Human biomimetic liver microphysiology systems in drug development and precision medicine

Mechanisms of NAFLD development and therapeutic strategies

Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305

MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease

Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N., et al. (2013) · Nature · doi:10.1038/nature12271 · Cited by 2,170

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

Singh, S., Allen, A. M., Wang, Z., Prokop, L. J., Murad, M. H., & Loomba, R. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.014 · Cited by 1,748

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.050 · Cited by 1,619

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

Wouters, O. J., McKee, M., & Luyten, J. (2020) · JAMA · doi:10.1001/jama.2020.1166 · Cited by 1,531

Induced pluripotent stem cell technology: a decade of progress.

Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.245 · Cited by 1,525

Organoids as an in vitro model of human development and disease

Fatehullah, A., Tan, S. H., & Barker, N. (2016) · Nature Cell Biology · doi:10.1038/ncb3312 · Cited by 1,508

Mechanical communication in fibrosis progression

Long, Y., Niu, Y., Liang, K., & Du, Y. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.10.002 · Cited by 233

Organs-on-chips technologies – A guide from disease models to opportunities for drug development

Monteduro, A. G., Rizzato, S., Caragnano, G., Trapani, A., Giannelli, G., & Maruccio, G. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115271 · Cited by 193

Liver organ-on-chip models for toxicity studies and risk assessment

Messelmani, T., Morisseau, L., Sakai, Y., Legallais, C., Goff, A. L., Leclerc, É., & Jellali, R. (2022) · Lab on a Chip · doi:10.1039/d2lc00307d · Cited by 113

Bioprinting of Complex Multicellular Organs with Advanced Functionality—Recent Progress and Challenges Ahead

Bertassoni, L. E. (2021) · Advanced Materials · doi:10.1002/adma.202101321 · Cited by 98

Immune-mediated drug-induced liver injury: immunogenetics and experimental models

Gerussi, A., Natalini, A., Antonangeli, F., Mancuso, C., Agostinetto, E., Barisani, D., Di Rosa, F., Andrade, R., & Invernizzi, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094557 · Cited by 87

Developing tissue engineering strategies for liver regeneration

Wang, J., Huang, D., Yu, H., Cheng, Y., Ren, H., & Zhao, Y. (2022) · Engineered Regeneration · doi:10.1016/j.engreg.2022.02.003 · Cited by 79

Application of new approach methodologies for nonclinical safety assessment of drug candidates

Beilmann, M., Adkins, K., Boonen, H. C. M., Hewitt, P. G., Hu, W., Mader, R., Moore, S., Rana, P., Steger‐Hartmann, T., Villenave, R., et al. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01182-9 · Cited by 75

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Sunildutt, N., Parihar, P., Salih, A. R. C., Lee, S. H., & Choi, K. H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1139229 · Cited by 68

Artificial Intelligence in Medical Imaging and its Impact on the Rare Disease Community: Threats, Challenges and Opportunities

Hasani, N., Farhadi, F., Morris, M. A., Nikpanah, M., Rahmim, A., Xu, Y., Pariser, A., Collins, M. T., Summers, R. M., Jones, E. C., et al. (2021) · PET Clinics · doi:10.1016/j.cpet.2021.09.009 · Cited by 66

Gastrointestinal organs and organoids-on-a-chip: advances and translation into the clinics

Carvalho, M. R., Yan, L., Li, B., Zhang, C., He, Y., Reis, R. L., & Oliveira, J. M. (2023) · Biofabrication · doi:10.1088/1758-5090/acf8fb · Cited by 65

Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery

Ahmed, T. (2022) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2022.100194 · Cited by 56

Engineering Organ-on-a-Chip to Accelerate Translational Research

Ko, J., Park, D., Lee, S., Gümüşcü, B., & Jeon, N. L. (2022) · Micromachines · doi:10.3390/mi13081200 · Cited by 55

Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering

Hu, Y., Zhu, T., Cui, H., & Cui, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403762 · Cited by 53

Organoids‐On‐a‐Chip for Personalized Precision Medicine

Man, Y., Liu, Y., Chen, Q., Zhang, Z., Li, M., Xu, L., Tan, Y., & Liu, Z. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401843 · Cited by 52

Liver microphysiological platforms for drug metabolism applications

Kulsharova, G., & Kurmangaliyeva, A. (2021) · Cell Proliferation · doi:10.1111/cpr.13099 · Cited by 49

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

Véliz, D. S., Lin, K., & Sahlgren, C. (2023) · Smart Medicine · doi:10.1002/smmd.20220030 · Cited by 47

Constructing biomimetic liver models through biomaterials and vasculature engineering

Lv, W., Zhou, H., Aazmi, A., Yu, M., Xu, X., Yang, H., Huang, Y. Y. S., & Ma, L. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac079 · Cited by 45

Patient‐Derived Microphysiological Systems for Precision Medicine

Ko, J., Song, J., Choi, N., & Kim, H. N. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202303161 · Cited by 40

Recent Advances in Drug Delivery System Fabricated by Microfluidics for Disease Therapy

Jia, F., Gao, Y., & Wang, H. (2022) · Bioengineering · doi:10.3390/bioengineering9110625 · Cited by 40

Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening

Dong, H., Li, Z., Bian, S., Song, G., Song, W., Zhang, M., Xie, H., Zheng, S., Yang, X., Li, T., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.020 · Cited by 39

Biomimetic hepatic lobules from three-dimensional imprinted cell sheets

Wang, J., Huang, D., Chen, H., & Zhao, Y. (2024) · Science Bulletin · doi:10.1016/j.scib.2024.02.030 · Cited by 37

Liver organoids: established tools for disease modeling and drug development

Sun, X.-C., Kong, D.-F., Zhao, J., Faber, K. N., Xia, Q., & He, K. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000105 · Cited by 37

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Tricot, T., Verfaillie, C. M., & Kumar, M. (2022) · Cells · doi:10.3390/cells11030442 · Cited by 36

Bioprinting of a Hepatic Tissue Model Using HumanInduced Pluripotent Stem Cell-derived Hepatocytes for Drug-Induced Hepatotoxicity Evaluation

He, J., Wang, J., Pang, Y., Yu, H., Qin, X., Su, K., Xu, T., & Ren, H. (2022) · International Journal of Bioprinting · doi:10.18063/ijb.v8i3.581 · Cited by 36

Development of a Hybrid Polymer-Based Microfluidic Platform for Culturing Hepatocytes towards Liver-on-a-Chip Applications

Kulsharova, G., Kurmangaliyeva, A., Darbayeva, E., Rojas–Solórzano, L., & Toxeitova, G. (2021) · Polymers · doi:10.3390/polym13193215 · Cited by 34

Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury

Shi, Q., Arefin, A., Ren, L., Papineau, K. S., Barnette, D. A., Schnackenberg, L. K., Hawes, J. J., Avigan, M., Mendrick, D. L., Ewart, L. C., et al. (2022) · Current Protocols · doi:10.1002/cpz1.478 · Cited by 34

Microfluidic human physiomimetic liver model as a screening platform for drug induced liver injury

Dey, S., Bhat, A., Janani, G., Shandilya, V., Gupta, R., & Mandal, B. B. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122627 · Cited by 29

Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques

Guo, K., & van den Beucken, T. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01317-2 · Cited by 28

An Immunocompetent Microphysiological System to Simultaneously Investigate Effects of Anti-Tumor Natural Killer Cells on Tumor and Cardiac Microtissues

Nguyen, O. T. P., Misun, P. M., Lohasz, C., Lee, J., Wang, W., Schroeder, T., & Hierlemann, A. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.781337 · Cited by 28

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation

Moreau, M., Mallick, P., Smeltz, M. G., Haider, S., Nicolas, C. I., Pendse, S. N., Leonard, J. A., Linakis, M. W., McMullen, P. D., Clewell, R. A., et al. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.894569 · Cited by 28

Developing Liver Microphysiological Systems for Biomedical Applications

Wang, J., Wu, X., Zhao, J., Ren, H., & Zhao, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302217 · Cited by 27

Metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models

Leslie, J., Krishnamurthy, K. A., Gopalsamy, I. K., Inácio, P., Huch, M., Gallage, S., Oakley, F., & Vacca, M. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01162-9 · Cited by 27

Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on testing and interpretation of comparative in vitro metabolism studies

Panel), E. P. O. P. P. P. A. T. R. (. P., Hernández, A. F., Adriaanse, P., Aldrich, A., Berny, P. J., Čoja, T., Duquesne, S., Focks, A., Marinovich, M., Millet, M., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6970 · Cited by 25

Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization

Mei, X., Yang, Z., Wang, X., Shi, A., Blanchard, J., Elahi, F. M., Kang, H., Orive, G., & Zhang, Y. S. (2025) · Lab on a Chip · doi:10.1039/d4lc00280f · Cited by 24

Metabolites in the regulatory risk assessment of pesticides in the EU

Pelkonen, O., Abass, K. M., Morte, J. M. P., Panzarea, M., Testai, E., Rudaz, S. L., Louisse, J., Gundert‐Remy, U., Wolterink, G., Jean-Lou, D., et al. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1304885 · Cited by 24

Microtechnology-based in vitro models: Mimicking liver function and pathophysiology

Lee, S. Y., Kim, D., Sung, J. H., & Sung, J. H. (2021) · APL Bioengineering · doi:10.1063/5.0061896 · Cited by 23

Hepatic Extracellular Matrix and Its Role in the Regulation of Liver Phenotype

Arteel, G. E. (2024) · Seminars in Liver Disease · doi:10.1055/a-2404-7973 · Cited by 22

The Convergence of Artificial Intelligence and Microfluidics in Drug Research and Development

Qiao, D., Li, H., Zhang, X., Chen, X., Jiang, Z., Zou, J., Zhao, D., Zhu, W., Qian, X. H., & Li, H. (2025) · Engineering · doi:10.1016/j.eng.2025.07.025 · Cited by 22

Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy

Xia, M., Varmazyad, M., Plá-Palacín, I., Gavlock, D. C., DeBiasio, R., LaRocca, G. M., Reese, C. E., Florentino, R. M., Faccioli, L. A. P., Brown, J. A., et al. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1423936 · Cited by 22

Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata

Miedel, M. T., Varmazyad, M., Xia, M., Brooks, M. M., Gavlock, D. C., Reese, C. E., Behari, J., Soto–Gutiérrez, A., Gough, A., Taylor, D. L., et al. (2025) · Cell Reports Methods · doi:10.1016/j.crmeth.2025.101028 · Cited by 21

Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective

Miedel, M. T., Schurdak, M. E., Stern, A. M., Soto–Gutiérrez, A., Strobl, E. V., Behari, J., & Taylor, D. L. (2025) · Seminars in Liver Disease · doi:10.1055/a-2649-1560 · Cited by 20

Sophisticated Interfaces Between Biosensors and Organoids: Advancing Towards Intelligent Multimodal Monitoring Physiological Parameters

Chen, Y., Liu, S., Chen, Y., Wang, M., Liu, Y., Qu, Z., Du, L., & Wu, C. (2025) · Biosensors · doi:10.3390/bios15090557 · Cited by 20

In silico modeling of endocrine organ-on-a-chip systems

Sung, B. (2022) · Mathematical Biosciences · doi:10.1016/j.mbs.2022.108900 · Cited by 20

Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem

Li, S., Li, C., Khan, M. I., Liu, J., Shi, Z., Gao, D. Y., Qiu, B., & Ding, W. (2023) · Microsystems & Nanoengineering · doi:10.1038/s41378-023-00544-w · Cited by 20

Design, Simulation, and Evaluation of Polymer-Based Microfluidic Devices via Computational Fluid Dynamics and Cell Culture “On-Chip”

Bakuova, N., Toktarkan, S., Dyussembinov, D., Azhibek, D. M., Rakhymzhanov, A., Κώστας, Κ., & Kulsharova, G. (2023) · Biosensors · doi:10.3390/bios13070754 · Cited by 20

A high-resolution haplotype-resolved Reference panel constructed from the China Kadoorie Biobank Study

Yu, C., Lan, X., Tao, Y., Guo, Y., Sun, D., Qian, P., Zhou, Y., Walters, R. G., Li, L., Zhu, Y., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad779 · Cited by 20

Curcumin and analogues in mitigating liver injury and disease consequences: From molecular mechanisms to clinical perspectives

Jiang, Z., Liu, L., Su, H., Cao, Y., Ma, Z., Gao, Y., & Huang, D. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155234 · Cited by 18

Iteration of Tumor Organoids in Drug Development: Simplification and Integration

Zhao, R., Feng, Q., Xia, Y., Liao, L., & Xie, S. (2025) · Pharmaceuticals · doi:10.3390/ph18101540 · Cited by 17

Opportunities and considerations for studying liver disease with microphysiological systems on a chip

Otumala, A. E., Hellen, D. J., Luna, C. A., Delgado, P., Dissanayaka, A., Ugwumadu, C., Oshinowo, O. T., Islam, M. M., Shen, L., Karpen, S. J., et al. (2023) · Lab on a Chip · doi:10.1039/d2lc00940d · Cited by 17

Microscale tissue engineering of liver lobule models: advancements and applications

Wang, Q., Liu, J., Yin, W., Wang, A., Zheng, J., Wang, Y., & Dong, J. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1303053 · Cited by 17

Biomimetic Liver Lobules from Multi‐Compartmental Microfluidics

Huang, D., Wu, Z., Wang, J., Wang, J., & Zhao, Y. (2024) · Advanced Science · doi:10.1002/advs.202406573 · Cited by 17

Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing

Wallace, J., Jackson, G. R., Kaluzhny, Y., Ayehunie, S., Lansley, A. B., Roper, C. S., & Hayden, P. J. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad058 · Cited by 16

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

Saydmohammed, M., Jha, A., Mahajan, V., Gavlock, D. C., Shun, T. Y., DeBiasio, R., Lefever, D. E., Li, X., Reese, C. E., Kershaw, E. E., et al. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211009228 · Cited by 16

Predictive intelligence powered attentional stacking matrix factorization algorithm for the computational drug repositioning

Yan, S., Yang, A., Kong, S., Bai, B., & Li, X. (2021) · Applied Soft Computing · doi:10.1016/j.asoc.2021.107633 · Cited by 14

Biomimetic Vascularized iPSC‐Hepatocyte Spheroids for Liver Regeneration

Wang, J., Huang, D., Ren, H., & Zhao, Y. (2025) · Advanced Science · doi:10.1002/advs.202405662 · Cited by 13

Reconstitution of human tissue barrier function for precision and personalized medicine

Kim, J., Yoon, T., Lee, S. W., Kim, P. J., & Kim, Y. (2024) · Lab on a Chip · doi:10.1039/d4lc00104d · Cited by 13

Hepatic hypertension on-a-chip identifies GPR116 as a hydrostatic pressure mechanosensor to regulate vascular injury in cirrhosis

Long, Y., Liang, K., Niu, Y., Wang, R., Liu, R., Zhang, Y., Ao, Y., Jin, Y., Wu, Z., Wu, B., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu7596 · Cited by 13

Cell therapy for end-stage liver disease: Current state and clinical challenge

Zhang, L., Deng, Y., Bai, X., Wei, X., Ren, Y., Chen, S., & Deng, H. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003332 · Cited by 12

A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

Aleman, J., Ravikumar, K., Wiegand, C., Schurdak, M. E., Vernetti, L. A., Gavlock, D. C., Reese, C. E., DeBiasio, R., LaRocca, G., Angarita, Y. D., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07006-7 · Cited by 12

Animal Study Translation: The Other Reproducibility Challenge

Berridge, B. R. (2021) · ILAR Journal · doi:10.1093/ilar/ilac005 · Cited by 12

Human Liver Organoid Models for Assessment of Drug Toxicity at the Preclinical Stage

Karabicici, M., Akbari, S., Ertem, Ö., Gümüştekin, M., & Erdal, E. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230411100121 · Cited by 12

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

Beaudoin, J. J., Clemens, L., Miedel, M. T., Gough, A., Zaidi, F., Ramamoorthy, P., Wong, K. E., Sarangarajan, R., Battista, C., Shoda, L. K. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119692 · Cited by 12

The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine

Müller, W. E. G., Neufurth, M., Wang, S., Schröder, H. C., & Wang, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s446405 · Cited by 12

Predicting the Effects of Drug Combinations Using Probabilistic Matrix Factorization

Nafshi, R., & Lezon, T. R. (2021) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2021.708815 · Cited by 12

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

Lefever, D. E., Miedel, M. T., Pei, F., DiStefano, J. K., DeBiasio, R., Shun, T. Y., Saydmohammed, M., Chikina, M. D., Vernetti, L. A., Soto–Gutiérrez, A., et al. (2022) · Metabolites · doi:10.3390/metabo12060528 · Cited by 12

Constructing biomimetic microenvironments for liver regeneration

(2025) · doi:10.1186/s12951-025-03729-9 · Cited by 11

Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

Mugaanyi, J., Huang, J., Fang, J., Musinguzi, A., Lu, C., & Chen, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13061272 · Cited by 11

Construction of complex three-dimensional vascularized liver tissue model in vitro based on a biphasic cell-laden embedding medium

Lv, W., Yu, H., Aazmi, A., Naren, T., Cheng, W., Yu, M., Wang, Z., Xu, X., Yang, H., & Ma, L. (2025) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ada836 · Cited by 10

Advances in antituberculosis drug-induced liver injury: Molecular mechanisms, genetic insights, and emerging animal-free prediction models

Yang, R., Zhu, J., Jin, X., Li, Y., Wang, D., & Chao, J. (2025) · Toxicology · doi:10.1016/j.tox.2025.154359 · Cited by 9

Cellular Efficacy of Fattigated Nanoparticles and Real-Time ROS Occurrence Using Microfluidic Hepatocarcinoma Chip System: Effect of Anticancer Drug Solubility and Shear Stress

Kim, H., Kim, E.-J., Ngo, H. V., Nguyen, H. D., Park, C., Choi, K. H., Park, J.-B., & Lee, B. (2023) · Pharmaceuticals · doi:10.3390/ph16091330 · Cited by 9

Building in vitro models for mechanistic understanding of liver regeneration in chronic liver diseases

Karnawat, K., Parthasarathy, R., Sakhrie, M., Karthik, H., Krishna, K. V., & Balachander, G. M. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00738g · Cited by 8

Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment

Ip, B. C., Madnick, S. J., Zheng, S., van Tongeren, T. C. A., Hall, S. J., Li, H., Martin, S., Spriggs, S., Carmichael, P. L., Chen, W., et al. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae018 · Cited by 8

A physiological oxygen gradient liver-zonation-on-a-chip reveals HIF-2α intervention in hepatic lipotoxicity

Wang, Y., Li, X., Han, J., Kong, F., Xu, Z., Hu, H., & Wang, L. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.11.044 · Cited by 7

Engineering liver organoids-on-a-chip

Zhu, J., Dressman, A. S., Gall, K., & Park, S. E. (2026) · Frontiers in Lab on a Chip Technologies · doi:10.3389/frlct.2025.1719128 · Cited by 7

Organ-on-a-chip Technology Roadmap: Regulatory Framework, Industry Adoption, Key Players, Technology Transfer, Validation, and Ethical Considerations

Bonaccorsi, S. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837673476-00461 · Cited by 7

Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis

Nivedita, J., Megha, P., Senthilathiban, D. P., Sivachandran, R., Ramprasath, A., Rajkumar, M., & Anitha, T. S. (2025) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2025054888 · Cited by 7

Newly identified genetic variants associated with idiosyncratic drug-induced liver injury

Stolz, A. (2022) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000822 · Cited by 7

Biomimetic Nanoscale Systems for Targeted Delivery in Cancer: Current Advances and Future Prospects

Singh, D., & Poonia, N. (2024) · Current Drug Metabolism · doi:10.2174/0113892002323535240830093452 · Cited by 6

Multimodal induction of stem cells synergistically mediates enhanced cartilage-bone cross-talk in a 3D bioprinted human osteochondral microphysiological system

Dey, S., Mehra, P., Jaiswal, C., Jadhav, T. D., Kirtonia, A., Bhar, B., Mishra, S. B., Gupta, R., & Mandal, B. B. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123719 · Cited by 6

Comparative Analysis of Species-Specific Hepatocyte Function and Drug Effects in a Liver Microphysiological System PhysioMimix LC12 and 96-Well Plates

Negi, C. K., Sakolish, C., Tsai, H.-H. D., Nitsche, K. S., Gang, H., Bajaj, P., Ferguson, S., Stanko, J. P., Hewitt, P. G., Kukla, D. A., et al. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00554 · Cited by 6

Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system

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