The many functions of ESCRTs

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,473

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

Itakura, E., Kishi‐Itakura, C., & Mizushima, N. (2012) · Cell · doi:10.1016/j.cell.2012.11.001 · Cited by 1,385

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Raiborg, C., & Stenmark, H. (2009) · Nature · doi:10.1038/nature07961 · Cited by 1,359

Nuclear envelope rupture and repair during cancer cell migration

Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318

DNA breaks and chromosome pulverization from errors in mitosis

Crasta, K., Ganem, N. J., Dagher, R., Lantermann, A. B., Ivanova, E. V., Pan, Y., Nezi, L., Protopopov, A., Chowdhury, D., & Pellman, D. (2012) · Nature · doi:10.1038/nature10802 · Cited by 1,227

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

Gibbings, D., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 1,037

Exosomes as a new frontier of cancer liquid biopsy

Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855

Mechanisms governing autophagosome biogenesis

Nakatogawa, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0241-0 · Cited by 903

Exosomes as mediators of intercellular crosstalk in metabolism

Isaac, R., Reis, F. C. G., Ying, W., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.006 · Cited by 860

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Han, Q.-F., Li, W.-J., Hu, K.-S., Gao, J., Zhai, W.-L., Yang, J.-H., & Zhang, S.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 678

Machinery, regulation and pathophysiological implications of autophagosome maturation

Zhao, Y. G., Codogno, P., & Zhang, H. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00392-4 · Cited by 582

Computed structures of core eukaryotic protein complexes

Humphreys, I. R., Pei, J., Baek, M., Krishnakumar, A., Anishchenko, I., Ovchinnikov, S., Zhang, J., Ness, T. J., Banjade, S., Bagde, S. R., et al. (2021) · Science · doi:10.1126/science.abm4805 · Cited by 542

RAB31 marks and controls an ESCRT-independent exosome pathway

Wei, D., Zhan, W., Gao, Y., Huang, L., Gong, R., Wang, W., Zhang, R., Wu, Y., Gao, S., & Kang, T. (2020) · Cell Research · doi:10.1038/s41422-020-00409-1 · Cited by 512

Phosphoinositides as membrane organizers

Posor, Y., Jang, W., & Haucke, V. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00490-x · Cited by 469

Current Strategies for Exosome Cargo Loading and Targeting Delivery

Zeng, H., Guo, S., Ren, X., Wu, Z., Liu, S., & Yao, X. (2023) · Cells · doi:10.3390/cells12101416 · Cited by 464

The ins-and-outs of exosome biogenesis, secretion, and internalization

Arya, S. B., Collie, S. P., & Parent, C. A. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.06.006 · Cited by 427

Plant-derived exosome-like nanoparticles and their therapeutic activities

Kim, J., Li, S., Zhang, S., & Wang, J. (2021) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2021.05.006 · Cited by 415

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

Teng, F., & Fussenegger, M. (2020) · Advanced Science · doi:10.1002/advs.202003505 · Cited by 401

Recent Advances in DNA Origami-Engineered Nanomaterials and Applications

Zhan, P., Peil, A., Jiang, Q., Wang, D., Mousavi, S., Xiong, Q., Shen, Q., Shang, Y., Ding, B., Lin, C., et al. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00028 · Cited by 383

Autophagosome biogenesis: From membrane growth to closure

Melia, T. J., Lystad, A. H., & Simonsen, A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202002085 · Cited by 340

Pyroptosis, metabolism, and tumor immune microenvironment

Du, T., Gao, J., Li, P., Wang, Y., Qi, Q., Liu, X., Li, J., Wang, C., & Du, L. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.492 · Cited by 335

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

Schuck, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.246322 · Cited by 336

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297

Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

Settembre, C., & Perera, R. M. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00676-x · Cited by 303

Towards targeting of shared mechanisms of cancer metastasis and therapy resistance

Weiß, F., Lauffenburger, D. A., & Friedl, P. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00427-0 · Cited by 295

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

Rädler, J., Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.02.013 · Cited by 298

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Tsuchiya, K. (2020) · Microbiology and Immunology · doi:10.1111/1348-0421.12771 · Cited by 245

Targeting lysosomes in human disease: from basic research to clinical applications

Cao, M., Luo, X., Wu, K., & He, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00778-y · Cited by 225

An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission

Pfitzner, A.-K., Mercier, V., Jiang, X., von Filseck, J. M., Baum, B., Šarić, A., & Roux, A. (2020) · Cell · doi:10.1016/j.cell.2020.07.021 · Cited by 212

Extracellular vesicle analysis

Hendrix, A., Lippens, L., Pinheiro, C., Théry, C., Jaular, L. M., Lötvall, J. O., Lässer, C., Hill, A. F., & Witwer, K. W. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00240-z · Cited by 197

Autophagy and endocytosis – interconnections and interdependencies

Birgisdottir, Å. B., & Johansen, T. (2020) · Journal of Cell Science · doi:10.1242/jcs.228114 · Cited by 175

Autophagosome biogenesis comes out of the black box

Chang, C., Jensen, L. E., & Hurley, J. H. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00669-y · Cited by 178

Immune Cell-Derived Exosomes in the Cancer-Immunity Cycle

Yan, W., & Jiang, S. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.02.013 · Cited by 170

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

Wang, J., Fang, N., Xiong, J., Du, Y., Cao, Y., & Ji, W.-K. (2021) · Nature Communications · doi:10.1038/s41467-021-21525-5 · Cited by 157

A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes

Fordjour, F. K., Guo, C., Ai, Y., Daaboul, G. G., & Gould, S. J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102394 · Cited by 152

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Gentili, M., Liu, B., Papanastasiou, M., Dele-Oni, D. O., Schwartz, M. A., Carlson, R. J., Al’Khafaji, A. M., Krug, K., Brown, A., Doench, J. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36132-9 · Cited by 151

Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

Dang, X. T. T., Jayasinghe, M. K., Zhang, D. X., Pirisinu, M., & Le, M. T. N. (2020) · Cells · doi:10.3390/cells9102191 · Cited by 154

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

Coyne, A. N., Baskerville, V., Zaepfel, B. L., Dickson, D. W., Rigo, F., Bennett, F., Lusk, C. P., & Rothstein, J. D. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe1923 · Cited by 143

Extracellular vesicles and particles impact the systemic landscape of cancer

Lucotti, S., Kenific, C. M., Zhang, H., & Lyden, D. C. (2022) · The EMBO Journal · doi:10.15252/embj.2021109288 · Cited by 145

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

Vietri, M., Schultz, S. W., Bellanger, A., Jones, C. M., Petersen, L. I., Raiborg, C., Skarpen, E., Pedurupillay, C. R. J., Kjos, I., Kip, E., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0537-5 · Cited by 137

Lysosomes drive the piecemeal removal of mitochondrial inner membrane

Prashar, A., Bussi, C., Fearns, A., Capurro, M., Gao, X., Sesaki, H., Gutierrez, M. G., & Jones, N. L. (2024) · Nature · doi:10.1038/s41586-024-07835-w · Cited by 141

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Chen, Q.-T., Zhang, Z., Huang, Q., Chen, H., Hong, W., Lin, T., Zhao, W., Wang, X., Ju, C.-Y., Wu, L.-Z., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00642-5 · Cited by 141

Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

Niekamp, P., Scharte, F., Sokoya, T., Vittadello, L., Kim, Y., Deng, Y., Südhoff, E., Hilderink, A., Imlau, M., Clarke, C. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29481-4 · Cited by 131

Extracellular vesicles, RNA sequencing, and bioinformatic analyses: Challenges, solutions, and recommendations

Miceli, R. T., Chen, T.-Y., Nose, Y., Tichkule, S., Brown, B., Fullard, J. F., Saulsbury, M. D., Heyliger, S. O., Gnjatic, S., Kyprianou, N., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70005 · Cited by 132

Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies

Wu, Y., Li, J., Zeng, Y., Pu, W., Mu, X., Sun, K., Peng, Y., & Shen, B. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00187-z · Cited by 126

Sealing holes in cellular membranes

Zhen, Y., Radulovic, M., Vietri, M., & Stenmark, H. (2021) · The EMBO Journal · doi:10.15252/embj.2020106922 · Cited by 126

Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily

Liu, J., Tassinari, M., de Souza, D. P., Naskar, S., Noel, J. K., Bohuszewicz, O., Buck, M., Williams, T. A., Baum, B., & Low, H. H. (2021) · Cell · doi:10.1016/j.cell.2021.05.041 · Cited by 115

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

Derevnina, L., Contreras, M. P., Adachi, H., Upson, J., Cruces, A. V., Xie, R., Sklenář, J., Menke, F. L. H., Mugford, S. T., MacLean, D., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001136 · Cited by 119

Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation

Mercier, V., Larios, J., Molinard, G., Goujon, A., Matile, S., Grüenberg, J., & Roux, A. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0546-4 · Cited by 119

ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells

Matsui, T., Hiragi, S., Osaki, F., Sakamaki, Y., & Fukuda, M. (2021) · EMBO Reports · doi:10.15252/embr.202051475 · Cited by 113

Molecular Determinants of Flavivirus Virion Assembly

Barnard, T. R., Abram, Q. H., Lin, Q. F., Wang, A. B., & Sagan, S. M. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.12.007 · Cited by 107

Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

Liu, P., Zhang, Z., & Yao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.603416 · Cited by 112

Intratumoral heterogeneity and drug resistance in cancer

Fu, Y.-C., Liang, S.-B., Luo, M., & Wang, X. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03734-w · Cited by 129

Extracellular signals regulate the biogenesis of extracellular vesicles

Jin, Y., Ma, L., Zhang, W., Yang, W., Feng, Q., & Wang, H. (2022) · Biological Research · doi:10.1186/s40659-022-00405-2 · Cited by 121

Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology

Asleh, K., Dery, V., Taylor, C., Davey, M., Djeungoue‐Petga, M., & Ouellette, R. J. (2023) · Biomarker Research · doi:10.1186/s40364-023-00540-2 · Cited by 117

ESCRT-III-mediated membrane repair in cell death and tumor resistance

Liu, J., Kang, R., & Tang, D. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0200-0 · Cited by 109

Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury

Feng, J., Zhang, Y., Zhu, Z., Gu, C., Waqas, A., & Chen, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703989 · Cited by 107

Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis

Tran, H. L., Zheng, W., Issadore, D., Im, H., Cho, Y., Zhang, Y., Liu, D., Liu, Y., Li, B., Liu, F., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c00706 · Cited by 117

Archaeal extracellular vesicles are produced in an ESCRT-dependent manner and promote gene transfer and nutrient cycling in extreme environments

Liu, J., Cvirkaitė‐Krupovič, V., Commère, P., Yang, Y., Zhou, F., Forterre, P., Shen, Y., & Krupovìč, M. (2021) · The ISME Journal · doi:10.1038/s41396-021-00984-0 · Cited by 99

The role and applications of extracellular vesicles in osteoporosis

Fang, F., Yang, J., Wang, J., Li, T., Wang, E., Zhang, D., Liu, X., & Zhou, C. (2024) · Bone Research · doi:10.1038/s41413-023-00313-5 · Cited by 113

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape

Omo‐Lamai, S., Wang, Y., Patel, M. N., Milosavljevic, A., Zuschlag, D. W., Poddar, S., Wu, J., Wang, L., Dong, F., Espy, C. L., et al. (2025) · Nature Nanotechnology · doi:10.1038/s41565-025-01974-5 · Cited by 170

Biogenesis and Biological Functions of Extracellular Vesicles in Cellular and Organismal Communication With Microbes

Fang, Y., Wang, Z., Liu, X., & Tyler, B. M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.817844 · Cited by 100

A Comprehensive Review on the Applications of Exosomes and Liposomes in Regenerative Medicine and Tissue Engineering

Shafiei, M., Ansari, M. N. M., Razak, S. I. A., & Khan, M. U. A. (2021) · Polymers · doi:10.3390/polym13152529 · Cited by 100

Nanoparticle entry into cells; the cell biology weak link

Griffiths, G. W., Grüenberg, J., Marsh, M., Wohlmann, J., Jones, A. T., & Parton, R. G. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114403 · Cited by 101

Extracellular Vesicles and Viruses: Two Intertwined Entities

Moulin, C., Crupi, M. J. F., Ilkow, C. S., Bell, J. C., & Boulton, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021036 · Cited by 96

The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection

Ju, Y., Bai, H., Ren, L., & Zhang, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169060 · Cited by 93

Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation

Marie, P. P., Fan, S., Mason, J. D., Wells, A., Mendes, C. C., Wainwright, S. M., Scott, S., Fischer, R., Harris, A. L., WILSON, C. G., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12311 · Cited by 88

Lysosomal quality control: molecular mechanisms and therapeutic implications

Yang, H., & Tan, J. X. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.01.001 · Cited by 86

Termination of STING responses is mediated via ESCRT‐dependent degradation

Balka, K. R., Venkatraman, R., Saunders, T. L., Shoppee, A., Pang, E. S., Magill, Z., Homman‐Ludiye, J., Huang, C., Lane, R. M., York, H. M., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112712 · Cited by 92

Principles of membrane remodeling by dynamic ESCRT-III polymers

Pfitzner, A.-K., von Filseck, J. M., & Roux, A. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.04.005 · Cited by 86

HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors

Guan, L., Wu, B., Li, T., Beer, L. A., Sharma, G., Li, M., Lee, C. N., Liu, S., Yang, C., Huang, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31713-6 · Cited by 87

Lysosomal microautophagy: an emerging dimension in mammalian autophagy

Kuchitsu, Y., & Taguchi, T. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.11.005 · Cited by 93

The ESCRTs – converging on mechanism

Pavlin, M. R., & Hurley, J. H. (2020) · Journal of Cell Science · doi:10.1242/jcs.240333 · Cited by 87

Overcoming the blood-brain barrier: Exosomes as theranostic nanocarriers for precision neuroimaging

Li, C., Qin, S., Wen, Y., Zhao, W. G., Huang, Y., & Liu, J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.002 · Cited by 86

Recognising the signals for endosomal trafficking

Weeratunga, S., Paul, B., & Collins, B. M. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.02.005 · Cited by 83

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

Wang, X., Xu, P., Bentley‐DeSousa, A., Hancock-Cerutti, W. F., Cai, S., Johnson, B., Tonelli, F., Shao, L., Talaia, G., Alessi, D. R., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01653-6 · Cited by 85

Endocytosis blocks the vesicular secretion of exosome marker proteins

Ai, Y., Guo, C., García-Contreras, M., B., L. S. S., Saftics, A., Shodubi, O., Raghunandan, S., Xu, J., Tsai, S. J., Dong, Y. W., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi9156 · Cited by 84

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties

Jeppesen, D. K., Sanchez, Z., Kelley, N. M., Hayes, J. B., Ambroise, J., Koory, E., Krystofiak, E., Taneja, N., Zhang, Q., Dungan, M. M., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01621-0 · Cited by 88

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Gupta, S., Yano, J., Mercier, V., Htwe, H. H., Shin, H. R., Rademaker, G., Cakir, Z., Ituarte, T., Wen, K. W., Kim, G., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00644-7 · Cited by 79

Biomimetic Exosomes: A New Generation of Drug Delivery System

Wang, X., Zhao, X., Zhong, Y., Shen, J., & An, W. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.865682 · Cited by 79

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes

Rose, K. M., Jepson, T. A., Shukla, S., Maya-Romero, A., Kampmann, M., Xu, K., & Hurley, J. H. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315690121 · Cited by 81

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

Hunt, L. C., Schadeberg, B., Stover, J., Haugen, B., Pagala, V., Wang, Y., Puglise, J. M., Barton, E. R., Peng, J., & Demontis, F. (2021) · Nature Communications · doi:10.1038/s41467-021-21738-8 · Cited by 78

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Tan, S., Yang, Y., Yang, W., Han, Y., Huang, L., Yang, R., Hu, Z., Tao, Y., Liu, L., Li, Y., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02634-z · Cited by 85

Native and Bioengineered Exosomes for Ischemic Stroke Therapy

Khan, H. L., Pan, J., Li, Y.-F., Zhang, Z., & Yang, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.619565 · Cited by 79

Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

Chutipongtanate, S., Morrow, A. L., & Newburg, D. S. (2022) · Cells · doi:10.3390/cells11152345 · Cited by 77

Built to last: lysosome remodeling and repair in health and disease

Zoncu, R., & Perera, R. M. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.12.009 · Cited by 75

The Endo-Lysosomal Damage Response

Meyer, H. H., & Kravić, B. (2024) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030222-102505 · Cited by 79

Microglia as hunters or gatherers of brain synapses

Pereira‐Iglesias, M., Maldonado-Teixidó, J., Melero, A., Piriz, J., Galea, E., Ransohoff, R. M., & Sierra, A. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01818-w · Cited by 83

The Therapeutic Potential of Exosomes in Soft Tissue Repair and Regeneration

Wan, R., Hussain, A., Behfar, A., Moran, S. L., & Zhao, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073869 · Cited by 74

The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Olmos, Y. (2022) · Membranes · doi:10.3390/membranes12060633 · Cited by 74

Exosome and virus infection

Peng, Y., Yang, Y., Li, Y., Shi, T., Luan, Y., & Yin, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154217 · Cited by 76

From Exosome Biogenesis to Absorption: Key Takeaways for Cancer Research

Lau, N. C. H., & Yam, J. W. P. (2023) · Cancers · doi:10.3390/cancers15071992 · Cited by 81

Role of Extracellular Vesicles in Autoimmune Pathogenesis

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De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment

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