Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
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Abstract
This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13-18 years from two schools, who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes were collected at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms. We enrolled 314 participants; of these, 13 participants were lost to follow-up, leaving 301 participants for analysis. The most common cardiovascular signs and symptoms were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). One participant could have more than one sign and/or symptom. Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessments. Cardiovascular manifestations were found in 29.24% of patients, ranging from tachycardia or palpitation to myopericarditis. Myopericarditis was confirmed in one patient after vaccination. Two patients had suspected pericarditis and four patients had suspected subclinical myocarditis. In conclusion, Cardiovascular manifestation in adolescents after BNT162b2 mRNA COVID-19 vaccination included tachycardia, palpitation, and myopericarditis. The clinical presentation of myopericarditis after vaccination was usually mild and temporary, with all cases fully recovering within 14 days. Hence, adolescents receiving mRNA vaccines should be monitored for cardiovascular side effects. Clinical Trial Registration: NCT05288231.
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This complicates signal detection because clinical suspicion of an adverse vaccine reaction following an event commonly seen in clinical practice will be lower than for SAEs like myocarditis.
“This complicates signal detection because clinical suspicion of an adverse vaccine reaction following an event commonly seen in clinical practice will be lower than for SAEs like myocarditis.[50]”
From Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults (2022) · cites this paper as [50]
The Introduction (page not provided) says that attributing reported cardiovascular events to vaccination is difficult because such events also occur commonly in unvaccinated people. It does not say that clinicians are less likely to suspect a vaccine reaction after a common event than after a serious adverse event such as myocarditis. (LLM, conf=0.82)
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The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury
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Diagnosis of Acute Myocarditis Following mRNA Vaccines against SARS-CoV-2: A Methodological Review
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Updated profiling of COVID-19 vaccine adverse events using VAERS case reports
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- Authors
- Mansanguan, S., Charunwatthana, P., Piyaphanee, W., Dechkhajorn, W., Poolcharoen, A., & Mansanguan, C.
- Affiliations
- Bhumibol Adulyadej Hospital (TH)
- Mahidol University (TH)
- Samitivej Srinakarin Hospital (TH)
- Corresponding author
- Mansanguan, Chayasin
- Venue
- Tropical Medicine and Infectious Disease
- Publisher
- MDPI AG
- Published
- 2022-08-19
- Volume
- 7
- Issue
- 8
- Pages
- 196
- ISSN
- 2414-6366 (ISSN-L)
- PMC
- PMC9414075
- OpenAlex
- W4292575540
- Cited by
- 83
- References
- 36
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 19 · 2023: 39 · 2022: 12
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Tropical Medicine and Infectious Disease (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department of Clinical Tropical Medicine, Mahidol University
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- BNT162b2 mRNA vaccine, COVID-19 vaccines, adolescents, cardiovascular adverse events, myocarditis, pericarditis, myopericarditis, tachycardia, palpitations, cardiac biomarkers, vaccine safety
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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