The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.
Immunology of the ageing kidney
Abstract
Immunosenescence involves a series of ageing-induced alterations in the immune system and is characterized by two opposing hallmarks: defective immune responses and increased systemic inflammation. The immune system is modulated by intrinsic and extrinsic factors and undergoes profound changes in response to the ageing process. Immune responses are therefore highly age-dependent. Emerging data show that immunosenescence underlies common mechanisms responsible for several age-related diseases and is a plastic state that can be modified and accelerated by non-heritable environmental factors and pharmacological intervention. In the kidney, resident macrophages and fibroblasts are continuously exposed to components of the external environment, and the effects of cellular reprogramming induced by local immune responses, which accumulate with age, might have a role in the increased susceptibility to kidney disease among elderly individuals. Additionally, because chronic kidney disease, especially end-stage renal disease, is often accompanied by immunosenescence, which affects these patients independently of age, and many kidney diseases are strongly age-associated, treatment approaches that target immunosenescence might be particularly clinically relevant.
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In the citing paper
“Moreover, older individuals become more susceptible to acute kidney injury (AKI) and chronic kidney disease (CKD).123,147”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [123]
In the citing paper
“Elderly individuals exhibit immunological phenotypes characterized by reduced numbers of naive lymphocytes, increased pro-inflammatory T cells, and diminished phagocytic activity in monocyte lineage cells, similar to CKD patients.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [123]
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Cited by
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Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
“Moreover, older individuals become more susceptible to acute kidney injury (AKI) and chronic kidney disease (CKD).(123,147) Age-related alterations in multiple cell types, such as tubular epithelial cells, resident and circulating leukocytes, contribute to kidney injury.”
BackgroundCellular senescence: the good, the bad and the unknown
Huang, W., Hickson, L. J., Eirin, A., Kirkland, J. L., & Lerman, L. O. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00601-z · Cited by 1,150
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238
Metadata
- Authors
- Sato, Y., & Yanagita, M.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Sato, Yuki
- Yanagita, Motoko
- Venue
- Nature Reviews Nephrology
- Published
- 2019-09-02
- Volume
- 15
- Issue
- 10
- Pages
- 625-640
- ISSN
- 1745-8323 (ISSN-L)
- 1759-5061
- 1759-507X
- OpenAlex
- W2970022555
- Cited by
- 126
- References
- 242
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 13 · 2023: 17 · 2022: 29 · 2021: 20 · 2020: 15 · 2019: 1
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (17H04187, 19K22620, 18H04673)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- immunosenescence, inflammaging, kidney aging, chronic kidney disease, end-stage renal disease, renal macrophages, renal fibroblasts, age-related immune dysfunction, systemic inflammation, cellular reprogramming, age-related diseases
- MeSH terms
- Immunosenescence, Aging, Animals, Humans, Kidney
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