Protein transmission in neurodegenerative disease

Neuropathological stageing of Alzheimer-related changes.

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The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Staging of brain pathology related to sporadic Parkinson’s disease

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Alzheimer's disease: the amyloid cascade hypothesis

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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Overdependence on degraded gist memory in Alzheimer's disease.

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

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Mechanisms underlying inflammation in neurodegeneration

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Phases of Aβ-deposition in the human brain and its relevance for the development of AD

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Sevigny, J., Chiao, P., Bussière, T., Weinreb, P. H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016) · Nature · doi:10.1038/nature19323 · Cited by 3,059

α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 2,868

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563

Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

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Cryo-EM structures of tau filaments from Alzheimer’s disease

Fitzpatrick, A. W. P., Falcon, B., He, S., Murzin, A. G., Murshudov, G., Garringer, H. J., Crowther, R. A., Ghetti, B., Goedert, M., & Scheres, S. H. W. (2017) · Nature · doi:10.1038/nature23002 · Cited by 2,061

Protein misfolding, evolution and disease.

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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Transmission and spreading of tauopathy in transgenic mouse brain

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Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W. (2008) · Nature Medicine · doi:10.1038/nm1747 · Cited by 1,722

Microglia in neurodegeneration

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Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., Wolozin, B., Butovsky, O., Kügler, S., & Ikezu, T. (2015) · Nature Neuroscience · doi:10.1038/nn.4132 · Cited by 1,591

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

Volpicelli-Daley, L. A., Luk, K. C., Patel, T. P., Tanik, S. A., Riddle, D. M., Stieber, A., Meaney, D. F., Trojanowski, J. Q., & Lee, V. M.-Y. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.033 · Cited by 1,569

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

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Propagation of Tau Misfolding from the Outside to the Inside of a Cell

Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W. W., Ross, C. A., Dawson, V. L., & Dawson, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507360102 · Cited by 1,228

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

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PET Imaging of Tau Deposition in the Aging Human Brain

Schöll, M., Lockhart, S. N., Schonhaut, D. R., O’Neil, J. P., Janabi, M., Ossenkoppele, R., Baker, S. L., Vogel, J. W., Faria, J., Schwimmer, H. D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.028 · Cited by 1,214

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

Luk, K. C., Kehm, V. M., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M. ‐. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112457 · Cited by 1,136

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

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Selective neuronal vulnerability in Parkinson disease

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Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

Lu, J., Qiang, W., Yau, W., Schwieters, C. D., Meredith, S. C., & Tycko, R. (2013) · Cell · doi:10.1016/j.cell.2013.08.035 · Cited by 1,105

Construction of a human cell landscape at single-cell level

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

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Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

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Structural and functional characterization of two alpha-synuclein strains

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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

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Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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Exosomal cell-to-cell transmission of alpha synuclein oligomers

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Prion-like spreading of pathological α-synuclein in brain

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

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Structures of filaments from Pick’s disease reveal a novel tau protein fold

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Neuronal activity enhances tau propagation and tau pathology in vivo

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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

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The pathological process underlying Alzheimer’s disease in individuals under thirty

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Vagotomy and subsequent risk of Parkinson's disease

Svensson, E., Horváth‐Puhó, E., Thomsen, R. W., Djurhuus, J. C., Pedersen, L., Borghammer, P., & Sørensen, H. T. (2015) · Annals of Neurology · doi:10.1002/ana.24448 · Cited by 806

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

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Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry

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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

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Detection of oligomeric forms of α‐synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

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The role of microglia in amyloid clearance from the AD brain

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Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697

Proteopathic tau seeding predicts tauopathy in vivo

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Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

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Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

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Cerebral Amyloid Angiopathy

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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

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The release and trans-synaptic transmission of Tau via exosomes

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

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Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

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