Inter-homologue repair in fertilized human eggs?
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Some results were interpreted to indicate repair of a CRISPR-Cas9-targeted gene allele by homology-directed repair with the cell's other allele as the donor template.
“Some results were interpreted to indicate repair of a CRISPR-Cas9targeted gene allele by homology-directed repair with the cell's other allele as the donor template 114 .”
From The promise and challenge of therapeutic genome editing (2020) · cites this paper as [114]
CRISPR-Cas9-induced deletions larger than the PCR fragment can eliminate one or both primer annealing sites, leading to amplification of only one allele and a false impression of unsuccessful targeting or a single homozygous event.
“CRISPR-Cas9-induced deletions larger than these fragments in either direction would eliminate one or both PCR primer annealing sites.This in turn can lead to amplification of only one allele, giving the false impression that targeting was unsuccessful or that there is a single homozygous event at the on-target site (9,10,15).”
From Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos (2021) · cites this paper as [9]
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- Authors
- Egli, D., Zuccaro, M. V., Kosicki, M., Church, G. M., Bradley, A., & Jasin, M.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Wellcome Sanger Institute (GB)
- Harvard University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Egli, Dieter
- Jasin, Maria
- Venue
- Nature
- Published
- 2018-08
- Volume
- 560
- Issue
- 7717
- Pages
- E5-E7
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2952775612
- Cited by
- 111
- References
- 19
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 21 · 2018: 26 · 2017: 4
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Oregon Health and Science University
- Leona M. and Harry B. Helmsley Charitable Trust
- South Australian Health and Medical Research Institute
- Temple University
- Consorzio Interuniversitario Biotecnologie
- Moxie Foundation
- La Trobe University
- University of Adelaide
- Government of Jiangxi Province
- Universitas Diponegoro
- Institute for Basic Science (IBSR021-D1, R021-D1)
- Directorate for Biological Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- human embryo, CRISPR/Cas9, DNA double-strand break repair, metaphase II oocytes, germline gene therapy, zygote, homologous recombination
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