Cited by 625Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingAmyotrophic Lateral Sclerosis Research

The DOI matches its Crossref record; 258 of the 258 references it cites were found in a registry or an index.

Protein transmission in neurodegenerative disease

Open access

Peng, Chao, Trojanowski, John Q., Lee, Virginia M.-Y.·2020·Nature Reviews Neurology

DOI 10.1038/s41582-020-0333-7PMC PMC9242841

Open this paper in CoChat — free account

Abstract

Most neurodegenerative diseases are characterized by the intracellular or extracellular aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α-synuclein in Parkinson disease, and TAR DNA-binding protein 43 in amyotrophic lateral sclerosis. Accumulating evidence from both human studies and disease models indicates that intercellular transmission and the subsequent templated amplification of these misfolded proteins are involved in the onset and progression of various neurodegenerative diseases. The misfolded proteins that are transferred between cells are referred to as 'pathological seeds'. Recent studies have made exciting progress in identifying the characteristics of different pathological seeds, particularly those isolated from diseased brains. Advances have also been made in our understanding of the molecular mechanisms that regulate the transmission process, and the influence of the host cell on the conformation and properties of pathological seeds. The aim of this Review is to summarize our current knowledge of the cell-to-cell transmission of pathological proteins and to identify key questions for future investigation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41582-020-0333-7

Cites

258 of 258 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

4 retracted

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
Masliah, E., Rockenstein, E. M., Mante, M., Crews, L. A., Spencer, B. J., Adame, A., Patrick, C., Trejo, M., Ubhi, K. K., Rohn, T. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019338 · Cited by 422
Retracted
RETRACTED ARTICLE: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
Ngolab, J., Trinh, I., Rockenstein, E., Mante, M., Florio, J., Trejo, M., Masliah, D., Adame, A., Masliah, E., & Rissman, R. A. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0445-5 · Cited by 200
Retracted
RETRACTED ARTICLE: LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Bae, E.-J., Kim, D.-K., Kim, C., Mante, M., Adame, A., Rockenstein, E., Ulusoy, A., Klinkenberg, M., Jeong, G. R., Bae, J. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05958-z · Cited by 149
Retracted
RETRACTED ARTICLE: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
Spencer, B. J., Valera, E., Rockenstein, E. M., Overk, C., Mante, M., Adame, A., Zago, W. M., Seubert, P. A., Barbour, R., Schenk, D., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0410-8 · Cited by 91
Retracted
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484

Show all 257 references

Sorted by citations

Items 501–600 of 624

Profiling the Misfolded Proteome in Human Disease
Onwudiwe, V. C., & Genereux, J. C. (2024) · Israel Journal of Chemistry · doi:10.1002/ijch.202300131 · Cited by 1
Zero-length crosslinking: A breakthrough approach for evaluating target engagement in α-synuclein immunotherapy
Rochet, J., Qi, W., & Kirik, D. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2024.100036 · Cited by 1
Mesial Temporal Lobe Epilepsy
Walker, M. C., Thom, M., & Vivekananda, U. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0018 · Cited by 1
Soluble N-Terminal Domain of the Prion Protein Interferes with Fibrillization of α-Synuclein to Form Off-Pathway Assemblies that Lack Cellular Seeding Activity
Grover, P. L., Dec, R., Mamashli, F., Winter, R., Winklhofer, K. F., & Tatzelt, J. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00085 · Cited by 1
I. Demenz: Medizinische Aspekte
Knell, S., Thal, D. R., & Lipp, V. (2022) · Verlag Karl Alber eBooks · doi:10.5771/9783495999370-17
Protective Effects of Cannabis in Neuroinflammation-Mediated Alzheimer's Disease
Kashif, M., Waseem, M., Vijendra, P. D., & Pandurangan, A. K. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5652-1.ch002 · Cited by 2
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivoPreprint
Dominguez‐Meijide, A., Parrales, V., Vasili, E., González‐Lizárraga, F., König, A., Lázaro, D. F., Lannuzel, A., Haı̈k, S., Bel, E. D., Chehín, R. N., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.06.371229 · Cited by 1
Ataxin-2 Disordered Region Promotes Huntingtin Protein Aggregation And Neurodegeneration In Drosophila Models Of Huntington’s DiseasePreprint
Huelsmeier, J., Walker, E., Bakthavachalu, B., & Ramaswami, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.01.462783 · Cited by 1
FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagyPreprint
Wu, S., Yin, Y., & Du, L. (2022) · Research Square · doi:10.21203/rs.3.rs-1411533/v1 · Cited by 1
Mitochondrial dysfunction underlies cortical atrophy in prodromal synucleinopathiesPreprint
Rahayel, S., Tremblay, C., Vo, A., Mišić, B., Lehéricy, S., Arnulf, I., Vidailhet, M., Corvol, J., the ICEBERG Study Group, Gagnon, J., et al. (2022) · medRxiv · doi:10.1101/2022.09.01.22279508 · Cited by 1
LRP10 as a novel α-synuclein regulator in Lewy body diseasesPreprint
Mascaro, A. C., Grochowska, M. M., Boumeester, V., Dits, N. F. J., Bilgiҫ, E. N., Breedveld, G. J., Vergouw, L. J. M., de Jong, F. J., van Royen, M. E., Bonifati, V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.12.540510 · Cited by 1
SARS-CoV-2 infection leads to Tau pathological signature in neuronsPreprint
Primio, C. D., Quaranta, P., Mignanelli, M., Siano, G., Bimbati, M., Piazza, C. R., Spezia, P. G., Perrera, P., Basolo, F., Poma, A. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.17.541098 · Cited by 1
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neuronsPreprint
Wang, G., Guasp, R. J., Salam, S., Chuang, E., Morera, A., Smart, A. J., Jimenez, D., Shekhar, S., Friedman, E., Melentijevic, I., et al. (2024) · eLife · doi:10.7554/elife.95443.2 · Cited by 1
Fibril fragmentation generates diversity in seed populationPreprint
Pedrola, J. A., Todorovska, M., Singh, S., Friedler, A., & Rüdiger, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.12.623277 · Cited by 1
Advances in Disease Modifying Therapies for Parkinson's Disease
Hassanzadeh, K., & Mouradian, M. M. (2025) · Wiley eBooks · doi:10.1002/9783527844678.ch2 · Cited by 1
FAM171A2 in Parkinson’s disease: mechanistic insights for a future therapeutic target
Wu, K., Zhang, Y., Wang, T., Wu, J., Huang, Y., Yuan, P., & Yu, J. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2589798 · Cited by 1
Templated seeding induces the formation of Alzheimer paired helical tau filaments in human brain organoidsPreprint
Bacioglu, M., Katsinelos, P., Schweighauser, M., Gallo, F., Mueller, K., Christou, R., Brandes, J., Lövestam, S., Cowley, S. A., McEwan, W. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.30.755295 · Cited by 1
Mechanistic insight into the spread of tau pathology
Fyfe, I. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0360-4
Striatal seeding of protofibrillar alpha-synuclein causes cortical hyperreactivity in behaving micePreprint
Blumenstock, S., Sun, F., Marinković, P., Sgobio, C., Liebscher, S., & Herms, J. W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.28.314526
Aptamers for the Diagnosis and Therapy of Neurodegenerative Diseases
Qu, J. T., & Zhang, J. (2021) · Springer eBooks · doi:10.1007/978-981-33-4838-7_12
The proSAAS chaperone provides neuroprotection and attenuates transsynaptic α–synuclein spread in rodent models of Parkinson’s diseasePreprint
Lindberg, I., Shu, Z., Lam, H. A., Helwig, M., Yucer, N., Laperle, A., Svendsen, C. N., Monte, D. A. D., & Maidment, N. T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.29.462435
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases
Brás, I. C. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8891
Redox regulation of yeast Hsp70 modulates protein quality control while directly triggering an Hsf1-dependent cytoprotective responsePreprint
Santiago, A., & Morano, K. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.08.487668
Motor and non-motor effects of apomorphine infusion
Borgemeester, R. W. K. (2022) · doi:10.33612/diss.220478491
Estudo estrutural-funcional do NBD (Nucleotide Binding Domain) e do PBD (Peptide Binding Domain) da proteína HspA1A
de Oliveira, C. S. (2022) · doi:10.11606/d.75.2022.tde-13122022-095321
Avaliação do papel do BDNF no mecanismo anti-apoptótico da Ouabaína frente a um estímulo excitotóxico moderado no hipocampo de ratos.
Port’s, N. M. D. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2022.tde-27012023-100010
Linking Genetic Risks to Pathological α-Synuclein Transmission in Parkinson’s Disease
Mi, X., Chen, L., Xie, J., & Song, N. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01031-y
Revisão sistemática da Cannabis sativa L. como alternativa para o tratamento de doenças degenerativas e produção in silíco de analise ADME.
Verissimo, R. M. D. O. (2022) · doi:10.52446/cursoengbiotecnologiacdsa.2022.tccmon.verissimo
Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer’s diseasePreprint
Yu, M., Risacher, S. L., Nho, K. T., Wen, Q., Oblak, A. L., Unverzagt, F. W., Apostolova, L. G., Farlow, M. R., Brosch, J. R., Clark, D. G., et al. (2023) · medRxiv · doi:10.1101/2023.08.12.23294017
Dissimilar accumulation of human β-amyloid and tau from enriched extracts in neuronal and endothelial cellsPreprint
Rabanal‐Ruiz, Y., Pedrero-Prieto, C. M., Sanchez-Rodriguez, L., Flores‐Cuadrado, A., Saiz‐Sánchez, D., Frontiñán-Rubio, J., Úbeda‐Bañón, I., Durán‐Prado, M., Martı́nez-Marcos, A., & Peinado, J. R. (2023) · Research Square · doi:10.21203/rs.3.rs-3343553/v1
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neuronsPreprint
Wang, G., Guasp, R. J., Salam, S., Chuang, E., Morera, A., Smart, A. J., Jiménez, D., Shekhar, S., Friedman, E., Melentijevic, I., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.13.565361
A Retrospective Study on Classifying Gait Signals Using Entropy Measures
Suliman, W., Ravi, V., & Pham, T. D. (2023) · IEEE Region 10 Conference (TENCON) · doi:10.1109/tencon58879.2023.10322319
dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradationPreprint
Zhang, S., Wang, L., Yi, S., Tsai, Y.-T., Wang, H., Li, S., Wang, R. L., Liu, Y., Yan, W., Liu, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.07.570521
Additional file 4 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Bichmann, M., Oriol, N. P., Ercan-Herbst, E., Schöndorf, D. C., Ramos, B. G., Schwärzler, V., Neu, M., Schlüter, A., Wang, X., Jin, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14903711
Additional file 1 of Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
Bai, B., Vanderwall, D., Li, Y., Wang, X., Poudel, S., Wang, H., Dey, K. K., Chen, P., Yang, K., & Peng, J. (2021) · Figshare · doi:10.6084/m9.figshare.15162179
The long term effects of uncoupling interventions as a therapy for dementia in humans
Holt, A. G., & Davies, A. M. (2024) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2024.111825
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUSPreprint
Vazquez‐Sanchez, S., Tilkin, B., Gasset-Rosa, F., Zhang, S., Piol, D., McAlonis‐Downes, M., Artates, J. W., Govea-Perez, N., Verresen, Y., Guo, L. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.03.593639
Mosaic midbrain organoids: a new tool to study Progressive Supranuclear Palsy and advancing clinical neurology researchPreprint
Parrotta, E. I., Lucchino, V., Zannino, C., Valente, D., Scalise, S., Benedetto, G. L., Iazzetta, M. R., Talarico, M., Conforti, F. S., Agostino, S. D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.03.597136
Intercellular transfer of plasmid DNA between in vitro cultured HEK293 cells following transient transfection
Gerdes, C., & Basmanav, F. B. (2024) · Plasmid · doi:10.1016/j.plasmid.2024.102729
Authentic hSAA related with AA amyloidosis: New method of purification, folding and amyloid polymorphism
Katina, N., Marchenkov, V. V., Lapteva, Y. S., Balobanov, V. A., Ilyina, N. B., Ryabova, N. A., Evdokimov, S., Suvorina, M. Y., Surin, A. K., & Glukhov, A. S. (2024) · Biophysical Chemistry · doi:10.1016/j.bpc.2024.107293
Advances in Developing Small Molecule Drugs for Alzheimer's Disease
Zhang, W., Zhang, L., Lv, M., Fu, Y., Meng, X., Wang, M., & Wang, H. (2024) · Current Alzheimer Research · doi:10.2174/0115672050329828240805074938 · Cited by 1
Pathophysiological Basis of Neurodegeneration in Parkinson’s Disease
Galindo, L. S. M., González‐Escamilla, G., & Groppa, S. (2024) · Neuromethods · doi:10.1007/978-1-0716-4083-8_1
Research Progress of Neurogenic Exosomes in the Treatment of Alzheimer’s Disease
黄, 思. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1492563
Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
Shimizu, M., & Okuno, T. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00661
Substance P in Alzheimer’s and Parkinson’s disease
Cinzia, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22194-1.00024-0
Utilizing machine learning algorithms to identify biomarkers associated with Alzheimer's disease and ferroptosis-related genes
Wang, D., Lin, C., Liu, G., Wang, X., Han, S., & Han, Z. (2025) · Technology and Health Care · doi:10.1177/09287329251322278
An In Vivo Model of α-Synuclein Spread from Gut to BrainPreprint
Barnhill, L. M., Khuansuwan, S., El-Nachef, W. N., Ha, S. M., Arellano, M., Hasan, K. M. M., Kim, A., & Bronstein, J. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.13.643189
Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral SclerosisPreprint
Lauria, F., Maniscalco, F., Perrucci, C., Marchioretto, M., Bruno, I., Tomè, G., Cella, F., Busarello, E., Sevegnani, M., Lunelli, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.15.654227
One night of sleep deprivation reduces spatially patterned human brain clearance: implications for simulated tau propagationPreprint
Brennan, G. S., Thompson, T., Oliveri, H., Vinje, V., Ringstad, G. A., Eide, P. K., Goriely, A., & Rognes, M. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.03.657596
New aspects of analyzing amyloid fibrils
Lin, X., Zi, Y., Li, F., & Li, J. (2025) · Data Analytics and Topology · doi:10.4310/daat.250513010418
Spatiotemporally Resolved Profiling of Protein Movement by TransitID
Guo, H., Zhang, C., & Qin, W. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4694-6_16 · Cited by 1
Prediction of future brain disorder risk using imaging data in 46,090 adultsPreprint
Tie, Y., Zhong, S., Yang, W., Pan, L., Yang, L., Duan, J., Li, H., Sai, K., Chen, S., Li, Z., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7238162/v1
Molecular Glues as Activators for PPI
Qi, X. (2025) · Wiley eBooks · doi:10.1002/9783527845828.ch13
Bibliometric Mapping of Research Trends and Hotspots of Microglia in Spinal Cord Injury (2000–2024)
Cai, Z., Xiong, G., Wu, J., Zhang, H., Huang, J. Z., Yu, Q., & Lin, W. (2025) · Brain and Behavior · doi:10.1002/brb3.70881
Prion and “Prion-Like” Detection: From Conventional Methods to Microfluidics or Lab-on-Chip Platforms to Monitor Seeding and Spreading of Misfolded Proteins
del Rı́o, J. A., Lidón, L., & Gavı́n, R. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-97055-9_6
Maladies à prions ou encéphalopathies spongiformes transmissibles
Brandel, J., & Haı̈k, S. (2025) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/s0246-0378(25)44895-7
Analytical Review on Normal Brain Aging, Alzheimer’s Disease, and Stage 4S Neuroblastoma: Novel Insights Into Neuroprotection, Neurodegeneration, and Spontaneous Regression
Aygün, N. (2025) · Cureus · doi:10.7759/cureus.93818
Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease
Dybala, A., Pils, M., Bannach, O., Tamgüney, G., & Riesner, D. (2025) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.70083
Identifying the biomarkers associated with G protein-coupled receptors of parkinson’s disease
Yang, H., Wu, X., Yun, Y., Bao, Z., Peng, D., Wu, Z., & Zhang, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-31148-1
The application of fecal microbiota transplantation in Parkinson’s disease
Wang, B., Ma, D., Li, N., & Luo, T. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1713899
Additional file 1 of Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice
Keskin, I., Ekhtiari Bidhendi, E., Marklund, M., Andersen, P. M., Brännström, T., Marklund, S. L., & Nordström, U. (2021) · Figshare · doi:10.6084/m9.figshare.14826085
Additional file 2 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Bichmann, M., Prat Oriol, N., Ercan-Herbst, E., Schöndorf, D. C., Gomez Ramos, B., Schwärzler, V., Neu, M. A., Schlüter, A., Wang, X., Jin, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14903705
Additional file 1 of Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein
Martínez-Valbuena, I., Valenti‐Azcarate, R., Villegas, I. A., Marcilla, I., Marti-Andres, G., Caballero, M.-C., Riverol, M., Tuñon, M.-T., Fraser, P. E., & Luquin, M.-R. (2021) · Figshare · doi:10.6084/m9.figshare.14391481
Additional file 1 of Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice
Son, G., Yoo, S.-J., Kang, S., Rasheed, A., Jung, D. H., Park, H., Cho, B., Steinbusch, H. W. M., Chang, K.-A., Suh, Y.-H., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13520646
Additional file 3 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Bichmann, M., Prat Oriol, N., Ercan-Herbst, E., Schöndorf, D. C., Gomez Ramos, B., Schwärzler, V., Neu, M. A., Schlüter, A., Wang, X., Jin, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14903708
Additional file 1 of Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease
Rimal, S., Li, Y., Vartak, R. S., Geng, J., Tantray, I., Li, S., Huh, S., Vogel, H. S., Glabe, C., Grinberg, L. T., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16829900
Additional file 1 of Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology
Paterno, G., Bell, B. M., Gorion, K.-M. M., Prokop, S., & Giasson, B. I. (2022) · Figshare · doi:10.6084/m9.figshare.20176025
Additional file 1 of Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies
van Wetering, J., Geut, H., Bol, J. G. J. M., Galis, Y., Timmermans, E., Twisk, J. W. R., Hepp, D. H., Morella, M. L., Pihlstrøm, L., Lemstra, A. W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26716930
Additional file 1 of A novel gene, TARDBP, and the protein it encodes can predict glioma patient prognosis and establish a prediction model
Fang, X., Wu, F., & Jiang, C. (2023) · Figshare · doi:10.6084/m9.figshare.22774204
Additional file 1 of Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease
Hall, S., Orru, C. D., Serrano, G. E., Galasko, D., Hughson, A. G., Groveman, B. R., Adler, C. H., Beach, T. G., Caughey, B., & Hansson, O. (2022) · Figshare · doi:10.6084/m9.figshare.20130877
Additional file 1 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Bichmann, M., Prat Oriol, N., Ercan-Herbst, E., Schöndorf, D. C., Gomez Ramos, B., Schwärzler, V., Neu, M. A., Schlüter, A., Wang, X., Jin, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14903699
Additional file 1 of Remodeling Alzheimer-amyloidosis models by seeding
Ulm, B. S., Borchelt, D. R., & Moore, B. D. (2021) · Figshare · doi:10.6084/m9.figshare.14037362
Additional file 1 of Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS
Vazquez‐Sanchez, S., Tilkin, B., Gasset-Rosa, F., Zhang, S., Piol, D., McAlonis‐Downes, M., Artates, J. W., Govea-Perez, N., Verresen, Y., Guo, L. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26019613
AI-enhanced EEG and source localization for retrospective analysis of Alzheimer’s disease and mild cognitive impairment
Du, M., Li, H., Huang, X., Shi, Y., An, Y., Chen, Z., Gao, S., Zhang, H., & Yao, Y. (2025) · Brain-Apparatus Communication A Journal of Bacomics · doi:10.1080/27706710.2025.2604895
Praja1 E3 ubiquitin ligase and the role it plays in neurodegeneration
Watabe, K. (2025) · FEBS Journal · doi:10.1111/febs.70383
Integrative Nanomedicine Approaches and Secondary Metabolites in Neurodegenerative Diseases
Çakar, B., Çadirci, C., & Kilic, K. D. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-1365-8.ch013
Mechanisms of Neurodegeneration and the Neuroprotective Role of Secondary Metabolites
Yashwant, R. P. B., & Wong, E. H. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-1365-8.ch002
Malattie da prioni o encefalopatie spongiformi trasmissibili
Brandel, J., & Haı̈k, S. (2026) · EMC - Neurologia · doi:10.1016/s1634-7072(25)51362-4
MONNA alleviates MPTP-induced Parkinson's disease in zebrafish by activating TFEB dependently on ER Calcium.
Tang, M., Luo, T., Kang, C., Wang, F., Yang, D.-X., Cui, R., Li, C.-J., Zhang, Y.-H., Liu, Y.-Y., Li, M., et al. (2026) · Cell Calcium · doi:10.1016/j.ceca.2026.103125
Exploring insulin aggregation at neutral pH and its inhibition via caffeic acid: a biophysical and bioinformatics analysis
Altwaijry, N. A., Almajhad, D. A., Al-Bagmi, M. S., Alafaleq, N. O., Alshehri, E., Alzharani, A. A., Alokail, M. S., Aldobiyan, I., Albahili, R. A., Khan, M. S., et al. (2026) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2026.2619872
Protein aggregation inhibitors induce divergent transcriptional responses in a cellular model of ɑ-synuclein seeded aggregation
Minsel, P. V., den Haute, C. V., Vonck, E., Hentati, S., Curcio, M., Song, X., Yu, Q., Versele, M., Young, K. W., Chaltin, P., et al. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01540-3
Optimal control of Alzheimer’s disease model via multi-target combination therapy
Dong, M., Guo, Z., Zhang, Y., Luo, J., & Zhang, J. (2026) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2026.112425
Glial metabolic states in human sporadic amyotrophic lateral sclerosis uncovered by spatial single-cell proteomics.Preprint
Ohtsuki, G., Hikosaka, M., Kinoshita, M., Uemura, K., Hossain, M. S., Abe, M., Parvez, M. S. A., Punyawatthananukool, S., Yoshida, M., & Tsuruyama, T. (2026) · Research Square · doi:10.21203/rs.3.rs-9006017/v1
Interactive effects of retinal biomarkers and sleep on cognition: longitudinal evidence from community-dwelling older adults
Chu, T., Hsieh, Y.-T., Chiou, J., Liu, Y.-L., Chen, Y., & Chen, J. (2026) · GeroScience · doi:10.1007/s11357-026-02159-1
Beyond peripheral symptoms: Hyperthyroidism as a risk factor for neurodegenerative disorders
Garg, R. (2026) · Global Journal of Health Sciences and Research · doi:10.25259/gjhsr_64_2025
Brain on a chip : to reconstruct multi-nodal neuronal networks in vitro for neurodegenerative disease modelling
Pan, T. (2022) · theses.fr (ABES) · doi:10.70675/cc75098bzeae8z422az9994zc22da8675cd5
Impact of α-synuclein fibrillar strains and ß-amyloid assemblies on cultured mouse cortical neurons endo-lysosomal logistics
Chou, Q.-L. (2021) · theses.fr (ABES) · doi:10.70675/d60d2c8cze696z4500za571zfe56e6cc9082
Role of extracellular space in neurodegenerative diseases
Estaún‐Panzano, J. (2024) · theses.fr (ABES) · doi:10.70675/98d1d96eza025z406ezba93z33e0820c3cf3
Balancing Gene Ontology annotation specificity in protein function prediction based on the protein sequence large graphPreprint
Shao, J., Chen, S., Wang, Z., Chen, Z., & Liu, B. (2026) · Genome Research · doi:10.1101/gr.280816.125
Computational strategies for drug discovery in neurodegeneration: Targeting Alzheimer’s and Parkinson’s disease
Ben-Hadda, A., Guerguer, F., Khedraoui, M., Yamari, I., & Chtita, S. (2026) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2026.100395
The human olfactory bulb in Huntington's disease: sex-specific differences in volume and gliosis
Flores-Thomas, A. P., Retamosa-Sanchez, E., Gómez, A. A., Flores‐Cuadrado, A., Saiz‐Sánchez, D., Astillero‐Lopez, V., Rábano, A., Martı́nez-Marcos, A., & Úbeda‐Bañón, I. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107413
Limitations of Stem Cell Therapy for Parkinson’s Disease
Li, Z., Peng, S., Jia, O. Y., & Liu, R. (2026) · Cells · doi:10.3390/cells15090839
Imaging of Central Nervous System Disorders of Protein Folding
Saini, J. S., Johnson, A. C., Prasad, S., & Soni, N. (2026) · Seminars in Roentgenology · doi:10.1016/j.ro.2026.150989
tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegenerationPreprint
Nguyen, L. D., Kobayashi, A., Ndayisaba, A., Khurana, V., Ivanov, P., & Krichevsky, A. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.15.725455
Neuroprotective role of cyanidin in Alzheimer’s and Parkinson’s disease: current insights and the road ahead
Bashir, B., andotra, N., Sharma, P., Sharma, T., Chauhan, S., Awasthi, A., Singh, S., Singh, T., Singh, S. K., & Vishwas, S. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02271-w
Engineered neuronal exosomes mediate α-synuclein clearance to ameliorate Parkinson’s disease
Chen, L., Lin, X., Fu, M., Chen, S., Yan, Z., Diao, Y., Chen, G., Huang, Z., Sun, Y., Lin, Y. Y., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04552-6
Propagation of α-synuclein pathology: models, mechanisms and future goals
Zolin, A., Weber, S. A., Xie, Y. X., & Burré, J. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00038-9
Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies
Delva, A., Joza, S., Tremblay, C., Vo, A., Filiatrault, M., Carrier, M., Taylor, J., O'Brien, J. T., Firbank, M., Thomas, A. J., et al. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01267-6
The Association Between Alzheimer’s Disease-Related Biomarkers And Parkinson’s Disease Based On Single-Cell Sequencing Analysis Combined With Mendelian Randomization
Duan, X., Huang, D., Zhong, H., Guo, X., Lu, X., Wu, J., & Huang, L. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02558-1
Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease
Ji, Y., Lu, L., Chen, K., Zhang, R., Lu, Y., Shi, Y., & Fang, X. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70040

Authors: Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y.
Affiliations: University of California, Los Angeles (US)
University of Pennsylvania (US)
Corresponding author: Lee, Virginia M.-Y.
ORCID: Peng, Chao
Trojanowski, John Q.
Lee, Virginia M.-Y.
Venue: Nature Reviews Neurology
Publisher: Springer Science and Business Media LLC
Published: 2020-03-23
Volume: 16
Issue: 4
Pages: 199-212
ISSN: 1759-4758 (ISSN-L)
1759-4766
DOI: 10.1038/s41582-020-0333-7
PMC: PMC9242841
OpenAlex: W3012646333
Cited by: 625
References: 257
Citations by year: 2026: 73 · 2025: 106 · 2024: 116 · 2023: 99 · 2022: 92 · 2021: 100 · 2020: 39
FWCI: 10.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (U19AG062418)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: protein transmission, neurodegenerative diseases, protein aggregation, amyloid-beta, tau protein, alpha-synuclein, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, intercellular protein transfer
MeSH terms: Huntingtin Protein, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Axonal Transport, Brain, Cell Communication, DNA-Binding Proteins, Endocytosis, Humans, Huntington Disease, Membrane Fusion, Neuroglia, Neurons, Parkinson Disease, Amyloid beta-Peptides, tau Proteins, Neurodegenerative Diseases, Genetic Predisposition to Disease, Protein Transport, Nanotubes, alpha-Synuclein, Exosomes, Protein Aggregation, Pathological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Protein transmission in neurodegenerative disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks