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Cited by 1,067Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesMedical and Biological Sciences

Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography

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Schmahmann, J. D., Pandya, D. N., Wang, R., Dai, G., D'Arceuil, H. E., de Crespigny, A. J., Wedeen, V. J.·2007·Brain
DOI 10.1093/brain/awl359
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Abstract

Understanding the long association pathways that convey cortical connections is a critical step in exploring the anatomic substrates of cognition in health and disease. Diffusion tensor imaging (DTI) is able to demonstrate fibre tracts non-invasively, but present approaches have been hampered by the inability to visualize fibres that have intersecting trajectories (crossing fibres), and by the lack of a detailed map of the origins, course and terminations of the white matter pathways. We therefore used diffusion spectrum imaging (DSI) that has the ability to resolve crossing fibres at the scale of single MRI voxels, and identified the long association tracts in the monkey brain. We then compared the results with available expositions of white matter pathways in the monkey using autoradiographic histological tract tracing. We identified 10 long association fibre bundles with DSI that match the observations in the isotope material: emanating from the parietal lobe, the superior longitudinal fasciculus subcomponents I, II and III; from the occipital-parietal region, the fronto-occipital fasciculus; from the temporal lobe, the middle longitudinal fasciculus and from rostral to caudal, the uncinate fasciculus, extreme capsule and arcuate fasciculus; from the occipital-temporal region, the inferior longitudinal fasciculus; and from the cingulate gyrus, the cingulum bundle. We suggest new interpretations of the putative functions of these fibre bundles based on the cortical areas that they link. These findings using DSI and validated with reference to autoradiographic tract tracing in the monkey represent a considerable advance in the understanding of the fibre pathways in the cerebral white matter. By replicating the major features of these tracts identified by histological techniques in monkey, we show that DSI has the potential to cast new light on the organization of the human brain in the normal state and in clinical disorders.

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  • Ex vivo imaging and tracing or physically and numerically simulated phantoms allow validation to some extent, and in specific circumstances such as basic fiber configurations.

    “Ex vivo imaging and tracing17–23 or physically24–30 and numerically simulated phantoms31–34 allow validation to some extent, and in specific circumstances such as basic fiber configurations.”

    From Tractography-based connectomes are dominated by false-positive connections (2016) · cites this paper as [20]

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Authors
Schmahmann, J. D., Pandya, D. N., Wang, R., Dai, G., D'Arceuil, H. E., de Crespigny, A. J., & Wedeen, V. J.
Affiliations
Boston University (US)
ORCID
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
2007-02-09
Volume
130
Issue
3
Pages
630-653
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
DOI
10.1093/brain/awl359
OpenAlex
W2116818517
Cited by
1,067
References
114
Citations by year
2026: 16 · 2025: 29 · 2024: 31 · 2023: 31 · 2022: 46 · 2021: 54 · 2020: 45 · 2019: 54 · 2018: 49 · 2017: 54 · 2016: 57 · 2015: 104 · 2014: 80 · 2013: 76 · 2012: 71
FWCI
47.49
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Brain (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • Centre d'Imagerie BioMédicale
  • National Institutes of Health (1s10rr016811-01, MH64044)
  • Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
  • National Institute of Mental Health (MH64044)
  • National Institute of Neurological Disorders and Stroke (NS41285, R01NS041285)
  • National Center for Research Resources (P41-RR-14075, S10RR016811, P41RR014075)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
Keywords
white matter tracts, diffusion spectrum imaging, crossing fibers, superior longitudinal fasciculus, middle longitudinal fasciculus, uncinate fasciculus, extreme capsule, arcuate fasciculus, inferior longitudinal fasciculus, cingulum, monkey brain, neural tracing, cortical connectivity
MeSH terms
Animals, Autoradiography, Brain, Frontal Lobe, Gyrus Cinguli, Macaca mulatta, Nerve Fibers, Neural Pathways, Occipital Lobe, Parietal Lobe, Temporal Lobe, Diffusion Magnetic Resonance Imaging

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