The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
Open accessAbstract
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD) is arguably the clearest instance of crosstalk between neurodegenerative and cerebrovascular processes. The pathogenic pathways of CAA and AD intersect at the levels of Aβ generation, its circulation within the interstitial fluid and perivascular drainage pathways and its brain clearance, but diverge in their mechanisms of brain injury and disease presentation. Here, we review the evidence for and the pathogenic implications of interactions between CAA and AD. Both pathologies seem to be driven by impaired Aβ clearance, creating conditions for a self-reinforcing cycle of increased vascular Aβ, reduced perivascular clearance and further CAA and AD progression. Despite the close relationship between vascular and plaque Aβ deposition, several factors favour one or the other, such as the carboxy-terminal site of the peptide and specific co-deposited proteins. Amyloid-related imaging abnormalities that have been seen in trials of anti-Aβ immunotherapy are another probable intersection between CAA and AD, representing overload of perivascular clearance pathways and the effects of removing Aβ from CAA-positive vessels. The intersections between CAA and AD point to a crucial role for improving vascular function in the treatment of both diseases and indicate the next steps necessary for identifying therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, brains from COVID patients also show ischemic and hemorrhagic lesions, as well as microglial activation [79], which can be seen in many AD patients with cerebral amyloid angiopathy [80].”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [80]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Recently, vascular deposits of Aβ peptides (amyloid angiopathy) are increasingly recognized as a common pathology in AD cases, supporting that Aβ peptides circulate within the interstitial fluid, including CSF, and blood vessels through perivascular (e.g. lymphatic) drainage pathways during the crosstalk between the brain and the vascular system [77].”
From Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease (2020) · cites this paper as [77]
The cited source says what the claim attributes to it.
In the citing paper
“Recently, vascular deposits of Aβ peptides (amyloid angiopathy) are increasingly recognized as a common pathology in AD cases, supporting that Aβ peptides circulate within the interstitial fluid, including CSF, and blood vessels through perivascular (e.g. lymphatic) drainage pathways during the crosstalk between the brain and the vascular system [77].”
From Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease (2020) · cites this paper as [77]
The cited source says what the claim attributes to it.
In the citing paper
“Inflammation does, however, not seem to be a major component in CAA-related microhemorrhage or microinfarction [38], with the exception of a rare clinical subtype: CAA-related inflammation [6].”
From Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy (2021) · cites this paper as [6]
In the citing paper
“AQP4 levels are reduced in CAA; since AQP4 plays a vital role in glymphatic Aβ clearance in AD brain parenchyma, this consequently impairs Aβ clearance [606, 608].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [608]
In the citing paper
“AQP4 levels are reduced in CAA; since AQP4 plays a vital role in glymphatic Aβ clearance in AD brain parenchyma, this consequently impairs Aβ clearance [606, 608].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [608]
In the citing paper
“Chronic inflammation‐induced disruption of the BBB is an early biomarker of human cognitive dysfunction and often leads to dementia, 113 and both Aβ deposits and tau pathology aggravate vascular damage. 114 , 115”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [115]
In the citing paper
“There is overwhelming evidence for cerebrovascular alterations in AD pathology and amyloid-β deposition around leptomeningeal vessels is a hall mark of cerebral amyloid angiopathy, occurring in almost all AD patients”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Greenberg et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Sevigny, J., Chiao, P., Bussière, T., Weinreb, P. H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016) · Nature · doi:10.1038/nature19323 · Cited by 3,059
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078
Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022
The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960
Self-citation
Cited by
Sorted by citations
Items 401–500 of 954
Contemporary perspectives in cerebral amyloid angiopathy
Sellimi, A., Schwartze, J., Humphries, F., Panteleienko, L., Mallon, D. H., Banerjee, G., & Werring, D. J. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2526113 · Cited by 10
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
de Oliveira, A. P., Baghel, D., Holcombe, B., Chase, W., Ward, T., Wang, S. J., & Ghosh, A. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02911-5 · Cited by 10
Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation
Panteleienko, L., Banerjee, G., Mallon, D. H., Thiankhaw, K., Oliver, R., Harvey, V., Ambler, G., Zandi, M. S., Jäger, H. R., & Werring, D. J. (2025) · Annals of Neurology · doi:10.1002/ana.78029 · Cited by 10
Losa, M., Ramusino, M. C., Cama, I., Gualco, L., Gandoglia, I., Massa, F., Donniaquio, A., Mortola, P., Argenti, L., Lombardo, L., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.044784 · Cited by 10
Abushakra, S. R., Doraiswamy, P. M., Hey, J. A., Tosun, D., Barkhof, F., Barakos, J. A., Petrella, J. R., Kesslak, J. P., Power, A., Sabbagh, M. N., et al. (2025) · CNS Drugs · doi:10.1007/s40263-025-01251-y · Cited by 11
Atayde, A. L., Fischer, C. E., Schweizer, T. A., & Muñoz, D. G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215276 · Cited by 10
Models of cerebral amyloid angiopathy-related intracerebral hemorrhage
Vargas-George, S. A., & Dave, K. R. (2022) · Brain Hemorrhages · doi:10.1016/j.hest.2022.05.001 · Cited by 10
Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease
Sarg, B., Korde, D. S., Marksteiner, J., & Humpel, C. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2705153 · Cited by 10
Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey
Chan, A. W. S., Cho, I. K., Li, C., Zhang, X., Patel, S., Rusnak, R., Raper, J., Bachevalier, J., Moran, S. P., Chi, T., et al. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100044 · Cited by 10
Piccarducci, R., Caselli, M. C., Zappelli, E., Ulivi, L., Daniele, S., Siciliano, G., Ceravolo, R., Mancuso, M., Baldacci, F., & Martini, C. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220216 · Cited by 10
Schmidt, K., Power, M. C., Ciarleglio, A., & Nadareishvili, Z. (2022) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2022.106744 · Cited by 10
Venular amyloid accumulation in transgenic Fischer 344 Alzheimer’s disease rats
Bishay, J., Beckett, T. L., Lai, A. Y., Hill, M. E., McMahon, D., & McLaurin, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-19549-y · Cited by 10
Lee, B., Tsai, H.-H. C., Liu, C., Chen, Y., Tsai, L., Jeng, J., & Yen, R. (2023) · Stroke · doi:10.1161/strokeaha.122.040503 · Cited by 10
Validation of 3‐ and 5‐point severity scales to assess ARIA‐E
Bracoud, L., Klein, G., Lyons, M., Scelsi, M. A., Wojtowicz, J., Bullain, S., Purcell, D. D., Fiebach, J. B., Barakos, J. A., & Suhy, J. (2023) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12503 · Cited by 10
Beta-Amyloid Enhances Vessel Formation in Organotypic Brain Slices Connected to Microcontact Prints
Steiner, K., & Humpel, C. (2023) · Biomolecules · doi:10.3390/biom14010003 · Cited by 10
Pillai, J. A., Bena, J., Tousi, B., Rothenberg, K. G., Keene, C. D., & Leverenz, J. B. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13704 · Cited by 11
Marazuela, P., Bonaterra‐Pastra, A., Faura, J., Peñalba, A., Pizarro, J., Pancorbo, O., Rodríguez‐Luna, D., Vert, C., Rovira, À., Pujadas, F., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10050989 · Cited by 11
Sciacca, M. F. M., Natale, G. D., Milardi, D., & Pappalardo, G. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105085 · Cited by 10
Identifying Genetic Risk for Amyloid-Related Imaging Abnormalities
Hardy, J., & Schott, J. M. (2023) · Neurology · doi:10.1212/wnl.0000000000208096 · Cited by 11
The emerging role of the HTRA1 protease in brain microvascular disease
Haffner, C. (2023) · Frontiers in Dementia · doi:10.3389/frdem.2023.1146055 · Cited by 10
Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease
Phillips, J. S., Robinson, J. L., Cousins, K. A. Q., Wolk, D. A., Lee, E. B., McMillan, C. T., Trojanowski, J. Q., Grossman, M., & Irwin, D. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0808-23.2023 · Cited by 9
Using Neuroimaging to Study Cerebral Amyloid Angiopathy and Its Relationship to Alzheimer’s Disease
Wheeler, K. V., Andrei Irimia, A., & Braskie, M. N. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230553 · Cited by 9
Modeling of age-related neurological disease: utility of zebrafish
Kanoh, T., Mizoguchi, T., Tonoki, A., & Itoh, M. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1399098 · Cited by 9
Updated imaging markers in cerebral amyloid angiopathy: What radiologists need to know
Tanaka, F., Maeda, M., Kishi, S., Kogue, R., Umino, M., Ishikawa, H., Ii, Y., Shindo, A., & Sakuma, H. (2024) · Japanese Journal of Radiology · doi:10.1007/s11604-024-01720-2 · Cited by 9
Ehn, E., Eisfeldt, J., Laffita‐Mesa, J. M., Thonberg, H., Schoumans, J., Portaankorva, A. M., Viitanen, M. H., Lindstrand, A., Nennesmo, I., & Graff, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-86645-0 · Cited by 9
Sin, M., Dage, J. L., Nho, K. T., Dowling, N. M., Seyfried, N. T., Bennett, D. A. A., Levey, A. I., & Ahmed, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041070 · Cited by 9
Rodríguez-López, A., Esteban, D., Domínguez‐Romero, A. N., & Gevorkian, G. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115189 · Cited by 9
Reijner, N., Frigerio, I., Bouwman, M. M. A., Boon, B. D. C., Guizard, N., Jubault, T., Hoozemans, J. J. M., Rozemüller, A. J. M., Bouwman, F. H., Barkhof, F., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01727-5 · Cited by 9
Afrakoti, L. G. M. P., Moghadam, S. D., & Hadinezhad, P. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251329188 · Cited by 12
Jeon, S. Y., Wang, S., Roh, H. W., Kim, K. Y., Chang, Y. Y., Kim, E., Bae, J. N., & Ryu, S. (2025) · Journal of Korean Medical Science · doi:10.3346/jkms.2025.40.e215 · Cited by 9
Pascual‐Lucas, M., Lacosta, A. M., Montañés, M., Canudas, J., Loscos, J., Monleón, I., Allué, J. A., Sarasa, L., Fandos, N., Romero, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70776 · Cited by 10
Predisposing Factors, Pathologies, and Precipitating Factors Causing Intracerebral Hemorrhage
Hosking, A., Samarasekera, N., Moullaali, T. J., Whiteley, W. N., Putri, V. P., Rodrigues, M. A., Smith, C., Murthy, S. B., Gaist, D., Venturelli, P. M., et al. (2025) · Stroke · doi:10.1161/strokeaha.125.051831 · Cited by 9
Greenberg, S. M. (2026) · New England Journal of Medicine · doi:10.1056/nejmra2411298 · Cited by 9
Self-citationClinical Utility of the Pathogenesis-Related Proteins in Alzheimer’s Disease
Zhou, B., & Fukushima, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228661 · Cited by 10
Palmieri, I., Valente, M., Farina, L. M., Gana, S., Minafra, B., Zangaglia, R., Pansarasa, O., Sproviero, D., Costa, A. C., Pacchetti, C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083870 · Cited by 9
Biological and Social Determinants of Hypertension Severity Before vs After Intracerebral Hemorrhage
Abramson, J. R., Castello, J. P., Keins, S., Kourkoulis, C., Rodriguez-Torres, A., Myserlis, E. P., Alabsi, H., Warren, A. D., Henry, J. Q. A., Gurol, M. E., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200003 · Cited by 9
Self-citationAmyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis
Sulik, A., Toczyłowski, K., Kulczyńska‐Przybik, A., & Mroczko, B. (2022) · Viruses · doi:10.3390/v14040725 · Cited by 9
Recent advances and future therapy development for Alzheimer's disease and related disorders
Hong, M., & Bitan, G. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.391182 · Cited by 9
Fluid biomarkers in cerebral amyloid angiopathy
Savar, S. M., Ma, B., Hone, E., Jahan, F., Markovic, S. J., Pedrini, S., Shemehsavar, S., Easwaran, V., Taddei, K., Gardener, S. L., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1347320 · Cited by 9
Self-citationA Streamlined Workflow for Microscopy-Driven MALDI Imaging Mass Spectrometry Data Collection
Esselman, A. B., Ward, M. S., Marshall, C. R., Pingry, E. L., Dufresne, M., Farrow, M. A., Schrag, M., & Spraggins, J. M. (2024) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.4c00365 · Cited by 9
Vestergaard, M. B., Bakhtiari, A., Osler, M., Mortensen, E. L., Lindberg, U., Law, I. G., Lauritzen, M., Benedek, K., & Larsson, H. B. W. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01652-z · Cited by 9
Elia, A., Parodi‐Rullán, R. M., Vázquez‐Torres, R., Carey, A. M., Zhao, H., Javadov, S. A., & Fossati, S. (2026) · Advanced Science · doi:10.1002/advs.202511924 · Cited by 9
Yu, Y., Zhang, N., Xiang, B., Ding, N., Liu, J., Huang, J., Zhao, M., Zhao, Y., Wang, Y., & Ma, Z. (2023) · Neurophotonics · doi:10.1117/1.nph.10.1.015005 · Cited by 9
Tian, M., & Shen, L. (2020) · ACS Macro Letters · doi:10.1021/acsmacrolett.0c00262 · Cited by 9
Blood Transfusion and Brain Amyloidosis
Greenberg, S. M. (2023) · JAMA · doi:10.1001/jama.2023.14522 · Cited by 9
Self-citationPyun, J.-M., Kang, M. J., Baek, S. J., Lee, K. S., Park, Y. H., & Kim, S. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.49 · Cited by 8
The Spectrum of Cerebral Small Vessel Disease
Muir, R. T., & Smith, E. E. (2024) · Neurologic Clinics · doi:10.1016/j.ncl.2024.03.003 · Cited by 8
Snorradottir, A. O., Hakonarson, H., & Palsdottir, A. (2024) · Brain Pathology · doi:10.1111/bpa.13291 · Cited by 7
Rech, M. A., Carpenter, C. R., Aggarwal, N. T., & Hwang, U. (2025) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2024.12.002 · Cited by 8
Exploring the origins of frequent tau-PET signal in vermal and adjacent regions
Kling, A., Kusche‐Palenga, J., Palleis, C., Jäck, A., Bernhardt, A. M., Frontzkowski, L. K., Roemer, S. N., Slemann, L., Zaganjori, M., Scheifele, M., et al. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07199-x · Cited by 8
Diagnosis, pathomechanisms and therapy of cerebral amyloid angiopathy-related inflammation (CAA-ri)
Seifert, R. M., Klingebiel, R., & Schäbitz, W. (2025) · Neurological Research and Practice · doi:10.1186/s42466-025-00382-3 · Cited by 8
Signs of Alzheimer’s Disease: Tied to Aging
Chen, J., Zhu, Z., & Xu, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26114974 · Cited by 10
Szabo‐Reed, A. N., & Key, M. N. (2025) · Nutrients · doi:10.3390/nu17111804 · Cited by 8
Jin, Z., Liu, N., & Wei, H. P. (2025) · PLoS ONE · doi:10.1371/journal.pone.0324652 · Cited by 8
Cao, T., Yang, C., Zhang, J., Yan, Y., Chen, Z., Peng, X., Xia, C., Pan, M., Zou, C., & Lü, T. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107101 · Cited by 8
Caughey, B. W., Artikis, E., Shoup, D. W., Orru, C. D., Alam, P., Parveen, S., King, S., Soukup, J., Hughson, A. G., & Priola, S. A. (2025) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00007-25 · Cited by 8
Goldstein, M. R., & Cheslock, M. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110645 · Cited by 8
Are we ready to use anti-amyloid therapy in Alzheimer's disease?
Brucki, S. M. D., César‐Freitas, K. G., Spera, R. R., Borges, C. R., & Smid, J. (2022) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2022-s117 · Cited by 8
van den Berg, E., Nilsson, J., Kersten, I., Brinkmalm, G., de Kort, A. M., Klijn, C. J. M., Schreuder, F. H. B. M., Jäkel, L., Gobom, J., Portelius, E., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220977 · Cited by 8
Pathogenesis of cerebral amyloid angiopathy caused by chaotic glymphatics—Mini-review
Lui, F., Alcaide, J., Knowlton, S., Ysit, M., & Zhong, N. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1180237 · Cited by 8
Non-human Primate Models of Alzheimer’s Disease
Li, Y., & Gu, B. J. (2023) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2023.00006 · Cited by 8
Nagaraja, N., DeKosky, S. T., Duara, R., Kong, L., Wang, W., Vaillancourt, D. E., & Albayram, S. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103437 · Cited by 8
The potential impact of periodontitis on cerebral small vessel disease
Bezerra, B. D. B., Fisher, M., Pirih, F. Q. M., & Casarin, M. (2023) · Molecular Oral Microbiology · doi:10.1111/omi.12443 · Cited by 8
Gaudreault, R., Hervé, V., van de Ven, T. G. M., Mousseau, N., & Ramassamy, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201549 · Cited by 8
Cerebrospinal Fluid Inflammatory Markers in Alzheimer’s Disease: Influence of Comorbidities
Wang, Y., Emre, C., Gyllenhammar-Schill, H., Fjellman, K., Eyjolfsdottir, H., Eriksdotter, M., Schultzberg, M., & Hjorth, E. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210330162207 · Cited by 8
Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures
Korde, D. S., & Humpel, C. (2022) · Biomolecules · doi:10.3390/biom12091164 · Cited by 8
Michno, W., Koutarapu, S., Camacho, R., Toomey, C. E., Stringer, K. M., Minta, K., Ge, J., Jha, D., Fernández-Rodrı́guez, J., Brinkmalm, G., et al. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15694 · Cited by 9
Precision 1070 nm Ultrafast Laser‐Induced Photothrombosis of Depth‐Targeted Vessels In Vivo
Zhu, L., Wang, M., Fu, P., Liu, Y., Zhang, H., Roe, A. W., & Xi, W. (2023) · Small Methods · doi:10.1002/smtd.202200917 · Cited by 8
Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer’s disease and controls
Chen, C., Khnaijer, M. K., Beaudin, A. E., McCreary, C. R., Gee, M., Saad, F., Frayne, R., Ismail, Z., Pike, G. B., Camicioli, R. M., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1139196 · Cited by 8
Bonnar, O., Shaw, K., Anderle, S., Grijseels, D. M., Clarke, D., Bell, L., King, S. L., & Hall, C. N. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231172842 · Cited by 8
Tang, Y., Wei, J., Wang, X., Long, T., Xiang, X., Qu, L., Wang, X., Yu, C., Xiao, X., Hu, X., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-00954 · Cited by 8
Shaaban, C. E., Tudorascu, D., Glymour, M. M., Cohen, A. D., Thurston, R. C., Snyder, H. M., Hohman, T. J., Mukherjee, S., Yu, L., & Snitz, B. E. (2022) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2022.978350 · Cited by 9
Wojtas, A., Rathore, S., Dammer, E. B., Yu, L., Seifar, F., Gadhavi, J. D., Shantaraman, A., Duong, D. M., Wu, F., Liu, Y., et al. (2025) · SSRN Electronic Journal · doi:10.1101/2025.10.08.25337413 · Cited by 9
Functional border-associated macrophages limit Alzheimer’s Disease progressionPreprint
Adler, D. I., Pinheiro-Rosa, N., Millet, A., Gajic, Z. Z., Cheng, E., Gamallo‐Lana, B., Morizawa, Y. M., Klann, E., Gan, W., Mar, A. C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.31.703045 · Cited by 8
Maeda, T., Shimamori, K., Kurita, H., Tokuraku, K., & Kuragano, M. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113958 · Cited by 7
Sánchez-Puebla, L., López‐Cuenca, I., Salobrar‐García, E., González-Jiménez, M., Vázquez, A. A., Matamoros, J. A., Ramirez, A. I., Fernández‐Albarral, J. A., Elvira‐Hurtado, L., Saido, T. C., et al. (2024) · Biomolecules · doi:10.3390/biom14070828 · Cited by 7
Bonaterra‐Pastra, A., Solé, M., Lope‐Piedrafita, S., Lucas-Parra, M., Castellote, L., Marazuela, P., Pancorbo, O., Rodríguez‐Luna, D., & Hernández‐Guillamón, M. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01541-5 · Cited by 7
Wu, Y., Lehtonen, Š., Trontti, K., Kauppinen, R., Kettunen, P., Leinonen, V., Laakso, M., Kuusisto, J., Hiltunen, M., Hovatta, I., et al. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00576-y · Cited by 7
Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors
Carlsen, J., Fossati, S., Østergaard, L., Gutiérrez‐Jiménez, E., & Palmfeldt, J. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70122 · Cited by 7
Akkol, E. K., Karatoprak, G. Ş., Dumlupınar, B., Açıkara, Ö. B., Arıcı, R., Yücel, Ç., Aynal, L. C., & Sobarzo‐Sánchez, E. (2025) · Molecules · doi:10.3390/molecules30091982 · Cited by 8
Liao, F., Calvo-Rodríguez, M., Chhaya, M., Sefrin, J. P., Charych, E. I., Mezler, M., Clausznitzer, D., McGlame, E. J., Zhao, K., Rodgers, A., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02892-5 · Cited by 7
Distinct cerebrovascular pathways underlying Alzheimer’s disease-related neurodegeneration
Mohanty, R., Wheatley, S., Chiotis, K., Marseglia, A., Westman, E., & Initiative, A. D. N. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02970-8 · Cited by 7
The meninges as a neuroimmune interface: structure, barriers and roles in CNS disease
Joost, S., Kaddatz, H., Vankriekelsvenne, E., & Brandenburg, L. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00795-5 · Cited by 7
Intracisternal injection of beta-amyloid seeds promotes cerebral amyloid angiopathy
Yuan, Q., Xian, Y., Huang, Y., Wu, W., Song, Y., & Lin, Z. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.038 · Cited by 7
Michiels, L., Dobbels, L., Demeestere, J., Demaerel, P., Laere, K. V., & Lemmens, R. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103107 · Cited by 7
Crosstalk between peripheral immunity and central nervous system in Alzheimer’s disease
Yang, H.-C., Qin, Q., Wang, M., Yin, Y., Li, R., & Tang, Y. (2023) · Cellular Immunology · doi:10.1016/j.cellimm.2023.104743 · Cited by 9
Martín‐Jiménez, P., Sánchez-Tornero, M., Velasco, S. L., Guerrero‐Molina, M. P., González‐Sánchez, M., Martín, A. H.-S., Blanco-Palmero, V. A., Calleja, P., Francisco-Gonzalo, J., Hilario, A., et al. (2023) · Neurología (English Edition) · doi:10.1016/j.nrleng.2023.07.002 · Cited by 7
Ramli, S. M. A. Z., Hamid, H. A., Nassir, C. M. N. C. M., Rahaman, S. N. A., Mehat, M. Z., Kumar, J., Lee, S., & Mustapha, M. (2024) · Vessel Plus · doi:10.20517/2574-1209.2024.22 · Cited by 7
Beura, S. K., Panigrahi, A. R., Yadav, P., Kulkarni, P. P., Lakhanpal, V., Singh, B., & Singh, S. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04589-4 · Cited by 8
Exploring non-canonical targets in Alzheimer’s disease: a departure from the norm
Jain, S., & Chauhan, N. (2024) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-024-00908-7 · Cited by 7
Ge, W., Yan, Y., Hu, Y., Lin, S., & Mao, P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877241307246 · Cited by 7
Altered Clearance in Alzheimer's Disease and Cerebral Amyloid Angiopathy
Mohammadi, S., Dolatshahi, M., Rahmani, F., & Raji, C. A. (2025) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2024.12.004 · Cited by 7
Zedde, M., Piazza, F., & Pascarella, R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051697 · Cited by 9
Erythrocyte Load in Cerebrospinal Fluid Linked with Hippocampal Atrophy in Alzheimer’s Disease
Christodoulou, R. C., Vamvouras, G., Lorentzen, L. Y., & Vassiliou, E. K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134670 · Cited by 7
Wang, R., Xu, Z., Li, Y., Li, W., Gao, X.-R., Liu, C., & Liu, C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104644 · Cited by 7
Li, D., Qin, W., Guo, Y., Xia, M., Li, S., Zhang, J., & Zang, W. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06436-7 · Cited by 7
Effect of diphenylalanine on model phospholipid membrane organization
Bar, L., Losada‐Pérez, P., & Troncoso, J. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.122196 · Cited by 7
Evaluating [68Ga]Ga-p14-032 as a Novel PET Tracer for Diagnosis Cerebral Amyloid Angiopathy
Zhang, Q., Zhao, X., Lei, P., Kung, H. F., Yang, Z., Zhu, L., Wang, S., Zhu, H., Meng, X., Duan, Y., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.702185 · Cited by 7
Qu, W., Zhang, L., Liang, X., Yu, Z., Huang, H., Zhao, J., Guo, Y., Zhou, X., Xu, S., Luo, H., et al. (2023) · Biosensors · doi:10.3390/bios13010110 · Cited by 7
Alzheimer's disease: A need for personalized therapeutic approaches
Frenkel, D. (2020) · Drug Development Research · doi:10.1002/ddr.21652 · Cited by 7
Metadata
- Authors
- Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Greenberg, Steven M.
- Venue
- Nature Reviews Neurology
- Published
- 2019-12-11
- Volume
- 16
- Issue
- 1
- Pages
- 30-42
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- PMC
- PMC7268202
- OpenAlex
- W2995183059
- Cited by
- 947
- References
- 232
- Citations by year
- 2026: 146 · 2025: 198 · 2024: 179 · 2023: 154 · 2022: 113 · 2021: 104 · 2020: 52
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG026484)
- National Institute of Neurological Disorders and Stroke (RF1NS110054, R01NS096730, U24NS100591)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebral amyloid angiopathy, Alzheimer's disease, amyloid-beta, amyloid-beta clearance, amyloid-related imaging abnormalities, anti-amyloid immunotherapy, vascular function
- MeSH terms
- Alzheimer Disease, Brain, Humans, Signal Transduction, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
