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Cited by 574

The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.

Acute heart failure

Open access
Arrigo, Mattia, Jessup, Mariell, Mullens, Wilfried, Reza, Nosheen, Shah, Ajay M., Sliwa, Karen, Mebazaa, Alexandre·2020·Nature Reviews Disease Primers

Abstract

Acute heart failure (AHF) is a syndrome defined as the new onset (de novo heart failure (HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of HF, mostly related to systemic congestion. In the presence of an underlying structural or functional cardiac dysfunction (whether chronic in ADHF or undiagnosed in de novo HF), one or more precipitating factors can induce AHF, although sometimes de novo HF can result directly from the onset of a new cardiac dysfunction, most frequently an acute coronary syndrome. Despite leading to similar clinical presentations, the underlying cardiac disease and precipitating factors may vary greatly and, therefore, the pathophysiology of AHF is highly heterogeneous. Left ventricular diastolic or systolic dysfunction results in increased preload and afterload, which in turn lead to pulmonary congestion. Fluid retention and redistribution result in systemic congestion, eventually causing organ dysfunction due to hypoperfusion. Current treatment of AHF is mostly symptomatic, centred on decongestive drugs, at best tailored according to the initial haemodynamic status with little regard to the underlying pathophysiological particularities. As a consequence, AHF is still associated with high mortality and hospital readmission rates. There is an unmet need for increased individualization of in-hospital management, including treatments targeting the causative factors, and continuation of treatment after hospital discharge to improve long-term outcomes. Acute heart failure (AHF) is a syndrome characterized by signs and symptoms of heart failure (typically systemic congestion) that occurs in the presence of an underlying cardiac dysfunction (previously diagnosed, undiagnosed or new-onset) and precipitating factors. AHF is associated with high mortality and hospital readmission rates.

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Metadata

Authors
Arrigo, M., Jessup, M., Mullens, W., Reza, N., Shah, A. M., Sliwa, K., & Mebazaa, A.
Venue
Nature Reviews Disease Primers
Published
2020-03-05
Volume
6
Issue
1
Pages
16-16
ISSN
2056-676X (ISSN-L)
OpenAlex
W3010255050
Cited by
574
References
149
FWCI
14.68
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Acute heart failure. https://app.cochat.ai/papers/10.1038/s41572-020-0151-7
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Arrigo, M., Jessup, M., Mullens, W., Reza, N., Shah, A. M., Sliwa, K., & Mebazaa, A. (2020). Acute heart failure. Nature Reviews Disease Primers. https://doi.org/10.1038/s41572-020-0151-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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