The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
Open accessAbstract
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD) is arguably the clearest instance of crosstalk between neurodegenerative and cerebrovascular processes. The pathogenic pathways of CAA and AD intersect at the levels of Aβ generation, its circulation within the interstitial fluid and perivascular drainage pathways and its brain clearance, but diverge in their mechanisms of brain injury and disease presentation. Here, we review the evidence for and the pathogenic implications of interactions between CAA and AD. Both pathologies seem to be driven by impaired Aβ clearance, creating conditions for a self-reinforcing cycle of increased vascular Aβ, reduced perivascular clearance and further CAA and AD progression. Despite the close relationship between vascular and plaque Aβ deposition, several factors favour one or the other, such as the carboxy-terminal site of the peptide and specific co-deposited proteins. Amyloid-related imaging abnormalities that have been seen in trials of anti-Aβ immunotherapy are another probable intersection between CAA and AD, representing overload of perivascular clearance pathways and the effects of removing Aβ from CAA-positive vessels. The intersections between CAA and AD point to a crucial role for improving vascular function in the treatment of both diseases and indicate the next steps necessary for identifying therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, brains from COVID patients also show ischemic and hemorrhagic lesions, as well as microglial activation [79], which can be seen in many AD patients with cerebral amyloid angiopathy [80].”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [80]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Recently, vascular deposits of Aβ peptides (amyloid angiopathy) are increasingly recognized as a common pathology in AD cases, supporting that Aβ peptides circulate within the interstitial fluid, including CSF, and blood vessels through perivascular (e.g. lymphatic) drainage pathways during the crosstalk between the brain and the vascular system [77].”
From Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease (2020) · cites this paper as [77]
The cited source says what the claim attributes to it.
In the citing paper
“Recently, vascular deposits of Aβ peptides (amyloid angiopathy) are increasingly recognized as a common pathology in AD cases, supporting that Aβ peptides circulate within the interstitial fluid, including CSF, and blood vessels through perivascular (e.g. lymphatic) drainage pathways during the crosstalk between the brain and the vascular system [77].”
From Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease (2020) · cites this paper as [77]
The cited source says what the claim attributes to it.
In the citing paper
“Inflammation does, however, not seem to be a major component in CAA-related microhemorrhage or microinfarction [38], with the exception of a rare clinical subtype: CAA-related inflammation [6].”
From Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy (2021) · cites this paper as [6]
In the citing paper
“AQP4 levels are reduced in CAA; since AQP4 plays a vital role in glymphatic Aβ clearance in AD brain parenchyma, this consequently impairs Aβ clearance [606, 608].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [608]
In the citing paper
“AQP4 levels are reduced in CAA; since AQP4 plays a vital role in glymphatic Aβ clearance in AD brain parenchyma, this consequently impairs Aβ clearance [606, 608].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [608]
In the citing paper
“Chronic inflammation‐induced disruption of the BBB is an early biomarker of human cognitive dysfunction and often leads to dementia, 113 and both Aβ deposits and tau pathology aggravate vascular damage. 114 , 115”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [115]
In the citing paper
“There is overwhelming evidence for cerebrovascular alterations in AD pathology and amyloid-β deposition around leptomeningeal vessels is a hall mark of cerebral amyloid angiopathy, occurring in almost all AD patients”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Greenberg et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Sevigny, J., Chiao, P., Bussière, T., Weinreb, P. H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016) · Nature · doi:10.1038/nature19323 · Cited by 3,059
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078
Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022
The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960
Self-citation
Cited by
Sorted by citations
Items 101–200 of 954
Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Narasimhan, S., Holtzman, D. M., Apostolova, L. G., Cruchaga, C., Masters, C. L., Hardy, J., Villemagne, V. L., Bell, J. S., Cho, M., & Hampel, H. J. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01669-5 · Cited by 70
Yang, H. S., Onos, K. D., Choi, K., Keezer, K. J., Skelly, D. A., Carter, G. W., & Howell, G. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108739 · Cited by 69
Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
Bello-Corral, L., Gomes, L., Fernández-Fernández, J. A., Fernández-García, D., Verdejo, I. C., & Sánchez-Valdeón, L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122132 · Cited by 73
Giorgi, F. S., Galgani, A., Puglisi‐Allegra, S., Limanaqi, F., Busceti, C. L., & Fornai, F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24718 · Cited by 69
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Pizzo, M. E., Plowey, E. D., Khoury, N., Kwan, W., Abettan, J., DeVos, S. L., Discenza, C. B., Earr, T., Joy, D., Lye-Barthel, M., et al. (2025) · Science · doi:10.1126/science.ads3204 · Cited by 63
van Veluw, S. J., Arfanakis, K., & Schneider, J. A. (2022) · Stroke · doi:10.1161/strokeaha.121.032608 · Cited by 68
Role of Neuron and Glia in Alzheimer’s Disease and Associated Vascular Dysfunction
Bandyopadhyay, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.653334 · Cited by 64
Alkhalifa, A. E., Mokhlf, A. A., Ali, H., Al-Ghraiybah, N. F., & Syropoulou, V. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15090437 · Cited by 68
Cerebral Amyloid Angiopathy and Blood-Brain Barrier Dysfunction
Gireud, M., Mack, A. F., McCullough, L. D., & Urayama, A. (2020) · The Neuroscientist · doi:10.1177/1073858420954811 · Cited by 66
Cerebral Small Vessel Disease and Depression Among Intracerebral Hemorrhage Survivors
Castello, J. P., Pasi, M., Kubiszewski, P., Abramson, J. R., Charidimou, A., Kourkoulis, C., DiPucchio, Z., Schwab, K. M., Anderson, C. D., Gurol, M. E., et al. (2021) · Stroke · doi:10.1161/strokeaha.121.035488 · Cited by 61
Self-citationBlood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
Peng, B., Hao, S., Tong, Z., Bai, H., Pan, S., Lim, K., Li, L., Voelcker, N. H., & Huang, W. (2022) · Lab on a Chip · doi:10.1039/d2lc00305h · Cited by 61
Key questions for the evaluation of anti-amyloid immunotherapies for Alzheimer’s disease
Liu, K. Y., Villain, N., Ayton, S., Ackley, S. F., Planche, V., Howard, R. J., & Thambisetty, M. (2023) · Brain Communications · doi:10.1093/braincomms/fcad175 · Cited by 60
Salloway, S., Wojtowicz, J., Voyle, N., Lane, C., Klein, G., Lyons, M., Rossomanno, S., Mazzo, F., Bullain, S., Barkhof, F., et al. (2024) · JAMA Neurology · doi:10.1001/jamaneurol.2024.3937 · Cited by 62
Yang, Y., Murzin, A. G., Peak‐Chew, S., Franco, C., Garringer, H. J., Newell, K. L., Ghetti, B. F., Goedert, M., & Scheres, S. H. W. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01694-8 · Cited by 60
Söderberg, L., Johannesson, M., Gkanatsiou, E., Nygren, P., Fritz, N., Zachrisson, O., Rachalski, A., Svensson, A.-S., Button, E. B., Dentoni, G., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-61691-2 · Cited by 62
Dickerson, B. C., Atri, A., Clevenger, C. K., Karlawish, J. H., Knopman, D. S., Lin, P., Norman, M., Onyike, C. U., Sano, M., Scanland, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14337 · Cited by 62
Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab
Sveikata, L., Charidimou, A., & Viswanathan, A. (2021) · Stroke · doi:10.1161/strokeaha.121.036873 · Cited by 61
Ehtiati, S., Alizadeh, M., Farhadi, F., Khalatbari, K., Ajiboye, B. O., Rahimi, V. B., & Askari, V. R. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105637 · Cited by 58
Neuroimaging in Dementia: More than Typical Alzheimer Disease
Haller, S., Jäger, H. R., Vernooij, M. W., & Barkhof, F. (2023) · Radiology · doi:10.1148/radiol.230173 · Cited by 58
The glymphatic system and cerebral small vessel disease
Ang, P. S., Zhang, D. M., Azizi, S., de Matos, S. N., & Brorson, J. R. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107557 · Cited by 58
Notch signaling in cancer: Complexity and challenges on the path to clinical translation
Ferreira, A. P. A., & Aster, J. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.008 · Cited by 56
Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease
Kalaria, R. N., & Falla, D. S. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.07.004 · Cited by 56
tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β
Park, L., Zhou, J., Koizumi, K., Wang, G., Anfray, A., Ahn, S. J., Seo, J., Zhou, P., Zhao, L., Paul, S. M., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1140-20.2020 · Cited by 59
Yamada, K., & Iwatsubo, T. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05225-z · Cited by 62
Tian, M., Zuo, C., Civelek, A. C., Carrió, I., Watanabe, Y., Kang, K. W., Murakami, K., Garibotto, V., Prior, J. O., Barthel, H., et al. (2022) · Phenomics · doi:10.1007/s43657-022-00068-9 · Cited by 52
Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity
Seifar, F., Fox, E. J., Shantaraman, A., Liu, Y., Dammer, E. B., Modeste, E., Duong, D. M., Yin, L., Trautwig, A. N., Guo, Q., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.14360 · Cited by 52
Hereditary Cerebral Small Vessel Diseases and Stroke: A Guide for Diagnosis and Management
Guey, S., Oberstein, S. A. J. L., Tournier‐Lasserve, E., & Chabriat, H. (2021) · Stroke · doi:10.1161/strokeaha.121.032620 · Cited by 52
Mehla, J., Singh, I., Diwan, D., Nelson, J. W., Lawrence, M., Lee, E., Bauer, A. Q., Holtzman, D. M., & Zipfel, G. J. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01293-5 · Cited by 52
Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients
Zhao, J., Rostgaard, K., Lauwers, E., Dahlén, T., Ostrowski, S. R., Erikstrup, C., Pedersen, O. B., Strooper, B. D., Lemmens, R., Hjalgrim, H., et al. (2023) · JAMA · doi:10.1001/jama.2023.14445 · Cited by 51
Huang, P., Zhang, L., Tan, Y., & Chen, S. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00337-1 · Cited by 54
Chimeric antigen receptor macrophages target and resorb amyloid plaques
Kim, A. B., Xiao, Q., Yan, P., Pan, Q., Pandey, G., Grathwohl, S., Gonzales, E. R., Xu, I., Cho, Y., Haecker, H., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.175015 · Cited by 50
van Veluw, S. J., Benveniste, H., Bakker, E. N. T. P., Carare, R. O., Greenberg, S. M., Iliff, J. J., Lorthois, S., Nostrand, W. E. V., Petzold, G. C., Shih, A. Y., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05277-1 · Cited by 50
Self-citationde Kort, A. M., Kuiperij, H. B., Marques, T. M., Jäkel, L., van den Berg, E., Kersten, I., van Berckel‐Smit, H. E. P., Duering, M., Stoops, E., Abdo, W. F., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26610 · Cited by 49
Self-citationTipping points in neurodegeneration
Simons, M., Levin, J., & Dichgans, M. (2023) · Neuron · doi:10.1016/j.neuron.2023.05.031 · Cited by 52
Ullah, R., & Lee, E. J. (2023) · Experimental Neurobiology · doi:10.5607/en23014 · Cited by 51
Astrocytes in selective vulnerability to neurodegenerative disease
Zimmer, T. S., Orr, A. L., & Orr, A. G. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.02.008 · Cited by 57
Menze, I., Bernal, J., Kaya, P., Akı, Ç., Pfister, M., Geisendörfer, J., Yakupov, R., Coello, R. D., Hernández, M. V., Heneka, M. T., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01603-8 · Cited by 50
The Role of Basement Membranes in Cerebral Amyloid Angiopathy
Howe, M. D., McCullough, L. D., & Urayama, A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.601320 · Cited by 50
Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review
Biffi, E. Z., Turple, Z., Chung, J., & Biffi, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266974 · Cited by 48
Moda, F., Ciullini, A., Dellarole, I. L., Lombardo, A., Campanella, N., Bufano, G., Cazzaniga, F. A., & Giaccone, G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2810255 · Cited by 49
Liang, S., Liu, H., Wang, X., Lin, H., Zheng, L., Zhang, Y., Peng, L., Huang, S., & Chen, L. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111263 · Cited by 50
Hao, Y., Guo, M., Feng, Y., Dong, Q., & Cui, M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00058 · Cited by 51
Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench
Wang, H., Zhang, C., Qiu, Y., Chen, A., Li, Y., & Hu, B. (2021) · Aging and Disease · doi:10.14336/ad.2021.0514 · Cited by 47
The Neuroprotective and Neurodegeneration Effects of Heme Oxygenase-1 in Alzheimer’s Disease
Si, Z., & Wang, X. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200720 · Cited by 46
Zellner, A., Müller, S. A., Lindner, B., Beaufort, N., Rozemüller, A. J. M., Arzberger, T., Gassen, N. C., Lichtenthaler, S. F., Küster, B., Haffner, C., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01303-6 · Cited by 47
Neuropathology of the Alzheimer's continuum: an update
Jellinger, K. A. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3050 · Cited by 52
Early life predictors of late life cerebral small vessel disease in four prospective cohort studies
Backhouse, E. V., Shenkin, S. D., McIntosh, A. M., Bastin, M. E., Whalley, H. C., Hernandez, M. V., Maniega, S. M., Harris, M. A., Stolicyn, A., Campbell, A. I., et al. (2021) · Brain · doi:10.1093/brain/awab331 · Cited by 45
Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau
Tsai, H.-H. C., Chen, Y., Yen, R., Lo, Y.-L., Yang, K., Jeng, J., Tsai, L., & Chang, C.-F. (2021) · Brain · doi:10.1093/brain/awab332 · Cited by 47
Patel, A. G., Nehete, P. N., Krivoshik, S. R., Pei, X., Cho, E. L., Nehete, B. P., Ramani, M. D., Shao, Y., Williams, L. E., Wisniewski, T., et al. (2021) · Brain · doi:10.1093/brain/awab129 · Cited by 44
Petralla, S., Panayotova, M., Franchina, E., Fricker, G., & Puris, E. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070948 · Cited by 46
Vascular Dementia: From Pathophysiology to Therapeutic Frontiers
Yang, H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14186611 · Cited by 48
Jana, A., Wang, X., Leasure, J. W., Magana, L., Wang, L., Kim, Y.-M., Dodiya, H., Toth, P. T., Sisodia, S. S., & Rehman, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-20889-y · Cited by 43
Neuroprotective Effects of Lactoferrin in Alzheimer’s and Parkinson’s Diseases: A Narrative Review
Yong, S. J., Veerakumarasivam, A., Lim, W. L., & Chew, J. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00679 · Cited by 46
McKay, N. S., Gordon, B. A., Hornbeck, R. C., Dincer, A., Flores, S. E., Keefe, S., Joseph‐Mathurin, N., Jack, C. R., Koeppe, R. A., Millar, P. R., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01359-8 · Cited by 44
Monoclonal Antibody Therapy in Alzheimer’s Disease
Neațu, M., Covaliu, A., Ioniță, I., Jugurt, A., Davidescu, E. I., & Popescu, B. O. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010060 · Cited by 46
Hey, J. A., Abushakra, S. R., Blennow, K., Reiman, E. M., Hort, J., Prins, N. D., Sheardová, K., Kesslak, P. J., Shen, L. Z., Zhu, X., et al. (2024) · Drugs · doi:10.1007/s40265-024-02067-8 · Cited by 47
The impact of rare genetic variants on Alzheimer disease
Deyn, L. D., & Sleegers, K. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01062-1 · Cited by 46
Down syndrome and Alzheimer's disease: insights into biomarkers, clinical symptoms, and pathology
Rafii, M. S., Schlachetzki, Z., Barroeta, I., Head, E., Fortea, J., & Ances, B. M. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00237-6 · Cited by 44
Molecular mechanisms of cognitive impairment associated with stroke
Kaur, M., & Sharma, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00901-0 · Cited by 43
Kim, S. E., Kim, H. J., Jang, H., Weiner, M. W., DeCarli, C. S., Na, D. L., & Seo, S. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810490 · Cited by 42
Xiong, M., Wang, C., Gratuze, M., Saadi, F., Bao, X., Bosch, M. E., Lee, C., Jiang, H., Serrano, J. R., Gonzales, E. R., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00610-x · Cited by 41
Genome-Wide Association Studies of ARIA From the Aducanumab Phase 3 ENGAGE and EMERGE Studies
Loomis, S. J., Miller, R., Castrillo‐Viguera, C., Umans, K., Cheng, W., O'Gorman, J. T., Hughes, R. A., Haeberlein, S. B., & Whelan, C. D. (2023) · Neurology · doi:10.1212/wnl.0000000000207919 · Cited by 41
Amyloid β oligomer induces cerebral vasculopathy via pericyte-mediated endothelial dysfunction
Chen, S., Guo, D., Zhu, Y., Xiao, S., Xie, J., Zhang, Z., Hu, Y., Huang, J., Ma, X., Ning, Z., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01423-w · Cited by 43
Potential Role of Venular Amyloid in Alzheimer’s Disease Pathogenesis
Morrone, C. D., Bishay, J., & McLaurin, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061985 · Cited by 43
Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy
Beaudin, A. E., McCreary, C. R., Mazerolle, E. L., Gee, M., Sharma, B., Subotic, A., Zwiers, A. M., Cox, E., Nelles, K., Charlton, A., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200136 · Cited by 41
Margraf, N. G., Jensen‐Kondering, U., Weiler, C., Leypoldt, F., Maetzler, W., Philippen, S., Bartsch, T., Flüh, C., Röcken, C., Möller, B., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.783996 · Cited by 40
Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches
Chen, H., Zeng, Y., Wang, D., Li, Y., Xing, J., Zeng, Y., Liu, Z., Zhou, X., & Fan, H. J. (2024) · Molecules · doi:10.3390/molecules29071478 · Cited by 41
The role of neuroinflammation in cerebral amyloid angiopathy
van den Brink, H., Voigt, S., Kozberg, M., & van Etten, E. S. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2024.105466 · Cited by 39
ExHiF: Alzheimer's disease detection using exemplar histogram-based features with CT and MR images
Kaplan, E., Bayğın, M., Barua, P. D., Doğan, Ş., Tuncer, T., Altunışık, E., Palmer, E. E., & Acharya, U. R. (2023) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2023.103971 · Cited by 39
Lecanemab: Appropriate Use Recommendations by Korean Dementia Association
Park, K. H., Kim, G. H., Kim, C., Koh, S., Moon, S. Y., Park, Y. H., Seo, S. W., Yoon, B., Lim, J., Kim, B. C., et al. (2024) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2024.23.4.165 · Cited by 39
Region-specific drivers of CSF mobility measured with MRI in humans
Hirschler, L., Runderkamp, B. A., Decker, A., van Harten, T. W., Scheyhing, P., Ehses, P., Petitclerc, L., Layer, J., Pracht, E., Coolen, B. F., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02073-3 · Cited by 39
Nielsen, J. E., Pedersen, K. S., Vestergård, K., Maltesen, R. G., Christiansen, G., Lundbye‐Christensen, S., Moos, T., Kristensen, S. R., & Pedersen, S. (2020) · Biomedicines · doi:10.3390/biomedicines8070199 · Cited by 39
Multimodal comparisons of QSM and PET in neurodegeneration and aging
Cogswell, P. M., & Fan, A. P. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120068 · Cited by 38
The vascular contribution of apolipoprotein E to Alzheimer’s disease
Chen, F., Zhao, J., Meng, F., He, F., Ni, J., & Fu, Y. (2024) · Brain · doi:10.1093/brain/awae156 · Cited by 39
Early-Onset Cerebral Amyloid Angiopathy and Alzheimer Disease Related to an APP Locus Triplication
Grangeon, L., Cassinari, K., Rousseau, S., Croisile, B., Formaglio, M., Moreaud, O., Boutonnât, J., Meur, N. L., Miné, M., Coste, T., et al. (2021) · Neurology Genetics · doi:10.1212/nxg.0000000000000609 · Cited by 38
Anti-Amyloid Therapy, AD, and ARIA: Untangling the Role of CAA
Sin, M., ZAMRINI, E. Y., Ahmed, A., Nho, K. T., & Hajjar, I. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216792 · Cited by 39
Wan, T., Fu, M., Jiang, Y., Jiang, W., Li, P., & Zhou, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03448-1 · Cited by 38
The dense-core plaques of Alzheimer’s disease are granulomas
Lemke, G., & Huang, Y. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20212477 · Cited by 37
Retinal Dysfunction in Alzheimer’s Disease and Implications for Biomarkers
Liao, C., Xu, J., Chen, Y., & Ip, N. Y. (2021) · Biomolecules · doi:10.3390/biom11081215 · Cited by 37
Singh, C. S. B., Choi, K. B., Munro, L., Wang, H. Y., Pfeifer, C. G., & Jefferies, W. A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103503 · Cited by 36
Mesenchymal Stem Cell-Derived Exosomes as a Neuroregeneration Treatment for Alzheimer’s Disease
Shah, S., Mansour, H. M., Aguilar, T. M., & Lucke-Wold, B. P. (2024) · Biomedicines · doi:10.3390/biomedicines12092113 · Cited by 37
Kim, J., & Kim, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9010082 · Cited by 36
Chin, E., Jaqua, E. E., Safaeipour, M., & Ladue, T. (2022) · Cureus · doi:10.7759/cureus.31065 · Cited by 36
Subotic, A., McCreary, C. R., Saad, F., Nguyen, A., Alvarez-Veronesi, A., Zwiers, A. M., Charlton, A., Beaudin, A. E., Ismail, Z., Pike, G. B., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210138 · Cited by 35
Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
Pinho, J., Quintas-Neves, M., Dogan, I., Reetz, K., Reich, A., & Costa, A. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-95821-x · Cited by 35
Cerebral Superficial Siderosis
Weidauer, S., Neuhaus, E., & Hattingen, E. (2022) · Clinical Neuroradiology · doi:10.1007/s00062-022-01231-5 · Cited by 34
Kim, D. S., Ko, B., Ryuk, J. A., & Park, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082900 · Cited by 35
Szalárdy, L., Fakan, B., Maszlag-Török, R., Ferencz, E., Reisz, Z., Radics, B., Csizmadia, S., Szpisjak, L., Annus, Á., Zádori, D., et al. (2023) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12946 · Cited by 33
Whitman, E. T., Ryan, C. P., Abraham, W. C., Addae, A., Corcoran, D. L., Elliott, M. L., Hogan, S., Ireland, D. R., Keenan, R. J., Knodt, A. R., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.01.008 · Cited by 36
Bonnar, O., Eyre, B., & van Veluw, S. J. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00535 · Cited by 32
Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease
Davis, M. R., Robinson, E., Koronyo, Y., Salobrar‐García, E., Rentsendorj, A., Gaire, B. P., Mirzaei, N., Kayed, R., Sadun, A. A., Ljubimov, A. V., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01935-y · Cited by 34
Unzeta, M., Hernández‐Guillamón, M., Sun, P., & Solé, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073365 · Cited by 34
The correlation between neuropathology levels and cognitive performance in centenarians
Zhang, M., Ganz, A. B., Rohde, S. K., Lorenz, L. M. C., Rozemüller, A. J. M., van Vliet, K., Graat, M., Sikkes, S. A. M., Reinders, M. J. T., Scheltens, P., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13087 · Cited by 34
Common Signaling Pathways Involved in Alzheimer’s Disease and Stroke: Two Faces of the Same Coin
Das, T. K., Ganesh, B. P., & Fatima-Shad, K. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220108 · Cited by 33
Endothelial‐derived plasma exosome proteins in Alzheimer’s disease angiopathy
Abner, E. L., Elahi, F. M., Jicha, G. A., Mustapić, M., Al‐Janabi, O. M., Kramer, J. H., Kapogiannis, D., & Goetzl, E. J. (2020) · The FASEB Journal · doi:10.1096/fj.202000034r · Cited by 34
Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
Natale, G., Zhang, Y., Hanes, D. W., & Clouston, S. (2023) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221111658 · Cited by 35
The relationship between TGF-β1 and cognitive function in the brain
Su, C., Miao, J., & Guo, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110820 · Cited by 35
Cerebral Amyloid Angiopathy–Related Inflammation and Biopsy-Positive Primary Angiitis of the CNS
Grangeon, L., Boulouis, G., Capron, J., Bala, F., Renard, D., Raposo, N., Ozkul-Wermester, O., Triquenot-Bagan, A., Ayrignac, X., Wallon, D., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000209548 · Cited by 32
Beaman, C. B., Kozii, K., Hilal, S., Liu, M., Spagnolo‐Allende, A., Serra, G. P., Chen, C., Cheng, C., Zambrano, D., Arikan, B., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200142 · Cited by 32
Metadata
- Authors
- Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Greenberg, Steven M.
- Venue
- Nature Reviews Neurology
- Published
- 2019-12-11
- Volume
- 16
- Issue
- 1
- Pages
- 30-42
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- PMC
- PMC7268202
- OpenAlex
- W2995183059
- Cited by
- 947
- References
- 232
- Citations by year
- 2026: 146 · 2025: 198 · 2024: 179 · 2023: 154 · 2022: 113 · 2021: 104 · 2020: 52
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG026484)
- National Institute of Neurological Disorders and Stroke (RF1NS110054, R01NS096730, U24NS100591)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebral amyloid angiopathy, Alzheimer's disease, amyloid-beta, amyloid-beta clearance, amyloid-related imaging abnormalities, anti-amyloid immunotherapy, vascular function
- MeSH terms
- Alzheimer Disease, Brain, Humans, Signal Transduction, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
