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Regulation of type I interferon responses

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Ivashkiv, Lionel B., Donlin, Laura T.·2014·Nature Reviews Immunology
DOI 10.1038/nri3581
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Abstract

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs). Host, pathogen and environmental factors regulate the responses of cells to this signalling pathway and thus calibrate host defences while limiting tissue damage and preventing autoimmunity. Here, we summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation. These regulatory mechanisms determine the biological outcomes of type I IFN responses and whether pathogens are cleared effectively or chronic infection or autoimmune disease ensues.

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Metadata

Authors
Ivashkiv, L. B., & Donlin, L. T.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2013-12-23
Volume
14
Issue
1
Pages
36-49
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri3581
OpenAlex
W2000177767
Cited by
3,297
References
23
FWCI
6.80
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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