The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
The α-cell in diabetes mellitus
Abstract
Findings from the past 10 years have placed the glucagon-secreting pancreatic α-cell centre stage in the development of diabetes mellitus, a disease affecting almost one in every ten adults worldwide. Glucagon secretion is reduced in patients with type 1 diabetes mellitus, increasing the risk of insulin-induced hypoglycaemia, but is enhanced in type 2 diabetes mellitus, exacerbating the effects of diminished insulin release and action on blood levels of glucose. A better understanding of the mechanisms underlying these changes is therefore an important goal. RNA sequencing reveals that, despite their opposing roles in the control of blood levels of glucose, α-cells and β-cells have remarkably similar patterns of gene expression. This similarity might explain the fairly facile interconversion between these cells and the ability of the α-cell compartment to serve as a source of new β-cells in models of extreme β-cell loss that mimic type 1 diabetes mellitus. Emerging data suggest that GABA might facilitate this interconversion, whereas the amino acid glutamine serves as a liver-derived factor to promote α-cell replication and maintenance of α-cell mass. Here, we survey these developments and their therapeutic implications for patients with diabetes mellitus.
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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
A genome-wide association study identifies novel risk loci for type 2 diabetes
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550
Baron, M., Veres, A., Wolock, S. L., Faust, A. L., Gaujoux, R., Vetere, A., Ryu, J. H., Wagner, B. K., Shen-Orr, S. S., Klein, A. M., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.011 · Cited by 1,508
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415
A Single-Cell Transcriptome Atlas of the Human Pancreas
Muraro, M. J., Dharmadhikari, G., Grün, D., Gröen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.002 · Cited by 1,307
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136
The genetic architecture of type 2 diabetes
Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., Ma, C., Fontanillas, P., Moutsianas, L., McCarthy, D. J., et al. (2016) · Nature · doi:10.1038/nature18642 · Cited by 1,051
The interaction of hepatic lipid and glucose metabolism in liver diseases
Bechmann, L. P., Hannivoort, R. A., Gerken, G., Hotamışlıgil, G. S., Trauner, M., & Canbay, A. E. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.025 · Cited by 1,033
Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922
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m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes
Jesus, D. F. D., Zhang, Z. S., Kahraman, S., Brown, N. K., Chen, M., Hu, J. Y., Gupta, M. K., He, C., & Kulkarni, R. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0089-9 · Cited by 237
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice
Krawczyk, K., Xue, S., Buchmann, P., Hamri, G. C., Saxena, P., Hussherr, M., Shao, J., Ye, H., Xie, M., & Fussenegger, M. (2020) · Science · doi:10.1126/science.aau7187 · Cited by 196
Circadian Entrainment Triggers Maturation of Human In Vitro Islets
Alvarez-Dominguez, J. R., Donaghey, J., Rasouli, N., Kenty, J. H. R., Helman, A., Charlton, J., Straubhaar, J. R., Meissner, A., & Melton, D. A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.011 · Cited by 189
Insulin resistance in type 2 diabetes mellitus
Accili, D., Deng, Z., & Liu, Q. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01114-y · Cited by 219
Metadata
- Authors
- Gromada, J., Chabosseau, P., & Rutter, G. A.
- Affiliations
- Regeneron (United States) (US)
- Hammersmith Hospital (GB)
- Corresponding author
- Gromada, Jesper
- Rutter, Guy A.
- Venue
- Nature Reviews Endocrinology
- Published
- 2018-10-11
- Volume
- 14
- Issue
- 12
- Pages
- 694-704
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2897922438
- Cited by
- 143
- References
- 148
- Citations by year
- 2026: 19 · 2025: 12 · 2024: 17 · 2023: 21 · 2022: 24 · 2021: 27 · 2020: 12 · 2019: 11
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Regeneron Pharmaceuticals
- National Institute for Health and Care Research (CL-2017-21-002, ACF-2010-21-012)
- Academy of Medical Sciences (SGL019\1078)
- Servier
- Medical Research Council (MR/N00275X/1, MR/M012646/1, MR/K001981/1, MR/L020149/1, MR/R010676/1, MR/N020472/1, MR/R022259/1, MR/K023667/1, MR/R014329/1, MR/L02036X/1)
- Biotechnology and Biological Sciences Research Council (BB/J015873/1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- alpha cells, glucagon secretion, type 1 diabetes, type 2 diabetes, hypoglycemia, GABA, glutamine, beta cell destruction, gene expression, diabetes treatment
- MeSH terms
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Glucagon, Humans, Insulin, Male, Role, Sensitivity and Specificity, Glucagon-Secreting Cells, Insulin-Secreting Cells
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