The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
Open accessAbstract
IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions. This Review focuses on recent advances in our understanding of the transcriptional, chromatin-based and metabolic mechanisms that underlie IFNγ-mediated polarization of macrophages to an ‘M1-like’ state, which is characterized by increased pro-inflammatory activity and macrophage resistance to tolerogenic and anti-inflammatory factors. In addition, I describe the newly discovered effects of IFNγ on other leukocytes, vascular cells, adipose tissue cells, neurons and tumour cells that have important implications for autoimmunity, metabolic diseases, atherosclerosis, neurological diseases and immune checkpoint blockade cancer therapy. Lionel Ivashkiv discusses new insight into the functions of IFNγ and summarizes our current understanding of IFNγ receptor signalling. In particular, the author focuses on recent studies on how IFNγ influences autoimmunity, immunometabolism, neurological diseases and cancer immunotherapy.
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Macrophage activation and polarization: nomenclature and experimental guidelines
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Self-citationThe future of immune checkpoint therapy
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Regulation of type I interferon responses
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Self-citationMutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
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Cited by
Immune Checkpoint Inhibitors in Cancer Therapy
Shiravand, Y., Khodadadi, F., Kashani, S. M. A., Hosseini-Fard, S. R., Hosseini, S., Sadeghirad, H., Ladwa, R., O’Byrne, K., & Kulasinghe, A. (2022) · Current Oncology · doi:10.3390/curroncol29050247 · Cited by 1,353
Roles of IFN-γ in tumor progression and regression: A review
Jorgovanovic, D., Song, M., Wang, L., & Zhang, Y. (2020) · Biomarker Research · doi:10.1186/s40364-020-00228-x · Cited by 1,234
Detection of immunogenic cell death and its relevance for cancer therapy
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03221-2 · Cited by 1,138
Ong, L.-T., Lee, W. C., Ma, S., Oguz, G., Niu, Z., Bao, Y., Yusuf, M., Lee, P. L., Goh, J. Y., Wang, P., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201376119 · Cited by 572
Targeting cytokine and chemokine signaling pathways for cancer therapy
Yi, M., Li, T., Niu, M., Zhang, H., Wu, Y., Wu, K., & Dai, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01868-3 · Cited by 455
Metadata
- Authors
- Ivashkiv, L. B.
- Venue
- Nature Reviews Immunology
- Published
- 2018-06-19
- Volume
- 18
- Issue
- 9
- Pages
- 545-558
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2808825101
- Cited by
- 1,358
- References
- 124
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
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