Regulatory T cells in the face of the intestinal microbiota

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368

Inducible Foxp3 + regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

γδ T cells: origin and fate, subsets, diseases and immunotherapy

Hu, Y., Hu, Q., Li, Y., Lu, L., Xiang, Z., Yin, Z., Kabelitz, D., & Wu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01653-8 · Cited by 418

Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway

Zhang, Y., Tu, S., Ji, X., Wu, J., Meng, J., Gao, J., Shao, X., Shi, S., Gan, W., Qiu, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45636-x · Cited by 338

A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut

Zhu, Y., Meerschaert, K. A., Galván-Peña, S., Bin, N., Yang, D., Basu, H., Kawamoto, R., Shalaby, A., Liberles, S. D., Mathis, D. J., et al. (2024) · Science · doi:10.1126/science.adk1679 · Cited by 121

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens

Rodrigues, P. F., Wu, S., Tršan, T., Panda, S. K., Fachi, J. L., Liu, Y. A., Du, S., de Oliveira, S., Antonova, A. U., Khantakova, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.020 · Cited by 84

PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens

Fu, L., Upadhyay, R., Pokrovskii, M. V., Chen, F. M., Romero‐Meza, G., Griesemer, A., & Littman, D. R. (2025) · Nature · doi:10.1038/s41586-025-08982-4 · Cited by 81

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis

Marin-Rodero, M., Cintado, E., Walker, A. J., Jayewickreme, T., Pinho-Ribeiro, F. A., Richardson, Q., Jackson, R. P., Chiu, I. M., Benoist, C. O., Stevens, B., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adu2910 · Cited by 72

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics

Raeber, M. E., Caspar, D., Zurbuchen, Y., Guo, N., Schmid, J., Michler, J., Martin, A. C., Steiner, U. C., Moor, A. E., Koning, F., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.016 · Cited by 73

Treg cell: Critical role of regulatory T-cells in depression

Gao, X. W., Tang, Y., Kong, L., Fan, Y., Wang, C., & Wang, R. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106893 · Cited by 51

The renaissance of oral tolerance: merging tradition and new insights

Cerovic, V., Pabst, O., & Mowat, A. M. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01077-7 · Cited by 51

Regulatory T cells and their role in allergic disease

Conrad, M. L., Barrientos, G., Cai, X., Mukherjee, S., Das, M., Victor, E. S., & Harb, H. (2024) · Allergy · doi:10.1111/all.16326 · Cited by 52

The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms

Karam, F., Deghel, Y. E., Iratni, R., Dakroub, A. H., & Eid, A. H. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01683-9 · Cited by 46

Common mechanisms of Gut microbe-based strategies for the treatment of intestine-related diseases: based on multi-target interactions with the intestinal barrier

Chen, K., Wang, H., Yang, Y., Tang, C., Sun, X., Zhou, J., Liu, S., Li, Q., Zhao, L., & Gao, Z. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02299-5 · Cited by 47

How does the microbiota control systemic innate immunity?

Jordan, C. K. I., & Clarke, T. B. (2024) · Trends in Immunology · doi:10.1016/j.it.2023.12.002 · Cited by 40

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

Ramanan, D., Chowdhary, K., Candéias, S. M., Sassone‐Corsi, M., Gélineau, A., Mathis, D. J., & Benoist, C. O. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311566120 · Cited by 32

Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

Wu, R., Wang, D., Cheng, L., Su, R. J., Li, B., Fan, C., Gao, C., & Wang, C. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03260-y · Cited by 35

Bioinspired approaches to encapsulate and deliver bacterial live biotherapeutic products

Brittain, N. Y., & Finbloom, J. A. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115663 · Cited by 34

Early life imprinting of intestinal immune tolerance and tissue homeostasis

Iza, Y. A. P., & Brown, C. C. (2024) · Immunological Reviews · doi:10.1111/imr.13321 · Cited by 33

ILC3s sense gut microbiota through STING to initiate immune tolerance

Zhou, W., Zhou, J., Ahmed, A., Kim, M. J., Guo, C., & Sonnenberg, G. F. (2025) · Immunity · doi:10.1016/j.immuni.2025.05.016 · Cited by 27

Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches

Mehmandar‐Oskuie, A., Jahankhani, K., Rostamlou, A., Mardafkan, N., Karamali, N., Razavi, Z. S., & Mardi, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122322 · Cited by 27

The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review

Sun, C., Zhu, D., Zhu, Q., He, Z., Lou, Y., & Chen, D. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1337223 · Cited by 26

New insights into gut microbiota–prostate cancer crosstalk

Laaraj, J., Lachance, G., Bergeron, A., Fradet, Y., Robitaille, K., & Fradet, V. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.03.015 · Cited by 25

Oral Nanoarmored Live Bacterial Biotherapeutics Bearing Polyphenol-Based Supraparticles Enhance Chemotherapy via Reestablishing Immuno-Oncology-Microbiome Axis

Liu, Q., Wu, Y., Fan, Q., Liu, J., Chen, Y., He, Y., Wei, W., Zhang, H., Zhao, Y., He, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c01158 · Cited by 22

Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria

Ding, W., Cheng, Y., Liu, X., Zhu, Z., Wu, L., Gao, J., Lei, W., Li, Y., Zhou, X., Wu, J., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1563450 · Cited by 26

Regulatory Potential of Food-Derived Bioactive Peptides on Gut Microbiota: A New Perspective against Immune-Mediated Inflammatory Diseases

Dong, Y., Chen, X., Abdelnaby, T., Guyonnet, V., Cai, X., & Wang, S. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c06148 · Cited by 23

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Heras, M. M. G. D. L., Carrasco, E., Pérez-Manrique, M., Inohara, N., Delgado-Pulido, S., Fernández-Almeida, Á., Gálvez-Castaño, M. I., Francos-Quijorna, I., Simó, C., García‐Cañas, V., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adv0985 · Cited by 22

Single cell suppression profiling of human regulatory T cells

Søndergaard, J. N., Tulyeu, J., Priest, D., Sakaguchi, S., & Wing, J. B. (2025) · Nature Communications · doi:10.1038/s41467-024-55746-1 · Cited by 17

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

Guo, X., Liu, H. N., Song, Y., Wang, J., Liu, D., Zheng, Z., Li, J., Li, B., Song, A., He, W., et al. (2026) · MedComm · doi:10.1002/mco2.70497 · Cited by 26

Effects of dietary citrus pulp level on the growth and intestinal health of largemouth bass (Micropterus salmoides)

Long, W. Y., Luo, J., Ou, H., Jiang, W., Zhou, H., Liu, Y., Zhang, L., Mi, H., & Deng, J. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13157 · Cited by 16

Akkermansia muciniphila ameliorates fatty liver through microbiota-derived α-ketoisovaleric acid metabolism and hepatic PI3K/Akt signaling

Liu, C., Ma, R., Li, H., Pan, X., Qian, H., Yang, T., & Tian, Y. (2025) · iScience · doi:10.1016/j.isci.2025.112458 · Cited by 16

Opposing functions of distinct regulatory T cell subsets in colorectal cancer

Huang, X., Feng, D., Mitra, S., Andretta, E. S., Hooshdaran, N., Ghelani, A. P., Wang, E. Y., Frost, J. N., Lawless, V. R., Vancheswaran, A., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.11.014 · Cited by 19

Systems immunology of regulatory T cells: can one circuit explain it all?

Tripathi, S., Tsang, J. S., & Park, K. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.007 · Cited by 15

The Gut Microbiota: Emerging Evidence in Autoimmune and Inflammatory Diseases

Zeng, L., Yang, Q., Luo, Y., Luo, Y., & Sun, L. (2025) · Research · doi:10.34133/research.1097 · Cited by 21

Targeting gut microbiota for immunotherapy of diseases

Yu, Y., Liu, X., Liao, C., Yu, R., Wang, X., Li, M., & Wang, Y. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03770-x · Cited by 14

The Role of Intestinal Microbiota and Immune System Interactions in Autoimmune Diseases

Yurtseven, B., Aydemir, E., & Ayaz, F. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s569016 · Cited by 19

Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?

Snethlage, C. M. F., de Wit, D. F., Wortelboer, K., Rampanelli, E., Hanssen, N. M. J., & Nieuwdorp, M. (2024) · Immunological Reviews · doi:10.1111/imr.13345 · Cited by 13

Pathogenic mechanisms in the evolution of food allergy

Martínez‐Blanco, M., Mukhatayev, Z., & Chatila, T. A. (2024) · Immunological Reviews · doi:10.1111/imr.13398 · Cited by 16

D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis

Lu, Y., Xiong, Y., Zhang, S., Wang, B., Feng, Y., Pu, Z., Wei, K., Chen, J., Chen, D., & Zhang, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1454713 · Cited by 13

Exosomes-Based Nanotherapeutic Strategies: An Important Approach for Spinal Cord Injury Repair

Ju, C., Dong, H., Liu, R., Wang, X., Xu, R., Hu, H., & Hao, D. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s539673 · Cited by 11

Targeting gut microbiota and metabolites in cancer radiotherapy

Ma, S., Li, X., Shang, S., Zhai, Z., Wu, M., Song, Q., & Chen, D. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70481 · Cited by 12

Gut Microbiota Defines Functional Direction of Colonic Regulatory T Cells with Unique TCR Repertoires

Byun, S., Lee, J., Choi, Y. H., Ko, H., Lee, C., Park, J. C., Kim, S. W., Lee, H., Sharma, A., Kim, K. S., et al. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300395 · Cited by 11

A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control

Wang, Y., Zhang, Y., Kim, K., Han, J., Okin, D. A., Jiang, Z., Yang, L., Subramaniam, A., Means, T. K., Nestle, F. O., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.10.010 · Cited by 11

The gut microbiome and cross-reactivity of food allergens: current understanding, insights, and future directions

Oliva, C. T., Musa, I., Kopulos, D., Ardalani, F., Maskey, A., Wilson, A., Yang, N., & Li, X.-M. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2024.1503380 · Cited by 11

Metabolic hallmarks of type 2 diabetes compromise T cell function

Liang, Y., Chen, W., Gao, Q., Tan, K. C. B., Lee, C., & Ling, G. S. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.08.005 · Cited by 11

Recent advances in flavonoids benefiting intestinal homeostasis

Luo, Y., Li, Y., Shi, C., Min, S., Li, B., Lu, Y., BingHai, C., Su, H., & He, Y. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105311 · Cited by 11

Regulatory T Cells for Control of Autoimmunity

Kawakami, R., & Sakaguchi, S. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-9781-7_5 · Cited by 13

Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases

Nai, S., Song, J., Su, W., & Liu, X. (2025) · Genes · doi:10.3390/genes16020208 · Cited by 12

Alteration in gut microbiota accompanied by increased intestinal permeability and Tfh/Tfr imbalance in patients with active SLE

Chu, X., Li, S., Wang, Y., Guo, D., Zhao, N., Han, Y., & Xing, Q. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1565416 · Cited by 13

Radiation-induced gut microbiota dysbiosis and Treg cells dysfunction: Mechanistic insights and clinical implications - A review

Wang, Z., Gu, M., Zhang, S., Huang, F., Li, Y., & Chang, P. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123844 · Cited by 9

Infants < 90 days of age with late-onset sepsis display disturbances of the microbiome-immunity interplay

Graspeuntner, S., Lupatsii, M., van Zandbergen, V., Dammann, M.-T., Pagel, J., Nguyen, D. N., Humberg, A., Göpel, W., Herting, E., Rupp, J., et al. (2024) · Infection · doi:10.1007/s15010-024-02396-6 · Cited by 9

Differences in the characteristics and functions of brain and spinal cord regulatory T cells

Watanabe, M., Matsui, A., Awata, N., Nagafuchi, A., Kawazoe, M., Harada, Y., & Ito, M. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03144-1 · Cited by 8

Impact of Mast Cell Activation on Neurodegeneration: A Potential Role for Gut–Brain Axis and Helicobacter pylori Infection

Boziki, M. K., Theotokis, P., Kesidou, E., Nella, M., Bakirtzis, C., Karafoulidou, E., Tzitiridou‐Chatzopoulou, M., Doulberis, M., Kazakos, E. I., Deretzi, G., et al. (2024) · Neurology International · doi:10.3390/neurolint16060127 · Cited by 8

Prdm16-dependent antigen-presenting cells induce tolerance to intestinal antigensPreprint

Fu, L., Upadhyay, R., Pokrovskii, M. V., Chen, F. M., Romero‐Meza, G., Griesemer, A. D., & Littman, D. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.23.604803 · Cited by 8

Inulin alleviates intestinal barrier dysfunction induced by chronic intermittent hypoxia by modulating intestinal microbiota in mice

Yu, X. M., Tang, R., & Liu, Z. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00156.2025 · Cited by 7

Tissue Regulatory T Cells

Feuerer, M., Gray, D. H. D., Rankin, L. C., Schmidleithner, L., & Liston, A. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082924-092651 · Cited by 8

Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

Sun, Q., Barrett, A. K., Ogishi, M., Lyu, H., Jiang, H., Liu, H., Zhao, Y., Rodriguez, G. E., Tao, P., Obenaus, M., et al. (2026) · Nature · doi:10.1038/s41586-026-10208-0 · Cited by 7

Gut Microbiota and Interorgan Communication Among the Gut, Brain, and Beyond

Shigehara, A., Kiyohara, H., Teratani, T., Nakamoto, N., Mikami, Y., & Kanai, T. (2025) · Internal Medicine · doi:10.2169/internalmedicine.5318-25 · Cited by 5

Peripherally induced RORγt + skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy

Zhang, K., Kim, S. M., Kwon, H., Kim, S. H., Kim, T., Sun, Z., Kim, H. L., Tyo, A., Kim, J. H., Kim, R. G., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.ado1375 · Cited by 5

Intratumor Rhodococcus sp. B513 drives DEN-induced hepatocellular carcinoma progression by modulating gut microbiota and angiogenesis

Liu, Q., Wang, J., Yao, Y., Sun, X., Fang, W. J., Zhang, Y., Liu, Z., & Zheng, Y. Z. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100428 · Cited by 5

Comprehensive characterisation of age-related changes in cell subpopulations and tissue structural properties in secondary lymphoid organs

Deng, Y., He, X., Peng, J., Pan, Y., Luo, Y., Ruan, Y., Hou, J., Jiang, B., Li, X., Liang, X., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08007-y · Cited by 8

Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens

Fu, L., & Littman, D. R. (2025) · Immunological Reviews · doi:10.1111/imr.70082 · Cited by 5

Tissue-resident regulatory T cells: modulators of local immunity

Shi, Y., Wang, L., Bao, C., Wang, G., & Sun, Z. (2026) · Trends in Immunology · doi:10.1016/j.it.2025.12.001 · Cited by 5

Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines

Montenegro, C., Perdomo-Celis, F., & Franco, M. A. (2024) · Viruses · doi:10.3390/v16060818 · Cited by 5

Smoking-related Lactobacillus and immune cell infiltration in colorectal cancer: evidence from a population-based study

Chen, S., Xin, J., Gu, D., Li, H., Zheng, R., Li, S., Zhang, Z., Du, M., & Wang, M. (2024) · Gut · doi:10.1136/gutjnl-2023-331865 · Cited by 5

Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders

Yu, M., Qu, M., Wang, Z., Zhen, C., Yang, B., Zhang, Y., Huang, H., Zhang, C., Song, J., Fan, X., et al. (2025) · Cells · doi:10.3390/cells14151164 · Cited by 5

High-fat diet, intestinal microecology and bone loss

Wang, N., Xue, T., & Li, Y. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01013-z · Cited by 4

From the gut to the brain: The involvement of the gut microbiota in the development and progression of glioblastoma

Toumazi, D., Charalambous, C., Constantinou, C., & Nicolaou, N. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf267 · Cited by 5

OMIP‐110: A 37‐Color Spectral Flow Cytometric Panel to Assess Transcription Factors and Chemokine Receptors in Human Intestinal Lymphoid Cells

Jiang, Q., Lindelauf, C., van Unen, V., Jong, A. E. V. D. M., Koning, F., & Pascutti, M. F. (2025) · Cytometry Part A · doi:10.1002/cyto.a.24914 · Cited by 4

A hierarchy of intestinal antigens instructs the CD4+ T cell receptor repertoire

Yi, J., Jung, J., Horton, D., Hsieh, P., Peng, Y., Wang, S. J., Newberry, R. D., Ericsson, A. C., Kim, K. S., Kau, A. L., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.011 · Cited by 5

E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis

Kim, D. V., Chen, A., Ng, C., Peres-Tintin, L., Park, S.-E., Acosta, M., Callaghan, R., Stanford, N., Perez-Rosario, M., Matthews, D. B., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116332 · Cited by 4

Intestinal γδ T17–IL-17A signaling disrupts hippocampal mitophagy in stress-induced depression and is restored by arketamine

Han, M., Xie, B., Yuan, Y., Xu, D., Shi, Y., Xu, M., Wu, Y., Zhang, Y., Wen, X., Wang, X., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03656-4 · Cited by 7

RORγt + dendritic cells are a distinct lymphoid-derived lineage

Rodrigues, P. F., Wu, S., Tršan, T., Bhattarai, B., Panda, S. K., Fachi, J. L., Cella, M., & Colonna, M. (2026) · Science Immunology · doi:10.1126/sciimmunol.aed7439 · Cited by 4

The role of intestinal bacteria in promoting tolerance to food

Ionescu, E., & Nagler‐Anderson, C. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102492 · Cited by 4

Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin

Hilaire, M., Mimoun, A., Cagnet, L., Villette, R., Roubanis, A., Sentenac, H., & Salomon, B. L. (2025) · Science Advances · doi:10.1126/sciadv.adx8037 · Cited by 4

Characterizing Duodenal Immune Microenvironment in Functional Dyspepsia: An AutoML-Driven Diagnostic Framework

Zhang, X., Fan, X., Hu, X., Qian, Z., Li, J., Wu, W., Chen, L., Wu, S., Ma, L., Chen, Y., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s524791 · Cited by 3

Powering shrimp growth: How Atractylodes macrocephala polysaccharide fuels Litopenaeus vannamei development through intestinal microbiota modulation

Chen, X., Deng, J., Dong, X., Yang, Q., Liu, H., Zhang, S., Xie, S., Zhang, W., Tan, B., & Chi, S. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742999 · Cited by 3

Gut mucosal immune responses – Implications for celiac disease and food allergy

Abadie, V. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101984 · Cited by 4

Vaccinations in preterm infants: Which and when?

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The Composition and Function of Intestinal Microbiota Were Altered in Farmed Bullfrog Tadpoles (Aquarana catesbeiana) during Metamorphosis

Zheng, X., Chen, Q., Liang, X. S., Kumar, V., Loor, A., Dong, H., Liu, C., Yang, J.-L., & Zhang, J. (2024) · Microorganisms · doi:10.3390/microorganisms12102020 · Cited by 3

Runx–CBFβ regulates the development of tolerogenic Thetis cells

Ogawa, C., Zou, C., Iza, Y. A. P., Yamashita, M., Park, T., Harada, J., Satoh‐Takayama, N., Kuroda, M., Brown, C. C., & Taniuchi, I. (2026) · Nature Immunology · doi:10.1038/s41590-026-02566-8 · Cited by 3

Decoding Peripheral Tolerance: TCR Rules for pTreg differentiation in the GutPreprint

Chi, X., Wang, C. H., Parisotto, Y. F., Nyberg, W. A., Cabric, V., Gélineau, A., Cao, Y., Owen, D. L., Ambjörnsson, J., Mathis, D. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683415 · Cited by 3

Molecular patterns of microbial and metabolic interactions in septic patients with persistent lymphopenia

Jing, J., Li, X., Liu, S., Yu, J., Wang, K., Li, Y., Wan, X., & Wan, X. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107093 · Cited by 2

Gut microbiota contributes to the maintenance of sublingually induced regulatory T cells and tolerance in mice

Winias, S., Bando, K., Temtanapat, B., Nakano, M., Saito, M., Sugawara, S., Komatsu, M., Hirayama, A., Fukuda, S., Abe, T., et al. (2025) · Allergology International · doi:10.1016/j.alit.2025.06.003 · Cited by 2

Low-Grade Inflammation: Pathophysiological Mechanisms and Drug Targets in Irritable Bowel Syndrome with Diarrhea

Ye, B., Fu, Z., Zhou, X., Wang, S., Ouyang, L., Chen, Z., & Deng, G. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s578822 · Cited by 3

Colorectal cancer-derived extracellular vesicles: at the crossroads of the tumor microenvironment and gut microbiota

Li, H., Zhang, W., Yan, W., Wang, K., Chen, S., Li, Y., Sheng, A., Shang, A., & Zeng, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1668737 · Cited by 2

The relativity of regulatory T cell suppression modes

Bai, L., Choudhary, V., & Feng, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1771099 · Cited by 2

Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes

Zou, M., Pezoldt, J., Mohr, J., Philipsen, L., Leufgen, A., Cerovic, V., Wiechers, C., Pils, M. C., Ortiz, D., Hao, L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114153 · Cited by 2

Regulatory T Cells Nanoextinguisher to Manipulate Multiple Immune Evasion for Immunotherapy

Zhao, C., Wang, C., Wang, R., Shan, W., Wang, W., & Deng, H. (2024) · ACS Nano · doi:10.1021/acsnano.4c04663 · Cited by 2

Furin-like enzyme dependency in KRAS-mutant colorectal cancer as a target for personalized treatment strategies

Siegfried, G., Liu, Y., He, Z., Évrard, S., Badiola, I., Pernot, S., Creemers, J. W. M., & Khatib, A. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189620 · Cited by 1

Acute myocardial infarction induces sex-specific, time-dependent remodeling of the gut microbiome and intestinal immune compartment in retired breeder C57BL/6N mice

Pal, E., Arjenaki, N. O., Lu, Y., Xia, J., & Chalifour, L. E. (2026) · Frontiers in Microbiomes · doi:10.3389/frmbi.2026.1818652 · Cited by 1

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation

Chi, X., Wang, C. H., Parisotto, Y. F., Nyberg, W. A., Cabric, V., Gélineau, A., Cao, Y., Owen, D. L., Ambjörnsson, J., Mathis, D. J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.001 · Cited by 6

Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases

Chen, Y., Shi, Y., & You, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02910-2 · Cited by 1

IL-2-producing TFH cells sustain Treg cell homeostasis and immune tolerance in the gut

Dave, S., Bachus, H., Santiago, N., Meloun, A., Smelkinson, M. G., Foote, J. B., Hill, T., Fucile, C., Rosenberg, A. F., & Ballesteros‐Tato, A. (2026) · Nature Immunology · doi:10.1038/s41590-026-02690-5 · Cited by 1

Mouse Models Enable the Functional Investigation of Tertiary Lymphoid Structures in Cancer

Jeevanandam, A., Yin, Z., Connolly, K. A., & Joshi, N. S. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4184-2_4 · Cited by 1

Uncovering the biological mechanism of acupuncture alleviating diabetic nephropathy through homeostasis regulation the of intestinal flora and T lymphocytesPreprint

Lu, X., Li, M., Ji, X.-Q., Wang, X., Hou, C., Li, S., Wang, M., Xie, Y., Wu, H., Shi, Z., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3628227/v1

Single cell suppression profiling of human regulatory T cellsPreprint

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Development of Regulatory T Cells in the Thymus and Periphery

van der Veeken, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00093-4

Intestinal flora and metabolite changes: Uncovering pathogenic mechanisms in myasthenia gravis

Wu, Q., Li, J., Li, H., Kan, H., Yuan, M., Chen, Y., Sun, X., Zhao, K., Zhao, L., & Zhang, X. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.578996

Gut Microbiota in Health and Disease: A Path to Personalized Medicine

Pulipati, S., Puttagunta, S. B., Aswini, S., Nandini, Y., & Lavanya, K. (2025) · Archives of Case Reports · doi:10.29328/journal.acr.1001152

The Roles of Bacteria in the Microbiome–Intervertebral Disc Axis

Melrose, J., Smith, M. M., & Diwan, A. D. (2025) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/5515716

Controlling the frontier: Regulatory T-cells and intestinal homeostasis

Bollrath, J., & Powrie, F. M. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.002 · Cited by 89

Development and maintenance of intestinal regulatory T cells

Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553

Microbial and dietary factors modulating intestinal regulatory T cell homeostasis

Kinoshita, M., & Takeda, K. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.018 · Cited by 12

Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease

Jacobse, J., Li, J., Rings, E. H. H. M., Samsom, J. N., & Goettel, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.716499 · Cited by 101

The Many Functions of Foxp3+ Regulatory T Cells in the Intestine

Cosovanu, C., & Neumann, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600973 · Cited by 109