The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Helicobacter pylori infection
Open accessAbstract
Helicobacter pylori infection causes chronic gastritis, which can progress to severe gastroduodenal pathologies, including peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. H. pylori is usually transmitted in childhood and persists for life if untreated. The infection affects around half of the population in the world but prevalence varies according to location and sanitation standards. H. pylori has unique properties to colonize gastric epithelium in an acidic environment. The pathophysiology of H. pylori infection is dependent on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors, resulting in distinct gastritis phenotypes that determine possible progression to different gastroduodenal pathologies. The causative role of H. pylori infection in gastric cancer development presents the opportunity for preventive screen-and-treat strategies. Invasive, endoscopy-based and non-invasive methods, including breath, stool and serological tests, are used in the diagnosis of H. pylori infection. Their use depends on the specific individual patient history and local availability. H. pylori treatment consists of a strong acid suppressant in various combinations with antibiotics and/or bismuth. The dramatic increase in resistance to key antibiotics used in H. pylori eradication demands antibiotic susceptibility testing, surveillance of resistance and antibiotic stewardship. Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.
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Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30753-3 · Cited by 6,142
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
Alm, R. A., Ling, L.-S. L., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., et al. (1999) · Nature · doi:10.1038/16495 · Cited by 1,893
Cure of duodenal ulcer associated with eradication of Helicobacter pylori
Rauws, E. A. J., & Tytgat, G. N. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91301-p · Cited by 922
Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota
Ferreira, R. M., Pereira-Marques, J., Pinto-Ribeiro, I., Costa, J. L., Carneiro, F., Machado, J. C., & Figueiredo, C. (2018) · Gut · doi:10.1136/gutjnl-2017-314205 · Cited by 697
Helicobacter pylori evolution and phenotypic diversification in a changing host
Suerbaum, S., & Josenhans, C. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1658 · Cited by 384
Self-citationThe Peopling of the Pacific from a Bacterial Perspective
Moodley, Y., Linz, B., Yamaoka, Y., Windsor, H. M., Breurec, S., Wu, J.-Y., Maady, A., Bernhöft, S., Thiberge, J.-M., Phuanukoonnon, S., et al. (2009) · Science · doi:10.1126/science.1166083 · Cited by 350
The Clinical Evidence Linking Helicobacter pylori to Gastric Cancer
Moss, S. F. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.12.001 · Cited by 321
AGA clinical practice guidelines on management of gastric intestinal metaplasia
Gupta, S., Li, D., El Serag, H. B., Davitkov, P., Altayar, O., Sultan, S., Falck-Ytter, Y., & Mustafa, R. A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.003 · Cited by 320
Cited by
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63
Analysis of dose-TSH response effect of levothyroxine soft-gel formulation
Trimboli, P., Piticchio, T., Dadda, Z., Stramazzo, I., Gamarra, E., Ruinelli, L., & Virili, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1340204 · Cited by 2
Lopez-Magaña, R., & Ottemann, K. M. (2026) · Journal of Bacteriology · doi:10.1128/jb.00394-25 · Cited by 1
Metadata
- Authors
- Malfertheiner, P., Camargo, M. C., El-Omar, E., Liou, J.-M., Peek, R., Schulz, C., Smith, S. I., & Suerbaum, S.
- Venue
- Nature Reviews Disease Primers
- Published
- 2023-04-20
- Volume
- 9
- Issue
- 1
- Pages
- 19-19
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W4366598306
- Cited by
- 1,191
- References
- 12
- FWCI
- 85.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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