The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Inflammasome activation at the crux of severe COVID-19
Open accessAbstract
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as obesity and diabetes. Severe disease is characterized by dysregulated cytokine release, pneumonia and acute lung injury, which can rapidly progress to acute respiratory distress syndrome, disseminated intravascular coagulation, multisystem failure and death. However, a mechanistic understanding of COVID-19 progression remains unclear. Here we review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, which are large multiprotein assemblies that are broadly responsive to pathogen-associated and stress-associated cellular insults, leading to secretion of the pleiotropic IL-1 family cytokines (IL-1β and IL-18), and pyroptosis, an inflammatory form of cell death. We further discuss potential mechanisms of inflammasome activation and clinical efforts currently under way to suppress inflammation to prevent or ameliorate severe COVID-19. This Progress article brings us up to date on the role of inflammasomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19, describing how they may be activated during infection and contribute to the overexuberant inflammatory response in severe disease, and the efforts being taken to target them therapeutically.
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Citations
Cites
Dexamethasone in Hospitalized Patients with Covid-19
The RECOVERY Collaborative Group (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2021436 · Cited by 11,477
Endothelial cell infection and endotheliitis in COVID-19
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics
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The trinity of COVID-19: immunity, inflammation and intervention
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
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Self-citationChemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Cited by
Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
Mansanguan, S., Charunwatthana, P., Piyaphanee, W., Dechkhajorn, W., Poolcharoen, A., & Mansanguan, C. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7080196 · Cited by 83
NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
Amin, S., Aktar, S., Rahman, M. M., & Chowdhury, M. M. H. (2022) · Microbes and Infection · doi:10.1016/j.micinf.2021.104913 · Cited by 51
Metadata
- Authors
- Vora, S. M., Lieberman, J., & Wu, H.
- Venue
- Nature Reviews Immunology
- Published
- 2021-08-09
- Volume
- 21
- Issue
- 11
- Pages
- 694-703
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W3191470838
- Cited by
- 325
- References
- 40
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
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