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Temporal plasticity of apical progenitors in the developing mouse neocortex
Open accessAbstract
The diverse subtypes of excitatory neurons that populate the neocortex are born from apical progenitors located in the ventricular zone. During corticogenesis, apical progenitors sequentially generate deep-layer neurons followed by superficial-layer neurons directly or via the generation of intermediate progenitors. Whether neurogenic fate progression necessarily implies fate restriction in single progenitor types is unknown. Here we specifically isolated apical progenitors and intermediate progenitors, and fate-mapped their respective neuronal progeny following heterochronic transplantation into younger embryos. We find that apical progenitors are temporally plastic and can re-enter past molecular, electrophysiological and neurogenic states when exposed to an earlier-stage environment by sensing dynamic changes in extracellular Wnt. By contrast, intermediate progenitors are committed progenitors that lack such retrograde fate plasticity. These findings identify a diversity in the temporal plasticity of neocortical progenitors, revealing that some subtypes of cells can be untethered from their normal temporal progression to re-enter past developmental states.
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“By the time the apical radial glial progenitors within the prefrontal subdomains start dividing asymmetrically, the number of neurons will increase rapidly and peaks between week 13 and 16 of gestation in human (E10-E15 rodents/E43-E50 primates), specifically in the dorsal telencephalon [44–47].”
From Development of prefrontal cortex (2022) · cites this paper as [45]
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Metadata
- Authors
- Oberst, P., Fièvre, S., Baumann, N., Concetti, C., Bartolini, G., & Jabaudon, D.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Jabaudon, Denis
- ORCID
- Venue
- Nature
- Published
- 2019-08-28
- Volume
- 573
- Issue
- 7774
- Pages
- 370-374
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2970999020
- Cited by
- 121
- References
- 43
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 10 · 2023: 15 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 9
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-04-15)
- Open access
- green
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Genève
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- apical progenitors, intermediate progenitor cells, neocortex development, cortical development, temporal plasticity, Wnt signaling, ventricular zone, neuronal lineage tracing
- MeSH terms
- Cell Plasticity, Animals, Cells, Cultured, Embryo, Mammalian, Neurons, Stem Cells, Time Factors, Neocortex, Mice, Neurogenesis
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