Cited by 292Bone Metabolism and DiseasesBone health and osteoporosis researchAdipokines, Inflammation, and Metabolic Diseases

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The role of osteoblasts in energy homeostasis

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Dirckx, Naomi, Moorer, Megan C., Clemens, Thomas L., Riddle, Ryan C.·2019·Nature Reviews Endocrinology

DOI 10.1038/s41574-019-0246-yPMC PMC6958555

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Abstract

Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmony with osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. In this article, we summarize the current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteoblast differentiation.

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Authors: Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C.
Affiliations: Johns Hopkins University (US)
Corresponding author: Riddle, Ryan C.
ORCID: Dirckx, Naomi
Moorer, Megan C.
Riddle, Ryan C.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2019-08-28
Volume: 15
Issue: 11
Pages: 651-665
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-019-0246-y
PMC: PMC6958555
OpenAlex: W2970822705
Cited by: 292
References: 192
Citations by year: 2026: 28 · 2025: 51 · 2024: 53 · 2023: 46 · 2022: 50 · 2021: 35 · 2020: 25 · 2019: 4
FWCI: 2.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01 BX003724, IK6 BX004984, I01 BX001234)
Office of Research and Development
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099134)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: osteoblasts, energy homeostasis, bone remodeling, osteocalcin, lipocalin, sclerostin, bone formation, osteogenic differentiation, insulin, feeding behaviour, adipose tissue metabolism, glucose, fatty acids, amino acids
MeSH terms: Animals, Energy Metabolism, Homeostasis, Humans, Osteoblasts, Osteogenesis, Osteocalcin, Bone Remodeling, Adaptor Proteins, Signal Transducing, Lipocalins

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The role of osteoblasts in energy homeostasis

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