Cure of duodenal ulcer associated with eradication of Helicobacter pylori

Rauws, E.A.J.; Tytgat, G.N.J.

doi:10.1016/0140-6736(90)91301-p

Cited by 922Helicobacter pylori-related gastroenterology studiesGastrointestinal Bleeding Diagnosis and TreatmentHepatitis C virus research

Cure of duodenal ulcer associated with eradication of Helicobacter pylori

Rauws, E.A.J., Tytgat, G.N.J.·1990·The Lancet

DOI 10.1016/0140-6736(90)91301-p

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Abstract

50 patients with intractable duodenal ulcer were randomly assigned to 4 weeks of treatment with colloidal bismuth subcitrate (CBS) alone (26 patients) or with amoxicillin and metronidazole (24 patients). 5 patients (all on triple therapy) withdrew because of side-effects. In 17 of the 45 patients who completed the treatment, Helicobacter pylori was eradicated, and there was no ulcer relapse during the first 12 months of follow-up. The ulcer relapse rate was significantly higher (17 of 21 [89%]) among patients who remained positive for H pylori. 9 patients who remained positive for H pylori and had ulcer relapses within 6 months of treatment with CBS alone, were subsequently given triple therapy. 7 of the 9 showed H pylori eradication and no relapses within the next 12 months. The 2 patients still H pylori-positive after triple therapy had further ulcer relapses. H pylori eradication, without altering acid output, will become the mainstay of duodenal ulcer treatment because it cures the disease.

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Authors: Rauws, E. A. J., & Tytgat, G. N. J.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Rauws, E.A.J.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1990-05
Volume: 335
Issue: 8700
Pages: 1233-1235
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(90)91301-p
OpenAlex: W2029865847
Cited by: 922
References: 23
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 10 · 2014: 18 · 2013: 11 · 2012: 14
FWCI: 106.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Keywords: duodenal ulcer, Helicobacter pylori eradication, bismuth subcitrate, amoxicillin, metronidazole, triple therapy, ulcer recurrence
MeSH terms: Administration, Oral, Amoxicillin, Anti-Ulcer Agents, Campylobacter, Campylobacter Infections, Drug Administration Schedule, Drug Evaluation, Drug Therapy, Combination, Duodenal Ulcer, Follow-Up Studies, Gastric Mucosa, Humans, Metronidazole, Organometallic Compounds, Prospective Studies, Recurrence, Randomized Controlled Trials as Topic

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Cure of duodenal ulcer associated with eradication of Helicobacter pylori

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