Nedergaard, Maiken

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 5,824

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science

Sleep and Wakefulness ResearchCerebrospinal fluid and hydrocephalus

Cited by 5,411

The glymphatic system: a beginner's guide

Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research

Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances

Cited by 2,075

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,678

The glymphatic pathway in neurological disorders.

Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2018) · The Lancet Neurology

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 1,560

Impairment of paravascular clearance pathways in the aging brain

Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 1,521

Uniquely Hominid Features of Adult Human Astrocytes

Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,488

New roles for astrocytes: redefining the functional architecture of the brain.

Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,334

Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain

Iliff, J. J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., Deane, R., & Nedergaard, M. (2013) · The Journal of Neuroscience

Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,319

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

Iliff, J. J., Chen, M. J., Plog, B. A., Zeppenfeld, D. M., Soltero, M., Yang, L., Singh, I., Deane, R., & Nedergaard, M. (2014) · The Journal of Neuroscience

Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,159

Glial regulation of the cerebral microvasculature

Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience

Barrier Structure and Function StudiesNeuroscience and Neuropharmacology Research

Cited by 1,153

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

Iliff, J. J., Lee, H., Yu, M., Feng, T., Logan, J., Nedergaard, M., & Benveniste, H. (2013) · Journal of Clinical Investigation

Cerebrospinal fluid and hydrocephalusAdvanced MRI Techniques and Applications

Cited by 1,148

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A. M., Olveda, G., Thomas, J. H., Nedergaard, M., & Kelley, D. H. (2018) · Nature Communications

Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,110

Perivascular spaces in the brain: anatomy, physiology and pathology

Wardlaw, J. M., Benveniste, H., Nedergaard, M., Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., et al. (2020) · Nature Reviews Neurology

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 870

An astrocytic basis of epilepsy

Tian, G.-F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H. R., et al. (2005) · Nature Medicine

Epilepsy research and treatmentNeuroscience and Neuropharmacology Research

Cited by 806

Astrocytic complexity distinguishes the human brain

Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 739

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 738

Garbage Truck of the Brain

Nedergaard, M. (2013) · Science

Cerebrospinal fluid and hydrocephalusNeuroinflammation and Neurodegeneration Mechanisms

Cited by 718

Vascular dysfunction—The disregarded partner of Alzheimer's disease

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., et al. (2019) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 711

Circadian control of brain glymphatic and lymphatic fluid flow

Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 704

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

Wang, X., Lou, N., Xu, Q., Tian, G.-F., Peng, W. G., Han, X., Kang, J., Takano, T., & Nedergaard, M. (2006) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 685

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, M., & Kipnis, J. (2017) · Journal of Clinical Investigation

Cerebrospinal fluid and hydrocephalusLymphatic System and Diseases

Cited by 640

Heterogeneity of astrocytic form and function.

Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 638

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N. A., Bekar, L., Betstadt, S., et al. (2013) · Cell Stem Cell

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 635