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Optimizing immunotherapy for colorectal cancer
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“In contrast, approximately 90% of patients with pMMR/MSS CRC have a low tumour mutational burden, are immune-cold and do not respond to ICB109 (figure 2).”
From Current and emerging concepts for systemic treatment of metastatic colorectal cancer (2025) · cites this paper as [109]
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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377
Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer
André, T., Shiu, K.-K., Kim, T. W., Jensen, B. V., Jensen, L. H., Punt, C., Smith, D., Garcia-Carbonero, R., Benavides, M., Gibbs, P., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2017699 · Cited by 3,099
Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30422-9 · Cited by 2,836
Overman, M. J., Lonardi, S., Wong, K. Y. M., Lenz, H.-J., Gelsomino, F., Aglietta, M., Morse, M. A., Van Cutsem, E., McDermott, R., Hill, A., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.9901 · Cited by 2,079
Immunotherapy in colorectal cancer: Rationale, challenges and potential
Ganesh, K., Stadler, Z. K., Cercek, A., Mendelsohn, R. B., Shia, J., Segal, N. H., & Diaz, L. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0126-x · Cited by 1,954
Self-citationChalabi, M., Fanchi, L. F., Dijkstra, K. K., Van den Berg, J. G., Aalbers, A. G., Sikorska, K., Lopez-Yurda, M., Grootscholten, C., Beets, G. L., Snaebjornsson, P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0805-8 · Cited by 1,417
Ganesh, K., & Massagué, J. (2021) · Nature Medicine · doi:10.1038/s41591-020-01195-4 · Cited by 1,123
Self-citationSpatially organized multicellular immune hubs in human colorectal cancer
Pelka, K., Hofree, M., Chen, J. H., Sarkizova, S., Pirl, J. D., Jorgji, V., Bejnood, A., Dionne, D. A., Ge, W. H., Xu, K. H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.08.003 · Cited by 917
Lenz, H.-J., Van Cutsem, E., Luisa Limon, M., Wong, K. Y. M., Hendlisz, A., Aglietta, M., García-Alfonso, P., Neyns, B., Luppi, G., Cardin, D. B., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.01015 · Cited by 728
Pembrolizumab for Microsatellite-Instability–High Advanced Colorectal Cancer
Ilson, D. H. (2020) · Journal watch · doi:10.1056/nejm-jw.na52865 · Cited by 172
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Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy
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Li, J.-J., Wang, J.-H., Tian, T., Liu, J., Zheng, Y., Mo, H., Sheng, H., Chen, Y., Wu, Q., Han, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42332-0 · Cited by 73
Sun, X., Zhou, L., Wang, Y., Deng, G., Cao, X., Ke, B., Wu, X., Gu, Y., Cheng, H., Xu, Q., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.04.013 · Cited by 66
Metadata
- Authors
- Ganesh, K.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Ganesh, Karuna
- ORCID
- Ganesh, Karuna
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2021-12-14
- Volume
- 19
- Issue
- 2
- Pages
- 93-94
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- PMC
- PMC9487162
- OpenAlex
- W4200537999
- Cited by
- 120
- References
- 12
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 41 · 2023: 21 · 2022: 5
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (U2CCA233284, K08CA230213, P30CA008748, R37CA266185)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal cancer, immunotherapy, microsatellite instability-high, mismatch repair deficiency, metastatic colorectal cancer, first-line therapy, tumor immune microenvironment, single-cell analysis, spatial analysis, preclinical models
- MeSH terms
- Antineoplastic Agents, Immunological, Humans, Immunotherapy, Colorectal Neoplasms, Tumor Microenvironment, Antibodies, Monoclonal, Humanized
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