Vertebrate Endoderm Development and Organ Formation

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works

Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913 · see citing works

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843 · see citing works

Efficient differentiation of human embryonic stem cells to definitive endoderm

D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730 · see citing works

Retinoic Acid Synthesis and Signaling during Early Organogenesis

Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098 · see citing works

Development of definitive endoderm from embryonic stem cells in culture

Kubo, A., Shinozaki, K., Shannon, J. M., Kouskoff, V., Kennedy, M., Woo, S. L. C., Fehling, H. J., & Keller, G. M. (2004) · Development · doi:10.1242/dev.01044 · Cited by 830 · see citing works

Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors

Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721 · see citing works

Depletion of definitive gut endoderm in <i>Sox17</i> -null mutant mice

Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704 · see citing works

Origin and organization of the zebrafish fate map

Kimmel, C. B., Warga, R. M., & Schilling, T. F. (1990) · Development · doi:10.1242/dev.108.4.581 · Cited by 698 · see citing works

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

Ciruna, B. G., & Rossant, J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00017-x · Cited by 695 · see citing works

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryoPreprint

Sun, X., Meyers, E. N., Lewandoski, M. B., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.14.1834 · Cited by 644 · see citing works

Gene function in mouse embryogenesis: get set for gastrulation

Tam, P., & Loebel, D. A. F. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2084 · Cited by 593 · see citing works

Generation and Regeneration of Cells of the Liver and Pancreas

Zaret, K. S., & Grompe, M. (2008) · Science · doi:10.1126/science.1161431 · Cited by 584 · see citing works

Regulation of early lung morphogenesis: questions, facts and controversies

Cardoso, W. V., & Lü, J. (2006) · Development · doi:10.1242/dev.02310 · Cited by 582 · see citing works

The initiation of liver development is dependent on Foxa transcription factors

Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581 · see citing works

Nodal signaling: developmental roles and regulation

Shen, M. M. (2007) · Development · doi:10.1242/dev.000166 · Cited by 537 · see citing works

SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER

Sancho, E., Batlle, E., & Clevers, H. C. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.092805 · Cited by 531 · see citing works

<i>Hex</i>: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors

Thomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528 · see citing works

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

Que, J., Okubo, T., Goldenring, J. R., Nam, K.-T., Kurotani, R., Morrisey, E. E., Taranova, O., Pevny, L., & Hogan, B. L. M. (2007) · Development · doi:10.1242/dev.003855 · Cited by 511 · see citing works

Fate map for the 32-cell stage ofXenopus laevis

Dale, L., & Slack, J. M. W. (1987) · Development · doi:10.1242/dev.99.4.527 · Cited by 507 · see citing works

Regulatory phases of early liver development: paradigms of organogenesis

Zaret, K. S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg837 · Cited by 504 · see citing works

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

Green, J. B. A., & Smith, J. C. (1990) · Nature · doi:10.1038/347391a0 · Cited by 500 · see citing works

Molecular Genetics of Axis Formation in Zebrafish

Schier, A. F., & Talbot, W. S. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143752 · Cited by 489 · see citing works

The formation of the mesoderm in urodelean amphibians

Nieuwkoop, P. D. (1969) · Development Genes and Evolution · doi:10.1007/bf00578701 · Cited by 475 · see citing works

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

Martı́nez-Barberá, J. P., Clements, M., Thomas, P. Q., Rodríguez, T. A., Meloy, D., Kioussis, D., & Beddington, R. S. P. (2000) · Development · doi:10.1242/dev.127.11.2433 · Cited by 471 · see citing works

Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells

Yasunaga, M., Tada, S., Torikai-Nishikawa, S., Nakano, Y., Okada, M., Jakt, L. M., Nishikawa, S., Chiba, T., Era, T., & Nishikawa, S.-I. (2005) · Nature Biotechnology · doi:10.1038/nbt1167 · Cited by 471 · see citing works

Transcriptional Control of Lung Morphogenesis

Maeda, Y., Davé, V., & Whitsett, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00028.2006 · Cited by 467 · see citing works

Fgf10is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis

Bhushan, A., Itoh, N., Kato, S., Thiery, J. P., Czernichow, P., Bellusci, S., & Scharfmann, R. (2001) · Development · doi:10.1242/dev.128.24.5109 · Cited by 459 · see citing works

Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture

Tada, S., Era, T., Furusawa, C., Sakurai, H., Nishikawa, S., Kinoshita, M., Nakao, K., Chiba, T., & Nishikawa, S.-I. (2005) · Development · doi:10.1242/dev.02005 · Cited by 456 · see citing works

Developmental biology of the pancreas: A comprehensive review

Gittes, G. K. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 449 · see citing works

BMP-4 is required for hepatic specification of mouse embryonic stem cell–derived definitive endoderm

Gouon–Evans, V., Boussemart, L., Gadue, P. J., Nierhoff, D., Koehler, C. I., Kubo, A., Shafritz, D. A., & Keller, G. M. (2006) · Nature Biotechnology · doi:10.1038/nbt1258 · Cited by 426 · see citing works

The Endoderm of the Mouse Embryo Arises by Dynamic Widespread Intercalation of Embryonic and Extraembryonic Lineages

Kwon, G. S., Viotti, M., & Hadjantonakis, A.-K. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.017 · Cited by 402 · see citing works

Fates of the blastomeres of the 32-cell-stage Xenopus embryo

Moody, S. A. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90296-x · Cited by 382 · see citing works

Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2

Gao, N., White, P., & Kaestner, K. H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.010 · Cited by 370 · see citing works

The onecut transcription factor HNF6 is required for normal development of the biliary tract

Clotman, F., Lannoy, V. J., Reber, M., Cereghini, S., Cassiman, D. M., Jacquemin, P., Roskams, T., Rousseau, G. G., & Lemaigre, F. P. (2002) · Development · doi:10.1242/dev.129.8.1819 · Cited by 368 · see citing works

Early mouse endoderm is patterned by soluble factors from adjacent germ layers

Wells, J. M., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.8.1563 · Cited by 366 · see citing works

Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development

McLin, V. A., Rankin, S. A., & Zorn, A. M. (2007) · Development · doi:10.1242/dev.001230 · Cited by 364 · see citing works

Haploinsufficiency of the forkhead geneFoxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mahlapuu, M., Enerbäck, S., & Carlsson, P. (2001) · Development · doi:10.1242/dev.128.12.2397 · Cited by 358 · see citing works

Origin and development of the zebrafish endoderm

Warga, R. M., & Nüsslein‐Volhard, C. (1999) · Development · doi:10.1242/dev.126.4.827 · Cited by 355 · see citing works

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1β

Coffinier, C., Gresh, L., Fiette, L., Tronche, F., Schütz, G., Babinet, C., Pontoglio, M., Yaniv, M., & Barra, J. (2002) · Development · doi:10.1242/dev.129.8.1829 · Cited by 354 · see citing works

SnapShot: Noncanonical Wnt Signaling Pathways

Semënov, M. V., Habas, R., MacDonald, B. T., & He, X. (2007) · Cell · doi:10.1016/j.cell.2007.12.011 · Cited by 349 · see citing works

Xsox17α and -β Mediate Endoderm Formation in Xenopus

Hudson, C., Clements, D., Friday, R. V., Stott, D., & Woodland, H. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80423-7 · Cited by 348 · see citing works

The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis

Dufort, D., Schwartz, L., Harpal, K., & Rossant, J. (1998) · Development · doi:10.1242/dev.125.16.3015 · Cited by 327 · see citing works

The Nodal Precursor Acting via Activin Receptors Induces Mesoderm by Maintaining a Source of Its Convertases and BMP4

Ben-Haim, N., Lu, C. C., Guzman-Ayala, M., Pescatore, L., Mesnard, D., Bischofberger, M., Naef, F., Robertson, E. J., & Constam, D. B. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.07.005 · Cited by 321 · see citing works

Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung

Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M., & Deutsch, G. H. (2004) · Development · doi:10.1242/dev.01570 · Cited by 313 · see citing works

Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development

Stafford, D., & Prince, V. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00929-6 · Cited by 309 · see citing works

Cdx2 is essential for axial elongation in mouse development

Chawengsaksophak, K., de Graaff, W., Rossant, J., Deschamps, J., & Beck, F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401654101 · Cited by 305 · see citing works

Intestine-Specific Ablation of Mouse atonal homolog 1 (Math1) Reveals a Role in Cellular Homeostasis

Shroyer, N. F., Helmrath, M. A., Wang, V. Y.-C., Antalffy, B. A., Henning, S., & Zoghbi, H. Y. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.047 · Cited by 305 · see citing works

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Yamamoto, M., Saijoh, Y., Perea-Gómez, A., Shawlot, W., Behringer, R. R., Ang, S., Hamada, H., & Meno, C. (2004) · Nature Cell Biology · doi:10.1038/nature02418 · Cited by 304 · see citing works

Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

Spence, J. R., Lange, A. W., Lin, S. J., Kaestner, K. H., Lowy, A. M., Kim, I., Whitsett, J. A., & Wells, J. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.012 · Cited by 302 · see citing works

Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract

van den Brink, G. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00054.2006 · Cited by 300 · see citing works

Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues

Tremblay, K. D., & Zaret, K. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.003 · Cited by 299 · see citing works

A molecular pathway leading to endoderm formation in zebrafish

Alexander, J. S., & Stainier, D. Y. R. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80016-0 · Cited by 295 · see citing works

Embryonic development of the liver†

Zhao, R., & Duncan, S. A. (2005) · Hepatology · doi:10.1002/hep.20691 · Cited by 292 · see citing works

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

Zaret, K. S. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2318 · Cited by 285 · see citing works

Pancreas and beta-cell development: from the actual to the possible

Murtaugh, L. C. (2006) · Development · doi:10.1242/dev.02770 · Cited by 284 · see citing works

Sox17 and β-catenin cooperate to regulate the transcription of endodermal genes

Sinner, D. I., Rankin, S. A., Lee, M. M., & Zorn, A. M. (2004) · Development · doi:10.1242/dev.01176 · Cited by 281 · see citing works

Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse

Lawson, K. A., Pedersen, R. A., & van de Geer, S. (1987) · Development · doi:10.1242/dev.101.3.627 · Cited by 279 · see citing works

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motifPreprint

Germain, S., Howell, M. T., Esslemont, G., & Hill, C. S. (2000) · Genes & Development · doi:10.1101/gad.14.4.435 · Cited by 273 · see citing works

<i>Hex</i> homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

Bort, R., Martinez-Barbera, J. P., Beddington, R. S. P., & Zaret, K. S. (2004) · Development · doi:10.1242/dev.00965 · Cited by 267 · see citing works

Pivotal roles for eomesodermin during axis formation,epithelium-to-mesenchyme transition and endoderm specification in the mouse

Arnold, S. J., Hofmann, U. K., Bikoff, E. K., & Robertson, E. J. (2008) · Development · doi:10.1242/dev.014357 · Cited by 264 · see citing works

Genetic control of single lumen formation in the zebrafish gut

Bagnat, M., Cheung, I. D., Mostov, K. E., & Stainier, D. Y. R. (2007) · Nature Cell Biology · doi:10.1038/ncb1621 · Cited by 262 · see citing works

Formation of Multiple Hearts in Mice following Deletion of β-catenin in the Embryonic Endoderm

Lickert, H., Kutsch, S., Kanzler, B., Tamai, Y., Taketo, M. M., & Kemler, R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00206-x · Cited by 260 · see citing works

p38 and a p38-Interacting Protein Are Critical for Downregulation of E-Cadherin during Mouse Gastrulation

Zohn, I. E., Li, Y., Skolnik, E. Y., Anderson, K. V., Han, J., & Niswander, L. A. (2006) · Cell · doi:10.1016/j.cell.2006.03.048 · Cited by 251 · see citing works

Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate

Kumar, M. E., Jordan, N., Melton, D. A., & Grapin‐Botton, A. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00183-0 · Cited by 247 · see citing works

Foxf1andFoxf2control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production

Ormestad, M., Astorga, J., Landgren, H., Wang, T., Johansson, B. R., Miura, N., & Carlsson, P. (2006) · Development · doi:10.1242/dev.02252 · Cited by 240 · see citing works

Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps

Que, J., Choi, M., Ziel, J. W., Klingensmith, J., & Hogan, B. L. M. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00096.x · Cited by 239 · see citing works

β-Catenin is essential for pancreatic acinar but not islet development

Murtaugh, L. C., Law, A. C., Dor, Y., & Melton, D. A. (2005) · Development · doi:10.1242/dev.02063 · Cited by 237 · see citing works

The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo

Norris, D. P., Brennan, J., Bikoff, E. K., & Robertson, E. J. (2002) · Development · doi:10.1242/dev.129.14.3455 · Cited by 234 · see citing works

<i>Mixl1</i>is required for axial mesendoderm morphogenesis and patterning in the murine embryo

Hart, A. H., Hartley, L., Sourris, K., Stadler, E. S., Li, R., Stanley, E. G., Tam, P. P. L., Elefanty, A. G., & Robb, L. (2002) · Development · doi:10.1242/dev.129.15.3597 · Cited by 229 · see citing works

Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer

Lawson, K. A., Meneses, J. J., & Pedersen, R. A. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90253-8 · Cited by 227 · see citing works

From endoderm formation to liver and pancreas development in zebrafish

Ober, E. A., Field, H. A., & Stainier, D. Y. R. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00327-1 · Cited by 223 · see citing works

Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis

Xanthos, J. B., Kofron, M. J., Wylie, C., & Heasman, J. (2001) · Development · doi:10.1242/dev.128.2.167 · Cited by 221 · see citing works

Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes

Soto–Gutiérrez, A., Kobayashi, N., Rivas‐Carrillo, J. D., Navarro–Álvarez, N., Zhao, D., Okitsu, T., Noguchi, H., Basma, H., Tabata, Y., Chen, Y., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1257 · Cited by 218 · see citing works

Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo

Burtscher, I., & Lickert, H. (2009) · Development · doi:10.1242/dev.028415 · Cited by 213 · see citing works

Activin receptor patterning of foregut organogenesis

Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes &amp; Development · doi:10.1101/gad.14.15.1866 · Cited by 212 · cited 1× · see citing works

Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development

Molotkov, A., Molotkova, N., & Duester, G. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20256 · Cited by 211 · see citing works

Cell migration during gastrulation

Keller, R. E. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.006 · Cited by 209 · see citing works

Bmp and Fgf signaling are essential for liver specification in zebrafish

Shin, D., Shin, C. H., Tucker, J. A., Ober, E. A., Rentzsch, F., Poss, K. D., Hammerschmidt, M., Mullins, M. C., & Stainier, D. Y. R. (2007) · Development · doi:10.1242/dev.000281 · Cited by 207 · see citing works

The Stomach Mesenchymal Transcription Factor Barx1 Specifies Gastric Epithelial Identity through Inhibition of Transient Wnt Signaling

Kim, B., Buchner, G., Milétich, I., Sharpe, P. T., & Shivdasani, R. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.01.015 · Cited by 204 · see citing works

Chapter 5 Early Embryonic Development of Xenopus laevis

Keller, R. E. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60273-3 · Cited by 203 · see citing works

Development of the mammalian liver and ventral pancreas is dependent on GATA4

Watt, A. J., Zhao, R., Li, J., & Duncan, S. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-37 · Cited by 200 · see citing works

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

Goessling, W., North, T. E., Lord, A. M., Ceol, C. J., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.-P. G., Puder, M., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.05.526 · Cited by 192 · see citing works

Transcriptional dynamics of endodermal organ formation

Sherwood, R. I., Chen, T. A., & Melton, D. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21810 · Cited by 191 · see citing works

FGF signaling is necessary for establishing gut tube domains alongthe anterior–posterior axis in vivo

Sordet‐Dessimoz, J., Opoka, R. J., Kordich, J. J., Grapin‐Botton, A., & Wells, J. M. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.10.001 · Cited by 189 · see citing works

TheXenopus Brachyurypromoter is activated by FGF and low concentrations ofactivinandsuppressed by high concentrationsof activin and by paired-type homeodomain proteinsPreprint

Latinkic, B. V., Umbhauer, M., Neal, K. A., Lerchner, W., Smith, J. C., & Cunliffe, V. T. (1997) · Genes & Development · doi:10.1101/gad.11.23.3265 · Cited by 187 · see citing works

Fgf10 regulates hepatopancreatic ductal system patterning and differentiation

Dong, P. D. S., Munson, C., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C. J., & Stainier, D. Y. R. (2007) · Nature Genetics · doi:10.1038/ng1961 · Cited by 185 · see citing works

Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation

Mizoguchi, T., Verkade, H. M., Heath, J. K., Kuroiwa, A., & Kikuchi, Y. (2008) · Development · doi:10.1242/dev.020107 · Cited by 185 · see citing works

Mode of action of VegT in mesoderm and endoderm formation

Clements, D., Friday, R. V., & Woodland, H. R. (1999) · Development · doi:10.1242/dev.126.21.4903 · Cited by 182 · see citing works

A glimpse into the molecular entrails of endoderm formationPreprint

Stainier, D. Y. R. (2002) · Genes & Development · doi:10.1101/gad.974902 · Cited by 177 · see citing works

Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus

Chen, Y., Pan, F. C., Brandes, N., Afelik, S., Sölter, M., & Pieler, T. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.03.030 · Cited by 172 · see citing works

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

Hunter, M. P., Wilson, C., Jiang, X., Cong, R., Vasavada, H., Kaestner, K. H., & Bogue, C. W. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.028 · Cited by 170 · see citing works

Anterior Endomesoderm Specification inXenopusby Wnt/β-catenin and TGF-β Signalling Pathways

Zorn, A. M., Butler, K., & Gurdon, J. B. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9257 · Cited by 170 · see citing works

Wnt/β-catenin signaling is required for development of the exocrine pancreas

Wells, J. M., Esni, F., Boivin, G. P., Aronow, B. J., Stuart, W. D., Combs, C., Sklenka, A. M., Leach, S. D., & Lowy, A. M. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-4 · Cited by 164 · see citing works

Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish developmentPreprint

Matsui, T., Raya, Á., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodrı́guez-Esteban, C., & Belmonte, J. C. I. (2005) · Genes & Development · doi:10.1101/gad.1253605 · Cited by 163 · see citing works

Inhibition of Tgfβ signaling by endogenous retinoic acid is essential for primary lung bud induction

Chen, F. F., Desai, T., Qian, J., Niederreither, K., Lü, J., & Cardoso, W. V. (2007) · Development · doi:10.1242/dev.006221 · Cited by 161 · see citing works

BMP signalling regulates anteroposterior endoderm patterning in zebrafish

Tiso, N., Filippi, A., Pauls, S., Bortolussi, M., & Argenton, F. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00252-6 · Cited by 161 · see citing works

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signalingPreprint

Li, Y., Rankin, S. A., Sinner, D. I., Kenny, A. P., Krieg, P. A., & Zorn, A. M. (2008) · Genes & Development · doi:10.1101/gad.1687308 · Cited by 157 · see citing works

Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives

Wang, Z., Dollé, P., Cardoso, W. V., & Niederreither, K. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.05.019 · Cited by 156 · see citing works

Molecular Basis of Vertebrate Endoderm Development

Zorn, A. M., & Wells, J. M. (2007) · International review of cytology · doi:10.1016/s0074-7696(06)59002-3 · Cited by 156 · see citing works

Wnt5a is essential for intestinal elongation in mice

Cervantes, S., Yamaguchi, T. P., & Hebrok, M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.020 · Cited by 155 · see citing works

An FGF Response Pathway that Mediates Hepatic Gene Induction in Embryonic Endoderm Cells

Calmont, A., Wandzioch, E., Tremblay, K. D., Minowada, G., Kaestner, K. H., Martin, G. R., & Zaret, K. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.06.015 · Cited by 154 · see citing works

Gene regulatory network controlling embryonic specification in the sea urchin

Oliveri, P., & Davidson, E. H. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.06.004 · Cited by 149 · see citing works

Zebrafish pou5f1/pou2, Homolog of Mammalian Oct4, Functions in the Endoderm Specification Cascade

Lunde, K., Belting, H., & Driever, W. (2004) · Current Biology · doi:10.1016/j.cub.2003.11.022 · Cited by 146 · see citing works

Bmp2 Signaling Regulates the Hepatic versus Pancreatic Fate Decision

Chung, W., Shin, C. H., & Stainier, D. Y. R. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.019 · Cited by 144 · see citing works

A Cellular Framework for Gut-Looping Morphogenesis in Zebrafish

Horne‐Badovinac, S., Rebagliati, M. R., & Stainier, D. Y. R. (2003) · Science · doi:10.1126/science.1085397 · Cited by 141 · see citing works

Mesendoderm Extension and Mantle Closure in Xenopus laevis Gastrulation: Combined Roles for Integrin α5β1, Fibronectin, and Tissue Geometry

Davidson, L. A., Hoffstrom, B. G., Keller, R. E., & DeSimone, D. W. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0537 · Cited by 138 · see citing works

Essential Role of Glycosaminoglycans in Fgf Signaling during Mouse Gastrulation

García‐García, M. J., & Anderson, K. V. (2003) · Cell · doi:10.1016/s0092-8674(03)00715-3 · Cited by 137 · see citing works

A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene

Ho, C., Houart, C., Wilson, S. W., & Stainier, D. Y. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80485-0 · Cited by 135 · see citing works

Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish

Hagos, E. G., & Dougan, S. T. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-22 · Cited by 132 · see citing works

A genetic regulatory network for Xenopus mesendoderm formation

Loose, M., & Patient, R. K. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.04.014 · Cited by 132 · see citing works

The roles of three signaling pathways in the formation and function of the Spemann Organizer

Xanthos, J. B., Kofron, M. J., Tao, Q., Schaible, K., Wylie, C. C., & Heasman, J. (2002) · Development · doi:10.1242/dev.129.17.4027 · Cited by 131 · see citing works

Chemokine Signaling Controls Endodermal Migration During Zebrafish Gastrulation

Nair, S., & Schilling, T. F. (2008) · Science · doi:10.1126/science.1160038 · Cited by 127 · see citing works

The Xenopus tadpole gut: fate maps and morphogenetic movements

Chalmers, A. D., & Slack, J. M. W. (2000) · Development · doi:10.1242/dev.127.2.381 · Cited by 127 · see citing works

A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone

Lemaire, P., Darras, S., Caillol, D. H., & Kodjabachian, L. (1998) · Development · doi:10.1242/dev.125.13.2371 · Cited by 126 · see citing works

TGF-β signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosisPreprint

Ogata, S., Morokuma, J., Hayata, T., Kolle, G., Niehrs, C., Ueno, N., & Cho, K. W. Y. (2007) · Genes & Development · doi:10.1101/gad.1541807 · Cited by 124 · see citing works

Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos

Gregorieff, A., Grosschedl, R., & Clevers, H. C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600191 · Cited by 123 · see citing works

Retinoic Acid Signaling Organizes Endodermal Organ Specification along the Entire Antero-Posterior Axis

Bayha, E., Jørgensen, M. C., Serup, P., & Grapin‐Botton, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005845 · Cited by 121 · see citing works

Haploinsufficiency of the Mouse Forkhead Box f1 Gene Causes Defects in Gall Bladder Development

Kalinichenko, V. V., Zhou, Y., Bhattacharyya, D., Kim, W., Shin, B., Bambal, K., & Costa, R. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112162200 · Cited by 117 · see citing works

The POU Domain Protein Spg (Pou2/Oct4) Is Essential for Endoderm Formation in Cooperation with the HMG Domain Protein Casanova

Reim, G., Mizoguchi, T., Stainier, D. Y. R., Kikuchi, Y., & Brand, M. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00396-4 · Cited by 117 · see citing works

Vegfc is required for vascular development and endoderm morphogenesis in zebrafish

Ober, E. A., Olofsson, B., Mäkinen, T., Jin, S., Shoji, W., Koh, G. Y., Alitalo, K. K., & Stainier, D. Y. R. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400047 · Cited by 113 · see citing works

Activin/Nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1

Osada, S., Saijoh, Y., Frisch, A., Yeo, C., Adachi, H., Watanabe, M., Whitman, M., Hamada, H., & Wright, C. V. E. (2000) · Development · doi:10.1242/dev.127.11.2503 · Cited by 113 · see citing works

MicroRNA Expression Patterns and Function in Endodermal Differentiation of Human Embryonic Stem Cells

Tzur, G., Levy, A., Meiri, E., Barad, O., Spector, Y., Bentwich, Z., Mizrahi, L., Katzenellenbogen, M., Ben-Shushan, E., Reubinoff, B. E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003726 · Cited by 110 · see citing works

Axis specification and morphogenesis in the mouse embryo require<i>Nap1</i>, a regulator of WAVE-mediated actin branching

Rakeman, A. S., & Anderson, K. V. (2006) · Development · doi:10.1242/dev.02473 · Cited by 107 · see citing works

The mammalian twisted gastrulation gene functions in foregut and craniofacial development

Petryk, A., Anderson, R. M., Jarcho, M. P., Leaf, I. A., Carlson, C. S., Klingensmith, J., Shawlot, W., & O’Connor, M. B. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.11.015 · Cited by 104 · see citing works

Cdx4 is a direct target of the canonical Wnt pathway

Pilon, N., Oh, K., Sylvestre, J.-R., Bouchard, N., Savory, J. G. A., & Lohnes, D. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.005 · Cited by 104 · see citing works

Molecular integration ofcasanovain the Nodal signalling pathway controlling endoderm formation

Aoki, T. O., David, N. B., Minchiotti, G., Saint-Etienne, L., Dickmeis, T., Persico, G. M., Strähle, U., Mourrain, P., & Rosa, F. (2002) · Development · doi:10.1242/dev.129.2.275 · Cited by 101 · see citing works

Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1

Ivins, S. M., van Bueren, K. L., Roberts, C., James, C. T., Lindsay, E., Baldini, A., Ataliotis, P., & Scambler, P. J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.06.026 · Cited by 97 · see citing works

The location of the pregut endoderm in the chick embryo at the primitive streak stage as determined by radioautographic mapping

Rosenquist, G. C. (1971) · Developmental Biology · doi:10.1016/0012-1606(71)90131-x · Cited by 97 · see citing works

Liver Development

Zorn (2008) · StemBook · doi:10.3824/stembook.1.25.1 · Cited by 96 · see citing works

Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling

Poulain, M., Fürthauer, M., Thisse, B., Thisse, C., & Lepage, T. (2006) · Development · doi:10.1242/dev.02387 · Cited by 96 · see citing works

Regulation of the early expression of the Xenopus nodal-related 1 gene, Xnr1

Hyde, C. E., & Old, R. W. (2000) · Development · doi:10.1242/dev.127.6.1221 · Cited by 96 · see citing works

Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation

Tam, P. P. L., Khoo, P.-L., Lewis, S. L., Bildsoe, H., Wong, N., Tsang, T. E., Gad, J. M., & Robb, L. (2007) · Development · doi:10.1242/dev.02724 · Cited by 94 · see citing works

Fate and plasticity of the endoderm in the early chick embryo

Kimura, W., Yasugi, S., Stern, C. D., & Fukuda, K. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.09.009 · Cited by 90 · see citing works

Region‐specific gastrointestinal Hox code during murine embryonal gut development

Kawazoe, Y., Sekimoto, T., Araki, M., Takagi, K., Araki, K., & Yamamura, K. (2002) · Development Growth & Differentiation · doi:10.1046/j.1440-169x.2002.00623.x · Cited by 90 · see citing works

Evolution of the mechanisms and molecular control of endoderm formation

Grapin‐Botton, A., & Constam, D. B. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.01.001 · Cited by 89 · see citing works

Eomesodermin Is a Localized Maternal Determinant Required for Endoderm Induction in Zebrafish

Bjornson, C. R. R., Griffin, K. J. P., Farr, G. H., Terashima, A., Himeda, C. L., Kikuchi, Y., & Kimelman, D. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.08.010 · Cited by 88 · see citing works

Multiple Regulatory Regions Control the Complex Expression Pattern of the Mouse Cdx2 Homeobox Gene

Benahmed, F., Groß, I., Gaunt, S. J., Beck, F., Jehan, F., Domon–Dell, C., Martin, E., Kédinger, M., Freund, J., & Duluc, I. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.045 · Cited by 87 · see citing works

Hepatic induction in the avian embryo: Specificity of reactive endoderm and inductive mesoderm

Fukuda-Taira, S. (1981) · Development · doi:10.1242/dev.63.1.111 · Cited by 87 · see citing works

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives

Tamplin, O. J., Kinzel, D., Cox, B., Bell, C., Rossant, J., & Lickert, H. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-511 · Cited by 85 · see citing works

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Grapin‐Botton, A. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041946ag · Cited by 85 · see citing works

Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue

Shimizu, T., Bae, Y., & Hibi, M. (2006) · Development · doi:10.1242/dev.02660 · Cited by 84 · see citing works

Suckling defect in mice lacking the soluble haemopoietin receptor NR6

Alexander, W. S., Rakar, S., Robb, L., Farley, A., Willson, T. A., Zhang, J., Hartley, L., Kikuchi, Y., Kojima, T., Nomura, H., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80266-8 · Cited by 84 · see citing works

Role of the Homeodomain Transcription Factor Bapx1 in Mouse Distal Stomach Development

Verzi, M. P., Stanfel, M. N., Moses, K. A., Kim, B., Zhang, Y., Schwartz, R. J., Shivdasani, R. A., & Zimmer, W. E. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.009 · Cited by 83 · see citing works

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo

Lee, J. D., Silva-Gagliardi, N. F., Tepaß, U., McGlade, C. J., & Anderson, K. V. (2007) · Development · doi:10.1242/dev.000885 · Cited by 82 · see citing works

Endoderm Specification and Differentiation in Xenopus Embryos

Horb, M. E., & Slack, J. M. W. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0347 · Cited by 78 · see citing works

Vegetal pole cells and commitment to form endoderm in Xenopus laevis

Wylie, C. C., Snape, A. M., Heasman, J., & Smith, J. C. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90052-2 · Cited by 78 · see citing works

Epiblast and primitive-streak origins of the endoderm in the gastrulating chick embryo

Lawson, A., & Schoenwolf, G. C. (2003) · Development · doi:10.1242/dev.00579 · Cited by 77 · see citing works

Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo

Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., & Tam, P. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.04.001 · Cited by 77 · see citing works

Bone morphogenetic protein signaling pathway plays multiple roles during gastrointestinal tract development

Barbara, P. D. S., Williams, J., Goldstein, A. M., Doyle, A. M., Nielsen, C. M., Winfield, S., Faure, S., & Roberts, D. J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20554 · Cited by 77 · see citing works

Live Analysis of Endodermal Layer Formation Identifies Random Walk as a Novel Gastrulation Movement

Pézeron, G., Mourrain, P., Courty, S., Ghislain, J. J., Becker, T. S., Rosa, F., & David, N. B. (2008) · Current Biology · doi:10.1016/j.cub.2008.01.028 · Cited by 76 · see citing works

SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals

Moniot, B., Biau, S., Faure, S., Nielsen, C. M., Berta, P., Roberts, D. J., & Barbara, P. D. S. (2004) · Development · doi:10.1242/dev.01259 · Cited by 73 · see citing works

Hox gene function in vertebrate gut morphogenesis: the case of the caecum

Zacchetti, G., Duboule, D., & Zákány, J. (2007) · Development · doi:10.1242/dev.010991 · Cited by 72 · see citing works

Global analysis of the transcriptional network controlling <i>Xenopus</i> endoderm formation

Sinner, D., Kirilenko, P., Rankin, S., Wei, E., Howard, L., Kofron, M., Heasman, J., Woodland, H. R., & Zorn, A. M. (2006) · Development · doi:10.1242/dev.02358 · Cited by 71 · see citing works

Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function

Tam, P., Khoo, P., Wong, N., Tsang, T. E., & Behringer, R. R. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.07.005 · Cited by 71 · see citing works

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiationPreprint

Egea, J., Erlacher, C., Montañez, E., Burtscher, I., Yamagishi, S., Hess, M., Hampel, F., Sanchez, R., Rodriguez-Manzaneque, M., Bösl, M., et al. (2008) · Genes & Development · doi:10.1101/gad.486708 · Cited by 68 · see citing works

Developmental gene regulatory networks in the zebrafish embryo

Chan, T.-M., Longabaugh, W. J. R., Bolouri, H., Chen, H., Tseng, W.-F., Chao, C.-H., Jang, T., Lin, Y.-I., Hung, S.-C., Wang, H., et al. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.09.005 · Cited by 66 · see citing works

Intestinal morphogenesis

Rubin, D. C. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280145082 · Cited by 66 · see citing works

Integration of multiple signal transducing pathways on Fgf response elements of the Xenopus caudal homologue Xcad3

Haremaki, T., Tanaka, Y., Hongo, I., Yuge, M., & Okamoto, H. (2003) · Development · doi:10.1242/dev.00718 · Cited by 65 · see citing works

Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells

Spence, J. R., & Wells, J. M. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21366 · Cited by 64 · see citing works

Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3

Maretto, S., Müller, P.-S., Aricescu, A. R., Cho, K. W. Y., Bikoff, E. K., & Robertson, E. J. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.021 · Cited by 60 · see citing works

INHIBITION OF TGF BETA SIGNALING BY ENDOGENOUS RETINOIC ACID IS ESSENTIAL FOR PRIMARY LUNG BUD INDUCTION

Cardoso, W. V., Desai, T., Qian, J., Niederreither, K., Lü, J., & Chen, F. F. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a199-b · Cited by 59 · see citing works

Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafish

Xiang, F., Hagos, E. G., Xu, B., Sias, C. M., Kawakami, K., Burdine, R. D., & Dougan, S. T. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.008 · Cited by 57 · see citing works

Refinement of gene expression patterns in the early Xenopus embryo

Wardle, F. C., & Smith, J. C. (2004) · Development · doi:10.1242/dev.01340 · Cited by 50 · see citing works

Cdx4 is required in the endoderm to localize the pancreas and limitβ-cell number

Kinkel, M. D., Eames, S. C., Alonzo, M. R., & Prince, V. (2008) · Development · doi:10.1242/dev.010660 · Cited by 50 · see citing works

Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish

Mizoguchi, T., Izawa, T., Kuroiwa, A., & Kikuchi, Y. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.073 · Cited by 50 · see citing works

Deconstructing the pharyngeal metamere

Graham, A. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21182 · Cited by 48 · see citing works

Synthèse du glycogène dans les hépatocytes en voie de différenciation: rôle des mésenchymes homologue et hétérologues

Douarin, N. M. L. (1968) · Developmental Biology · doi:10.1016/0012-1606(68)90092-4 · Cited by 48 · see citing works

Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo

García‐García, M. J., Shibata, M., & Anderson, K. V. (2008) · Development · doi:10.1242/dev.022897 · Cited by 45 · see citing works

The role ofMixerin patterning the earlyXenopusembryo

Kofron, M. J., Wylie, C., & Heasman, J. (2004) · Development · doi:10.1242/dev.01132 · Cited by 43 · see citing works

Bmp signaling is necessary and sufficient for ventrolateral endoderm specification in Xenopus

Wills, A. E., Dickinson, K., Khokha, M. K., & Baker, J. C. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21631 · Cited by 41 · see citing works

SDF-1α regulates mesendodermal cell migration during frog gastrulation

Fukui, A., Goto, T., Kitamoto, J., Homma, M., & Asashima, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.007 · Cited by 39 · see citing works

Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification

Brown, J. L., Snir, M., Noushmehr, H., Kirby, M., Hong, S., ELKAHLOUN, A. G., & Feldman, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805589105 · Cited by 38 · see citing works

VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula

Hilton, E. N., Rex, M., & Old, R. W. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.08.004 · Cited by 36 · see citing works

Cdx2 initiates histodifferentiation of the midgut endoderm

Stringer, E. J., Pritchard, C. A., & Beck, F. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.024 · Cited by 28 · see citing works

Molecular analysis of endoderm regionalization

Yasugi, S., & Mizuno, T. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.00984.x · Cited by 26 · see citing works

Control of gastrula cell motility by the Goosecoid/Mix.1/ Siamois network: Basic patterns and paradoxical effects

Luu, O., Nagel, M., Wacker, S., Lemaire, P., & Winklbauer, R. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21522 · Cited by 24 · see citing works

Regional specification of the endoderm in the early chick embryo

Kimura, W., Yasugi, S., & Fukuda, K. (2007) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2007.00933.x · Cited by 22 · see citing works

A role for GATA factors in Xenopus gastrulation movements

Fletcher, G., Jones, G. E., Patient, R. K., & Snape, A. M. (2006) · Mechanisms of Development · doi:10.1016/j.mod.2006.07.007 · Cited by 22 · see citing works

Genomic profiling of Mixer and Sox17β targets during Xenopus endoderm development

Dickinson, K., Leonard, J., & Baker, J. C. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20636 · Cited by 17 · see citing works

Integrated genomic characterization of pancreatic ductal adenocarcinoma

Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019 · see citing works

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K. A., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,911 · see citing works

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

Sarkar, A., & Hochedlinger, K. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.007 · Cited by 915 · see citing works

Contextual determinants of TGFβ action in development, immunity and cancer

David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851 · see citing works

An in vivo model of human small intestine using pluripotent stem cells

Watson, C. L., Mahé, M. M., Múnera, J. O., Howell, J. C., Sundaram, N., Poling, H. M., Schweitzer, J. I., Vallance, J. E., Mayhew, C. N., Sun, Y., et al. (2014) · Nature Medicine · doi:10.1038/nm.3737 · Cited by 561 · see citing works

Modeling mouse and human development using organoid cultures

Huch, M., & Koo, B. (2015) · Development · doi:10.1242/dev.118570 · Cited by 543 · see citing works

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

Ouchi, R., Togo, S., Kimura, M., Shinozawa, T., Koido, M., Koike, H., Thompson, W., Karns, R. A., Mayhew, C. N., McGrath, P. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.007 · Cited by 537 · see citing works

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Chu, L.-F., Leng, N., Zhang, J., Hou, Z., Mamott, D., Vereide, D. T., Choi, J., Kendziorski, C., Stewart, R., & Thomson, J. A. (2016) · Genome Biology · doi:10.1186/s13059-016-1033-x · Cited by 477 · see citing works

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

Wong, A. P., Bear, C. E., Chin, S., Pasceri, P., Thompson, T., Huan, L., Ratjen, F. A., Ellis, J., & Rossant, J. (2012) · Nature Biotechnology · doi:10.1038/nbt.2328 · Cited by 422 · see citing works

Generation of lung organoids from human pluripotent stem cells in vitro

Miller, A. J., Dye, B. R., Ferrer-Torres, D., Hill, D. R., Overeem, A. W., Shea, L. D., & Spence, J. R. (2019) · Nature Protocols · doi:10.1038/s41596-018-0104-8 · Cited by 418 · see citing works

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations

Loh, K. M., Ang, L. T., Zhang, J., Kumar, V., Ang, J., Auyeong, J. Q., Lee, K. L., Choo, S. H., Lim, C. Y. Y., Nichane, M., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.007 · Cited by 418 · see citing works

Organoids by design

Takebe, T., & Wells, J. M. (2019) · Science · doi:10.1126/science.aaw7567 · Cited by 417 · see citing works

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

Wang, Y., Song, W., Wang, J., Wang, T., Xiong, X., Qi, Z., Fu, W., Yang, X., & Chen, Y.-G. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191130 · Cited by 399 · see citing works

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

Fordham, R. P., Yui, S., Hannan, N. R. F., Soendergaard, C., Madgwick, A., Schweiger, P. J., Nielsen, O. H., Vallier, L., Pedersen, R. A., Nakamura, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.015 · Cited by 397 · see citing works

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

Fang, Y., Chen, H., Wang, C., & Liang, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2974 · Cited by 390 · see citing works

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

Green, M. D., Chen, A. F., Nostro, M. C., D’Souza, S. L., Schaniel, C., Lemischka, I. R., Gouon–Evans, V., Keller, G. M., & Snoeck, H. W. (2011) · Nature Biotechnology · doi:10.1038/nbt.1788 · Cited by 386 · see citing works

Intestinal development and differentiation

Noah, T. K., Donahue, B., & Shroyer, N. F. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.09.006 · Cited by 384 · see citing works

The emergent landscape of the mouse gut endoderm at single-cell resolution

Nowotschin, S., Setty, M., Kuo, Y.-Y., Liu, V., Garg, V., Sharma, R., Simon, C. S., Saiz, N., Gardner, R., Boutet, S. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1127-1 · Cited by 383 · see citing works

Disease modelling in human organoids

Lancaster, M. A., & Huch, M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039347 · Cited by 379 · see citing works

Orchestrating liver development

Gordillo, M., Evans, T., & Gouon-Evans, V. (2015) · Development · doi:10.1242/dev.114215 · Cited by 375 · see citing works

Organoids — Preclinical Models of Human Disease

Li, M., & Belmonte, J. C. I. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1806175 · Cited by 360 · see citing works

Generation of functional thyroid from embryonic stem cells

Antonica, F., Kasprzyk, D. F., Opitz, R., Iacovino, M., Liao, X.-H., Dumitrescu, A. M., Refetoff, S., Peremans, K., Manto, M., Kyba, M., et al. (2012) · Nature · doi:10.1038/nature11525 · Cited by 359 · see citing works

Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish

McCauley, H. A., & Wells, J. M. (2017) · Development · doi:10.1242/dev.140731 · Cited by 322 · see citing works

Pancreas Organogenesis: From Lineage Determination to Morphogenesis

Shih, H.-P., Wang, A., & Sander, M. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122405 · Cited by 315 · see citing works

Self-organization of a human organizer by combined Wnt and Nodal signalling

Martyn, I., Kanno, T. Y. N., Ruzo, A., Siggia, E. D., & Brivanlou, A. H. (2018) · Nature · doi:10.1038/s41586-018-0150-y · Cited by 301 · see citing works

Mechanisms of thymus organogenesis and morphogenesis

Gordon, J., & Manley, N. R. (2011) · Development · doi:10.1242/dev.059998 · Cited by 294 · see citing works

A Poised Chromatin Platform for TGF-β Access to Master Regulators

Xi, Q., Wang, Z., Zaromytidou, A.-I., Zhang, X. H.-F., Chow-Tsang, L.-F., Liu, J. X., Kim, H., Barlas, A., Manova-Todorova, K. O., Kaartinen, V., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.032 · Cited by 287 · see citing works

Enhancing the precision of genetic lineage tracing using dual recombinases

He, L., Li, Y., Li, Y., Pu, W., Huang, X., Tian, X., Wang, Y., Zhang, H., Liu, Q., Zhang, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4437 · Cited by 273 · see citing works

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling

Múnera, J. O., Sundaram, N., Rankin, S. A., Hill, D. R., Watson, C. L., Mahé, M. M., Vallance, J. E., Shroyer, N. F., Sinagoga, K. L., Zarzoso-Lacoste, A., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.05.020 · Cited by 252 · see citing works

Organoid Models of Human Gastrointestinal Development and Disease

Dedhia, P. H., Bertaux‐Skeirik, N., Zavros, Y. L., & Spence, J. R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.042 · Cited by 246 · see citing works

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

He, S., Wang, L.-H., Liu, Y., Li, Y., Chen, H.-T., Xu, J.-H., Peng, W., Lin, G.-W., Wei, P.-P., Li, B., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02210-0 · Cited by 234 · see citing works

Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells

Hawkins, F. J., Krämer, P., Jacob, A., Driver, I. H., Thomas, D. C., McCauley, K. B., Skvir, N. J., Crane, A. M., Kurmann, A. A., Hollenberg, A. N., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89950 · Cited by 232 · see citing works

Wnt/β-catenin promotes gastric fundus specification in mice and humans

McCracken, K. W., Aihara, E., Martin, B., Crawford, C. M., Broda, T. R., Tréguier, J., Zhang, X., Shannon, J. M., Montrose, M. H., & Wells, J. M. (2017) · Nature · doi:10.1038/nature21021 · Cited by 222 · see citing works

Morphogenesis and maturation of the embryonic and postnatal intestine

Chin, A. M., Hill, D. R., Aurora, M., & Spence, J. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.011 · Cited by 222 · see citing works

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

Ang, L. T., Tan, A. K. Y., Autio, M. I., Goh, S. H., Choo, S. H., Lee, K. L., Tan, J., Pan, B., Lee, J. J. H., Lum, J. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.087 · Cited by 220 · see citing works

Bioengineering Approaches for the Advanced Organoid Research

Yi, S. A., Zhang, Y., Rathnam, C., Pongkulapa, T., & Lee, K. (2021) · Advanced Materials · doi:10.1002/adma.202007949 · Cited by 218 · see citing works

Vertebrate intestinal endoderm development

Spence, J. R., Lauf, R., & Shroyer, N. F. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22540 · Cited by 217 · see citing works

Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

Gao, S., Yan, L., Wang, R., Li, J., Yong, J., Zhou, X., Wei, Y., Wu, X., Wang, X., Fan, X., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0105-4 · Cited by 208 · see citing works

Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells

Cheng, X., Ying, L., Lü, L., Galvão, A. M., Mills, J. A., Lin, H. C., Kotton, D. N., Shen, S. S., Nostro, M. C., Choi, J. K., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.024 · Cited by 205 · see citing works

Building and Regenerating the Lung Cell by Cell

Whitsett, J. A., Kalin, T. V., Xu, Y. J., & Kalinichenko, V. V. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2018 · Cited by 202 · see citing works

Gut‐liver axis at the frontier of host‐microbial interactions

Brandl, K., Kumar, V., & Eckmann, L. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00361.2016 · Cited by 201 · see citing works

Human airway organoid engineering as a step toward lung regeneration and disease modeling

Tan, Q., Choi, K. M., Sicard, D., & Tschumperlin, D. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.046 · Cited by 191 · see citing works

Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

Han, L., Chaturvedi, P., Kishimoto, K., Koike, H., Nasr, T., Iwasawa, K., Giesbrecht, K., Witcher, P. C., Eicher, A. K., Haines, L. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17968-x · Cited by 178 · see citing works

Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review

Rinaldi, L., Pafundi, P. C., Galiero, R., Caturano, A., Morone, M. V., Silvestri, C., Giordano, M., Salvatore, T., & Sasso, F. C. (2021) · Antioxidants · doi:10.3390/antiox10020270 · Cited by 178 · see citing works

‘Human-on-a-chip’ Developments: A Translational Cutting-edge Alternative to Systemic Safety Assessment and Efficiency Evaluation of Substances in Laboratory Animals and Man?

Marx, U., Walles, H., Hoffmann, S., Lindner, G., Horland, R., Sonntag, F., Klotzbach, U., Sakharov, D. A., Tonevitsky, A., & Lauster, R. (2012) · Alternatives to Laboratory Animals · doi:10.1177/026119291204000504 · Cited by 174 · see citing works

How to make an intestine

Wells, J. M., & Spence, J. R. (2014) · Development · doi:10.1242/dev.097386 · Cited by 174 · see citing works

Generation of Functional Thymic Epithelium from Human Embryonic Stem Cells that Supports Host T Cell Development

Parent, A. V., Russ, H. A., Khan, I. S., LaFlam, T. N., Metzger, T. C., Anderson, M. S., & Hebrok, M. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.004 · Cited by 173 · see citing works

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

Wells, J. M., & Watt, F. M. (2018) · Nature · doi:10.1038/s41586-018-0073-7 · Cited by 169 · see citing works

Cellular and molecular mechanisms coordinating pancreas development

Bastidas-Ponce, A., Scheibner, K., Lickert, H., & Bakhti, M. (2017) · Development · doi:10.1242/dev.140756 · Cited by 166 · see citing works

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

Xu, X., Browning, V. L., & Odorico, J. S. (2011) · Mechanisms of Development · doi:10.1016/j.mod.2011.08.001 · Cited by 157 · see citing works

Anatomy and Physiology of the Small Bowel

Volk, N. R., & Lacy, B. E. (2016) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2016.08.001 · Cited by 157 · see citing works

The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression

Jiang, W., Liu, Y., Liu, R., Zhang, K., & Zhang, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.008 · Cited by 153 · see citing works

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification

Trisno, S. L., Philo, K. E. D., McCracken, K. W., Catá, E. M., Ruiz-Torres, S., Rankin, S. A., Han, L., Nasr, T., Chaturvedi, P., Rothenberg, M. E., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.008 · Cited by 152 · see citing works

SOX17 links gut endoderm morphogenesis and germ layer segregation

Viotti, M., Nowotschin, S., & Hadjantonakis, A.-K. (2014) · Nature Cell Biology · doi:10.1038/ncb3070 · Cited by 150 · see citing works

Generation of intestinal surface: an absorbing tale

Walton, K. D., Freddo, A. M., Wang, S., & Gumucio, D. L. (2016) · Development · doi:10.1242/dev.135400 · Cited by 147 · see citing works

The molecular and morphogenetic basis of pancreas organogenesis

Larsen, H. L., & Grapin‐Botton, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.005 · Cited by 146 · see citing works

Gut–Liver Axis Derangement in Non-Alcoholic Fatty Liver Disease

Poeta, M., Pierri, L., & Vajro, P. (2017) · Children · doi:10.3390/children4080066 · Cited by 145 · see citing works

Charting human development using a multi-endodermal organ atlas and organoid models

Yu, Q., Kilik, U., Holloway, E. M., Tsai, Y.-H., Harmel, C., Wu, A., Wu, J. H., Czerwinski, M. J., Childs, C. J., He, Z., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.028 · Cited by 145 · see citing works

EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development

Lu, H., Ma, J., Yang, Y., Shi, W., & Luo, L. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.021 · Cited by 142 · see citing works

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

Jiang, W., Wang, J., & Zhang, Y. (2012) · Cell Research · doi:10.1038/cr.2012.119 · Cited by 141 · see citing works

Gut-like ectodermal tissue in a sea anemone challenges germ layer homology

Steinmetz, P. R. H., Aman, A. J., Kraus, J. E. M., & Technau, U. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0285-5 · Cited by 135 · see citing works

An RNAi Screen Reveals Intestinal Regulators of Branching Morphogenesis, Differentiation, and Stem Cell Proliferation in Planarians

Forsthoefel, D. J., James, N., Escobar, D., Stary, J. M., Vieira, A. P., Waters, F. A., & Newmark, P. A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.008 · Cited by 133 · see citing works

Directed Differentiation of Human Embryonic Stem Cells into Thymic Epithelial Progenitor-like Cells Reconstitutes the Thymic Microenvironment In Vivo

Sun, X., Xu, J., Lu, H., Liu, W., Miao, Z., Sui, X. Y., Liu, H., Li, S., Du, W., He, Q., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.014 · Cited by 133 · see citing works

Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis

Grosse, A. S., Pressprich, M. F., Curley, L. B., Hamilton, K. L., Margolis, B. L., Hildebrand, J. D., & Gumucio, D. L. (2011) · Development · doi:10.1242/dev.065789 · Cited by 131 · see citing works

Wnt and FGF mediated epithelial‐mesenchymal crosstalk during lung development

Volckaert, T., & Langhe, S. D. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24234 · Cited by 130 · see citing works

Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix

Gilpin, S. E., Ren, X., Okamoto, T., Guyette, J. P., Mou, H., Rajagopal, J., Mathisen, D. J., Vacanti, J. P., & Ott, H. C. (2014) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2014.05.080 · Cited by 130 · see citing works

Organoid-based modeling of intestinal development, regeneration, and repair

Sprangers, J., Zaalberg, I. C., & Maurice, M. M. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00665-z · Cited by 129 · see citing works

Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease

Gkatzis, K., Taghizadeh, S., Huh, D., Stainier, D. Y. R., & Bellusci, S. (2018) · European Respiratory Journal · doi:10.1183/13993003.00876-2018 · Cited by 128 · see citing works

The Dynamics of Morphogenesis in the Early Mouse EmbryoPreprint

Rivera‐Pérez, J. A., & Hadjantonakis, A. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015867 · Cited by 127 · see citing works

Cdx2 regulates patterning of the intestinal epithelium

Grainger, S. J., Savory, J. G. A., & Lohnes, D. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.025 · Cited by 125 · see citing works

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

Li, Q. V., Dixon, G., Verma, N., Rosen, B. P., Gordillo, M., Luo, R., Xu, C., Wang, Q., Soh, C.-L., Yang, D., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0408-9 · Cited by 124 · see citing works

The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

Günther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168870 · Cited by 123 · see citing works

Stomach Organ and Cell Lineage Differentiation: From Embryogenesis to Adult Homeostasis

Willet, S. G., & Mills, J. C. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.006 · Cited by 123 · see citing works

A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification

Rankin, S. A., Han, L., McCracken, K. W., Kenny, A. P., Anglin, C. T., Grigg, E., Crawford, C. M., Wells, J. M., Shannon, J. M., & Zorn, A. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.060 · Cited by 116 · see citing works

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

Mahaddalkar, P. U., Scheibner, K., Pfluger, S., Ansarullah, Sterr, M., Beckenbauer, J., Irmler, M., Beckers, J., Knöbel, S., & Lickert, H. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0492-5 · Cited by 115 · see citing works

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells

Drukker, M., Tang, C. Z., Ardehali, R., Rinkevich, Y., Seita, J., Lee, A. S., Mosley, A. R., Weissman, I. L., & Soen, Y. (2012) · Nature Biotechnology · doi:10.1038/nbt.2239 · Cited by 114 · see citing works

Epithelial origin of eosinophilic esophagitis

Rochman, M., Azouz, N. P., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.008 · Cited by 111 · see citing works

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

Mithal, A., Capilla, A., Heinze, D. M., Berical, A. C., Villacorta-Martín, C., Vedaie, M., Jacob, A., Abo, K. M., Szymaniak, A. D., Peasley, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13916-6 · Cited by 111 · see citing works

Generation of stomach tissue from mouse embryonic stem cells

Noguchi, T.-A. K., Ninomiya, N., Sekine, M., Komazaki, S., Wang, P., Asashima, M., & Kurisaki, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3200 · Cited by 108 · see citing works

Mechanically induced development and maturation of human intestinal organoids in vivo

Poling, H. M., Wu, D. X.-Y., Brown, N. E., Baker, M. L., Hausfeld, T. A., Huynh, N., Chaffron, S., Dunn, J., Hogan, S. P., Wells, J. M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0243-9 · Cited by 107 · see citing works

Organoids as a model system for studying human lung development and disease

Nadkarni, R. R., Abed, S., & Draper, J. S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.091 · Cited by 106 · see citing works

SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity

Taylor, C. A., Hutchens, S., Liu, C., Jursa, T., Shawlot, W., Aschner, M., Smith, D. R., & Mukhopadhyay, S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005628 · Cited by 106 · see citing works

Concise Review: The Relevance of Human Stem Cell-Derived Organoid Models for Epithelial Translational Medicine

Hynds, R. E., & Giangreco, A. (2012) · Stem Cells · doi:10.1002/stem.1290 · Cited by 105 · see citing works

Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2

Brade, T., Kumar, S., Cunningham, T. J., Chatzi, C. A., Zhao, X., Cavallero, S., Li, P., Sucov, H. M., Ruiz‐Lozano, P., & Duester, G. (2010) · Development · doi:10.1242/dev.054239 · Cited by 103 · see citing works

Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans

Shojaie, S., Ermini, L., Ackerley, C., Wang, J., Chin, S., Yeganeh, B., Bilodeau, M., Sambi, M., Rogers, I., Rossant, J., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.01.004 · Cited by 102 · see citing works

Role of Intestinal HIF-2α in Health and Disease

Ramakrishnan, S. K., & Shah, Y. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105202 · Cited by 98 · see citing works

The promise of stem cell-derived islet replacement therapy

Melton, D. (2021) · Diabetologia · doi:10.1007/s00125-020-05367-2 · Cited by 96 · see citing works

Modelling the endocrine pancreas in health and disease

Bakhti, M., Böttcher, A., & Lickert, H. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0132-z · Cited by 96 · see citing works

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Miao, Y., Pek, N. M. Q., Tan, C. P. B., Jiang, C., Yu, Z., Iwasawa, K., Shi, M. Y., Kechele, D. O., Sundaram, N., Pastrana-Gomez, V., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.041 · Cited by 95 · see citing works

The endoderm: a divergent cell lineage with many commonalities

Nowotschin, S., Hadjantonakis, A.-K., & Campbell, K. (2019) · Development · doi:10.1242/dev.150920 · Cited by 94 · see citing works

Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes

Touboul, T., Chen, S., To, C. C., Mora-Castilla, S., Sabatini, K., Tukey, R. H., & Laurent, L. C. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.028 · Cited by 94 · see citing works

Generating human intestinal tissues from pluripotent stem cells to study development and disease

Sinagoga, K. L., & Wells, J. M. (2015) · The EMBO Journal · doi:10.15252/embj.201490686 · Cited by 93 · see citing works

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interfacePreprint

Schmitt, B. M., Rudolph, K. L. M., Karagianni, P., Fonseca, N. A., White, R. J., Talianidis, I., Odom, D. T., Marioni, J. C., & Kutter, C. (2014) · Genome Research · doi:10.1101/gr.176784.114 · Cited by 93 · see citing works

Epithelial cell plasticity drives endoderm formation during gastrulation

Scheibner, K., Schirge, S., Burtscher, I., Büttner, M., Sterr, M., Yang, D., Böttcher, A., Ansarullah, M., Irmler, M., Beckers, J., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00694-x · Cited by 92 · see citing works

Minireview: Intrinsic and Extrinsic Factors in Thyroid Gland Development: An Update

Felice, M. D., & Lauro, R. D. (2011) · Endocrinology · doi:10.1210/en.2011-0204 · Cited by 91 · see citing works

Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development

Genga, R. M. J., Kernfeld, E. M., Parsi, K. M., Parsons, T. J., Ziller, M. J., & Maehr, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.076 · Cited by 91 · see citing works

The endocrine pancreas: insights into development, differentiation, and diabetes

Mastracci, T. L., & Sussel, L. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.44 · Cited by 91 · see citing works

Morphogenetics of early thyroid development

Fagman, H., & Nilsson, M. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0084 · Cited by 90 · see citing works

Synthesis of digestive enzymes, food processing, and nutrient absorption in decapod crustaceans: a comparison to the mammalian model of digestion

Vogt, G. (2021) · Zoology · doi:10.1016/j.zool.2021.125945 · Cited by 90 · see citing works

The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform

Hussey, G. S., Keane, T. J., & Badylak, S. F. (2017) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2017.76 · Cited by 88 · see citing works

Vertebrate endoderm development

Weatherbee, B. A. T., Rankin, S. A., & Zorn, A. M. (2026) · Development · doi:10.1242/dev.205164

Endoderm development: from patterning to organogenesis

Grapin‐Botton, A., & Melton, D. A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01957-5 · Cited by 279 · see citing works

Understanding endoderm development: More than just a series of tubes

Murtaugh, L. C., & Wells, J. M. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22587 · Cited by 1 · see citing works

At new heights – endodermal lineages in development and disease

Ober, E. A., & Grapin‐Botton, A. (2015) · Development · doi:10.1242/dev.121095 · Cited by 2 · see citing works

Blackwell Publishing, Ltd.Review Endoderm development in vertebrates: fate mapping, induction and regional specification

Fukuda, K., & Kikuchi, Y. (2015)