The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
Regulatory T cells in the face of the intestinal microbiota
Abstract
Regulatory T cells (T reg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders. Startling new information has appeared in recent years on their diversity, the importance of the transcription factor FOXP3, how T cell receptors influence their fate and the unexpected and varied cellular partners that influence T reg cell homeostatic setpoints. We also revisit some tenets, maintained by the echo chambers of Reviews, that rest on uncertain foundations or are a subject of debate.
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In the citing paper
“In addition, the gut microbiome regulates the activity of retinoic acid receptor-related orphan receptor gamma-positive (RORγ+) Treg cells, dysregulation of which can lead to diseases such as colitis, food allergy, and colon cancer.622,701–704”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [622]
In the citing paper
“Notably, certain gut microbiota and their metabolites may stimulate or inhibit the differentiation of naive CD4+ T cells into TH17 cells.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [622]
In the citing paper
“The gut microbiome participates in extensive bidirectional communication with the immune system.622,696”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [622]
In the citing paper
“Emerging evidence has underscored the neuroimmune role of Treg cells and TH17 cells in the gut–brain axis, extending to neuropathological conditions such as AD, suggesting potential areas for future research.621,622”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [622]
Citations
Cites
Items 201–207 of 207
Differences in FOXP3 and CD127 expression in Treg-like cells in patients with IPEX syndrome
Boldt, A., Kentouche, K., Fricke, S., Borte, S., Kahlenberg, F., & Sack, U. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.04.001 · Cited by 10
Chowdhary, K., Léon, J., Ramanan, D., Mathis, D., & Benoist, C. (2023) · bioRxiv · doi:10.1101/2023.05.18.541358 · Cited by 8
Self-citationIntestinal microbes direct CX3CR1+cells to balance intestinal immunity
Kim, M., Hill, A. A., Wu, W.-J. H., & Diehl, G. E. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1559683 · Cited by 7
Dikiy, S., Levine, A. G., Giovanelli, P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.16.492030 · Cited by 6
Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte programPreprint
London, M., Bilate, A. M. B., Castro, T. B. R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.04.134650 · Cited by 3
Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsetsPreprint
Ramanan, D., Chowdhary, K., Candéias, S. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.17.541199 · Cited by 3
Self-citationGélineau, A., Marcelin, G., Ouhachi, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537402 · Cited by 1
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu, Y., Hu, Q., Li, Y., Lu, L., Xiang, Z., Yin, Z., Kabelitz, D., & Wu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01653-8 · Cited by 418
Zhang, Y., Tu, S., Ji, X., Wu, J., Meng, J., Gao, J., Shao, X., Shi, S., Gan, W., Qiu, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45636-x · Cited by 338
A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut
Zhu, Y., Meerschaert, K. A., Galván-Peña, S., Bin, N., Yang, D., Basu, H., Kawamoto, R., Shalaby, A., Liberles, S. D., Mathis, D. J., et al. (2024) · Science · doi:10.1126/science.adk1679 · Cited by 121
Self-citationRodrigues, P. F., Wu, S., Tršan, T., Panda, S. K., Fachi, J. L., Liu, Y. A., Du, S., de Oliveira, S., Antonova, A. U., Khantakova, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.020 · Cited by 84
Metadata
- Authors
- Ramanan, D., Pratama, A., Zhu, Y., Venezia, O., Sassone-Corsi, M., Chowdhary, K., Galván-Peña, S., Sefik, E., Brown, C., Gélineau, A., Mathis, D., & Benoist, C.
- Affiliations
- Harvard University (US)
- Yale University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Benoist, Christophe
- ORCID
- Venue
- Nature Reviews Immunology
- Published
- 2023-06-14
- Volume
- 23
- Issue
- 11
- Pages
- 749-762
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W4380610291
- Cited by
- 126
- References
- 201
- Citations by year
- 2026: 32 · 2025: 47 · 2024: 40 · 2023: 7
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai150686-05)
- National Institute of Allergy and Infectious Diseases (R01-AI150686, R01AI125603)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- regulatory T cells, gut microbiota, Foxp3, T cell receptor signaling, Treg cell homeostasis, immune homeostasis, diet
- MeSH terms
- Gastrointestinal Microbiome, Antigens, Humans, Intestines, Receptors, Antigen, T-Cell, T-Lymphocytes, Regulatory, Forkhead Transcription Factors
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