The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Specializations for reward-guided decision-making in the primate ventral prefrontal cortex
Open accessAbstract
The estimated values of choices, and therefore decision-making based on those values, are influenced by both the chance that the chosen items or goods can be obtained (availability) and their current worth (desirability) as well as by the ability to link the estimated values to choices (a process sometimes called credit assignment). In primates, the prefrontal cortex (PFC) has been thought to contribute to each of these processes; however, causal relationships between particular subdivisions of the PFC and specific functions have been difficult to establish. Recent lesion-based research studies have defined the roles of two different parts of the primate PFC - the orbitofrontal cortex (OFC) and the ventral lateral frontal cortex (VLFC) - and their subdivisions in evaluating each of these factors and in mediating credit assignment during reward-based decision-making.
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“Conversely, area 14 in the medial OFC/caudal vmPFC appears more important for comparing values of alternative options.”
From Prefrontal cortex and depression (2022) · cites this paper as [115]
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“In summary, detailed parcellation studies in macaques have shown the importance of central regions of OFC in updating the valuations of expected outcomes on the basis of an animal's current state (area 13) and translating that information into goals for action selection (area 11).”
From Prefrontal cortex and depression (2022) · cites this paper as [115]
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“In a more recent study, damage to the lateral OFC (mainly area 12 as shown in Fig. 1, and extending around the inferior convexity, but described as VLPFC—ventrolateral prefrontal cortex) was found to impair the ability to make choices based on whether reward versus non-reward had been received (Rudebeck et al., 2017; Murray and Rudebeck, 2018)”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Murray and Rudebeck, 2018
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Metadata
- Authors
- Murray, E. A., & Rudebeck, P. H.
- Affiliations
- National Institutes of Health (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Murray, Elisabeth A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2018-05-23
- Volume
- 19
- Issue
- 7
- Pages
- 404-417
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC6432632
- OpenAlex
- W2804557255
- Cited by
- 169
- References
- 151
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 26 · 2021: 35 · 2020: 28 · 2019: 17 · 2018: 5
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH110822, ZIAMH002887)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- ventral prefrontal cortex, orbitofrontal cortex, credit assignment, value-based choice, desirability, availability, lesion studies, non-human primates
- MeSH terms
- Animals, Decision Making, Humans, Learning, Macaca mulatta, Neurons, Reward, Prefrontal Cortex
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