinav, E. (2023) · Acta Physiologica · doi:10.1111/apha.14001 · Cited by 20
Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis
Elkrief, L., Ganne‐Carrié, N., Manceau, H., Tanguy, M., Valainathan, S. R., Riescher‐Tuczkiewicz, A., Biquard, L., Barget, N., Chaffaut, C., Louvet, A., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.025 · Cited by 21
Molecular mechanisms of alcohol's effects on the human body: A review and update
Renu, K., Myakala, H., Chakraborty, R., Bhattacharya, S., Abuwani, A. M., Lokhandwala, M., Vellingiri, B., & Gopalakrishnan, A. V. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23502 · Cited by 20
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease
Li, Y., Yunrui, L. U., Mozuo, N. I. A. N., Sheng, Q., ZHANG, C., Han, C. Q., Dou, X., & Ding, Y. (2023) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(23)60443-1 · Cited by 21
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Rungratanawanich, W., Ballway, J. W., Wang, X., Won, K., Hardwick, J. P., & Song, B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108547 · Cited by 22
Transcriptomic Profiling Identifies Novel Hepatic and Intestinal Genes Following Chronic Plus Binge Ethanol Feeding in Mice
Jiang, L., Chu, H., Gao, B., Lang, S., Wang, Y., Duan, Y., & Schnabl, B. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06461-6 · Cited by 20
Self-citation
The Role of Epigenetic Changes in the Progression of Alcoholic Steatohepatitis
Kim, H.-G., Cho, J.-H., Kim, J., & Kim, S.-J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.691738 · Cited by 20
Management of alcohol withdrawal syndrome in patients with alcohol-associated liver disease
Ratner, J., Blaney, H. L., & Rastegar, D. A. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000372 · Cited by 21
Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease
Li, W., Gao, W., Yan, Q. S., Yang, L., Zhu, Q., & Chu, H. (2024) · Biomedicines · doi:10.3390/biomedicines13010074 · Cited by 19
Dual-channel fluorescent probe targeting the Golgi apparatus for simultaneously detecting viscosity and ONOO− in acute alcoholic liver injury
Zheng, Z., Gong, S., Gong, S., Tan, X., & Feng, G. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138082 · Cited by 19
Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption
Vogle, A., Qian, T., Zhu, S., Burnett, E., Fey, H., Zhu, Z., Keshavarzian, A., Shaikh, M. W., Hoshida, Y., Kim, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59188-9 · Cited by 19
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH
Maeda, H., Ishima, Y., Saruwatari, J., Mizuta, Y., Minayoshi, Y., Ichimizu, S., Yanagisawa, H., Nagasaki, T., Yasuda, K., Oshiro, S., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.039 · Cited by 22
Hepatoprotective potential of bioflavonoids
Polimati, H., Pragada, R. R., Thuấn, N. H., & Tatipamula, V. B. (2022) · Studies in natural products chemistry · doi:10.1016/b978-0-12-823944-5.00014-4 · Cited by 19
Modulation of interleukin‐36 based inflammatory feedback loop through the hepatocyte‐derived IL‐36R‐P2X7R axis improves steatosis in alcoholic steatohepatitis
Shang, Y., Yang, H., Li, X., Zhang, Y., Chen, N., Jiang, X., Zhang, Z., Zuo, R., Wang, H., Lan, X., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15858 · Cited by 19
The Protective Effects of Corn Oligopeptides on Acute Alcoholic Liver Disease by Inhibiting the Activation of Kupffer Cells NF-κB/AMPK Signal Pathway
Wei, Y., Li, M., Feng, Z., Zhang, D., Sun, M., Wang, Y., & Chen, X. (2022) · Nutrients · doi:10.3390/nu14194194 · Cited by 19
Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate-Activated Protein Kinase/Sirtuin 1 Pathway in Alcohol-Related Liver Disease.
Zhu, L., Xu, J.-J., Li, H.-D., Li, J.-J., Cheng, M., Niu, X.-N., Jia, P.-C., Liu, J.-Y., Huang, C., Lv, X.-W., et al. (2023) · Laboratory investigation; a journal of technical methods and pathology · doi:10.1016/j.labinv.2022.100041 · Cited by 19
Current and future treatment for alcoholic‐related liver diseases
Yoon, E. L., & Kim, W. K. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16257 · Cited by 19
β-hydroxybutyrate: A crucial therapeutic target for diverse liver diseases
Li, K., Wang, W., Jia-bin, W., & Xiao, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115191 · Cited by 21
Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles
Aghara, H., Chadha, P., Zala, D., & Mandal, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1205821 · Cited by 21

Authors: Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H.
Affiliations: Heidelberg University (DE)
University of Pittsburgh (US)
National Institutes of Health (US)
Hospital Clínic de Barcelona (ES)
Medical University of Graz (AT)
Inserm (FR)
University of Southern California (US)
ORCID: Bataller, Ramon
Gao, Bin
Gual, Antoni
Lackner, Carolin
Mathurin, Philippe
Mueller, Sebastian
Tsukamoto, Hidekazu
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2018-08-16
Volume: 4
Issue: 1
Pages: 16-16
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/s41572-018-0014-7
OpenAlex: W4210980460
Cited by: 1,271
References: 244
Citations by year: 2026: 126 · 2025: 200 · 2024: 249 · 2023: 230 · 2022: 176 · 2021: 145 · 2020: 75 · 2019: 57 · 2018: 9
FWCI: 10.57
Type: journal article
Language: en
Update notices: correction (2018-08-28)
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: U.S. Department of Veterans Affairs (IK6BX004205, I01 BX001991)
National Institute on Alcohol Abuse and Alcoholism (R01AA011576)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords: alcoholic liver disease, alcoholic fatty liver, alcoholic steatohepatitis, alcoholic hepatitis, liver cirrhosis, hepatocellular carcinoma, liver fibrosis, hepatic steatosis, oxidative stress, acetaldehyde toxicity, liver inflammation, alcoholism, liver fibrosis diagnosis, serum biomarkers, alcohol abstinence, liver transplantation
MeSH terms: Global Burden of Disease, Alcohol Drinking, Fatty Liver, Alcoholic, Humans, Liver Diseases, Alcoholic, Liver Neoplasms, Quality of Life, Liver Transplantation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alcoholic liver disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks