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Pyramidal cell regulation of interneuron survival sculpts cortical networks
Open accessAbstract
Complex neuronal circuitries such as those found in the mammalian cerebral cortex have evolved as balanced networks of excitatory and inhibitory neurons. Although the establishment of appropriate numbers of these cells is essential for brain function and behaviour, our understanding of this fundamental process is limited. Here we show that the survival of interneurons in mice depends on the activity of pyramidal cells in a critical window of postnatal development, during which excitatory synaptic input to individual interneurons predicts their survival or death. Pyramidal cells regulate interneuron survival through the negative modulation of PTEN signalling, which effectively drives interneuron cell death during this period. Our findings indicate that activity-dependent mechanisms dynamically adjust the number of inhibitory cells in nascent local cortical circuits, ultimately establishing the appropriate proportions of excitatory and inhibitory neurons in the cerebral cortex.
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“Moreover, preventing programmed cell death in pyramidal cells by genetically ablating the proapoptotic Bcl-2 family members Bax and Bak (Lindsten et al., 2000) from these cells is sufficient to abolish the programmed cell death of cortical interneurons (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“Consistent with this idea, increasing or decreasing the excitability of pyramidal cells using DREADDs during the period of interneuron programmed cell death respectively enhances or diminishes the survival of cortical interneurons (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“First, long-term Ca2+ imaging experiments in vivo indicate that activity levels at the onset of the cell death period predict the fate of interneurons (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“This process seems to impact all classes of interneurons (Denaxa et al., 2018; Priya et al., 2018; Wong et al., 2018) (Figure 6A).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“This is consistent with the observation that interneuron cell death occurs progressively in vivo, with early-born infragranular layer interneurons disappearing before late-born supragranular layer interneurons (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“In other words, interneurons with relatively low levels of activity immediately before the period of interneuron cell death have an increased probability of undergoing apoptosis.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“it is perhaps not surprising that these cells play a critical role in the survival of cortical interneurons (Figure 6B).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“Second, experimentally increasing the activity of pyramidal cells (which increases interneuron survival) non-cell autonomously represses the expression of PTEN in interneurons (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“Interestingly, PTEN levels rise in cortical interneurons during the period of programmed cell death in a temporal pattern that coincides with the normal development of interneurons, transiently increasing first in infragranular layer interneurons and, subsequently, in superficial layer interneurons (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“First, genetic deletion of PTEN from postmitotic MGE-derived interneurons dramatically increases their survival (Wong et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Wong et al., 2018
In the citing paper
“This observation is in line with previous findings that the excitatory identity controls the survival and wiring of local interneurons60,61.”
From Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas (2019) · cites this paper as [61]
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
(1966) · Medical Entomology and Zoology · Cited by 10,293
Signal detection theory and psychophysics
Ingleby, D. (1967) · Journal of Sound and Vibration · doi:10.1016/0022-460x(67)90197-6 · Cited by 8,616
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,212
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
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Items 101–200 of 271
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Wei, A. D., Wakenight, P., Zwingman, T. A., Bard, A. M., Sahai, N., Willemsen, M. H., Schelhaas, H. J., Stegmann, A. P. A., Verhoeven, J. S., de Man, R. A., et al. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00509.2021 · Cited by 20
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Selten, M. M., Bernard, C., Mukherjee, D., Hamid, F., Hanusz-Godoy, A., Oozeer, F., Zimmer, C., & Marín, Ó. (2025) · Nature · doi:10.1038/s41586-025-08933-z · Cited by 19
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Wong, F. K., Selten, M. M., Rosés-Novella, C., Sreenivasan, V., Pallas‐Bazarra, N., Serafeimidou‐Pouliou, E., Hanusz-Godoy, A., Oozeer, F., Edwards, R. H., & Marín, Ó. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111037 · Cited by 20
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Park, H., Yamamoto, Y., & Tanaka, K. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.036 · Cited by 19
Mahadevan, V., Mitra, A., Zhang, Y., Yuan, X. Q., Peltekian, A., Chittajallu, R., Esnault, C., Maric, D., Rhodes, C. T., Pelkey, K. A., et al. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.712609 · Cited by 19
Wiegreffe, C., Wahl, T., Joos, N. S., Bonnefont, J., Vanderhaeghen, P., Liu, P., & Britsch, S. (2022) · EMBO Reports · doi:10.15252/embr.202154104 · Cited by 19
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Ortolani, D., Manot-Saillet, B., Orduz, D., Ortíz, F. C., & Angulo, M. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00477 · Cited by 18
Pati, S., Saba, K., Salvi, S. S., Tiwari, P., Chaudhari, P. R., Verma, V., Mukhopadhyay, S., Kapri, D., Suryavanshi, S., Clement, J. P., et al. (2020) · eLife · doi:10.7554/elife.56171 · Cited by 17
Pan, L., Tan, B., Tang, W., Luo, M., Liu, Y., Yu, L., & Yin, Y. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113197 · Cited by 18
Iannone, A. F., & García, N. V. D. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.005 · Cited by 19
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Teissier, A., & Pierani, A. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.010 · Cited by 20
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Ruiz-Reig, N., Hakanen, J., & Tissir, F. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.375298 · Cited by 17
Islam, R., White, J. D., Arefin, T. M., Mehta, S. S., Liu, X., Polis, B., Giuliano, L., Ahmed, S., Bowers, C. A., Zhang, J., et al. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00616-0 · Cited by 18
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Casanova, M. F., Sokhadze, E. M., Casanova, M., Opriș, I. C., Abujadi, C., Marcolin, M. A., & Li, X. (2020) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2020.02.004 · Cited by 18
Input-specific control of interneuron numbers in nascent striatal networks
Sreenivasan, V., Serafeimidou‐Pouliou, E., Exposito-Alonso, D., Bercsényi, K., Bernard, C., Bae, S., Oozeer, F., Hanusz-Godoy, A., Edwards, R. H., & Marín, Ó. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118430119 · Cited by 16
Self-citationRyner, R. F., Derera, I. D., Armbruster, M., Kansara, A., Sommer, M., Pirone, A., Noubary, F., Jacob, M. H., & Dulla, C. G. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0572-22.2022 · Cited by 16
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Jochner, M. C. E., An, J., Lättig-Tünnemann, G., Kirchner, M., Dagane, A., Dittmar, G. A. G., Dirnagl, U., Eickholt, B. J., & Harms, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39438-1 · Cited by 16
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Liwang, J. K., Kronman, F. N., Pi, H.-J., Wu, Y.-T., Vanselow, D. J., Manjila, S. B., Parmaksiz, D., Shin, D., Ben‐Simon, Y., Taormina, M. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64549-x · Cited by 16
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Khalid, K., Frei, J., Aboouf, M. A., Köster-Hegmann, C., Gassmann, M., Fritschy, J., & Gasser, E. M. S. (2021) · eNeuro · doi:10.1523/eneuro.0006-21.2021 · Cited by 15
Song, C., Kang, X., Yang, F., Du, W., Zhang, J., Liu, L., Kang, J., Jia, N., Yue, H., Fan, L., et al. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0134 · Cited by 15
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Bragg-Gonzalo, L., de León-Reyes, N. S., & Nieto, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.011 · Cited by 17
Yokoi, R., Shigemoto-Kuroda, T., Matsuda, N., Odawara, A., & Suzuki, I. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.12.006 · Cited by 15
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Pöpplau, J. A., & Hanganu‐Opatz, I. L. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041502 · Cited by 15
Ibrahim, L. A., Wamsley, B., Alghamdi, N., Yusuf, N., Sevier, E., Hairston, A., Sherer, M., Jaglin, X. H., Xu, Q., Guo, L., et al. (2023) · eLife · doi:10.7554/elife.86842 · Cited by 14
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Balena, T., Lillis, K. P., Rahmati, N., Bahari, F., Dzhala, V. I., Berdichevsky, E., & Staley, K. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0436-23.2023 · Cited by 14
Subramanian, D., Eisenberg, C., Huang, A., Baek, J., Naveed, H., Komatireddy, S., Shiflett, M. W., Tran, T. S., & Santhakumar, V. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02839-4 · Cited by 13
László, Z. I., Bercsényi, K., Mayer, M., Lefkovics, K., Szabó, G., Katona, I., & Lele, Z. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz168 · Cited by 13
Venkataramanappa, S., Saaber, F., Abe, P., Schütz, D., Kumar, P. A., & Stumm, R. K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111157 · Cited by 14
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Graf, J., Rahmati, V., Majoros, M., Witte, O. W., Geis, C., Kiebel, S. J., Holthoff, K., & Kirmse, K. (2022) · eLife · doi:10.7554/elife.82756 · Cited by 15
Wang, Q., Li, Y., Tan, H., & Wang, Y. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.873658 · Cited by 12
Bugeon, S., Clara, H., Ryzynski, A., Cremer, H., & Platel, J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1960-20.2021 · Cited by 12
Kobayashi, H., Takemoto, K., Sanbo, M., Hirabayashi, M., Hirabayashi, T., Hirayama, T., Kiyonari, H., Abe, T., & Yagi, T. (2022) · iScience · doi:10.1016/j.isci.2022.105766 · Cited by 11
Baxter, R. A., & Levy, W. B. (2019) · Neural Networks · doi:10.1016/j.neunet.2019.09.025 · Cited by 11
Huang, J.-Y., Krebs, B. B., Miskus, M. L., Russell, M. L., Duffy, E. P., Graf, J. M., & Lu, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-75537-0 · Cited by 11
WDFY3 mutation alters laminar position and morphology of cortical neurons
Schaaf, Z. A., Tat, L., Cannizzaro, N., Panoutsopoulos, A. A., Green, R., Rülicke, T., Hippenmeyer, S., & Zarbalis, K. S. (2022) · Molecular Autism · doi:10.1186/s13229-022-00508-3 · Cited by 11
Damilou, A., Cai, L., Argunşah, A. Ö., Han, S., Kanatouris, G., Karatsoli, M., Hanley, O., Gesuita, L., Kollmorgen, S., Helmchen, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50658-6 · Cited by 10
Akgül, G., Abebe, D. T., Yuan, X. Q., Auville, K., & McBain, C. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-41920-9 · Cited by 10
Zhang, Y., Cai, Y., Wang, Y., Deng, X., Zhao, Y., Zhang, Y., & Xie, Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03371-3 · Cited by 10
Li, K., Figarella, K., Su, X., Kovalchuk, Y., Gorzolka, J., Neher, J. J., Mojtahedi, N., Casadei, N., Hedrich, U. B. S., & Garaschuk, O. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04753-4 · Cited by 10
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Xing, W., de Lima, A. D., & Voigt, T. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.687306 · Cited by 10
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Iannone, A. F., Akgül, G., Zhang, R., Wacks, S., Hussein, N., Macias, C. G., Donatelle, A., Bauriedel, J. M. J., Wright, C., Abramov, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114531 · Cited by 9
Kumaraguru, S., Morgan, J., & Wong, F. K. (2025) · Science Advances · doi:10.1126/sciadv.adq5842 · Cited by 10
Self-citationFate plasticity of interneuron specification
Mostajo-Radji, M. A., Mancia, W., Breevoort, A., Gonzalez-Ferrer, J., Schweiger, H. E., Lehrer, J., Zhou, L., Schmitz, M. T., Perez, Y., Mukhtar, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112295 · Cited by 9
Mancia, W., Steffen, D. M., Dale-Huang, F., Rakela, B., Breevoort, A., Romero-Rodriguez, R., Hasenstaub, A. R., Stryker, M. P., Weiner, J. A., & Álvarez-Buylla, A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313596120 · Cited by 11
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Huerga-Gómez, I., Martini, F. J., & López‐Bendito, G. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1098913 · Cited by 9
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Currey, L., Harvey, T. J., Pelenyi, A., Piper, M., & Thor, S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1586550 · Cited by 8
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Paternò, R., Vu, T., Hsieh, C., & Baraban, S. C. (2024) · Scientific Reports · doi:10.1038/s41598-024-52478-6 · Cited by 8
Dwivedi, D., Dumontier, D., Sherer, M., Lin, S., Mirow, A. M., Qiu, Y., Xu, Q., Liebman, S. A., Joseph, D., Datta, S. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49732-w · Cited by 10
Early-life maturation of the somatosensory cortex: sensory experience and beyond
Nwabudike, I., & Che, A. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1430783 · Cited by 8
Ocana-Santero, G., Warming, H., Munday, V., MacKay, H. A., Gibeily, C., Hemingway, C., Stacey, J. A., Saha, A., Lazarte, I. P., Bachetta, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59659-5 · Cited by 7
Rudy, M. J., Salois, G., Cubello, J., Newell, R., & Mayer‐Pröschel, M. (2023) · Development · doi:10.1242/dev.201068 · Cited by 7
Campbell, B. F. N., Cruz-Ochoa, N. A., Otomo, K., Lukacsovich, D., Espinosa, P., Abegg, A., Luo, W., Bellone, C., Földy, C., & Tyagarajan, S. K. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02517-5 · Cited by 7
Hsing, H.-W., Zhuang, Z.-H., Niou, Z., & Chou, S. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz291 · Cited by 8
Ramezanidoraki, N., Ouardi, D. E., Le, M., Moriceau, S., Ahmadi, M., Dossi, E., Rolland, D., Bun, P., Pen, G. L., Canaud, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065376 · Cited by 7
Portalés, A., Chamero, P., & Jurado, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03362-3 · Cited by 9
Self-citationImbriglio, T., Verhaeghe, R., Martinello, K., Pascarelli, M. T., Chece, G., Bucci, D., Notartomaso, S., Quattromani, M. J., Mascio, G., Scalabrì, F., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901093rrr · Cited by 7
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Kaganovsky, K., Kelley, K. W., Gschwind, T., Harary, P. M., Kochalka, J., White, A. D., Lerma‐Usabiaga, G., Chen, X., Revah, O., Gore, F., et al. (2026) · Nature · doi:10.1038/s41586-026-11032-2 · Cited by 6
How variable progenitor clones construct a largely invariant neocortex
Shen, Z., Yang, J., Zhang, Q., Wang, K., Lv, X., Hu, X., Ma, J., & Shi, S. (2023) · National Science Review · doi:10.1093/nsr/nwad247 · Cited by 7
Mathieu, R., Draia-Nicolau, T., Corbières, L., Govindan, A. D., Bensa, V., Pallesi‐Pocachard, E., Silvagnoli, L., Represa, A., Cardoso, C., Telley, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68059-8 · Cited by 6
Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration
Zhang, Y., Tan, Y.-T., Wang, M., Li, L., Huang, J.-F., & Wang, S. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1390324 · Cited by 6
Gregorio, R. D., Chen, X., Petit, E., Dobrenis, K., & Sze, J. Y. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz191 · Cited by 6
Banerjee, T., Pati, S., Tiwari, P., & Vaidya, V. A. (2022) · Journal of Biosciences · doi:10.1007/s12038-022-00308-0 · Cited by 6
Liu, M., Restelli, F. F., Micoli, E., Barbiera, G., Moors, R., Nouboers, E., Reverendo, M., Du, J. X., Bertels, H., Konstantopoulos, D., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02387-w · Cited by 5
Sahyoun, G. M., Do, T. D., Anqueira-González, A., Hornblass, A., & Canetta, S. (2024) · Developmental Neuroscience · doi:10.1159/000539584 · Cited by 5
Neural cell competition sculpting brain from cradle to grave
Li, Y., Gao, L., Sun, X., Duan, L., Jiang, M., & Wu, Q. (2025) · National Science Review · doi:10.1093/nsr/nwaf057 · Cited by 5
Wang, C.-F., Yang, J., Zhuang, Z.-H., Hsing, H.-W., Luhmann, H. J., & Chou, S. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac166 · Cited by 6
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Markert, F., & Storch, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.732682 · Cited by 5
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Batista‐Brito, R., Ward, C., & Fishell, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00020-5 · Cited by 6
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Boroujeni, K. B., Balaram, P., Tiesinga, P. H. E., & Womelsdorf, T. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102873 · Cited by 4
Pan, T., Lin, G., Li, X., VanHeyningen, D., Walker, J. C., Kohli, S., Saravanan, A., Kondur, A., Jaklic, D. C., Pantoja-Gutierrez, S., et al. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102833 · Cited by 4
Morimoto, K., Takahashi, R., Takahashi, G., Miyajima, M., & Nakajima, K. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00336-3 · Cited by 4
Shi, S., Chen, T., Su, H., & Zhao, M. (2025) · The Neuroscientist · doi:10.1177/10738584241310156 · Cited by 4
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Barber, M. J., McDonald, C., Chavez, G. J., Bird, C. W., & Valenzuela, C. F. (2022) · Data in Brief · doi:10.1016/j.dib.2022.108355 · Cited by 3
Villalba, A., Amberg, N., & Hippenmeyer, S. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch10 · Cited by 3
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Metadata
- Authors
- Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O.
- Affiliations
- King's College London (GB)
- Venue
- Nature
- Published
- 2018-05
- Volume
- 557
- Issue
- 7707
- Pages
- 668-673
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6207348
- OpenAlex
- W2803681151
- Cited by
- 286
- References
- 60
- Citations by year
- 2026: 25 · 2025: 33 · 2024: 37 · 2023: 37 · 2022: 42 · 2021: 41 · 2020: 26 · 2019: 35 · 2018: 9
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (103714/Z/14/Z, 103714MA)
- European Commission (H2020)
- Horizon 2020 Framework Programme
- Medical Research Council (MR/N026063/1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- pyramidal neurons, excitation-inhibition balance, cortical development, postnatal development, neuronal cell death, activity-dependent regulation, inhibitory interneurons, excitatory synaptic input
- MeSH terms
- Animals, Cell Count, Cell Survival, Cerebral Cortex, Female, Interneurons, Male, Neural Pathways, Cell Death, Pyramidal Cells, PTEN Phosphohydrolase, Mice
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