The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.
Crosstalk between metabolism and circadian clocks
Abstract
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest (sleep) phases that differ largely in their metabolic requirements. The circadian clock evolved as an autonomous timekeeping system that aligns behavioural patterns with the solar day and supports the body functions by anticipating and coordinating the required metabolic programmes. The key component of this synchronization is a master clock in the brain, which responds to light-darkness cues from the environment. However, to achieve circadian control of the entire organism, each cell of the body is equipped with its own circadian oscillator that is controlled by the master clock and confers rhythmicity to individual cells and organs through the control of rate-limiting steps of metabolic programmes. Importantly, metabolic regulation is not a mere output function of the circadian system, but nutrient, energy and redox levels signal back to cellular clocks in order to reinforce circadian rhythmicity and to adapt physiology to temporal tissue-specific needs. Thus, multiple systemic and molecular mechanisms exist that connect the circadian clock with metabolism at all levels, from cellular organelles to the whole organism, and deregulation of this circadian-metabolic crosstalk can lead to various pathologies.
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“Existing evidence shows that disturbed rest-activity rhythms, as, for example, in shift workers, lead to desynchronization of internal molecular clocks, thereby disturbing circadian biochemical processes, secretion of hormones, metabolic functions, and physiological parameters [66-68].”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [68]
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Metadata
- Authors
- Reinke, H., & Asher, G.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Weizmann Institute of Science (IL)
- Corresponding author
- Reinke, Hans
- Asher, Gad
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2019-01-11
- Volume
- 20
- Issue
- 4
- Pages
- 227-241
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2910084517
- Cited by
- 598
- References
- 213
- Citations by year
- 2026: 60 · 2025: 86 · 2024: 81 · 2023: 81 · 2022: 100 · 2021: 85 · 2020: 66 · 2019: 38
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Keywords
- circadian clock, metabolism, circadian rhythm, circadian pacemaker, light-dark cycle, sleep-wake cycle, redox signaling, nutrient signaling
- MeSH terms
- Animals, Brain, Circadian Rhythm, Humans, Mammals, Circadian Clocks
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