The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Distinct fibroblast subsets drive inflammation and damage in arthritis
Open accessAbstract
The identification of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (IMIDs)1,2. However, it remains unclear whether fibroblast subclasses with non-overlapping functions also exist and are responsible for the wide variety of tissue-driven processes observed in IMIDs, such as inflammation and damage 3-5. Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis. We show that deletion of fibroblast activation protein-α (FAPα)+ fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis. Single-cell transcriptional analysis identified two distinct fibroblast subsets within the FAPα+ population: FAPα+THY1+ immune effector fibroblasts located in the synovial sub-lining, and FAPα+THY1- destructive fibroblasts restricted to the synovial lining layer. When adoptively transferred into the joint, FAPα+THY1- fibroblasts selectively mediate bone and cartilage damage with little effect on inflammation, whereas transfer of FAPα+ THY1+ fibroblasts resulted in a more severe and persistent inflammatory arthritis, with minimal effect on bone and cartilage. Our findings describing anatomically discrete, functionally distinct fibroblast subsets with non-overlapping functions have important implications for cell-based therapies aimed at modulating inflammation and tissue damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While single-cell sequencing indicates common traits are preserved49–51, it will become increasingly pressing to define common and specific effects of CAFs.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [50]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Overwhelming evidence now points to a degree of specialization among CAFs, which may reflect the increasingly appreciated specialization of normal fibroblasts19,50.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [50]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Recent studies have implicated a range of mesenchymal progenitor cells (MPs) in the initiation and propagation of fibrosis28–30.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [28]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27584 · Cited by 9,631
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
Street, K., Risso, D., Fletcher, R. B., Das, D., Ngai, J., Yosef, N., Purdom, E., & Dudoit, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4772-0 · Cited by 3,159
Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372
Self-citationGAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Tirosh, I., Venteicher, A. S., Hebert, C. M., Escalante, L. E., Patel, A. P., Yizhak, K., Fisher, J. M., Rodman, C., Mount, C., Filbin, M. G., et al. (2016) · Nature · doi:10.1038/nature20123 · Cited by 1,245
Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis
Krenn, V., Morawietz, L., Burmester, G. R., Kinne, R. W., Müeller-Ladner, U., Müller, B., & Häupl, T. (2006) · Histopathology · doi:10.1111/j.1365-2559.2006.02508.x · Cited by 844
Cited by
Sorted by citations
Items 301–400 of 976
Levantovsky, R. M., Tastad, C., Zhang, J., Gettler, K., Sabic, K., Werner, R., Chasteau, C., Korie, U. M., Paguay, D., Bao, M., et al. (2024) · Med · doi:10.1016/j.medj.2024.03.021 · Cited by 30
CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis
Miyahara, J., Omata, Y., Chijimatsu, R., Okada, H., Ishikura, H., Higuchi, J., Tachibana, N., Nagata, K., Tani, S., Kono, K., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.183690 · Cited by 29
Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis
Chen, M., Wang, Z., Chen, H., Jin, L., Guo, X., & Zhou, S. (2025) · Nano Letters · doi:10.1021/acs.nanolett.4c05782 · Cited by 29
Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts
Farah, H., Young, S. P., Mauro, C., & Jones, S. W. (2020) · FEBS Journal · doi:10.1111/febs.15644 · Cited by 30
Qi, W., Jin, L., Wu, C., Liao, H., Zhang, M., Zhu, Z., Han, W., Chen, Q., & Ding, C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100702 · Cited by 28
Yin, C., Fu, L., Guo, S., Liang, Y., Shu, T., Shao, W., Xia, H., Xia, T., & Wang, M. (2024) · Advanced Science · doi:10.1002/advs.202409398 · Cited by 29
Wu, Y., Wang, X., Sun, X., Gao, X., Zhang, S., Shen, J., Tian, H., Chen, X., Huang, H., Jiang, S., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.009 · Cited by 28
New Developments in Transcriptomic Analysis of Synovial Tissue
Carr, H. L., Turner, J. D., Major, T., Scheel‐Toellner, D., & Filer, A. D. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00021 · Cited by 26
Self-citationToussirot, É., Bonnefoy, F., Vauchy, C., Perruche, S., & Saas, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.630170 · Cited by 28
Manresa, M. C., Wu, A., Nhu, Q. M., Chiang, A. W. T., Okamoto, K., Miki, H., Kurten, R. C., Pham, E., Duong, L., Lewis, N. E., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00472-w · Cited by 29
de Seny, D., Baiwir, D., Bianchi, E., Cobraiville, G., Deroyer, C., Poulet, C., Malaise, O., Paulissen, G., Kaiser, M.-J., Hauzeur, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010434 · Cited by 28
Wu, T., Zhang, X., Zhang, Q., Zou, Y., Ma, J., Chen, L., Zou, Y.-W., Xue, J., Ma, R., Chen, Z., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.810635 · Cited by 28
CD90-positive stromal cells associate with inflammatory and fibrotic changes in modic changes
Dudli, S., Karol, A. A., Giudici, L., Heggli, I., Laux, C. J., Spirig, J. M., Wanivenhaus, F., Betz, M., Germann, C., Farshad‐Amacker, N. A., et al. (2022) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2022.100287 · Cited by 28
Yaghi, O., Hanna, B. S., Langston, P. K., Michelson, D. A., Jayewickreme, T., Marin-Rodero, M., Benoist, C. O., & Mathis, D. J. (2023) · Nature Immunology · doi:10.1038/s41590-023-01669-w · Cited by 25
Edalat, S. G., Gerber, R., Houtman, M., Lückgen, J., Teixeira, R. L., Cisneros, M. D. P. P., Pfanner, T., Kuret, T., Ižanc, N., Micheroli, R., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109707 · Cited by 28
Zhang, R., Lin, X., Lin, R., Chen, Z., Miao, C., Wang, Y., Deng, X., Lin, J., Lin, S., Weng, S., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03159-7 · Cited by 32
Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics
Karsdal, M. A., Cox, T. R., Parker, A. L., Willumsen, N., Sand, J. M. B., Jenkins, G. R., Hansen, H. H., Oldenburger, A., Geillinger‐Kästle, K. E., Larsen, A. T., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14061856 · Cited by 29
Self-citationSanjurjo‐Rodríguez, C., Altaie, A., Mastbergen, S. C., Baboolal, T. G., Welting, T. J. M., Lafeber, F. P. J. G., Pandit, H. G., McGonagle, D., & Jones, E. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.579751 · Cited by 27
Fibroblasts in Rheumatoid Arthritis
Chu, C. (2020) · New England Journal of Medicine · doi:10.1056/nejmcibr2024718 · Cited by 27
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney
Arai, H., Sato, Y., & Yanagita, M. (2021) · Immunological Reviews · doi:10.1111/imr.12969 · Cited by 26
New potential therapeutic approaches targeting synovial fibroblasts in rheumatoid arthritis
Alcaraz, M. J. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114815 · Cited by 27
Cellular and molecular diversity in Rheumatoid Arthritis
Rivellese, F., & Pitzalis, C. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101519 · Cited by 28
Shinotsuka, N., & Denk, F. (2022) · BMJ Open Science · doi:10.1136/bmjos-2021-100235 · Cited by 32
Farina, L., Minnone, G., Alivernini, S., Caiello, I., MacDonald, L., Soligo, M., Manni, L., Tolusso, B., Coppola, S., Zara, E., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.818630 · Cited by 27
Rheumatoid arthritis and non-coding RNAs; how to trigger inflammation
Tofigh, R., Hosseinpourfeizi, M., Baradaran, B., Teimourian, S., & Safaralizadeh, R. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121367 · Cited by 30
Strategies to Improve Outcomes in Psoriatic Arthritis
Ritchlin, C. T., & Scher, J. U. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0876-z · Cited by 27
Mitochondria as disease-relevant organelles in rheumatoid arthritis
Weyand, C. M., Wu, B., Huang, T., Hu, Z., & Goronzy, J. J. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac107 · Cited by 29
Advancing skeletal health and disease research with single-cell RNA sequencing
Lin, P., Gan, Y., He, J., Lin, S., Xu, J., Chang, L., Zhao, L., Zhu, J. J., Zhang, L., Huang, S., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00538-3 · Cited by 26
Molecular Mechanism for Malignant Progression of Gastric Cancer Within the Tumor Microenvironment
Matsuoka, T., & Yashiro, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111735 · Cited by 28
Reflections on ‘older’ drugs: learning new lessons in rheumatology
Kerrigan, S., & McInnes, I. B. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0375-7 · Cited by 25
Julià, A., Avila-Pedretti, G., Celis, R., Sanmartí, R., Ramírez, J., Marsal, S., & Cañete, J. D. D. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02287-9 · Cited by 28
Friščić, J., Dürholz, K., Chen, X., Engdahl, C., Möller, L., Schett, G. A., Zaiss, M. M., & Hoffmann, M. H. (2021) · Nutrients · doi:10.3390/nu13051643 · Cited by 26
Self-citationFalconer, J., Pucino, V., Clayton, S. A., Marshall, J. L., Raizada, S. R., Adams, H. R., Philp, A., Clark, A. R., Filer, A. D., Raza, K., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.725641 · Cited by 26
Self-citationJuillerat‐Jeanneret, L., Tafelmeyer, P., & Golshayan, D. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01010 · Cited by 27
Najm, A., Costantino, F., Alivernini, S., Alunno, A., Bianchi, E., Bignall, J., Boyce, B. F., Cañete, J. D. D., Carubbi, F., Durez, P., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221875 · Cited by 26
Self-citationDoloff, J. C., Ma, M., Sadraei, A., Tam, H. H., Farah, S., Hollister‐Lock, J., Vegas, A. J., Omid Veiseh, A., Quiroz, V. M., Rakoski, A. I., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade9488 · Cited by 26
Fibroblast Activation Protein Targeting Probe with Gly–Pro Sequence for PET of Glioblastoma
Lai, C., Cao, R., Li, R., He, C., Wang, X., Shi, H., Qu, C., Qian, K., Song, S., Chen, W., et al. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00248 · Cited by 26
Single-cell transcriptomics in tissue engineering and regenerative medicine
Ruta, A., Krishnan, K., & Elisseeff, J. H. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00132-7 · Cited by 25
Highlights of Strategies Targeting Fibroblasts for Novel Therapies for Rheumatoid Arthritis
Chu, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.846300 · Cited by 27
Noda, S., Hosoya, T., Komiya, Y., Tagawa, Y., Endo, K., Komori, K., Koga, H., Takahara, Y., Sugimoto, K., Sekiya, I., et al. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02736-7 · Cited by 25
Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses?
Lebeau, G., Ah-Pine, F., Daniel, M., Bedoui, Y., Vagner, D., Frumence, É., & Gasque, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148038 · Cited by 25
Kuret, T., SodinŠemrl, S., Leskošek, B., & Ferk, P. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.822804 · Cited by 25
Wedderburn, L. R., Ramanan, A. V., Croft, A. P., Hyrich, K. L., & Dick, A. D. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-222553 · Cited by 24
Self-citationKomagamine, M., Komatsu, N., Ling, R., Okamoto, K., Tianshu, S., Matsuda, K., Takeuchi, T., Kaneko, Y., & Takayanagi, H. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00293-3 · Cited by 24
[68 Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis
Pan, Q., Yang, H., Zhou, Z., Li, M., Xu, J., Li, F., Luo, Y., & Li, M. (2024) · EJNMMI Research · doi:10.1186/s13550-023-01064-4 · Cited by 24
Hoffmann, M. H., Kirchner, H., Krönke, G., Riemekasten, G., & Bonelli, M. M. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224092 · Cited by 25
Wang, Y., Wang, J.-R., Ma, M., Gao, R., Wu, Y. Y., Zhang, C., Huang, P., Wang, W., Feng, Z., & Gao, J. (2024) · Biomaterials Research · doi:10.34133/bmr.0046 · Cited by 24
Yu-li, H., Liu, C., Chen, S., Sun, H., Jia, Z., Shi, J., Wang, L., Du, K., & Chang, Y. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.09.030 · Cited by 24
Yuan, W., Liu, J., Zhang, Z., Ye, C., Zhou, X., Wu, Y., Wu, Y., Li, Y., Zhang, Q., Xiong, X., et al. (2025) · International Journal of Oral Science · doi:10.1038/s41368-024-00329-5 · Cited by 26
Liu, F., Shi, H., Turner, J. D., Anscombe, R., Li, J., Sekine, T., Hammitzsch, A., Agarwal, D., Mahony, C. B., Chen, J., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.04.018 · Cited by 24
Self-citationTriaille, C., Vansteenkiste, L., Constant, M., Ambroise, J., de Bellefon, L. M., Toukap, A. N., Sokolova, T., Galant, C., Coulie, P. G., Carrasco, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.593083 · Cited by 25
Single Cell Omics for Musculoskeletal Research
Rai, M. F., Wu, C., Capellini, T. D., Guilak, F., Dicks, A. R., Muthuirulan, P., Grandi, F. C., Bhutani, N., & Westendorf, J. J. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00662-2 · Cited by 25
Huang, D., Jiao, X., Huang, S., Liu, J., Si, H., Qi, D., Pei, X., Lu, D., Wang, Y., & Li, Z. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.06.005 · Cited by 23
Deciphering Mesenchymal Drivers of Human Dupuytren’s Disease at Single-Cell Level
Dobie, R., West, C. C., Henderson, B. E. P., Wilson‐Kanamori, J. R., Markose, D., Kitto, L. J., Portman, J. R., Beltrán, M., Sohrabi, S., Akram, A. R., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.05.030 · Cited by 22
Krošel, M., Gabathuler, M., Maciukiewicz, M., Moser, L., Lee, G. I., Marks, M., Tomšič, M., Distler, O., Ospelt, C., & Klein, K. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102709 · Cited by 24
A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue
Lin, J., Sun, A. R., Li, J., Yuan, T., Cheng, W., Ke, L., Chen, J., Sun, W., Mi, S., & Zhang, P. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.764212 · Cited by 23
JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation
Nyirenda, M. H., Nijjar, J. S., Frleta‐Gilchrist, M., Gilchrist, D. S., Porter, D. R., Siebert, S., Goodyear, C. S., & McInnes, I. B. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002671 · Cited by 23
Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2022
Winthrop, K. L., Isaacs, J. D., Mease, P. J., Boumpas, D. T., Baraliakos, X., Gottenberg, J., Siebert, S., Mosca, M., Basu, N., Orange, D. E., et al. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223528 · Cited by 23
Synovial biopsies in inflammatory arthritis: precision medicine in rheumatoid arthritis
Small, A., & Wechalekar, M. D. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1707671 · Cited by 23
Site of invasion revisited: epigenetic drivers of joint destruction in RA
Ospelt, C. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-222554 · Cited by 22
The molecular subtypes of autoimmune diseases
Cheng, X., Meng, X., Chen, R., Song, Z., Li, S. C., Wei, S., Lv, H., Zhang, S., Tang, H., Jiang, Y., et al. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.03.026 · Cited by 27
Sendo, S., Machado, C. R. L., Boyle, D. L., Benschop, R. J., Perumal, N. B., Choi, E., Wang, W., & Firestein, G. S. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42856 · Cited by 22
Gu, Y., Liang, Z., Wang, Y., Zhou, Y. J., Shi, Y., Luo, J., Xu, X., Fang, K., Wang, H., Guo, B., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158478 · Cited by 22
Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for in vitro studies
Chakrabarti, S., Ai, M., HENSON, F. M. D., & Smith, E. S. J. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100051 · Cited by 23
Dorst, D. N., van Caam, A., Vitters, E. L., Walgreen, B., Helsen, M. M. A., Klein, C., Gudi, S., Wubs, T., Kumari, J., Vonk, M. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312681 · Cited by 22
Distinct Glucocorticoid Receptor Actions in Bone Homeostasis and Bone Diseases
Lee, S., Krüger, B. T., Ignatius, A. A., & Tuckermann, J. P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.815386 · Cited by 22
T cell–Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile
Yan, R., Moresco, P., Gegenhuber, B., & Fearon, D. T. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0593 · Cited by 24
Self-citationCellular characterisation of advanced osteoarthritis knee synovium
Mimpen, J. Y., Hedley, R., Ridley, A., Baldwin, M. J., Windell, D., Bhalla, A., Ramos‐Mucci, L., Buckley, C. D., Coles, M. C., Alvand, A., et al. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03110-x · Cited by 22
Self-citationFAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment
Hartmann, K. P., van Gogh, M., Freitag, P. C., Kast, F., Nagy‐Davidescu, G., Borsig, L., & Plückthun, A. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.08.018 · Cited by 22
Corte, G., Atzinger, A., Temiz, S. A., de Sousa, R. N., Mutlu, M. Y., Schönau, V., Raimondo, M. G., Kleyer, A., Kuwert, T., Ramming, A., et al. (2024) · RMD Open · doi:10.1136/rmdopen-2024-004294 · Cited by 22
Ricci, B., Tycksen, E., Celik, H., Belle, J. I., Fontana, F., Civitelli, R., & Faccio, R. (2020) · eLife · doi:10.7554/elife.54659 · Cited by 22
Hoover, P., Raparia, C., Lieb, D., Tzur, Y., Kang, J. B., Arazi, A., Leavitt, R., Mishra, R., Shah, S. I., Simmons, D. P., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241873 · Cited by 28
Self-citationInsights Into Leukocyte Trafficking in Inflammatory Arthritis – Imaging the Joint
Manning, J. E., Lewis, J. W., Marsh, L., & McGettrick, H. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.635102 · Cited by 24
Self-citationHonan, A. M., & Chen, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658984 · Cited by 21
Baldwin, M. J., Mimpen, J. Y., Cribbs, A. P., Stace, E. T., Philpott, M., Dakin, S. G., Carr, A. J., & Snelling, S. J. B. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.795748 · Cited by 22
New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology
Sandhu, G., & Thelma, B. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.834247 · Cited by 21
Li, M., Wu, B., Li, L., Lv, C., & Tian, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188945 · Cited by 23
Xu, S., Jiemy, W. F., Brouwer, E., Burgess, J. K., Heeringa, P., van der Geest, K. S. M., Alba-Rovira, R., Corbera‐Bellalta, M., Boots, A. M. H., Cid, M. C., et al. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103574 · Cited by 24
Sugimoto, H., Murahashi, Y., Chijimatsu, R., Miwa, S., Yano, F., Tanaka, S., & Saito, T. (2020) · Biomedical Research · doi:10.2220/biomedres.41.43 · Cited by 20
Bone health in patients with inflammatory bowel disease
Kreienbühl, A., Rogler, G., Burri, E., Biedermann, L., Meier, C., Juillerat, P., Restellini, S., Hruz, P. L., Vavricka, S. R., Aeberli, D., et al. (2024) · Swiss Medical Weekly · doi:10.57187/s.3407 · Cited by 22
Ali, A., Rahul., Jori, C., Kumar, J. S., Kumar, A., Kanika, Ansari, M. M., Ahmad, A., Ali, N., Yadav, P., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134903 · Cited by 20
Jung, S. M., Park, K., & Kim, K. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa751 · Cited by 20
A Pathogenic Th17/CD38+ Macrophage Feedback Loop Drives Inflammatory Arthritis through TNF-α
Muench, D. E., Sun, Z., Sharma, A., Tang, C., Crampton, J. C., Lao, C. R., Kersjes, K., Chang, W. Y., & Na, S. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101025 · Cited by 19
Thy-1-Integrin Interactions in cis and Trans Mediate Distinctive Signaling
Hu, P., Leyton, L., Hagood, J. S., & Barker, T. H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.928510 · Cited by 21
Friščić, J., Reinwald, C., Böttcher, M., Houtman, M., Euler, M., Chen, X., Walker, K., Kirchner, P., Zhu, H., Wirth, B., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42378 · Cited by 21
Palacios-García, J. M., Porras‐González, C., Moreno‐Luna, R., Maza-Solano, J. M., Polo-Padillo, J., Muñoz‐Bravo, J. L., & Sánchez‐Gómez, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093280 · Cited by 20
A roadmap for delivering a human musculoskeletal cell atlas
Baldwin, M. J., Buckley, C. D., Guilak, F., Hulley, P. A., Cribbs, A. P., & Snelling, S. J. B. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01031-2 · Cited by 17
Self-citationMetabolic and molecular imaging in inflammatory arthritis
de Sousa, R. N., Taşçılar, K., Corte, G., Atzinger, A., Minopoulou, I., Ohrndorf, S., Waldner, M. J., Schmidkonz, C., Kuwert, T., Knieling, F., et al. (2024) · RMD Open · doi:10.1136/rmdopen-2023-003880 · Cited by 20
Established rheumatoid arthritis. The pathogenic aspects
Bugatti, S., Cassione, E. B., Stefano, L. D., & Manzo, A. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.101478 · Cited by 20
Corbet, M., Pineda, M. A., Yang, K., Tarafdar, A., McGrath, S., Nakagawa, R., Lumb, F. E., Suckling, C. J., Harnett, W., & Harnett, M. M. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010069 · Cited by 22
Chen, Y. F., Chen, Z., Wang, W., Hua, Y., & Ji, M. (2024) · Research · doi:10.34133/research.0373 · Cited by 19
Matellan, C., Kennedy, C., Santiago‐Vela, M. I., Hochegger, J., Chathail, M. B. N., Wu, A., Shannon, C. E., Roche, H. M., Aceves, S. S., Godson, C., et al. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300762 · Cited by 19
Miyamoto, A. T., Shimagami, H., Kumanogoh, A., & Nishide, M. (2025) · Inflammation and Regeneration · doi:10.1186/s41232-025-00369-2 · Cited by 23
Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts
Liu, Y., Chen, X., Dai, Y., Jia, Y., Kieffer, Y., Xie, L., Zhou, Z., Tyler, L. A., Kim, A. C., Biffi, G., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.06.001 · Cited by 19
Cartilage Targets of Knee Osteoarthritis Shared by Both Genders
Li, C., & Zheng, Z. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020569 · Cited by 20
Singh, A., Haque, M., Madarampalli, B., Shi, Y., Wildman, B. J., Basit, A., Khuder, S., Prasad, B., Hassan, Q., Ouseph, M. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746503 · Cited by 20
Nielsen, M. A., Køster, D., Greisen, S. R., Troldborg, A., Stengaard‐Pedersen, K., Junker, P., Hørslev-Petersen, K., Hetland, M. L., Østergaard, M., Hvid, M., et al. (2022) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2021.1992860 · Cited by 19
Tissue microenvironment dictates inflammation and disease activity in rheumatoid arthritis
Cheng, C., Liao, H., & Wu, C. (2022) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2022.01.026 · Cited by 19
Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells
Kurenkova, A. D., Romanova, I. A., Kibirskiy, P. D., Timashev, P. S., & Medvedeva, E. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911169 · Cited by 21
Kubo, S., Miyazaki, Y., Nishino, T., Fujita, Y., Kono, M., Kawashima, T., Ishigaki, K., Kusaka, K., Tanaka, H., Ueno, M., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-226228 · Cited by 19
Metadata
- Authors
- Croft, A. P., Campos, J., Jansen, K., Turner, J. D., Marshall, J., Attar, M., Savary, L., Wehmeyer, C., Naylor, A. J., Kemble, S., Begum, J., Dürholz, K., Perlman, H., Barone, F., McGettrick, H. M., Fearon, D. T., Wei, K., Raychaudhuri, S., Korsunsky, I., Brenner, M. B., Coles, M., Sansom, S. N., Filer, A., & Buckley, C. D.
- Affiliations
- Queen Elizabeth Hospital Birmingham (GB)
- University of Oxford (GB)
- University of Münster (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Northwestern University (US)
- Cold Spring Harbor Laboratory (US)
- Brigham and Women's Hospital (US)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Corresponding author
- Buckley, Christopher D.
- ORCID
- Croft, Adam P.
- Campos, Joana
- Jansen, Kathrin
- Turner, Jason D.
- Marshall, Jennifer
- Attar, Moustafa
- Wehmeyer, Corinna
- Naylor, Amy J.
- Kemble, Samuel
- Begum, Jenefa
- Perlman, Harris
- Barone, Francesca
- McGettrick, Helen M.
- Fearon, Douglas T.
- Wei, Kevin
- Raychaudhuri, Soumya
- Korsunsky, Ilya
- Brenner, Michael B.
- Coles, Mark
- Sansom, Stephen N.
- Filer, Andrew
- Buckley, Christopher D.
- Venue
- Nature
- Published
- 2019-05-29
- Volume
- 570
- Issue
- 7760
- Pages
- 246-251
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6690841
- OpenAlex
- W2944564829
- Cited by
- 976
- References
- 28
- Citations by year
- 2026: 147 · 2025: 144 · 2024: 137 · 2023: 134 · 2022: 128 · 2021: 153 · 2020: 94 · 2019: 36
- FWCI
- 78.26
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-12-12)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (WT104551MA)
- Kennedy Trust for Rheumatology Research (KENN161701, KENN161703)
- National Institute for Health and Care Research (bircrf-2012-1, NF-SI-0617-10128, CL-2018-09-001)
- Academy of Medical Sciences (SGL021\1029)
- Versus Arthritis (19791, 21743, 20015, 14476, 19899, 18547, 21236)
- National Institutes of Health (5r01ar063759-07)
- Medical Research Council (MR/S025308/1, MR/N026977/1)
- National Heart, Lung, and Blood Institute (R01HL134375)
- National Human Genome Research Institute (U01HG009379)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR067677, R01-AR063759)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- arthritis, fibroblast activation protein, CD90, synovial lining, bone erosion, cartilage damage, joint inflammation, tissue damage, adoptive transfer, immune-mediated inflammatory diseases
- MeSH terms
- RNA-Seq, Fibroblast Activation Protein Alpha, Animals, Arthritis, Rheumatoid, Bone and Bones, Female, Fibroblasts, Humans, Inflammation, Joints, Male, Membrane Proteins, Endopeptidases, Serine Endopeptidases, Synovial Membrane, Gelatinases, Thy-1 Antigens, Mice, Single-Cell Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
