Diverse mechanisms for endogenous regeneration and repair in mammalian organs
Open accessAbstract
Mammalian organs comprise an extraordinary diversity of cell and tissue types. Regenerative organs, such as the skin and gastrointestinal tract, use resident stem cells to maintain tissue function. Organs with a lower cellular turnover, such as the liver and lungs, mostly rely on proliferation of committed progenitor cells. In many organs, injury reveals the plasticity of both resident stem cells and differentiated cells. The ability of resident cells to maintain and repair organs diminishes with age, whereas, paradoxically, the risk of cancer increases. New therapeutic approaches aim to harness cell plasticity for tissue repair and regeneration while avoiding the risk of malignant transformation of cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reprogramming of differentiated cells into progenitor-like cells is an important injury-repair paradigm independent of adult stem cells in various epithelial tissues in mammals.
“The reprogramming of differentiated cells into progenitor-like cells has recently been discovered as an important injury-repair paradigm independent of adult stem cells in a variety of epithelial tissues in mammals, 1 such as the lung, 2 intestine, 3 pancreas, 4 and liver.5,6”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., et al. (2017) · eLife · doi:10.7554/elife.27041 · Cited by 2,232 · see citing works
Self-citationVertebrate Endoderm Development and Organ Formation
Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812 · see citing works
Self-citationmTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., et al. (2014) · Nature · doi:10.1038/nature13255 · Cited by 776 · see citing works
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Raven, A., Lu, W.-Y., Man, T. Y., Ferreira-Gonzalez, S., O’Duibhir, E., Dwyer, B. J., Thomson, J. P., Meehan, R. R., Bogorad, R., Koteliansky, V., et al. (2017) · Nature · doi:10.1038/nature23015 · Cited by 533 · see citing works
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416 · see citing works
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style
Merrell, A. J., & Stanger, B. Z. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.24 · Cited by 369 · see citing works
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
Rebo, J., Mehdipour, M., Gathwala, R., Causey, K., Liu, Y., Conboy, M. J., & Conboy, I. M. (2016) · Nature Communications · doi:10.1038/ncomms13363 · Cited by 291 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [25]25. Simons, B.D. Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis. Proc. Natl Acad. Sci. USA 113 , 128-133 (2016).
- [91]91. Choi, E. et al. Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut , doi:10.1136/gutjnl-2017-313874 (2017). · DOI
- [96]96. Simmini, S. et al. Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nature Communications 5 , 5728, doi:10.1038/ncomms6728 (2014). This work demonstrated that one gene, Cdx2, functionally distinguishes intestinal stem cells gastric stem cells. · DOI
Cited by
Sorted by citations
Takebe, T., & Wells, J. M. (2019) · Science · doi:10.1126/science.aaw7567 · Cited by 417 · see citing works
Self-citationCai, B., Lin, D., Li, Y., Wang, L., Xie, J., Dai, T., Liu, F., Tang, M., Tian, L., Yuan, Y., et al. (2021) · Advanced Science · doi:10.1002/advs.202100584 · Cited by 187 · see citing works
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration
Qu, M., Xiong, L., Lyu, Y., Zhang, X., Shen, J., Guan, J., Chai, P., Lin, Z., Nie, B., Li, C., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00453-x · Cited by 138 · see citing works
Li, L., Cui, L., Lin, P., Liu, Z., Bao, S., Ma, X., Nan, H., Zhu, W., Cen, J., Mao, Y., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.01.009 · Cited by 134 · see citing works
Li, W., Yang, L., He, Q., Hu, C., Zhu, L., Ma, X., Ma, X., Bao, S., Li, L., Chen, Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.06.008 · Cited by 124 · see citing works
Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain
Fu, X.-D., & Mobley, W. C. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-083022-113120 · Cited by 16 · see citing works
- Authors
- Wells, J. M., & Watt, F. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Guy's Hospital (GB)
- Corresponding author
- Wells, James M.
- Watt, Fiona M.
- ORCID
- Watt, Fiona M.
- Venue
- Nature
- Published
- 2018-05
- Volume
- 557
- Issue
- 7705
- Pages
- 322-328
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2801674050
- Cited by
- 169
- References
- 9
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 15 · 2023: 18 · 2022: 21 · 2021: 32 · 2020: 22 · 2019: 23 · 2018: 8
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Wellcome Trust (Z/17/Z, 206439, 206439/Z/17/Z)
- Cancer Research UK (C219/A23522)
- National Institutes of Health
- Directorate for Biological Sciences
- Medical Research Council (MR/P018823/1, MR/PO18823/1)
- Biotechnology and Biological Sciences Research Council (BB/M007219/1)
- National Institute of Allergy and Infectious Diseases (U19AI116491)
- National Institute of Diabetes and Digestive and Kidney Diseases (U24DK085532, U01DK103117, U01DK085532, R01DK092456)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD093363)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- organ regeneration, tissue repair, progenitor cells, cellular plasticity, tissue homeostasis, aging, cancer risk, malignant transformation, liver regeneration, lung regeneration, skin regeneration
- MeSH terms
- Epidermal Cells, Aging, Animals, Cell Adhesion, Cell Transformation, Neoplastic, Epidermis, Extracellular Matrix, Humans, Infections, Inflammation, Regeneration, Wounds and Injuries, Cell Lineage, Regenerative Medicine, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
