The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Macrophages at CNS interfaces: ontogeny and function in health and disease
Abstract
The segregation and limited regenerative capacity of the CNS necessitate a specialized and tightly regulated resident immune system that continuously guards the CNS against invading pathogens and injury. Immunity in the CNS has generally been attributed to neuron-associated microglia in the parenchyma, whose origin and functions have recently been elucidated. However, there are several other specialized macrophage populations at the CNS borders, including dural, leptomeningeal, perivascular and choroid plexus macrophages (collectively known as CNS-associated macrophages (CAMs)), whose origins and roles in health and disease have remained largely uncharted. CAMs are thought to be involved in regulating the fine balance between the proper segregation of the CNS, on the one hand, and the essential exchange between the CNS parenchyma and the periphery, on the other. Recent studies that have been empowered by major technological advances have shed new light on these cells and suggest central roles for CAMs in CNS physiology and in the pathogenesis of diseases.
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In the citing paper
“They belong to CNS border-associated macrophages (CAMs) [367,368].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [367]
In the citing paper
“Single-cell profiling suggested functions shared with microglia and astrocytes in maintaining CNS homeostasis [372] and regulating barrier functions [367,378,379,380].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [367]
Citations
Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Structural and functional features of central nervous system lymphatic vessels
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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Self-citationTissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198
Research works printed but not linked: 1
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Cited by
Sorted by citations
Microglia Biology: One Century of Evolving Concepts
Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525
Self-citationMicroglia: Immune and non-immune functions
Borst, K., Dumas, A. A., & Prinz, M. (2021) · Immunity · doi:10.1016/j.immuni.2021.09.014 · Cited by 804
Self-citationMicroglia Heterogeneity in the Single-Cell Era
Masuda, T., Sankowski, R., Staszewski, O., & Prinz, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.010 · Cited by 784
Self-citationThe blood–brain barrier in health and disease: Important unanswered questions
Profaci, C. P., Munji, R. N., Pulido, R. S., & Daneman, R. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190062 · Cited by 811
Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00789-y · Cited by 704
Metadata
- Authors
- Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Prinz, Marco
- Venue
- Nature Reviews Neuroscience
- Published
- 2019-07-29
- Volume
- 20
- Issue
- 9
- Pages
- 547-562
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2965570118
- Semantic Scholar
- 7aa0033e693c776f7718f0c2d90733dadf1d5769
- Cited by
- 416
- References
- 196
- Citations by year
- 2026: 54 · 2025: 49 · 2024: 74 · 2023: 56 · 2022: 62 · 2021: 70 · 2020: 42 · 2019: 8
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- perivascular macrophages, choroid plexus macrophages, macrophage ontogeny, meninges, blood-brain barrier, neuroinflammation, neurodegenerative diseases
- MeSH terms
- Animals, Central Nervous System, Humans, Macrophages, Neurons, Inflammation Mediators, Neurodegenerative Diseases
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