Cited by 283Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Astrocytes in the initiation and progression of epilepsy

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Vezzani, Annamaria, Ravizza, Teresa, Bedner, Peter, Aronica, Eleonora, Steinhäuser, Christian, Boison, Detlev·2022·Nature Reviews Neurology

DOI 10.1038/s41582-022-00727-5PMC PMC10368155

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Abstract

Epilepsy affects ~65 million people worldwide. First-line treatment options include >20 antiseizure medications, but seizure control is not achieved in approximately one-third of patients. Antiseizure medications act primarily on neurons and can provide symptomatic control of seizures, but do not alter the onset and progression of epilepsy and can cause serious adverse effects. Therefore, medications with new cellular and molecular targets and mechanisms of action are needed. Accumulating evidence indicates that astrocytes are crucial to the pathophysiological mechanisms of epilepsy, raising the possibility that these cells could be novel therapeutic targets. In this Review, we discuss how dysregulation of key astrocyte functions - gliotransmission, cell metabolism and immune function - contribute to the development and progression of hyperexcitability in epilepsy. We consider strategies to mitigate astrocyte dysfunction in each of these areas, and provide an overview of how astrocyte activation states can be monitored in vivo not only to assess their contribution to disease but also to identify markers of disease processes and treatment effects. Improved understanding of the roles of astrocytes in epilepsy has the potential to lead to novel therapies to prevent the initiation and progression of epilepsy.

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Additional file 3 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 11 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 14 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 10 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 9 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 7 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 2 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 1 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 13 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 19 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 15 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 4 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 17 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 6 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 8 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 5 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 12 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Additional file 16 of Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
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Authors: Vezzani, A., Ravizza, T., Bedner, P., Aronica, E., Steinhäuser, C., & Boison, D.
Affiliations: Mario Negri Institute for Pharmacological Research (IT)
University of Bonn (DE)
Amsterdam Neuroscience (NL)
Rutgers, The State University of New Jersey (US)
Corresponding author: Vezzani, Annamaria
ORCID: Vezzani, Annamaria
Ravizza, Teresa
Bedner, Peter
Aronica, Eleonora
Steinhäuser, Christian
Boison, Detlev
Venue: Nature Reviews Neurology
Publisher: Springer Science and Business Media LLC
Published: 2022-10-24
Volume: 18
Issue: 12
Pages: 707-722
ISSN: 1759-4758 (ISSN-L)
1759-4766
DOI: 10.1038/s41582-022-00727-5
PMC: PMC10368155
OpenAlex: W4307338781
Cited by: 272
References: 207
Citations by year: 2026: 82 · 2025: 96 · 2024: 53 · 2023: 41
FWCI: 8.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Pure Amsterdam UMC (acceptedVersion, other-oa)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
Funders: Citizens United for Research in Epilepsy (NS065957, NS103740)
ZonMw
Bundesministerium für Bildung und Forschung (16GW0182, 01DN20001 CONNEX, 01DN20001, 16GW0182 CONNEXIN)
Epilepsy Society
National Institutes of Health (H2020, NS127846)
Horizon 2020 Framework Programme (H2020-MSCA, 952455, 722053, H2020-MSCA-ITN)
National Institute of Neurological Disorders and Stroke (R01NS061844, R01NS103740, R01NS065957, R01NS127846)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: astrocytes, epilepsy, epileptogenesis, hyperexcitability, gliotransmission, astrocyte metabolism, astrocyte activation, antiepileptic drugs, novel therapeutic targets
MeSH terms: Astrocytes, Epilepsy, Humans, Neurons, Seizures

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Astrocytes in the initiation and progression of epilepsy

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