The DOI matches its Crossref record; 216 of the 221 references it cites were found in a registry or an index.
The many functions of ESCRTs
Abstract
Cellular membranes can form two principally different involutions, which either exclude or contain cytosol. The 'classical' budding reactions, such as those occurring during endocytosis or formation of exocytic vesicles, involve proteins that assemble on the cytosol-excluding face of the bud neck. Inverse membrane involution occurs in a wide range of cellular processes, supporting cytokinesis, endosome maturation, autophagy, membrane repair and many other processes. Such inverse membrane remodelling is mediated by a heteromultimeric protein machinery known as endosomal sorting complex required for transport (ESCRT). ESCRT proteins assemble on the cytosolic (or nucleoplasmic) face of the neck of the forming involution and cooperate with the ATPase VPS4 to drive membrane scission or sealing. Here, we review similarities and differences of various ESCRT-dependent processes, with special emphasis on mechanisms of ESCRT recruitment.
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“This final event is carried out by the ESCRT-III membrane scission machinery that is recruited by ALIX and ESCRT-I to these scission sites (for review, see [16]).”
From Budding of a Retrovirus: Some Assemblies Required (2020) · cites this paper as [16]
In the citing paper
“A series of multi-protein ESCRT complexes (endosomal sorting complexes required for transport) recognise cargo modified through monoubiquitylation and transport these for degradation within the lysosome7.”
From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [7]
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Items 201–216 of 216
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MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis
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Self-citationWhen membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease
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5 of the 221 references couldn’t be matched to a known paper.
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Exosomes as a new frontier of cancer liquid biopsy
Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855
Mechanisms governing autophagosome biogenesis
Nakatogawa, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0241-0 · Cited by 903
Exosomes as mediators of intercellular crosstalk in metabolism
Isaac, R., Reis, F. C. G., Ying, W., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.006 · Cited by 860
Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer
Han, Q.-F., Li, W.-J., Hu, K.-S., Gao, J., Zhai, W.-L., Yang, J.-H., & Zhang, S.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 678
Machinery, regulation and pathophysiological implications of autophagosome maturation
Zhao, Y. G., Codogno, P., & Zhang, H. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00392-4 · Cited by 582
Metadata
- Authors
- Vietri, M., Radulovic, M., & Stenmark, H.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Stenmark, Harald
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2019-11-08
- Volume
- 21
- Issue
- 1
- Pages
- 25-42
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2985101511
- Cited by
- 962
- References
- 221
- Citations by year
- 2026: 117 · 2025: 159 · 2024: 165 · 2023: 144 · 2022: 150 · 2021: 152 · 2020: 74 · 2019: 1
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- ESCRT, membrane fission, membrane sealing, cytokinesis, endosome maturation, autophagy, membrane repair, viral replication, budding
- MeSH terms
- Spastin, Animals, Cell Membrane, Humans, Neurons, Nuclear Envelope, Phagosomes, Endosomes, Virus Replication, Protein Transport, Cytokinesis, Host-Pathogen Interactions, Exosomes, Endosomal Sorting Complexes Required for Transport
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