The DOI matches its Crossref record; 244 of the 244 references it cites were found in a registry or an index.
Advances in TRP channel drug discovery: from target validation to clinical studies
Open accessAbstract
Transient receptor potential (TRP) channels are multifunctional signalling molecules with many roles in sensory perception and cellular physiology. Therefore, it is not surprising that TRP channels have been implicated in numerous diseases, including hereditary disorders caused by defects in genes encoding TRP channels (TRP channelopathies). Most TRP channels are located at the cell surface, which makes them generally accessible drug targets. Early drug discovery efforts to target TRP channels focused on pain, but as our knowledge of TRP channels and their role in health and disease has grown, these efforts have expanded into new clinical indications, ranging from respiratory disorders through neurological and psychiatric diseases to diabetes and cancer. In this Review, we discuss recent findings in TRP channel structural biology that can affect both drug development and clinical indications. We also discuss the clinical promise of novel TRP channel modulators, aimed at both established and emerging targets. Last, we address the challenges that these compounds may face in clinical practice, including the need for carefully targeted approaches to minimize potential side-effects due to the multifunctional roles of TRP channels. This Review discusses recent findings in transient receptor potential (TRP) channel structural biology and the impact of these findings in drug development and clinical indications. It also addresses the challenges of modulating TRP channels and the need for targeted approaches to minimize potential side-effects due to the multifunctional roles of TRP channels.
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Cites
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Cited by
Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522
Explainable artificial intelligence for drug discovery and development: a comprehensive survey
Alizadehsani, R., Oyelere, S. S., Hussain, S., Jagatheesaperumal, S. K., Calixto, R. R., Rahouti, M., Roshanzamir, M., & De Albuquerque, V. H. C. (2024) · IEEE Access · doi:10.1109/access.2024.3373195 · Cited by 124
Xiong, J., Xiao, R., Zhao, J., Zhao, Q., Luo, M., Li, F., Zhang, W., & Wu, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04810-3 · Cited by 79
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients
Marchi, M., Salvi, E., Andelic, M., Mehmeti, E., D'Amato, I., Cazzato, D., Chiappori, F., Lombardi, R., Cartelli, D., Devigili, G., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002905 · Cited by 29
Go, E. J., Hwang, S.-M., Jo, H., Rahman, M. M., Park, J., Lee, J. Y., Jo, Y. Y., Lee, B.-G., Jung, Y., Berta, T., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01342-8 · Cited by 28
Metadata
- Authors
- Koivisto, A.-P., Belvisi, M. G., Gaudet, R., & Szallasi, A.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2021-09-15
- Volume
- 21
- Issue
- 1
- Pages
- 41-59
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W3199382522
- Cited by
- 537
- References
- 244
- FWCI
- 17.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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