Induced pluripotent stem cell technology: a decade of progress.

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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Embryonic Stem Cell Lines Derived from Human Blastocysts

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

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RNA-Guided Human Genome Engineering via Cas9

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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

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Cerebral organoids model human brain development and microcephaly

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Genome-scale CRISPR-Cas9 knockout screening in human cells

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Organoid Models and Applications in Biomedical Research

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Innovation in the pharmaceutical industry: New estimates of R&D costs

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

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High-Frequency off-Target Mutagenesis Induced by CRISPR-Cas Nucleases in Human Cells

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Organogenesis in a dish: Modeling development and disease using organoid technologies

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

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Rationally engineered Cas9 nucleases with improved specificity

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Human induced pluripotent stem cells free of vector and transgene sequences

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Cas-OFFinder: A fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

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Vascularized and functional human liver from an iPSC-derived organ bud transplant

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Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

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RNA-programmed genome editing in human cells

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A more efficient method to generate integration-free human iPS cells

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Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

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Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

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Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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Induced pluripotent stem cells generated without viral integration

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

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Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

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Organoids as an in vitro model of human development and disease

Fatehullah, A., Tan, S. H., & Barker, N. (2016) · Nature Cell Biology · doi:10.1038/ncb3312 · Cited by 1,508 · see citing works

Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin

Hanna, J. H., Wernig, M., Markoulaki, S., Sun, C., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L.-C., Townes, T. M., et al. (2007) · Science · doi:10.1126/science.1152092 · Cited by 1,493 · see citing works

Astroglia induce neurogenesis from adult neural stem cells

Song, H., Stevens, C. F., & Gage, F. H. (2002) · Nature · doi:10.1038/417039a · Cited by 1,452 · see citing works

Immunogenicity of induced pluripotent stem cells

Zhao, T., Zhang, Z., Rong, Z., & Xu, Y. (2011) · Nature · doi:10.1038/nature10135 · Cited by 1,449 · see citing works

Self-formation of optic cups and storable stratified neural retina from human ESCs

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Induced pluripotent stem cells from a spinal muscular atrophy patient

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

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Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.

Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., Zhao, T., Ye, J., Yang, W., Liu, K., et al. (2013) · Science · doi:10.1126/science.1239278 · Cited by 1,402 · see citing works

Modelling schizophrenia using human induced pluripotent stem cells

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RNA-guided gene activation by CRISPR-Cas9-based transcription factors

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The Brazilian Zika virus strain causes birth defects in experimental models

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Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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Zika virus impairs growth in human neurospheres and brain organoids

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FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

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Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

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Genetic engineering of human pluripotent cells using TALE nucleases

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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

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Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

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Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

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Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

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Variation in the safety of induced pluripotent stem cell lines

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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

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Engineering Stem Cell Organoids

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Induced Pluripotent Stem Cells: Past, Present, and Future

Yamanaka, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.005 · Cited by 846 · see citing works

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

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Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation

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In vitro generation of human pluripotent stem cell derived lung organoids

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A decade of transcription factor-mediated reprogramming to pluripotency

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Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Human iPSC-based modeling of late-onset disease via progerin-induced aging

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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J. R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.001 · Cited by 765 · see citing works

Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs

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LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

Nguyen, H. N., Byers, B., Cord, B. J., Shcheglovitov, A., Byrne, J., Gujar, P., Kee, K., Schüle, B., Dolmetsch, R. E., Langston, J. W., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.01.013 · Cited by 748 · see citing works

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

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A nonviral minicircle vector for deriving human iPS cells

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Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

Lee, A. S., Tang, C. Z., Rao, M. S., Weissman, I. L., & Wu, J. C. (2013) · Nature Medicine · doi:10.1038/nm.3267 · Cited by 720 · see citing works

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

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Characterization of the expression of MHC proteins in human embryonic stem cells

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International SMA Consortium Meeting (26–28 June 1992, Bonn, Germany)

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Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

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Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells.

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A transcription activator-like effector toolbox for genome engineering

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Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

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Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

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Pluripotent stem cells in disease modelling and drug discovery

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