The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Polycystic kidney disease
Open accessAbstract
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases. ADPKD is a common disease that mostly presents in adults, whereas ARPKD is a rarer and often more severe form of polycystic kidney disease (PKD) that usually presents perinatally or in early childhood. Cell biological and clinical research approaches have expanded our knowledge of the pathogenesis of ADPKD and ARPKD and revealed some mechanistic overlap between them. A reduced ‘dosage’ of PKD proteins is thought to disturb cell homeostasis and converging signalling pathways, such as Ca2+, cAMP, mechanistic target of rapamycin, WNT, vascular endothelial growth factor and Hippo signalling, and could explain the more severe clinical course in some patients with PKD. Genetic diagnosis might benefit families and improve the clinical management of patients, which might be enhanced even further with emerging therapeutic options. However, many important questions about the pathogenesis of PKD remain. In this Primer, we provide an overview of the current knowledge of PKD and its treatment.Autosomal dominant polycystic kidney disease (PKD) and autosomal recessive PKD are progressive cilia-related disorders that often lead to chronic kidney disease and end-stage renal disease. This Primer provides an overview of the current knowledge of PKD pathogenesis and its treatment.
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Autosomal dominant polycystic kidney disease
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Self-citationDefective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy
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Self-citationMutations in PRKCSH cause isolated autosomal dominant polycystic liver disease
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Cited by
Chronic Kidney Disease Diagnosis and Management: A Review
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Targeting integrin pathways: mechanisms and advances in therapy
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Bayır, H., Dixon, S. J., Tyurina, Y. Y., Kellum, J. A., & Kagan, V. E. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00689-x · Cited by 331
Ciliopathies and the Kidney: A Review
McConnachie, D. J., Stow, J. L., & Mallett, A. J. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.08.012 · Cited by 257
Metadata
- Authors
- Bergmann, C., Guay-Woodford, L. M., Harris, P. C., Horie, S., Peters, D. J. M., & Torres, V. E.
- Venue
- Nature Reviews Disease Primers
- Published
- 2018-12-06
- Volume
- 4
- Issue
- 1
- Pages
- 50-50
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W3148049993
- Cited by
- 807
- References
- 13
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- green
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