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Cited by 1Zebrafish Biomedical Research ApplicationsDevelopmental Biology and Gene RegulationGenomics and Phylogenetic Studies

The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.

Zebrafish relatives as models for functional comparative genetics and genomics

Podobnik, Marco, Lu, Yansong, Irion, Uwe, Currie, Peter D.·2026·Nature Reviews Genetics
DOI 10.1038/s41576-026-01007-4
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Abstract

Closely related species, such as danionin fishes of the Danio, Danionella and Devario genera, often differ in their biology despite their shared evolutionary history, providing a platform for defining the molecular basis for the divergence of phenotypic traits. Such an approach requires the availability of large-scale genomic data, which have been provided by recent reports detailing the genomes of several danionins. Facilitated by the large number of genetic tools that are available for manipulation of the most studied member of this subgroup - the zebrafish, Danio rerio - the danionins have emerged as a useful comparative model system. Here we review their phylogeny and outline the phenotypic traits that are distinct to individual species or genera. We highlight how functional genetic tools such as interspecies hybridization, mutagenesis and transgenesis, as well as the recently reported genome assemblies, have enabled new avenues for hypothesis-driven and technology-driven exploration that collectively establish danionins as important genetic models for understanding a wide range of evolutionary innovations.

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Crossref · 10.1038/s41576-026-01007-4

Cites

210 of 210 references verified0 citation errors · 0 not checkable

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Citations

Cites

Items 201–210 of 210

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Research works printed but not linked: 4

  1. Nelson, J. S. Fishes of the World 4th edn (Wiley, 2006).
  2. Fang, F. Danio kyathit, a new species of cyprinid fish from Myitkyina, northern Myanmar. Ichthyol. Explor. Freshw. 8, 273–280 (1998).
  3. Kullander, S. O. & Fang, F. Danio tinwini, a new species of spotted danio from northern Myanmar (Teleostei: Cyprinidae). Ichthyol. Explor. Freshw. 20, 223 (2009).
  4. Kullander, S. O. Description of Danio flagrans, and redescription of D. choprae, two closely related species from the Ayeyarwaddy River drainage in northern Myanmar (Teleostei: Cyprinidae). Ichthyol. Explor. Freshw. 23, 245 (2012).

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Metadata

Authors
Podobnik, M., Lu, Y., Irion, U., & Currie, P. D.
Affiliations
  • Australian Regenerative Medicine Institute (AU)
  • Stowers Institute for Medical Research (US)
  • Max Planck Institute for Biology (DE)
ORCID
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2026-09-10
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/s41576-026-01007-4
OpenAlex
W7212181586
Semantic Scholar
8e46d953615def571442c658324e93cc92b5c4d2
Cited by
1
References
208
Citations by year
2026: 1
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
zebrafish, Danio, comparative genomics, comparative genetics, interspecific hybridization, mutagenesis, transgenesis, genome assembly, evolutionary innovation, phenotypic divergence, phylogeny

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