Optimizing immunotherapy for colorectal cancer

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377

Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer

André, T., Shiu, K.-K., Kim, T. W., Jensen, B. V., Jensen, L. H., Punt, C., Smith, D., Garcia-Carbonero, R., Benavides, M., Gibbs, P., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2017699 · Cited by 3,099

Nivolumab in Patients with Metastatic DNA Mismatch Repair-Deficient or Microsatellite Instability-High Colorectal Cancer (CheckMate 142): An Open-Label, Multicentre, Phase 2 Study

Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30422-9 · Cited by 2,836

Durable Clinical Benefit with Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer

Overman, M. J., Lonardi, S., Wong, K. Y. M., Lenz, H.-J., Gelsomino, F., Aglietta, M., Morse, M. A., Van Cutsem, E., McDermott, R., Hill, A., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.9901 · Cited by 2,079

Immunotherapy in colorectal cancer: Rationale, challenges and potential

Ganesh, K., Stadler, Z. K., Cercek, A., Mendelsohn, R. B., Shia, J., Segal, N. H., & Diaz, L. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0126-x · Cited by 1,954

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

Chalabi, M., Fanchi, L. F., Dijkstra, K. K., Van den Berg, J. G., Aalbers, A. G., Sikorska, K., Lopez-Yurda, M., Grootscholten, C., Beets, G. L., Snaebjornsson, P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0805-8 · Cited by 1,417

Targeting metastatic cancer

Ganesh, K., & Massagué, J. (2021) · Nature Medicine · doi:10.1038/s41591-020-01195-4 · Cited by 1,123

Spatially organized multicellular immune hubs in human colorectal cancer

Pelka, K., Hofree, M., Chen, J. H., Sarkizova, S., Pirl, J. D., Jorgji, V., Bejnood, A., Dionne, D. A., Ge, W. H., Xu, K. H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.08.003 · Cited by 917

First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study

Lenz, H.-J., Van Cutsem, E., Luisa Limon, M., Wong, K. Y. M., Hendlisz, A., Aglietta, M., García-Alfonso, P., Neyns, B., Luppi, G., Cardin, D. B., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.01015 · Cited by 728

Pembrolizumab for Microsatellite-Instability–High Advanced Colorectal Cancer

Ilson, D. H. (2020) · Journal watch · doi:10.1056/nejm-jw.na52865 · Cited by 172

A multi-dimensional approach to unravel the intricacies of lactylation related signature for prognostic and therapeutic insight in colorectal cancer

Huang, H., Chen, K., Zhu, Y., Hu, Z., Wang, Y., Chen, J., Li, Y., Li, D., & Wei, P. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04955-9 · Cited by 134

CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer

Lv, Q., Zhang, Y., Gao, W., Wang, J., Hu, Y., Yang, H., Xie, Y., Lv, Y., Zhang, H., Wu, D., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107126 · Cited by 91

Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy

Zheng, W., Wu, J., Peng, Y., Sun, J., Cheng, P., & Huang, Q. (2022) · Cancers · doi:10.3390/cancers14194755 · Cited by 86

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

Li, J.-J., Wang, J.-H., Tian, T., Liu, J., Zheng, Y., Mo, H., Sheng, H., Chen, Y., Wu, Q., Han, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42332-0 · Cited by 73

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Sun, X., Zhou, L., Wang, Y., Deng, G., Cao, X., Ke, B., Wu, X., Gu, Y., Cheng, H., Xu, Q., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.04.013 · Cited by 66

Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective

Kaviarasan, V., Das, A., Deka, D., Saha, B., Banerjee, A., Sharma, N. R., Duttaroy, A. K., & Pathak, S. (2024) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04790-w · Cited by 50

Advancing translational research for colorectal immuno-oncology

Thomas, E., Wright, J. A., Blake, S. J., Page, A. J., Worthley, D. L., & Woods, S. L. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02392-x · Cited by 44

Biometallic ions and derivatives: a new direction for cancer immunotherapy

Zhao, L., Gui, Y., Cai, J., & Deng, X. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02225-w · Cited by 46

Current and emerging concepts for systemic treatment of metastatic colorectal cancer

Steup, C., Kennel, K. B., Neurath, M. F., Fichtner-Feigl, S., & Greten, F. R. (2025) · Gut · doi:10.1136/gutjnl-2025-335412 · Cited by 39

Region‐Specific CD16 + Neutrophils Promote Colorectal Cancer Progression by Inhibiting Natural Killer Cells

Zhang, Y., Wang, Z.-E., Lu, Y., Sanchez, D. J., Li, J., Wang, L., Meng, X., Chen, J., Kien, T. T., Zhong, M., et al. (2024) · Advanced Science · doi:10.1002/advs.202403414 · Cited by 33

Dark force rising: Reawakening and targeting of fetal-like stem cells in colorectal cancer

Fey, S. K., Vaquero-Siguero, N., & Jackstadt, R. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114270 · Cited by 32

Recent advances and challenges in colorectal cancer: From molecular research to treatment

Qi, G., Zhao, R., Gao, C., Ma, Z., Wang, S., & Xu, J. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i21.106964 · Cited by 40

Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer with [68Ga]Ga-FAPI-04 PET, [18F]FDG PET, and Contrast-Enhanced MRI: Lesion-to-Lesion Comparison with Pathology

Zhang, X., Lin, Z., Yuan, F., Lin, Z., Tao, K., Zhang, T., & Lan, X. (2024) · Journal of Nuclear Medicine · doi:10.2967/jnumed.124.267581 · Cited by 27

The efficacy and safety of anti-PD-1/PD-L1 in treatment of glioma: a single-arm meta-analysis

Zeng, Y., Wei, X., Guo, Q., Chen, S., Sheng, D., Liu, Z., Gong, Z., & Zeng, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1168244 · Cited by 27

Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth

Zhao, M., Zhou, L.-S., Zhang, Q.-C., Wang, M.-J., Dong, Y., Wang, Y., Pei, R.-X., He, E., Liang, Y., Shen, Y.-J., et al. (2025) · Advancement of science · doi:10.1002/advs.202407900 · Cited by 36

Neutrophil and Colorectal Cancer

Masui, H., Kawada, K., & Obama, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010006 · Cited by 26

Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

Wang, F., Qi, Q., Qin, B., Wang, Y., Huang, Y., Li, Q., Shen, X. H., Wang, X., Yang, S., Pan, G., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113318 · Cited by 23

From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer

Ding, X., Huang, H., Zhang, F., & Jiang, J. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01282-5 · Cited by 22

FSTL3 promotes tumor immune evasion and attenuates response to anti-PD1 therapy by stabilizing c-Myc in colorectal cancer

Li, H., Zheng, N., Guo, A., Tang, W., Li, M., Cao, Y., Ma, X., Cao, H., Ma, Y., Wang, H., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06469-0 · Cited by 22

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions

Sharma, S., Singh, N., Turk, A. A., Wan, I., Guttikonda, A., Dong, J. L., Zhang, X., & Opyrchal, M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i13.1815 · Cited by 22

Immunotherapy in Combination with Chemotherapy for Triple-negative Breast Cancer

Solano, E., Barrón, J. C. S., & González, C. C. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230517152538 · Cited by 19

Immunotherapy in colorectal cancer: Statuses and strategies

Li, Y., Cheng, Z., Li, S., & Zhang, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41354 · Cited by 24

Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies

Nie, S.-C., Jing, Y., Lu, L., Ren, S.-S., Ji, G., & Xu, H.-C. (2024) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v16.i5.1690 · Cited by 22

The next bastion to be conquered in immunotherapy: microsatellite stable colorectal cancer

Ding, K., Mou, P., Wang, Z., Liu, S., Liu, J., Lü, H., & Yu, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1298524 · Cited by 19

Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway

Feng, S., Li, S., Wu, Z., Li, Y., Wu, T., Zhou, Z., Liu, X., Chen, J., Fu, S., Wang, Z., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118854 · Cited by 16

Disruption of GPSM1/CSF1 signaling reprograms tumor-associated macrophages to overcome anti-PD-1 resistance in colorectal cancer

Chen, Y., Jia, H., Zhang, X., Zhao, H., Xiao, Y., Li, N., Yao, Y., & Xing, X. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010826 · Cited by 15

Immune landscape and response to oncolytic virus-based immunotherapy

Lin, C., Teng, W., Yang, T., Li, S., Xia, N., & Huang, C. (2024) · Frontiers of Medicine · doi:10.1007/s11684-023-1048-0 · Cited by 15

Improving the efficacy of immunotherapy for colorectal cancer: Targeting tumor microenvironment-associated immunosuppressive cells

Zou, D., Xin, X., Xu, Y., Xu, H., Huang, L., & Xu, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36446 · Cited by 16

No association between cholecystectomy and risk of colorectal cancer: a meta-analysis of cohort studies

Yu, L., Liu, W., Yan, Y., Jiang, Y. L., Gao, X., & Ruan, S. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04463-0 · Cited by 12

Survival outcomes in locally advanced dMMR rectal cancer: surgery plus adjunctive treatment vs. surgery alone

Ni, K., Zhan, Y., Liu, Z., Yuan, Z., Wang, S., Zhao, X., Ping, H., Liu, Y., Wang, W. “., Yan, S., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-11525-7 · Cited by 11

Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics

Chang-qin, L., & Li, J. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104543 · Cited by 12

Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer

Chang, Y., Long, M., Shan, H., Liu, L., Zhong, S., & Luo, J. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104629 · Cited by 12

Circular RNA circWBSCR22 facilitates colorectal cancer metastasis by enhancing CHD4's protein stability

Luo, J., Xu, S., Wang, J., He, L., & Li, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137135 · Cited by 9

Circulating IL6 is involved in the infiltration of M2 macrophages and CD8+ T cells

Huang, J., Xiao, R., Shi, S., Li, Q., Li, M., Xiao, M., Wang, Y., Yang, Y., Li, W., & Tang, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-92817-9 · Cited by 9

Patient-derived organoids (PDOs) as a promising platform for personalized treatment of colorectal cancer: current applications and future challenges

Liu, Y., Zhang, Y., Zhang, R., Zhang, C., & Liu, X. (2025) · Cancer Biology & Therapy · doi:10.1080/15384047.2025.2567802 · Cited by 11

Oxaliplatin lipidated prodrug synergistically enhances the anti-colorectal cancer effect of IL12 mRNA

Liu, H., Du, Y., Zhan, D., Yu, W., Li, Y., Wang, A., Yin, J., Cao, H., & Fu, Y. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01540-x · Cited by 8

Can rectal MRI and endorectal ultrasound accurately predict the complete response to neoadjuvant immunotherapy for rectal cancer?

Zhai, M., Lin, Z., Wang, H., Yang, J., Li, M., Li, X., Zhang, L., & Zhang, T. (2023) · Gastroenterology report · doi:10.1093/gastro/goae027 · Cited by 8

Penfluridol enhances anti-tumor immunity in colorectal cancer by inducing proteasome-mediated degradation of PD-L1 via the activation of AMPK

Wang, J., Zhang, Y., Chen, Q., Wang, X., Cui, R., & Hou, P. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102559 · Cited by 8

Construction and validation of a novel angiogenesis pattern to predict prognosis and immunotherapy efficacy in colorectal cancer

Li, Z., Liu, Y., Guo, P., & Wei, Y. (2023) · Aging · doi:10.18632/aging.205189 · Cited by 8

New sights of immunometabolism and agent progress in colitis associated colorectal cancer

Zhang, J., Chen, C., Yan, W., & Fu, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1303913 · Cited by 10

Impact and potential value of immunosenescence on solid gastrointestinal tumors

Zhang, T., Wen, R., Fan, H., Yu, Y., Jia, H., Peng, Z., Zhou, L., Yu, G., & Zhang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1375730 · Cited by 8

Evaluation of the efficacy and safety of first- and second-line immunotherapy in patients with metastatic colorectal cancer: a systematic review and network meta-analysis based on randomized controlled trials

Chen, K., Chen, W., Yue, R., Zhu, D., Cui, S., Zhang, X., Jin, Z., & Xiao, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1439624 · Cited by 8

Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer

Shi, R., Zhou, X., Pang, L., Wang, M., Li, Y., Chen, C., Ning, H., Zhang, L., Yue, G., Qiu, L., et al. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03307-0 · Cited by 8

Randomized Parallel-Group Phase II Study (NEOTERIC) of Atezolizumab With or Without Tiragolumab After Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Tang, W., Wu, A., Lan, P., Liu, C., Wang, Z., Wang, J., Chen, N., Wu, X., Jiao, Y., Liu, F., et al. (2026) · Journal of Clinical Oncology · doi:10.1200/jco-25-01883 · Cited by 8

Identification of the molecular subtypes and signatures to predict the prognosis, biological functions, and therapeutic response based on the anoikis‐related genes in colorectal cancer

Zhai, X., Chen, B., Hu, H., Deng, Y., Chen, Y., Hong, Y., Ren, X., & Jiang, C. (2024) · Cancer Medicine · doi:10.1002/cam4.7315 · Cited by 7

USP48 inhibits colorectal cancer progression and promotes M1-like macrophage polarization by stabilizing TAK1

Zhang, X., Zhao, J., Qi, G., Chen, Y., Guo, X., Zhang, J., Chen, S., Xu, X., Feng, J., Zhang, Q., et al. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114469 · Cited by 6

New strategies to enhance the efficacy of PD-1/PD-L1 inhibitors in treating microsatellite stable colorectal cancer

Chen, Y., & Tang, D. (2025) · Future Oncology · doi:10.1080/14796694.2025.2558287 · Cited by 6

Modulating the gut microbiota to enhance immune checkpoint inhibitor efficacy in colorectal cancer: mechanisms, therapeutic strategies, and clinical perspectives

Chen, Y., Wang, Y., Hu, J.-Y., Wang, E.-C., Jia, X.-H., Wang, J., Min, G., Jin, W.-L., & Jiang, L. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2652476 · Cited by 7

EPSTI1 as an immune biomarker predicts the prognosis of patients with stage III colon cancer

Wang, X., Cheng, W., Zeng, X., Dou, X., Zhou, Z., & Pei, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.987394 · Cited by 6

Neoadjuvant immunotherapy in colorectal cancer beyond immune checkpoint inhibitors: emerging from bench to bedside

Kanani, A., Veen, T., Alexeeva, M., Lea, D., & Søreide, K. (2023) · Minerva Surgery · doi:10.23736/s2724-5691.23.09854-4 · Cited by 6

A Review of 10-Year Survivability of Immunotherapy in the Management of Colon Cancer

Okoye, C., Tran, M., Soladoye, E., Akahara, D. E., Emeasoba, C. M., Ojinna, B. T., Kelechi, A. E., Obadare, O. O., Diala, C. S., Salaudeen, B. H., et al. (2023) · Cureus · doi:10.7759/cureus.43189 · Cited by 6

Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancer

Zhu, Y., Zhou, T., Zheng, Y., Yao, Y., Lin, M., Zeng, C., Yan, Y., Zhou, Y., Li, D.-D., & Zhang, J. (2025) · Genes and Immunity · doi:10.1038/s41435-025-00342-6 · Cited by 8

Overcoming conditional immune resistance in MSS and pMMR colorectal cancer: A sequential gating framework for immunotherapy

Farah, H. S., Polatova, D., Rizaev, J., Mhdy, F. A., Muhammad, F. A., Maharana, L., Bainsal, N., & Singh, R. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105353 · Cited by 5

Senescence-related signatures predict prognosis and response to immunotherapy in colon cancer

Hu, X., Zhu, X., Chen, Y., Zhang, W., Li, L., Liang, H., Байматович, У. Б., Donadon, M., Yusupbekov, A., & Zheng, Y. (2024) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-24-339 · Cited by 5

A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers

Zhou, Z., Fan, B., Cheng, H., Wang, M., Xie, J., Zou, M., & Yang, Y. (2022) · Biomolecules · doi:10.3390/biom12121826 · Cited by 4

Prognostic stratification of colorectal cancer by immune profiling reveals SPP1 as a key indicator for tumor immune status

Xiao, Y., Zhang, G., Xiao, Y., Li, Z., Liu, H., He, L., & Li, J. (2025) · ONCOLOGIE · doi:10.1515/oncologie-2025-0248 · Cited by 4

Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer

Du, J., Fan, Y., Fu, J., Ge, F., Zhu, H., Yang, S., Dai, J., Yuan, T., He, Q., Yang, B., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2590245 · Cited by 4

An infodemiology study on exploring the quality and reliability of colorectal cancer immunotherapy information

Mohamed, H., O’Malley, L., & Kelly, D. (2023) · Digital Health · doi:10.1177/20552076231205286 · Cited by 4

Exploration of the Molecular Mechanism of Curcuma aromatica Salisb’s Anticolorectal Cancer Activity via the Integrative Approach of Network Pharmacology and Experimental Validation

Yin, Z.-H., Tan, W., & Jiang, Y. (2024) · ACS Omega · doi:10.1021/acsomega.4c01759 · Cited by 4

Identification of crucial ubiquitin-associated genes for predicting the effects of immunotherapy and therapeutic agents in colorectal cancer

Cao, P., Li, Q., Zou, D., Wang, L., & Wang, Z. (2024) · Gene · doi:10.1016/j.gene.2024.148215 · Cited by 4

Machine Learning-Derived Neddylation Gene Signature for Predicting Prognosis and Immunotherapy Benefits in Colorectal Cancer

Yang, G., Xiao, J., He, H., Wang, J., Wang, Z., Jian, L., & Chen, Q. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s532644 · Cited by 3

The prognostic model based on tumor-associated neutrophils contributes to the stromal landscape and influences metabolic reprogramming in colorectal cancer

Yin, X., Jiang, Y., Huang, J., Luo, J., Xu, L., & Yang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1587947 · Cited by 3

USP21 drives immune evasion in colorectal cancer via deubiquitination and stabilization of β-catenin

Zhou, M., Han, A., Guan, B., Zhou, M., Zheng, C., Xiang, J., Mi, Y., Xie, B., Peng, L. I. A. N., Cai, S., et al. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01419-6 · Cited by 3

Unlocking the Potential of Therapy-Induced Cytokine Responses: Illuminating New Pathways in Cancer Precision Medicine

Gunturu, D. R., Hassan, M. I., Bedi, D., Datta, P. K., Manne, U., & Samuel, T. (2024) · Current Oncology · doi:10.3390/curroncol31030089 · Cited by 4

Doxorubicin-based ENO1 targeted drug delivery strategy enhances therapeutic efficacy against colorectal cancer

Liu, J., Hu, X., Yu, G., Wang, Q., Gu, L., Shen, J., Zhao, Q., Sun, H., Wang, S., Guo, Z., et al. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116220 · Cited by 3

The aminophospholipid transporter, ATP8B3, as a potential biomarker and target for enhancing the therapeutic effect of PD-L1 blockade in colon adenocarcinoma

Zhang, W., Xie, Y., Liu, Z., Zhang, J., Ni, B., Gao, W., Xing, W., Zhou, Y., & Si, T. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110907 · Cited by 3

SET facilitates immune escape of microsatellite stability colorectal cancer by inhibiting c‐Myc degradation

Gao, L., Li, Y., Wang, H., Liu, J., Zhang, R., Shan, W., Zeng, L., Zhao, Q., Li, Y., & Liu, J. (2024) · Cancer Science · doi:10.1111/cas.16368 · Cited by 3

Insights into the historical trajectory and research trends of immune checkpoint blockade in colorectal cancer: visualization and bibliometric analysis

Chang, Y., Zhou, C., Nie, K., Liu, J., & Zhang, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1478773 · Cited by 3

Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target

Chen, S., Jiang, Z., Song, W., Lu, C., Lin, Y., Xu, S. S., Xie, K., Wan, L., & Yuan, X. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03918-8 · Cited by 3

Immune-mediated hepatitis: Basic concepts and treatment

Velasco, J. A. V.-R., Calderón, D. K. T., Cerpa‐Cruz, S., Chávez, J. A. V., Martínez, J. F. U., García-Jiménez, E. S., Ledesma, J. M. A., Díaz‐González, Á., & Crespo, J. (2024) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2023.12.001 · Cited by 3

A hot and cold tumor‑related prognostic signature for stage II colorectal cancer

Zhou, M., Ge, X., Xu, X., Sheng, B., Wang, H., Shi, H., Liu, S., Tan, B., Xu, K., & Wang, J. (2024) · Oncology Letters · doi:10.3892/ol.2024.14552 · Cited by 3

ATM is associated with the prognosis of colorectal cancer: a systematic review

Wu, P., & Wen, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1470939 · Cited by 2

Human mesenchymal stem cell-derived miR-3614-5p exosomes suppress progression of colorectal cancer by targeting IL7Rα

Ye, M., Bian, Y., Lin, Y., Li, S., Jiang, L., Wu, J., Xie, Y., Ning, S., Liu, Y., Huang, J., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07859-y · Cited by 2

Tumor-mediated 4-1BB induces tumor proliferation and metastasis in the colorectal cancer cells

Kim, M. K., Shin, K.-J., Bae, S., Seo, J.-M., Jung, H., Moon, Y.-A., & Yang, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120899 · Cited by 2

The role of Sine Oculis Homeobox Homolog 2 in colon Cancer: Insights into prognosis, immune regulation, and therapeutic implications

Zhou, S., Jiang, D., Liu, Y., Wang, Q., Hu, M., Dai, K., Chen, L., Zhang, T., Cai, C., & Wang, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152038 · Cited by 2

Durable response to third-line combination therapy in a metastatic colorectal cancer patient with BRAF V600E mutation: A case report

Zhang, Q., Li, L., & Qian, X. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2471058 · Cited by 1

The Tumor‐Associated Neutrophils‐Related Signatures Predict Prognosis and Indicate Immune Landscape in Colorectal Carcinoma

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