Cited by 131Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Temporal plasticity of apical progenitors in the developing mouse neocortex

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Oberst, Polina, Fièvre, Sabine, Baumann, Natalia, Concetti, Cristina, Bartolini, Giorgia, Jabaudon, Denis·2019·Nature

Abstract

The diverse subtypes of excitatory neurons that populate the neocortex are born from apical progenitors located in the ventricular zone. During corticogenesis, apical progenitors sequentially generate deep-layer neurons followed by superficial-layer neurons directly or via the generation of intermediate progenitors. Whether neurogenic fate progression necessarily implies fate restriction in single progenitor types is unknown. Here we specifically isolated apical progenitors and intermediate progenitors, and fate-mapped their respective neuronal progeny following heterochronic transplantation into younger embryos. We find that apical progenitors are temporally plastic and can re-enter past molecular, electrophysiological and neurogenic states when exposed to an earlier-stage environment by sensing dynamic changes in extracellular Wnt. By contrast, intermediate progenitors are committed progenitors that lack such retrograde fate plasticity. These findings identify a diversity in the temporal plasticity of neocortical progenitors, revealing that some subtypes of cells can be untethered from their normal temporal progression to re-enter past developmental states.

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Crossref · 10.1038/s41586-019-1515-6

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  • The number of neurons increases rapidly and peaks between week 13 and 16 of gestation in humans, specifically in the dorsal telencephalon.

    “By the time the apical radial glial progenitors within the prefrontal subdomains start dividing asymmetrically, the number of neurons will increase rapidly and peaks between week 13 and 16 of gestation in human (E10-E15 rodents/E43-E50 primates), specifically in the dorsal telencephalon [44–47].”

    From Development of prefrontal cortex (2022) · cites this paper as [45]

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Authors
Oberst, P., Fièvre, S., Baumann, N., Concetti, C., Bartolini, G., & Jabaudon, D.
Affiliations
University of Geneva (CH)
Corresponding author
Jabaudon, Denis
Venue
Nature
Published
2019-08-28
Volume
573
Issue
7774
Pages
370-374
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2970999020
Cited by
121
References
43
Citations by year
2026: 12 · 2025: 10 · 2024: 10 · 2023: 15 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 9
FWCI
6.94
Type
journal article
Language
en
Open access
Locations
  • Nature (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Université de Genève
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
apical progenitors, intermediate progenitor cells, neocortex development, cortical development, temporal plasticity, Wnt signaling, ventricular zone, neuronal lineage tracing
MeSH terms
Cell Plasticity, Animals, Cells, Cultured, Embryo, Mammalian, Neurons, Stem Cells, Time Factors, Neocortex, Mice, Neurogenesis

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