The DOI matches its Crossref record; 311 of the 315 references it cites were found in a registry or an index.
Whipworm and roundworm infections
Open accessAbstract
Trichuriasis and ascariasis are neglected tropical diseases caused by the gastrointestinal dwelling nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a roundworm), respectively. Both parasites are staggeringly prevalent, particularly in tropical and subtropical areas, and are associated with substantial morbidity. Infection is initiated by ingestion of infective eggs, which hatch in the intestine. Thereafter, T. trichiura larvae moult within intestinal epithelial cells, with adult worms embedded in a partially intracellular niche in the large intestine, whereas A. lumbricoides larvae penetrate the gut mucosa and migrate through the liver and lungs before returning to the lumen of the small intestine, where adult worms dwell. Both species elicit type 2 anti-parasite immunity. Diagnosis is typically based on clinical presentation (gastrointestinal symptoms and inflammation) and the detection of eggs or parasite DNA in the faeces. Prevention and treatment strategies rely on periodic mass drug administration (generally with albendazole or mebendazole) to at-risk populations and improvements in water, sanitation and hygiene. The effectiveness of drug treatment is very high for A. lumbricoides infections, whereas cure rates for T. trichiura infections are low. Novel anthelminthic drugs are needed, together with vaccine development and tools for diagnosis and assessment of parasite control in the field.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“T. trichiuris infection is correlated with chronic colitis [60].”
From Intestinal Parasitic Infection and Nutritional Status in Children under Five Years Old: A Systematic Review (2022) · cites this paper as [60]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32279-7 · Cited by 13,867
Vos, T., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32154-2 · Cited by 13,220
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,192
A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni.
Katz, N., Chaves, A. C., & Pellegrino, J. (1973) · PubMed · Cited by 2,414
Kassebaum, N. J., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, J., Carter, A., Casey, D. C., Charlson, F. J., Coates, M. M., Coggeshall, M., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31460-x · Cited by 2,163
PCR inhibitors - occurrence, properties and removal
Schrader, C., Schielke, A., Ellerbroek, L., & Johne, R. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05384.x · Cited by 2,129
Fewtrell, L., Kaufmann, R. B., Kay, D., Enanoria, W. T. A., Haller, L., & Colford, J. M. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01253-8 · Cited by 1,690
Global numbers of infection and disease burden of soil transmitted helminth infections in 2010
Pullan, R. L., Smith, J. L., Jasrasaria, R., & BROOKER, S. J. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-37 · Cited by 1,475
Soil-transmitted helminth infections: updating the global picture
de Silva, N. R., Brooker, S. J., Hotez, P. J., Montresor, A., Engels, D., & Savioli, L. (2003) · Trends in Parasitology · doi:10.1016/j.pt.2003.10.002 · Cited by 1,162
Research works printed but not linked: 6
- Elliott, D. E. in Sleisenger and Fordtran’s Gastrintestinal and Liver Disease: Pathophysiology/Diagnosis/Management (eds Friedman, L. S., Feldman, M., Brandt, L. J.) 2435–2457 (Elsevier, Philadelphia, 2006).
- Pawlowski, Z. S. & Arfaa, F. in Tropical and Geographical Medicine (eds Warren, K. S. & Mahmoud, A. A. F. 347–358 (McGraw-Hill, 1984).
- Kopp, S. & Keiser, J. in Kucers’ the Use of Antibiotics: a Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, 7th edn (ed. Grayson, M. L. et al.) 3381–3384 (CRC Press, 2017).
- Husain, S. J., Zubairi, A. B., Sultan, N., Beg, M. A. & Mehraj, V. Recurrent episodes of upper airway blockage associated with Ascaris lumbricoides causing cardiopulmonary arrest in a young patient. BMJ Case Rep. 2009, bcr0120091415 (2009).
- Mejer, H. & Roepstorff, A. in Proc. 23rd International Conference of the World Association for the Advancement of Veterinary Parasitology 113 (International Conference of the World Association for the Advancement of Veterinary Parasitology, 2011).
- Arnold, M., Alves, J. & Plessis, J. in ABC of Pediatric Surgical Imaging (eds Andronikou, S., Alexander, A., Kilborn, T., Millar, A. J. W. & Daneman, A.) (Springer, 2010).
Cited by
Sorted by citations
Intestinal Parasitic Infections in 2023
Ahmed∥, M. (2023) · Gastroenterology Research · doi:10.14740/gr1622 · Cited by 126
Fauziah, N., Aviani, J. K., Agrianfanny, Y. N., & Fatimah, S. N. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7110371 · Cited by 122
“lumbricoides, particularly in endemic areas, where their distributions overlap [60].”
BackgroundGlobal prevalence of Ascaris infection in humans (2010–2021): a systematic review and meta-analysis
Holland, C. V., Sepidarkish, M., Deslyper, G., Abdollahi, A. A., Valizadeh, S., Mollalo, A., Mahjour, S., Ghodsian, S., Ardekani, A., Behniafar, H., et al. (2022) · Infectious Diseases of Poverty · doi:10.1186/s40249-022-01038-z · Cited by 136
The yin and yang of human soil-transmitted helminth infections
Loukas, A. C., Maizels, R. M., & Hotez, P. J. (2021) · International Journal for Parasitology · doi:10.1016/j.ijpara.2021.11.001 · Cited by 111
Zhao, L., Gao, F., Gao, S., Liang, Y., Long, H., Lv, Z., Su, Y., Ye, N., Zhang, L., Zhao, C., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1915-y · Cited by 83
Metadata
- Authors
- Else, K. J., Keiser, J., Holland, C. V., Grencis, R. K., Sattelle, D. B., Fujiwara, R. T., Bueno, L. L., Asaolu, S. O., Sowemimo, O. A., & Cooper, P. J.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Swiss Tropical and Public Health Institute (CH)
- Trinity College Dublin (IE)
- University College London (GB)
- Universidade Federal de Minas Gerais (BR)
- Obafemi Awolowo University (NG)
- St George's, University of London (GB)
- ORCID
- Venue
- Nature Reviews Disease Primers
- Published
- 2020-05-28
- Volume
- 6
- Issue
- 1
- Pages
- 44-44
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W3028760640
- Cited by
- 308
- References
- 315
- Citations by year
- 2026: 32 · 2025: 59 · 2024: 58 · 2023: 66 · 2022: 51 · 2021: 36 · 2020: 6
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Reviews Disease Primers (publishedVersion, cc-by)
- PubMed (publishedVersion)
- edoc (University of Basel) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Henry Royce Institute (EP/M022498/1, EP/F001452/1, EP/M010-619/1, EP/F007906/1, EP/F028431/1)
- Engineering and Physical Sciences Research Council (EP/F028431, EP/F007906, EP/F001452/1, EP/F007906/1, EP/F028431/1, EP/M010619, EP/F001452, EP/M010619/1, EP/M022498/1)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Keywords
- trichuriasis, ascariasis, Trichuris trichiura, Ascaris lumbricoides, nematodes, gastrointestinal nematodes, neglected tropical diseases, Th2 immune response, larval migration, mass drug administration, albendazole, mebendazole, vaccine development, water, sanitation and hygiene, parasite control
- MeSH terms
- Animals, Ascariasis, Humans, Trichuriasis, Trichuris, Prevalence, Ascaris lumbricoides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
