Cited by 169Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

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Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

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Murray, Elisabeth A., Rudebeck, Peter H.·2018·Nature Reviews Neuroscience

DOI 10.1038/s41583-018-0013-4PMC PMC6432632

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Abstract

The estimated values of choices, and therefore decision-making based on those values, are influenced by both the chance that the chosen items or goods can be obtained (availability) and their current worth (desirability) as well as by the ability to link the estimated values to choices (a process sometimes called credit assignment). In primates, the prefrontal cortex (PFC) has been thought to contribute to each of these processes; however, causal relationships between particular subdivisions of the PFC and specific functions have been difficult to establish. Recent lesion-based research studies have defined the roles of two different parts of the primate PFC - the orbitofrontal cortex (OFC) and the ventral lateral frontal cortex (VLFC) - and their subdivisions in evaluating each of these factors and in mediating credit assignment during reward-based decision-making.

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Authors: Murray, E. A., & Rudebeck, P. H.
Affiliations: National Institutes of Health (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Murray, Elisabeth A.
ORCID: Murray, Elisabeth A.
Rudebeck, Peter H.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-05-23
Volume: 19
Issue: 7
Pages: 404-417
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-018-0013-4
PMC: PMC6432632
OpenAlex: W2804557255
Cited by: 169
References: 151
Citations by year: 2026: 8 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 26 · 2021: 35 · 2020: 28 · 2019: 17 · 2018: 5
FWCI: 2.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH110822, ZIAMH002887)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: ventral prefrontal cortex, orbitofrontal cortex, credit assignment, value-based choice, desirability, availability, lesion studies, non-human primates
MeSH terms: Animals, Decision Making, Humans, Learning, Macaca mulatta, Neurons, Reward, Prefrontal Cortex

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Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

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