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Distinct fibroblast subsets drive inflammation and damage in arthritis
Open accessAbstract
The identification of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (IMIDs)1,2. However, it remains unclear whether fibroblast subclasses with non-overlapping functions also exist and are responsible for the wide variety of tissue-driven processes observed in IMIDs, such as inflammation and damage 3-5. Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis. We show that deletion of fibroblast activation protein-α (FAPα)+ fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis. Single-cell transcriptional analysis identified two distinct fibroblast subsets within the FAPα+ population: FAPα+THY1+ immune effector fibroblasts located in the synovial sub-lining, and FAPα+THY1- destructive fibroblasts restricted to the synovial lining layer. When adoptively transferred into the joint, FAPα+THY1- fibroblasts selectively mediate bone and cartilage damage with little effect on inflammation, whereas transfer of FAPα+ THY1+ fibroblasts resulted in a more severe and persistent inflammatory arthritis, with minimal effect on bone and cartilage. Our findings describing anatomically discrete, functionally distinct fibroblast subsets with non-overlapping functions have important implications for cell-based therapies aimed at modulating inflammation and tissue damage.
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“While single-cell sequencing indicates common traits are preserved49–51, it will become increasingly pressing to define common and specific effects of CAFs.”
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“Overwhelming evidence now points to a degree of specialization among CAFs, which may reflect the increasingly appreciated specialization of normal fibroblasts19,50.”
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“Recent studies have implicated a range of mesenchymal progenitor cells (MPs) in the initiation and propagation of fibrosis28–30.”
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27584 · Cited by 9,631
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
Street, K., Risso, D., Fletcher, R. B., Das, D., Ngai, J., Yosef, N., Purdom, E., & Dudoit, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4772-0 · Cited by 3,159
Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372
Self-citationGAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Tirosh, I., Venteicher, A. S., Hebert, C. M., Escalante, L. E., Patel, A. P., Yizhak, K., Fisher, J. M., Rodman, C., Mount, C., Filbin, M. G., et al. (2016) · Nature · doi:10.1038/nature20123 · Cited by 1,245
Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis
Krenn, V., Morawietz, L., Burmester, G. R., Kinne, R. W., Müeller-Ladner, U., Müller, B., & Häupl, T. (2006) · Histopathology · doi:10.1111/j.1365-2559.2006.02508.x · Cited by 844
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Ye, X., Ren, D., Chen, Q., Shen, J., Wang, B., Wu, S., & Zhang, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1556359 · Cited by 23
Zhao, F., Hu, Z., Li, G., Liu, M., Huang, Q., Ai, K., & Cai, X. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.04.026 · Cited by 26
Laouteouet, D., Bortolotti, O., Marinèche, L., Hannemann, N., Chambon, M., Glasson, Y., Dumé, A., Lima, J. D., Fournial, M., Touchet, D., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43299 · Cited by 20
Shimizu, K., Kikuta, J., Ohta, Y., Uchida, Y., Miyamoto, Y., Morimoto, A., Yari, S., Sato, T., Kamakura, T., Oshima, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40094-3 · Cited by 18
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Zhu, X., Lü, H., Jia, H., Wei, X., Xue, J., Li, W., Zhang, J., Wang, Y., Yan, J., Sun, H., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06300-0 · Cited by 17
ER O-glycosylation in synovial fibroblasts drives cartilage degradation
Tran, L. S., Chia, J., Guezennec, X. L., Tham, K. M., Nguyen, A. T., Sandrin, V., Chen, W. C., Leng, T. T., Sechachalam, S., Leong, K. P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57401-9 · Cited by 17
Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans
Torregrossa, M., Davies, L. C., Machens, H., Simon, J. C., Franz, S., & Rinkevich, Y. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01638-5 · Cited by 19
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Iwata, K., Mikami, Y., Kato, M., Yahagi, N., & Kanai∥, T. (2021) · Inflammation and Regeneration · doi:10.1186/s41232-021-00174-7 · Cited by 20
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Zhang, Y., Liu, K., Cheng, J., Zhou, C., Zhang, M., & Yuan, F. (2022) · Experimental Dermatology · doi:10.1111/exd.14613 · Cited by 17
Zhao, P., Ma, G., & Ma, L. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03700-0 · Cited by 17
Raggi, F., Bartolucci, M., Cangelosi, D., Rossi, C., Pelassa, S., Trincianti, C., Petretto, A., Filocamo, G., Civino, A., Eva, A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1134747 · Cited by 17
Zhao, J., Feng, Y., Liu, X., Li, H., Guo, H., Jin, K., & Long, X. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18172 · Cited by 17
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Kim, K., Lee, K.-G., Lee, S., Hong, B., Yun, H., Park, Y., Yoo, S., & Kim, W. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01188-0 · Cited by 17
Barrat, F. J., & Lu, T. T. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000659 · Cited by 17
Takeuchi, T., Tanaka, Y., Erdman, J., Kaneko, Y., Saitō, M., Higashitani, C., Smulders, R. A., & Lademacher, C. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02336-3 · Cited by 17
Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?
Brondello, J., Djouad, F., & Jørgensen, C. (2019) · Cells · doi:10.3390/cells8101257 · Cited by 17
Jariyasakulroj, S., Shu, Y., Lin, Z., Chen, J., Chang, Q., Ko, P.-F., & Chen, J.-F. (2025) · JCI Insight · doi:10.1172/jci.insight.184379 · Cited by 20
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Rao, D. A. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01291-0 · Cited by 19
Hu, Y., Chen, W., Lan, S., Ming, C., Xu, D., Li, H., Xu, H., Shi, D., Liu, W., Dai, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66202-z · Cited by 18
Cai, M., Ni, W., Han, L., Chen, W., & Peng, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.626342 · Cited by 16
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Cai, S., Hu, Z., Chen, Y., Zhong, J., & Dong, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940581 · Cited by 16
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Frommer, M. L., Langridge, B., Awad, L., Jasionowska, S., Denton, C. P., Abraham, D., Abu‐Hanna, J., & Butler, P. E. M. (2023) · Cells · doi:10.3390/cells12131784 · Cited by 16
Abebayehu, D., Pfaff, B. N., Bingham, G. C., Miller, A. E., Kibet, M., Ghatti, S., Griffin, D. R., & Barker, T. H. (2024) · Science Advances · doi:10.1126/sciadv.adf2675 · Cited by 18
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Su, Y., Wu, Z., Liu, Y., Liu, X., Kang, J., Jia, J., & Zhang, L. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114237 · Cited by 16
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Yang, F., Lu, C., Pan, Q., Zhang, R., Yang, M., Wang, Q., Li, M., Zeng, X., Luo, Y., & Leng, X. (2024) · Lara D. Veeken · doi:10.1093/rheumatology/keae577 · Cited by 16
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Takayanagi, H. (2020) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.96.013 · Cited by 19
Tsuchiya, H., & Fujio, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179534 · Cited by 16
Liu, L., Chen, H., Jiang, T., & He, D. (2021) · Modern Rheumatology · doi:10.1093/mr/roab108 · Cited by 16
Avouac, J., Kay, J., & Choy, E. (2025) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2025.152740 · Cited by 18
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Zhou, Y., Hou, Y., Yin, C., Gai, Y., Lan, X., Qin, C., & Xia, X. (2025) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000006175 · Cited by 15
Raimondo, M. G., Mohammadian, H., Angeli, M. R., Alivernini, S., Fedorchenko, V., Huang, K., Demmler, R., Rhein, P., Xu, C., Li, Y.-N., et al. (2026) · Nature Immunology · doi:10.1038/s41590-025-02351-z · Cited by 18
Self-citationFibroblasts as regulators of lung immunity, repair and fibrosis
Bell, P. T., & Belz, G. T. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01268-4 · Cited by 19
Huang, R., Jin, M., Liu, Y., Lu, Y., Zhang, M., Yan, P., Xian, S., Wang, S., Zhang, H., Zhang, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098977 · Cited by 15
Crowe, L. A. N., Akbar, M., de Vos, R., Kirwan, P., Kjær, M., Pedret, C., McInnes, I. B., Siebert, S., & Millar, N. L. (2023) · The Lancet Rheumatology · doi:10.1016/s2665-9913(23)00074-7 · Cited by 15
Paladines, N., Dawson, S., Ryan, W., Serrano-Lopez, R., Messer, R. L. W., Huo, Y., Cutler, C. W., Ramos‐Junior, E. S., & Morandini, A. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148216 · Cited by 15
Fang, Y., Huang, W., Zhu, X., Wang, X., Wu, X., Wang, H., Hong, W., Yan, S., Zhang, L., Deng, Y., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42795 · Cited by 15
Xu, S., Jiemy, W. F., Boots, A. M. H., Arends, S., van Sleen, Y., Nienhuis, P. H., van der Geest, K. S. M., Heeringa, P., Brouwer, E., & Sandovici, M. (2024) · Arthritis Care & Research · doi:10.1002/acr.25354 · Cited by 15
Rouse, J. R., Danner, R., Wahhab, A., Pereckas, M., Nguyen, C. P., McClune, M. E., Steere, A. C., Strle, K., Jutras, B. L., & Lochhead, R. B. (2024) · ACR Open Rheumatology · doi:10.1002/acr2.11710 · Cited by 15
Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets
Li, J., Dang, Y.-M., Liu, M., Gao, L., & Lin, H. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.102297 · Cited by 15
Two types of fibroblast drive arthritis
Wynn, T. A. (2019) · Nature · doi:10.1038/d41586-019-01594-9 · Cited by 15
Fibroblast cells reveal their ancestry
Buckley, C. D. (2021) · Nature · doi:10.1038/d41586-021-01204-7 · Cited by 15
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Anchang, C. G., Xu, C., Raimondo, M. G., Atreya, R. N., Maier, A., Schett, G. A., Zaburdaev, V., Rauber, S., & Ramming, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147506 · Cited by 15
Shen, C., Kuang, Y., Xu, S., Li, R., Wang, J., Zou, Y., Wang, C., Xu, S., Liang, L., Lin, C., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108273 · Cited by 15
Wen, Y., Zhang, M., Yao, Y., Gao, Y., Zhang, X., Lin, Y., & Cai, X. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.05.063 · Cited by 15
Wang, Y., Li, Y., Han, L., Wang, J., Zhang, C., Qi, E., Zhang, D., Zhang, X., Huan, Y., & Tian, J. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05537-w · Cited by 15
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Buckley, C. D. (2019) · Nature · doi:10.1038/d41586-019-02340-x · Cited by 15
Self-citationSchmidkonz, C., Kuwert, T., Götz, T., Ramming, A., & Atzinger, A. (2024) · Skeletal Radiology · doi:10.1007/s00256-024-04834-w · Cited by 14
Nieboga, E., Schuster, A., Drapala, D. M., Melnykova, M., Gut, A., Lipska, W., Kwitniewski, M., Migaczewski, M., Cześnikiewicz‐Guzik, M., Kaczmarzyk, T., et al. (2025) · mBio · doi:10.1128/mbio.00046-25 · Cited by 14
CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis
Sun, H. X., Lin, X., Liu, F., Zhang, Y., Ma, J., Huang, Z., Huang, J., Yao, L., Zhang, M., Chen, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61842-7 · Cited by 14
Martin, W. N., Hyde, C., Yung, A., Taffe, R., Patel, B., Premkumar, A., Bhattaram, P., Drissi, H., & Khan, N. M. (2025) · Cells · doi:10.3390/cells14201605 · Cited by 16
Yan, M., Su, J., & Li, Y. (2020) · BioScience Trends · doi:10.5582/bst.2020.03253 · Cited by 15
Nielsen, M. A., Køster, D., Mehta, A. Y., Stengaard‐Pedersen, K., Busson, P., Junker, P., Hørslev‐Petersen, K., Hetland, M. L., Østergaard, M., Hvid, M., et al. (2023) · Cells · doi:10.3390/cells12020327 · Cited by 14
Miki, H., & Manresa, M. C. (2023) · The Journal of Physiology · doi:10.1113/jp284620 · Cited by 15
Wan, L., Cai, Z., Schindler, F., Bahiraii, S., Brenner, M., Heiß, E. H., & Weckwerth, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1117638 · Cited by 15
Self-citationLiu, J., Li, B., Zhou, X., Liu, G., Li, C., Hu, Z., & Peng, R. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118736 · Cited by 16
Rigau, A. R., Liang, M., Devakumar, V., Neelagar, R., Matei, A., Györfi, A., Bergmann, C., Filla, T., Fedorchenko, V., Schett, G. A., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-226336 · Cited by 15
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Figueiredo, M. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1491318 · Cited by 16
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Schonfeldova, B., Zec, K., & Udalova, I. A. (2021) · Rheumatology · doi:10.1093/rheumatology/keab721 · Cited by 14
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Friščić, J., & Hoffmann, M. H. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.10.006 · Cited by 13
Cheng, J., Zhang, Y., Yang, J., Wang, Y., Xu, J., & Yuan, F. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07603-x · Cited by 16
Wang, J., Liu, C., Wang, T., Li, S., Bai, Y., Fulin, P., Wang, J., Han, J., Luo, R., Wan, X., et al. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.09.005 · Cited by 15
Li, X., Zhang, X., Liu, T., Zhang, G., Chen, D., & Lin, S. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1520400 · Cited by 13
Huang, Y., Wu, Y., Liu, H., Chen, Y., Xie, Q., & Yin, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1616618 · Cited by 17
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Pokatayev, V., Jaiswal, A., Shih, A. R., Segerstolpe, Å., Li, B., Creasey, E. A., Zhao, Y., Lin, C., Murphy, S. M., Chou, C., et al. (2026) · Nature · doi:10.1038/s41586-025-09907-x · Cited by 13
Papadopoulou, D., Roumelioti, F., Tzaferis, C., Chouvardas, P., Pedersen, A.-K., Charalampous, F., Christodoulou‐Vafeiadou, E., Ntari, L., Karagianni, N., Denis, M. C., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.165024 · Cited by 13
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Yamada, S., Nagafuchi, Y., & Fujio, K. (2023) · Immunological Medicine · doi:10.1080/25785826.2023.2235734 · Cited by 14
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He, J., Fang, B., Shan, S., & Li, Q. (2023) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2023.12.004 · Cited by 13
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Venken, K., Jarlborg, M., Stevenaert, F., Malfait, T. L. A., Vlieghe, C., Abraham, Y., Manuello, T., Decruy, T., Vanhee, S., Wils, H., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-226284 · Cited by 13
Wang, Z., Jiao, Y., Diao, W., Shi, T., Geng, Q., Wen, C., Xu, J., Deng, T., Li, X., Zhao, L., et al. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09044-3 · Cited by 13
Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis
Margraf, A., Chen, J., Christoforou, M., Claria-Ribas, P., Schneider, A. H., Cecconello, C., Bu, W., Imbert, P. R. C., Wright, T. D., Russo, S., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00227-1 · Cited by 13
Lee, M. S., Kim, S., Lee, J., Bae, Y., & Lee, S. K. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501471 · Cited by 13
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Wei, W., Li, J., Liu, X., Pan, W., Wang, M., Li, J., Yue, Y., & Hao, L. (2022) · Journal of Endodontics · doi:10.1016/j.joen.2022.07.009 · Cited by 13
Blüml, S., & Smolen, J. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00081-3 · Cited by 13
Inamo, J., Fierkens, R., Clay, M. R., Jonsson, A. H., Lin, C., Hayes, K., Rogers, N. D., Leach, H., & Yomogida, K. (2025) · JCI Insight · doi:10.1172/jci.insight.198074 · Cited by 15
Fritz, D., Inamo, J., & Zhang, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1076700 · Cited by 12
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Zhang, X.-L., Wang, X., Qian, J., Yang, W.-J., Xu, H., Xu, X.-D., & Zhang, G. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230530095305 · Cited by 12
Lin, W., Liu, Y., Zhang, S., Xu, S., Qiu, Q., Wang, C., Liu, D., Shen, C., Xu, M., Shi, M., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110502 · Cited by 12
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Self-citationZhao, S., Wang, J., Xue, M., Wu, B., Sheng, L., Wen, Y., Wang, G., Song, J., Du, D., & Xu, J. (2026) · Bone Research · doi:10.1038/s41413-025-00502-4 · Cited by 11
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Metadata
- Authors
- Croft, A. P., Campos, J., Jansen, K., Turner, J. D., Marshall, J., Attar, M., Savary, L., Wehmeyer, C., Naylor, A. J., Kemble, S., Begum, J., Dürholz, K., Perlman, H., Barone, F., McGettrick, H. M., Fearon, D. T., Wei, K., Raychaudhuri, S., Korsunsky, I., Brenner, M. B., Coles, M., Sansom, S. N., Filer, A., & Buckley, C. D.
- Affiliations
- Queen Elizabeth Hospital Birmingham (GB)
- University of Oxford (GB)
- University of Münster (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Northwestern University (US)
- Cold Spring Harbor Laboratory (US)
- Brigham and Women's Hospital (US)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Corresponding author
- Buckley, Christopher D.
- ORCID
- Croft, Adam P.
- Campos, Joana
- Jansen, Kathrin
- Turner, Jason D.
- Marshall, Jennifer
- Attar, Moustafa
- Wehmeyer, Corinna
- Naylor, Amy J.
- Kemble, Samuel
- Begum, Jenefa
- Perlman, Harris
- Barone, Francesca
- McGettrick, Helen M.
- Fearon, Douglas T.
- Wei, Kevin
- Raychaudhuri, Soumya
- Korsunsky, Ilya
- Brenner, Michael B.
- Coles, Mark
- Sansom, Stephen N.
- Filer, Andrew
- Buckley, Christopher D.
- Venue
- Nature
- Published
- 2019-05-29
- Volume
- 570
- Issue
- 7760
- Pages
- 246-251
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6690841
- OpenAlex
- W2944564829
- Cited by
- 976
- References
- 28
- Citations by year
- 2026: 147 · 2025: 144 · 2024: 137 · 2023: 134 · 2022: 128 · 2021: 153 · 2020: 94 · 2019: 36
- FWCI
- 78.26
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-12-12)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (WT104551MA)
- Kennedy Trust for Rheumatology Research (KENN161701, KENN161703)
- National Institute for Health and Care Research (bircrf-2012-1, NF-SI-0617-10128, CL-2018-09-001)
- Academy of Medical Sciences (SGL021\1029)
- Versus Arthritis (19791, 21743, 20015, 14476, 19899, 18547, 21236)
- National Institutes of Health (5r01ar063759-07)
- Medical Research Council (MR/S025308/1, MR/N026977/1)
- National Heart, Lung, and Blood Institute (R01HL134375)
- National Human Genome Research Institute (U01HG009379)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR067677, R01-AR063759)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- arthritis, fibroblast activation protein, CD90, synovial lining, bone erosion, cartilage damage, joint inflammation, tissue damage, adoptive transfer, immune-mediated inflammatory diseases
- MeSH terms
- RNA-Seq, Fibroblast Activation Protein Alpha, Animals, Arthritis, Rheumatoid, Bone and Bones, Female, Fibroblasts, Humans, Inflammation, Joints, Male, Membrane Proteins, Endopeptidases, Serine Endopeptidases, Synovial Membrane, Gelatinases, Thy-1 Antigens, Mice, Single-Cell Analysis
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