The DOI matches its Crossref record; 253 of the 253 references it cites were found in a registry or an index.
Mechanisms of cognitive dysfunction in CKD
Open accessAbstract
Cognitive impairment is an increasingly recognized major cause of chronic disability and is commonly found in patients with chronic kidney disease (CKD). Knowledge of the relationship between kidney dysfunction and impaired cognition may improve our understanding of other forms of cognitive dysfunction. Patients with CKD are at an increased risk (compared with the general population) of both dementia and its prodrome, mild cognitive impairment (MCI), which are characterized by deficits in executive functions, memory and attention. Brain imaging in patients with CKD has revealed damage to white matter in the prefrontal cortex and, in animal models, in the subcortical monoaminergic and cholinergic systems, accompanied by widespread macrovascular and microvascular damage. Unfortunately, current interventions that target cardiovascular risk factors (such as anti-hypertensive drugs, anti-platelet agents and statins) seem to have little or no effect on CKD-associated MCI, suggesting that the accumulation of uraemic neurotoxins may be more important than disturbed haemodynamic factors or lipid metabolism in MCI pathogenesis. Experimental models show that the brain monoaminergic system is susceptible to uraemic neurotoxins and that this system is responsible for the altered sleep pattern commonly observed in patients with CKD. Neural progenitor cells and the glymphatic system, which are important in Alzheimer disease pathogenesis, may also be involved in CKD-associated MCI. More detailed study of CKD-associated MCI is needed to fully understand its clinical relevance, underlying pathophysiology, possible means of early diagnosis and prevention, and whether there may be novel approaches and potential therapies with wider application to this and other forms of cognitive decline.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, renal insufficiency also leads to increased levels of circulating uraemic neurotoxins such as parathyroid hormone and neuropeptide Y, which adversely affect hippocampal neuronal apoptosis and the permeability of the BBB, respectively.257”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [257]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–253 of 253
l-Carnitine improves cognitive and renal functions in a rat model of chronic kidney disease
Ahmad, N. A., Armaly, Z., Berman, S., Jabour, A., Aga‐Mizrachi, S., Mosenego-Ornan, E., & Avital, A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.036 · Cited by 30
Badran, M., Golbidi, S., Ayas, N., & Laher, I. (2015) · Sleep Disorders · doi:10.1155/2015/387801 · Cited by 27
SHARMA, A. K., Yabes, J. G., Mawed, S. A., Wu, C. M., Stilley, C. S., Unruh, M. L., & Jhamb, M. (2016) · American Journal of Nephrology · doi:10.1159/000451059 · Cited by 27
Vinothkumar, G., Krishnakumar, S., Sureshkumar, Shivashekar, G., Sreedhar, S., Preethikrishnan, Dinesh, S., Sundaram, A., Balakrishnan, D., Riya, R., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.028 · Cited by 27
Ekblad, L. L., Toppala, S., Johansson, J. K., Koskinen, S. V. P., Sundvall, J., Rinne, J. O., Puukka, P. J., Viitanen, M. H., & Jula, A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170972 · Cited by 27
Moura, A., Madureira, J., Alija, P., Fernandes, J. C., Oliveira, J. G., Lopez, M., Filgueiras, M., Amado, L., Faria, M., Miranda, V. M. P., et al. (2013) · The Journal of Vascular Access · doi:10.5301/jva.5000182 · Cited by 26
Retinal capillary and arteriolar changes in patients with chronic kidney disease
Bosch, A., Scheppach, J. B., Harazny, J. M., Raff, U., Eckardt, K., Schmieder, R. E., & Schneider, M. P. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.03.008 · Cited by 26
Sil, S., Ghosh, R., Sanyal, M., Guha, D., & Ghosh, T. (2015) · Journal of Immunotoxicology · doi:10.3109/1547691x.2015.1030804 · Cited by 25
Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
van Gennip, A. C. E., Broers, N. J. H., ter Meulen, K. J., Canaud, B., Christiaans, M. H. L., Cornelis, T., Gelens, M. A. C. J., Hermans, M. M. H., Konings, C. J. A. M., van der Net, J. B., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222547 · Cited by 25
Indole-3-acetic acid induces microencephaly in mouse fetuses
Furukawa, S., Usuda, K., Abe, M., Hayashi, S., & Ogawa, I. (2007) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2006.12.001 · Cited by 24
Lin, Y., Wu, P., Kuo, M., Chen, C., Chiu, Y., Yang, Y., Lin, M., Hwang, S., & Chen, H. (2015) · Scientific Reports · doi:10.1038/srep08224 · Cited by 24
Gordon-Dseagu, V., Derkach, A., Xiao, Q., Williams, I., Sampson, J. N., & Stolzenberg‐Solomon, R. Z. (2019) · Metabolomics · doi:10.1007/s11306-019-1472-y · Cited by 24
Huang, S., Lin, C.-L., Yu, T., Kao, C., Liang, W., & Chou, T. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15112377 · Cited by 24
Körver, S., Geurtsen, G. J., Hollak, C. E. M., van Schaik, I. N., Longo, M. G. F., Lima, M. R., Vedolin, L., Dijkgraaf, M. G. W., & Langeveld, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37320-0 · Cited by 23
Luce, M., Bouchara, A., Pastural, M., Granjon, S., Szelag, J. C., Laville, M., Arkouche, W., Fouque, D. P., Soulage, C. O., & Koppe, L. (2018) · Toxins · doi:10.3390/toxins10050205 · Cited by 22
Siddiqui, M. R., Attar, F., Mohanty, V., Kim, K. S., Mayanil, C. S. K., & Tomita, T. (2018) · Child s Nervous System · doi:10.1007/s00381-018-3865-z · Cited by 22
Vinothkumar, G., Krishnakumar, S., Riya, R., & Venkataraman, P. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.08.073 · Cited by 22
Brain Activation in Uremic Anorexia
Aguilera, A. I., Sánchez-Tomero, J. A., & Selgas, R. (2007) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2006.10.020 · Cited by 21
Palkovits, M., Šebeková, K., Klenovics, K. S., Kebis, A., Fazeli, G., Bahner, U., & Heidland, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066543 · Cited by 21
Recent Advances in Understanding the Pathogenesis of Atherosclerosis in CKD Patients
Shah, S. V., Shukla, A. M., Bose, C., Basnakian, A. G., & Rajapurkar, M. M. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2014.10.024 · Cited by 19
Pabbidi, M. R., Juncos, J., Juncos, L. A., Renić, M., Tullos, H. J., LAZAR, J., Jacob, H. J., Harder, D. R., & Roman, R. J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00622.2012 · Cited by 19
Obayashi, K., Saeki, K., Maegawa, T., Sakai, T., Kitagawa, M., Otaki, N., Kataoka, H., & Kurumatani, N. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2773 · Cited by 19
Lizio, R., Babiloni, C., Percio, C. D., Losurdo, A., Vernò, L., de Tommaso, M., Montemurno, A., Dalfino, G., Cirillo, P., Soricelli, A., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180245 · Cited by 19
Menon, R. N., Radhakrishnan, A., Sreedharan, S. E., Sarma, P. S., Kumari, R. S., Kesavadas, C., Sasi, D., Lekha, V., Justus, S., & Unnikrishnan, J. P. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.06.014 · Cited by 19
Acute Kidney Injury Is Associated With an Increased Risk of Dementia
Kendrick, J., Holmen, J. R., Srinivas, T. R., You, Z., Chonchol, M., & Jovanovich, A. J. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2019.07.012 · Cited by 19
Relevance of brain lesion location for cognition in vascular mild cognitive impairment
Giorgio, A., Donato, I. D., Leucio, A. D., Zhang, J., Salvadori, E., Poggesi, A., Diciotti, S., Cosottini, M., Ciulli, S., Inzitari, D., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101789 · Cited by 18
Liu, A. J., Staffaroni, A. M., Rojas-Martinez, J. C., Olney, N. T., Alquezar-Burillo, C., Ljubenkov, P. A., La Joie, R., Fong, J. C., Taylor, J., Karydas, A., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.4284 · Cited by 18
Hobson, P., Lewis, A., Nair, H., Wong, S. P. Y., & Kumwenda, M. J. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-023520 · Cited by 17
Bird, M., Haber, N. E., Batchelor, F., Hill, K., & Wark, J. D. (2017) · Gait & Posture · doi:10.1016/j.gaitpost.2017.09.036 · Cited by 16
Serum Uric Acid is Independently Associated with Enlarged Perivascular Spaces
Yang, S., Zhang, X., Yuan, J., Yin, J., & Hu, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-16715-5 · Cited by 16
Weng, S., Shu, K., Tang, Y.-J., Sheu, W. H., Tarng, D., Wu, M.-J., Chen, Y., & Chuang, Y. (2012) · Internal Medicine · doi:10.2169/internalmedicine.51.5975 · Cited by 14
Kim, J. W., Ha, G. Y., & Jung, Y. W. (2014) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2014.07.003 · Cited by 14
Voice in Chronic Renal Failure
Balasubramanium, R. K., & Bhat, J. S. (2009) · Journal of Voice · doi:10.1016/j.jvoice.2009.03.001 · Cited by 14
Neuropeptide Y predicts cardiovascular events in chronic kidney disease patients
Zoccali, C., D’Arrigo, G., Leonardis, D., Pizzini, P., Postorino, M., Tripepi, G. L., & Mallamaci, F. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002030 · Cited by 14
Self-citationDonepezil Treatment for Alzheimer’s Disease in Chronic Dialysis Patients
Yiannopoulou, K. G., Anastasiou, A., Kyrozis, A., & Anastasiou, I. P. (2019) · Case Reports in Nephrology and Dialysis · doi:10.1159/000502682 · Cited by 13
Leptin-dependent neurotoxicity via induction of apoptosis in adult rat neurogenic cells
Segura, S., Efthimiadi, L., Porcher, C., Courtes, S., Coronas, V., Krantic, S. M., & Moyse, E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00350 · Cited by 12
Bründl, E., Proescholdt, M. A., Schödel, P., Bele, S., Höhne, J., Zeman, F., Stoerr, E.-M., Brawanski, A. T., & Schebesch, K.-M. (2018) · Neurological Research · doi:10.1080/01616412.2018.1508547 · Cited by 12
The influence of immunosuppressive drugs on neural stem/progenitor cell fate in vitro
Skardelly, M., Glien, A., Groba, C., Schlichting, N. S., Kamprad, M., Meixensberger, J., & Milošević, J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.08.025 · Cited by 11
The nature of impairments of memory in patients with end-stage renal disease (ESRD)
Jones, D. J. W., Harris, J. P., Vaux, E. C., Hadid, R., Kean, R., & Butler, L. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.008 · Cited by 10
Brain hemodynamics in patients with end-stage renal disease between hemodialysis sessions.
Farhoudi, M., Azar, S. A., & Abdi, R. (2012) · Iranian Journal of Kidney Diseases · Cited by 10
Information content of dendritic spines after motor learning
Viggiano, D., Speranza, L., Crispino, M., Bellenchi, G. C., di Porzio, U., Iemolo, A., Leonibus, E. D., Volpicelli, F., & Perrone‐Capano, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.020 · Cited by 10
Self-citationEffects of zolpidem/triazolam on cognitive performance 12 hours after acute administration
Matsunaga, Y., Tagaya, H., Fukase, Y., Hakamata, Y., Murayama, N., Kumagai, Y., & Kuroyama, M. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.06.011 · Cited by 10
Obstructive sleep apnea and hypertension in pediatric chronic kidney disease
Tsampalieros, A. K., Blinder, H., Hoey, L., Momoli, F., Barrowman, N. J., Feber, J., Spitale, N., & Katz, S. L. (2019) · Pediatric Nephrology · doi:10.1007/s00467-019-04295-7 · Cited by 10
Castillejos, N. A., Jiménez-González, A., & Hinojosa‐Azaola, A. (2019) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617719000262 · Cited by 9
Owolabi, L. F., Abdu, A., Aliyu, I., Owolabi, D. S., Nalado, A. M., Bappa, A., & Taura, A. A. (2016) · Journal of Neurosciences in Rural Practice · doi:10.4103/0976-3147.196433 · Cited by 8
Sanctis, C. D., Bellenchi, G. C., & Viggiano, D. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.01.036 · Cited by 8
Self-citationQuantifying barcodes of dendritic spines using entropy-based metrics
Viggiano, D., Srivastava, D. P., Speranza, L., Perrone‐Capano, C., Bellenchi, G. C., di Porzio, U., & Buckley, N. J. (2015) · Scientific Reports · doi:10.1038/srep14622 · Cited by 7
Self-citationNoguchi, Y., Nagasawa, H., Tachi, T., Tsuchiya, T., & Teramachi, H. (2019) · Die Pharmazie · doi:10.31083/ph.2019.9426 · Cited by 7
Ekblad, L. L., Toppala, S., Johansson, J. K., Koskinen, S. V. P., Sundvall, J., Rinne, J. O., Puukka, P. J., Viitanen, M. H., & Jula, A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-189008 · Cited by 6
Yang, N., Xu, L., Lin, P., & Cui, J. (2012) · PubMed Central · doi:10.3969/j.issn.1673-5374.2012.10.006 · Cited by 5
Cognitive decline reversed by cinacalcet
Wallace, H. J., Wallace, I. R., & McCaffrey, P. (2012) · QJM · doi:10.1093/qjmed/hcs081 · Cited by 4
[Transrectal longitudinal scanning in the diagnosis of diseases of the prostate gland].
Tsyb, A. F., Vs, P., & Tv, S. (1987) · PubMed · Cited by 3
The role of dialysis in the pathogenesis and treatment of dementia
Kelly, D. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy359 · Cited by 3
Cited by
Sorted by citations
Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 642
Self-citationHypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544
Klotho, Aging, and the Failing Kidney
Buchanan, S. J., Combet, E., Stenvinkel, P., & Shiels, P. G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00560 · Cited by 250
Romagnani, P., Agarwal, R., Chan, J. C. N., Levin, A., Kalyesubula, R., Karam, S., Nangaku, M., Rodríguez‐Iturbe, B., & Anders, H. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00589-9 · Cited by 237
Cerebral dysfunctions caused by sepsis during ageing
Manabe, T., & Heneka, M. T. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00643-7 · Cited by 191
Metadata
- Authors
- Viggiano, D., Wagner, C. A., Martino, G., Nedergaard, M., Zoccali, C., Unwin, R., & Capasso, G.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- University of Zurich (CH)
- Vita-Salute San Raffaele University (IT)
- University of Rochester Medicine (US)
- National Research Council (IT)
- AstraZeneca (United Kingdom) (GB)
- Corresponding author
- Capasso, Giovambattista
- ORCID
- Venue
- Nature Reviews Nephrology
- Published
- 2020-03-31
- Volume
- 16
- Issue
- 8
- Pages
- 452-469
- ISSN
- 1745-8323 (ISSN-L)
- 1759-5061
- 1759-507X
- OpenAlex
- W3015186969
- Cited by
- 392
- References
- 253
- Citations by year
- 2026: 60 · 2025: 106 · 2024: 63 · 2023: 56 · 2022: 56 · 2021: 40 · 2020: 10
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Reviews Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Lundbeckfonden (R155-2016–552)
- Novo Nordisk Fonden (NNF13OC0004258)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- chronic kidney disease, cognitive impairment, mild cognitive impairment, dementia, monoaminergic systems, cholinergic system, white matter injury, prefrontal cortex, sleep disorders, glymphatic system, neural progenitor cells, microvascular damage, executive function, attention and memory
- MeSH terms
- Glymphatic System, Animals, Cerebrovascular Circulation, Cerebrovascular Disorders, Hemodynamics, Humans, Risk Factors, Sleep Wake Disorders, Uremia, Renal Replacement Therapy, Genetic Predisposition to Disease, Lipid Metabolism, Renal Insufficiency, Chronic, Leukoencephalopathies, Neural Stem Cells, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
