The DOI matches its Crossref record; 253 of the 253 references it cites were found in a registry or an index.
CNS infection and immune privilege
Abstract
Classically, the CNS is described as displaying immune privilege, as it shows attenuated responses to challenge by alloantigen. However, the CNS does show local inflammation in response to infection. Although pathogen access to the brain parenchyma and retina is generally restricted by physiological and immunological barriers, certain pathogens may breach these barriers. In the CNS, such pathogens may either cause devastating inflammation or benefit from immune privilege in the CNS, where they are largely protected from the peripheral immune system. Thus, some pathogens can persist as latent infections and later be reactivated. We review the consequences of immune privilege in the context of CNS infections and ask whether immune privilege may provide protection for certain pathogens and promote their latency.
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“The first line of protection comes from endothelial, epithelial, and glial barriers (reviewed by Forrester et al. 2018 [58]).”
From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [58]
Citations
Cites
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Host microbiota constantly control maturation and function of microglia in the CNS
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Research works printed but not linked: 2
- Medawar, P. B. Immunity to homolgous grafted skin. Br. J. Exp. Pathol. 29, 58–69 (1948).
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Sorted by citations
McMenamin, P. G., Saban, D. R., & Dando, S. J. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.12.002 · Cited by 115
Self-citationGuo, Y., Chen, J., Ji, W., Xu, L., Xie, Y., He, S., Lai, C., Hou, K., Li, Z., Chen, G., et al. (2023) · Molecular Therapy Methods & Clinical Development · doi:10.1016/j.omtm.2023.08.021 · Cited by 47
Hridi, S. U., Franssen, A. J. P. M., Jiang, H.-R., & Bushell, T. J. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.01.002 · Cited by 20
Risk mitigation of immunogenicity: a key to personalized retinal gene therapy
Varin, J., Morival, C., Maillard, N., Adjali, O., & Cronin, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312818 · Cited by 19
Metadata
- Authors
- Forrester, J. V., McMenamin, P. G., & Dando, S. J.
- Affiliations
- Lions Eye Institute (AU)
- Monash University (AU)
- Corresponding author
- Forrester, John V.
- Venue
- Nature Reviews Neuroscience
- Published
- 2018-10-11
- Volume
- 19
- Issue
- 11
- Pages
- 655-671
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2895986434
- Cited by
- 313
- References
- 253
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 55 · 2023: 36 · 2022: 41 · 2021: 64 · 2020: 35 · 2019: 17 · 2018: 2
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- University of Aberdeen
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- central nervous system infection, immune privilege, neuroinflammation, blood-brain barrier, blood-retinal barrier, viral latency, viral reactivation, alloantigen tolerance
- MeSH terms
- Immune Privilege, Animals, Brain, Central Nervous System, Central Nervous System Infections, Encephalitis, Humans, Microglia
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