The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.
The cytoplasmic dynein transport machinery and its many cargoes
Open accessAbstract
Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division. Here, we focus on interphase cargoes of dynein, which include membrane-bound organelles, RNAs, protein complexes and viruses. A central challenge in the field is to understand how a single motor can transport such a diverse array of cargoes and how this process is regulated. The molecular basis by which each cargo is linked to dynein and its cofactor dynactin has started to emerge. Of particular importance for this process is a set of coiled-coil proteins — activating adaptors — that both recruit dynein–dynactin to their cargoes and activate dynein motility. Cytoplasmic dynein is a minus-end-directed microtubule-based motor that transports a wide range of cargoes, including organelles, RNAs, protein complexes and viruses. How a single motor can interact with and traffic such different cargoes has been unclear. Recent studies indicate how adaptor proteins, which can both activate dynein and link it to cargo, play an important role in this process.
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Metadata
- Authors
- Reck-Peterson, S. L., Redwine, W. B., Vale, R. D., & Carter, A. P.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2018-04-16
- Volume
- 19
- Issue
- 6
- Pages
- 382-398
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2800287140
- Cited by
- 659
- References
- 237
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
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