The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Ecology, evolution and spillover of coronaviruses from bats
Open accessAbstract
In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first SARS epidemic in 2002–2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly. More than 4,000 coronavirus sequences from 14 bat families have been identified, yet the true diversity of bat coronaviruses is probably much greater. Given that bats are the likely evolutionary source for several human coronaviruses, including strains that cause mild upper respiratory tract disease, their role in historic and future pandemics requires ongoing investigation. We review and integrate information on bat–coronavirus interactions at the molecular, tissue, host and population levels. We identify critical gaps in knowledge of bat coronaviruses, which relate to spillover and pandemic risk, including the pathways to zoonotic spillover, the infection dynamics within bat reservoir hosts, the role of prior adaptation in intermediate hosts for zoonotic transmission and the viral genotypes or traits that predict zoonotic capacity and pandemic potential. Filling these knowledge gaps may help prevent the next pandemic. Bats harbour a multitude of coronaviruses and owing to their diversity and wide distribution are prime reservoir hosts of emerging viruses. Ruiz-Aravena, McKee and colleagues analyse the currently available information on bat coronaviruses and discuss their role in recent and potential future spillovers.
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1 retracted
RETRACTED ARTICLE: Origin and cross-species transmission of bat coronaviruses in China
Latinne, A., Hu, B., Olival, K. J., Zhu, G., Zhang, L., Li, H., Chmura, A. A., Field, H. E., Zambrana-Torrelio, C., Epstein, J. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17687-3 · Cited by 339
RetractedA pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676
Origin and evolution of pathogenic coronaviruses
Cui, J., Li, F., & Shi, Z.-L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0118-9 · Cited by 5,515
Extrapulmonary manifestations of COVID-19
Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0968-3 · Cited by 3,185
Letko, M., Marzi, A., & Munster, V. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0688-y · Cited by 3,109
Self-citationEpidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses
Su, S., Wong, G., Shi, W., Liu, J., Lai, A. C. K., Zhou, J., Liu, W., Bi, Y., & Gao, G. F. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.03.003 · Cited by 2,948
Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England
Davies, N. G., Abbott, S., Barnard, R. C., Jarvis, C. I., Kucharski, A. J., Munday, J. D., Pearson, C. A. B., Russell, T. W., Tully, D. C., Washburne, A. D., et al. (2021) · Science · doi:10.1126/science.abg3055 · Cited by 2,581 · cited 2×
“In addition to the receptors, host proteases are needed to activate (cleave) the virus spike protein to enable entry, and this cleavage may be as important as host receptor binding in determining viral zoonotic potential 96,115 and potentially human-to-human transmissibility 92 .”
Bats Are Natural Reservoirs of SARS-Like Coronaviruses
Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J. H., Wang, H., Crameri, G., Hu, Z., Zhang, H., et al. (2005) · Science · doi:10.1126/science.1118391 · Cited by 2,560
Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England
Davies, N. G., Abbott, S., Barnard, R. C., Jarvis, C. I., Kucharski, A. J., Munday, J. D., Pearson, C. A. B., Russell, T. W., Tully, D. C., Washburne, A. D., et al. (2020) · doi:10.1101/2020.12.24.20248822 · Cited by 2,557
Cited by
Foley, N. M., Harris, A. J., Bredemeyer, K. R., Ruedi, M., Puechmaille, S. J., Teeling, E. C., Criscitiello, M. F., & Murphy, W. J. (2024) · Cell Genomics · doi:10.1016/j.xgen.2023.100482 · Cited by 31
Moore, K. A., Leighton, T., Ostrowsky, J. T., Anderson, C. J., Danila, R. N., Ulrich, A. K., Lackritz, E. M., Mehr, A. J., Baric, R. S., Baylor, N. W., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.02.032 · Cited by 25
Wallau, G. D. L., Barbier, E., Machado, L. C., da Silva, A. F., Dias, Y. J. M., Dezordi, F. Z., Tomazatos, A., Horváth, B., Lins, R. D., Bernard, E., et al. (2025) · Virus Evolution · doi:10.1093/ve/veaf094 · Cited by 2
Structural dynamics and allosteric communication of a SARS-like bat coronavirus spike glycoprotein
Balogun, T. A., Kearns, F. L., Calvó-Tusell, C., Tse, A. L., Acreman, C. M., Casalino, L., Lasso, G., Miller, E. H., Chandran, K., McLellan, J. S., et al. (2026) · Biophysical Journal · doi:10.1016/j.bpj.2026.04.023
Metadata
- Authors
- Ruiz-Aravena, M., McKee, C., Gamble, A., Lunn, T., Morris, A., Snedden, C. E., Yinda, C. K., Port, J. R., Buchholz, D. W., Yeo, Y. Y., Faust, C., Jax, E., Dee, L., Jones, D. N., Kessler, M. K., Falvo, C., Crowley, D., Bharti, N., Brook, C. E., Aguilar, H. C., Peel, A. J., Restif, O., Schountz, T., Parrish, C. R., Gurley, E. S., Lloyd-Smith, J. O., Hudson, P. J., Munster, V. J., & Plowright, R. K.
- Venue
- Nature Reviews Microbiology
- Published
- 2021-11-19
- Volume
- 20
- Issue
- 5
- Pages
- 299-314
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W3214432874
- Cited by
- 284
- References
- 172
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ruiz-Aravena, M., McKee, C., Gamble, A., Lunn, T., Morris, A., Snedden, C. E., Yinda, C. K., Port, J. R., Buchholz, D. W., Yeo, Y. Y., Faust, C., Jax, E., Dee, L., Jones, D. N., Kessler, M. K., Falvo, C., Crowley, D., Bharti, N., Brook, C. E., . . . Plowright, R. K. (2022). Ecology, evolution and spillover of coronaviruses from bats. Nature Reviews Microbiology. https://doi.org/10.1038/s41579-021-00652-2
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