The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.
Presynaptic calcium channels: specialized control of synaptic neurotransmitter release
Open accessAbstract
Chemical synapses are heterogeneous junctions formed between neurons that are specialized for the conversion of electrical impulses into the exocytotic release of neurotransmitters. Voltage-gated Ca2+ channels play a pivotal role in this process as they are the major conduits for the Ca2+ ions that trigger the fusion of neurotransmitter-containing vesicles with the presynaptic membrane. Alterations in the intrinsic function of these channels and their positioning within the active zone can profoundly alter the timing and strength of synaptic output. Advances in optical and electron microscopic imaging, structural biology and molecular techniques have facilitated recent breakthroughs in our understanding of the properties of voltage-gated Ca2+ channels that support their presynaptic functions. Here we examine the nature of these channels, how they are trafficked to and anchored within presynaptic boutons, and the mechanisms that allow them to function optimally in shaping the flow of information through neural circuits. Voltage-gated calcium channels have an essential role in the regulation of neurotransmitter release. Dolphin and Lee describe here how advances in the techniques available to study presynaptic voltage-gated calcium channels have provided insight into their composition, trafficking, regulation and contributions to presynaptic function.
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Cites
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Brown-Leung, J. M., & Cannon, J. R. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00072 · Cited by 164
The roles of mitochondria in global and local intracellular calcium signalling
Cartes-Saavedra, B., Ghosh, A., & Hajnóczky, G. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00820-1 · Cited by 126
Principles of synaptogenesis: Insights from Caenorhabditis elegans
Frankel, E. B., & Kurshan, P. T. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103056 · Cited by 7
Synaptic Vesicle Recycling at the Developing Presynapse
Kim, N., & Cousin, M. A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70206 · Cited by 2
“…P/Q-and N-type VGCCs account for the majority of the evoked calcium influx in both excitatory and inhibitory mammalian presyn-apses, which was revealed by exploiting pharmacological blockers for VGCC subtypes or by knocking out a specific VGCC subunit (Dolphin and Lee 2020; Reid et al. 2003).”
Metadata
- Authors
- Dolphin, A. C., & Lee, A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2020-03-11
- Volume
- 21
- Issue
- 4
- Pages
- 213-229
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W3010654069
- Cited by
- 283
- References
- 236
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
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