Large deletions induced by Cas9 cleavage

Multiplex Genome Engineering Using CRISPR/Cas Systems

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Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

Kosicki, M., Tomberg, K., & Bradley, A. (2018) · Nature Biotechnology · doi:10.1038/nbt.4192 · Cited by 1,883

Correction of a pathogenic gene mutation in human embryos

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CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

Shin, H. Y., Wang, C., Lee, H., Yoo, K. H., Zeng, X., Kuhns, T. M., Yang, C. M., Mohr, T., Liu, C., & Hennighausen, L. G. (2017) · Nature Communications · doi:10.1038/ncomms15464 · Cited by 317

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Zuckermann, M., Hovestadt, V., Knobbe-Thomsen, C. B., Zapatka, M., Northcott, P. A., Schramm, K., Belic, J., Jones, D. T. W., Tschida, B., Moriarity, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms8391 · Cited by 283

Inter-homologue repair in fertilized human eggs?

Egli, D., Zuccaro, M. V., Kosicki, M., Church, G. M., Bradley, A., & Jasin, M. (2018) · Nature · doi:10.1038/s41586-018-0379-5 · Cited by 111

Detailed Phenotypic and Molecular Analyses of Genetically Modified Mice Generated by CRISPR-Cas9-Mediated Editing

Parikh, B. A., Beckman, D. L., Patel, S. J., White, J. M., & Yokoyama, W. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116484 · Cited by 55

Efficient Detection, Quantification and Enrichment of Subtle Allelic Alterations

Chen, J., Zhang, X., Wang, T., Li, Z., Guan, G., & Hong, Y. (2012) · DNA Research · doi:10.1093/dnares/dss023 · Cited by 55

CRISPR/Cas9 therapeutics: progress and prospects

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Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

Leibowitz, M. L., Papathanasiou, S., Doerfler, P. A., Blaine, L. J., Sun, L., Yao, Y., Zhang, C.-Z., Weiss, M. J., & Pellman, D. (2021) · Nature Genetics · doi:10.1038/s41588-021-00838-7 · Cited by 583

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

Wang, D., Zhang, F., & Gao, G. (2020) · Cell · doi:10.1016/j.cell.2020.03.023 · Cited by 539

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

Cullot, G., Boutin, J., Toutain, J., Prat, F., Pennamen, P., Rooryck, C., Teichmann, M., Rousseau, E., Lamrissi-Garcia, I., Guyonnet-Duperat, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09006-2 · Cited by 474

DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing

Xue, C., & Greene, E. C. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.02.008 · Cited by 431

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Zuccaro, M. V., Xu, J., Mitchell, C., Marin, D., Zimmerman, R., Rana, B., Weinstein, E., King, R. T., Palmerola, K. L., Smith, M. E., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.025 · Cited by 303

CRISPR technologies for genome, epigenome and transcriptome editing

Villiger, L., Joung, J., Koblan, L. W., Weissman, J. S., Abudayyeh, O. O., & Gootenberg, J. S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00697-6 · Cited by 280

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Alanis-Lobato, G., Zohren, J., McCarthy, A., Fogarty, N. M. E., Kubikova, N., Hardman, E., Greco, M., Wells, D., Turner, J. M. A., & Niakan, K. K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004832117 · Cited by 234

Genotoxic effects of base and prime editing in human hematopoietic stem cells

Fiumara, M., Ferrari, S., Omer-Javed, A., Beretta, S., Albano, L., Canarutto, D., Varesi, A., Gaddoni, C., Brombin, C., Cugnata, F., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-01915-4 · Cited by 220

CRISPR-based genome editing through the lens of DNA repair

Nambiar, T. S., Baudrier, L., Billon, P., & Ciccia, A. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.12.026 · Cited by 227

Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage

Nahmad, A. D., Reuveni, E., Goldschmidt, E., Tenne, T., Liberman, M., Horovitz‐Fried, M., Khosravi, R., Kobo, H., Reinstein, E., Madi, A., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01377-0 · Cited by 246

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

Tsuchida, C. A., Brandes, N., Bueno, R., Trinidad, M. I., Mazumder, T., Yu, B., Hwang, B., Chang, C. R., Liu, J., Sun, Y., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.041 · Cited by 220

Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing

Tao, J., Bauer, D. E., & Chiarle, R. (2023) · Nature Communications · doi:10.1038/s41467-023-35886-6 · Cited by 232

In vivo prime editing of a metabolic liver disease in mice

Böck, D., Rothgangl, T., Villiger, L., Schmidheini, L., Matsushita, M., Mathis, N., Ioannidi, E. I., Rimann, N., Grisch‐Chan, H. M., Kreutzer, S., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl9238 · Cited by 201

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U. B., den Hoed, M., & Ameur, A. (2022) · Nature Communications · doi:10.1038/s41467-022-28244-5 · Cited by 205

Development of CRISPR-Cas systems for genome editing and beyond

Zhang, F. (2019) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583519000052 · Cited by 188

CRISPR/Cas gene therapy

Zhang, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30064 · Cited by 191

Precision genome editing using cytosine and adenine base editors in mammalian cells

Huang, T. P., Newby, G. A., & Liu, D. R. (2021) · Nature Protocols · doi:10.1038/s41596-020-00450-9 · Cited by 175

Assessment of Cas12a‐mediated gene editing efficiency in plants

Bernabé‐Orts, J. M., Casas‐Rodrigo, I., Minguet, E. G., Landolfi, V., García‐Carpintero, V., Gianoglio, S., Vázquez‐Vilar, M., Granell, A., & Orzáez, D. (2019) · Plant Biotechnology Journal · doi:10.1111/pbi.13113 · Cited by 148

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases

Lampe, G. D., King, R. T., Halpin-Healy, T. S., Klompe, S. E., Hogan, M. I., Vo, P. L. H., Tang, S., Chavez, A., & Sternberg, S. H. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01748-1 · Cited by 154

CRISPR/Cas-mediated gene targeting in plants: finally a turn for the better for homologous recombination

Huang, T., & Puchta, H. (2019) · Plant Cell Reports · doi:10.1007/s00299-019-02379-0 · Cited by 153

Microhomologies are prevalent at Cas9-induced larger deletions

Owens, D. D. G., Caulder, A., Frontera, V., Harman, J. R., Allan, A. J., Bucakci, A., Greder, L., Codner, G. F., Hublitz, P., McHugh, P. J., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz459 · Cited by 136

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

Ferrari, S., Jacob, A., Cesana, D., Laugel, M., Beretta, S., Varesi, A., Unali, G., Conti, A., Canarutto, D., Albano, L., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.09.001 · Cited by 133

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

Papathanasiou, S., Markoulaki, S., Blaine, L. J., Leibowitz, M. L., Zhang, C., Jaenisch, R., & Pellman, D. S. (2021) · Nature Communications · doi:10.1038/s41467-021-26097-y · Cited by 129

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL

Diorio, C. J., Murray, R. C., Naniong, M., Barrera, L. A., Camblin, A. J., Chukinas, J. A., Coholan, L. J., Edwards, A., Fuller, T. J., Gonzales, C., et al. (2022) · Blood · doi:10.1182/blood.2022015825 · Cited by 134

Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing

Weisheit, I., Kroeger, J. A., Malik, R., Klimmt, J., Crusius, D., Dannert, A., Dichgans, M., & Paquet, D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107689 · Cited by 125

Expanding the CRISPR Toolbox in Zebrafish for Studying Development and Disease

Liu, K., Petree, C., Requena, T., Varshney, P., & Varshney, G. K. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00013 · Cited by 139

Unintended CRISPR-Cas9 editing outcomes: a review of the detection and prevalence of structural variants generated by gene-editing in human cells

Hunt, J., Samson, C., du Rand, A., & Sheppard, H. M. (2023) · Human Genetics · doi:10.1007/s00439-023-02561-1 · Cited by 141

Simultaneous precise editing of multiple genes in human cells

Riesenberg, S., Chintalapati, M., Macak, D., Kanis, P., Maričić, T., & Pääbo, S. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz669 · Cited by 127

Cas9-induced large deletions and small indels are controlled in a convergent fashion

Kosicki, M., Allen, F., Steward, F., Tomberg, K., Pan, Y., & Bradley, A. (2022) · Nature Communications · doi:10.1038/s41467-022-30480-8 · Cited by 115

Efficient precise in vivo base editing in adult dystrophic mice

Xu, L. M., Zhang, C., Bailin, P. L., Wang, P., Gao, Y., Mohler, P. J., Mokadam, N. A., Ma, J., Arnold, W. D., & Han, R. (2021) · Nature Communications · doi:10.1038/s41467-021-23996-y · Cited by 118

Inter-homologue repair in fertilized human eggs?

Egli, D., Zuccaro, M. V., Kosicki, M., Church, G. M., Bradley, A., & Jasin, M. (2018) · Nature · doi:10.1038/s41586-018-0379-5 · Cited by 111

Global detection of DNA repair outcomes induced by CRISPR–Cas9

Liu, M., Zhang, W., Xin, C., Yin, J., Shang, Y., Chen, A., Li, J., Meng, F., & Hu, J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab686 · Cited by 117

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Bennett, E., Petersen, B. L., Johansen, I. E., Niu, Y., Yang, Z., Chamberlain, C. A., Met, Ö., Wandall, H. H., & Frödin, M. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa975 · Cited by 108

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Yin, J., Lu, R., Xin, C., Wang, Y., Ling, X., Li, D., Zhang, W., Liu, M., Xie, W., Kong, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28900-w · Cited by 104

Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases

Lim, K., Cho, S.-I., & Kim, J. (2022) · Nature Communications · doi:10.1038/s41467-022-27962-0 · Cited by 100

Off-target effects in CRISPR-Cas genome editing for human therapeutics: Progress and challenges

Kalter, N., Fuster‐García, C., Silva, A., Ronco-Díaz, V., Roncelli, S., Turchiano, G., Gorodkin, J., Cathomen, T., Benabdellah, K., Lee, C. M., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102636 · Cited by 121

Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing

Park, S. H., Cao, M., Pan, Y., Davis, T., Saxena, L., Deshmukh, H., Fu, Y., Treangen, T. J., Sheehan, V., & Bao, G. (2022) · Science Advances · doi:10.1126/sciadv.abo7676 · Cited by 92

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9

Stephens, C. J., Lauron, E. J., Kashentseva, E. A., Lu, Z. H., Yokoyama, W. M., & Curiel, D. T. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.009 · Cited by 89

Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications

Yu, M., Hu, S., Tang, B., Yang, H., & Sun, D. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108202 · Cited by 92

Efficient high-precision homology-directed repair-dependent genome editing by HDRobust

Riesenberg, S., Kanis, P., Macak, D., Wollny, D., Düsterhöft, D., Kowalewski, J., Helmbrecht, N., Maričić, T., & Pääbo, S. (2023) · Nature Methods · doi:10.1038/s41592-023-01949-1 · Cited by 87

Optimized nickase- and nuclease-based prime editing in human and mouse cells

Adikusuma, F., Lushington, C., Arudkumar, J., Godahewa, G. I., Chey, Y. C. J., Gierus, L., Piltz, S., Geiger, A., Jain, Y., Reti, D., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab792 · Cited by 90

Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites

Tao, J., Wang, Q., Mendez‐Dorantes, C., Burns, K. H., & Chiarle, R. (2022) · Nature Communications · doi:10.1038/s41467-022-31322-3 · Cited by 91

Correction of β-thalassemia by CRISPR/Cas9 editing of the α-globin locus in human hematopoietic stem cells

Pavani, G., Fabiano, A., Laurent, M., Amor, F., Cantelli, E., Chalumeau, A., Maule, G., Tachtsidi, A., Concordet, J., Cereseto, A., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020001996 · Cited by 88

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair

Wilde, J. J., Aida, T., del Rosario, R. C. H., Kaiser, T., Qi, P., Wienisch, M., Zhang, Q., Colvin, S. M., & Feng, G. (2021) · Cell · doi:10.1016/j.cell.2021.04.035 · Cited by 97

Genome editing methods in animal models

Lee, H., Yoon, D. E., & Kim, K. (2020) · Animal Cells and Systems · doi:10.1080/19768354.2020.1726462 · Cited by 83

Genome Editing in Patient iPSCs Corrects the Most Prevalent USH2A Mutations and Reveals Intriguing Mutant mRNA Expression Profiles

Sanjurjo-Soriano, C., Erkilic, N., Baux, D., Mamaeva, D. V., Hamel, C., Meunier, I., Roux, A., & Kalatzis, V. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.11.016 · Cited by 82

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells

Boutin, J., Rosier, J., Cappellen, D., Prat, F., Toutain, J., Pennamen, P., Bouron, J., Rooryck, C., Merlio, J., Lamrissi‐Garcia, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25190-6 · Cited by 82

Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System

Song, Y., Liu, Z., Zhang, Y., Chen, M., Sui, T., Lai, L., & Li, Z. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.06.019 · Cited by 74

Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Meng, D., Ragi, S. D., & Tsang, S. H. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.012 · Cited by 75

Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways

Schimmel, J., Muñoz-Subirana, N., Kool, H., van Schendel, R., van der Vlies, S., Kamp, J. A., de Vrij, F. M. S., Kushner, S. A., Smith, G. C. M., Boulton, S. J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112019 · Cited by 72

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

Azeez, S. S., Hamad, R. S., Hamad, B., Shekha, M. S., & Bergsten, P. (2024) · Frontiers in Genome Editing · doi:10.3389/fgeed.2024.1509924 · Cited by 88

Principles of and strategies for germline gene therapy

Wolf, D. P., Mitalipov, P. A., & Mitalipov, S. M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0473-8 · Cited by 75

Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion

Wen, W., Quan, Z.-J., Li, S.-A., Yang, Z.-X., Fu, Y.-W., Zhang, F., Li, G., Zhao, M., Yin, M., Xu, J., et al. (2021) · Genome biology · doi:10.1186/s13059-021-02462-4 · Cited by 77

Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy

Ferrari, S., Valeri, E., Conti, A., Scala, S., Aprile, A., Micco, R. D., Kajaste‐Rudnitski, A., Montini, E., Ferrari, G., Aiuti, A., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.04.014 · Cited by 75

Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks

van de Kooij, B., Kruswick, A., van Attikum, H., & Yaffe, M. B. (2022) · Nature Communications · doi:10.1038/s41467-022-32743-w · Cited by 68

Gene editing and its applications in biomedicine

Li, G., Li, X., Zhuang, S., Wang, L., Zhu, Y., Chen, Y., Sun, W. C., Wu, Z., Zhou, Z. L., Chen, J., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2057-0 · Cited by 66

Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls

Simkin, D., Papakis, V., Bustos, B. I., Ambrosi, C. M., Ryan, S. J., Baru, V., Williams, L. A., Dempsey, G. T., McManus, O. B., Landers, J. E., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.02.008 · Cited by 68

Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases

Hwang, G., Lee, S., Oh, M., Kim, S., Habib, O., Jang, H., Kim, H. S., Kim, Y., Kim, C. H., Kim, S., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01277-5 · Cited by 83

CRISPR/Cas9 for Sickle Cell Disease: Applications, Future Possibilities, and Challenges

Demirci, S., Leonard, A., Haro-Mora, J. J., Uchida, N., & Tisdale, J. F. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2018_331 · Cited by 50

In-depth assessment of the PAM compatibility and editing activities of Cas9 variants

Zhang, W., Yin, J., Zhangding, Z., Xin, C., Liu, M., Wang, Y., Chen, A., & Hu, J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab507 · Cited by 66

CRISPR gene editing in human embryos wreaks chromosomal mayhem

Ledford, H. K. (2020) · Nature · doi:10.1038/d41586-020-01906-4 · Cited by 64

Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment

Marchetti, F., Cardoso, R., Chen, C. L., Douglas, G. R., Elloway, J. M., Escobar, P. A., Harper, T. A., Heflich, R. H., Kidd, D., Lynch, A. M., et al. (2023) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2023.108466 · Cited by 71

Human germline genome editing

Lea, R. A., & Niakan, K. K. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0424-0 · Cited by 62

ON-Target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected

Boutin, J., Cappellen, D., Rosier, J., Amintas, S., Dabernat, S., Bedel, A., & Moreau‐Gaudry, F. (2022) · The CRISPR Journal · doi:10.1089/crispr.2021.0120 · Cited by 59

Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism

Bayraktar, E. C., La, K., Karpman, K., Unlu, G., Ozerdem, C., Ritter, D. J., Alwaseem, H., Molina, H., Hoffmann, H.-H., Millner, A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0206-9 · Cited by 60

Visual function restoration in a mouse model of Leber congenital amaurosis via therapeutic base editing

Jo, D. H., Jang, H., Cho, C. S., Han, J. H., Ryu, G., Jung, Y., Bae, S., & Kim, J. H. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.11.021 · Cited by 61

Engineering strategies to safely drive CAR T-cells into the future

Rossi, M., & Breman, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1411393 · Cited by 68

Recent advances in therapeutic gene-editing technologies

Liu, D., Cao, D., & Han, R. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.026 · Cited by 70

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Peterka, M., Akrap, N., Li, S., Wimberger, S., Hsieh, P.-P., Degtev, D., Bestas, B., Barr, J., van de Plassche, S., Mendoza-García, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28771-1 · Cited by 57

CRISPR technology: The engine that drives cancer therapy

Zhang, M., Eshraghian, E. A., Jammal, O. A., Zhang, Z.-B., & Zhu, X. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111007 · Cited by 54

Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice

Turocy, J. M., Adashi, E. Y., & Egli, D. M. (2021) · Cell · doi:10.1016/j.cell.2021.02.036 · Cited by 56

The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens

Huang, J. T., & Cook, D. E. (2022) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuac035 · Cited by 57

High-resolution genome-wide mapping of chromosome-arm-scale truncations induced by CRISPR–Cas9 editing

Lazar, N. H., Çelik, S., Chen, L., Fay, M. M., Irish, J. C., Jensen, J., Tillinghast, C. A., Urbanik, J., Bone, W. P., Roberts, G. H. L., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01758-y · Cited by 52

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins

Xu, D. Z., Besselink, S., Ramadoss, G. N., Dierks, P. H., Lubin, J. P., Pattali, R. K., Brim, J. I., Christenson, A. E., Colias, P. J., Ornelas, I. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63167-x · Cited by 60

Recent advances in functional genomics for parasitic nematodes of mammals

Castelletto, M. L., Gang, S. S., & Hallem, E. A. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.206482 · Cited by 52

European Court of Justice ruling regarding new genetic engineering methods scientifically justified: a commentary on the biased reporting about the recent ruling

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Life-Long AAV-Mediated CRISPR Genome Editing in Dystrophic Heart Improves Cardiomyopathy without Causing Serious Lesions in mdx Mice

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